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Vaginal Microbiome Shifts in Cervical Carcinogenesis Stages Open

Wen-Hsuan W. Lin, Tsai‐Yin Wei, Chia-Sui Weng, Chao-Chih Wu, Yu-Chia Hsiao , et al. · 2025

Persistent infection with high-risk human papillomavirus (HPV) is a critical factor in cervical dysplasia and cancer. Recent studies have linked vaginal microbiota composition to cervical neoplastic progression. We analyzed 109 vaginal swa…

An exploratory analysis of driver gene alterations and their potential prognostic relevance in endometrial cancer with POLE exonuclease domain mutations Open

Tsai‐Yin Wei, Chao-Chih Wu, Yun-Ting Hsu, Wen-Hsuan W. Lin, Li‐Chu Tsai , et al. · 2025

This exploratory study finds that POLE exonuclease domain mutations are associated with distinct mutational patterns that vary between tumor suppressor genes and oncogenes. These observations provide hypothesis-generating insights into pot…

Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia Open

Kalay Bertulfo, Pablo Pérez‐Durán, Hannah I. Miller, Cindy Ma, Alberto Ambesi‐Impiombato , et al. · 2025

Gamma Secretase Inhibitors (GSIs) effectively block oncogenic Notch homolog-1 (NOTCH1), a characteristic feature of T cell acute lymphoblastic leukemias (T-ALL). However, their clinical application has been stalled by the induction of seve…

Different Managements of the same disease- Malignant Ovarian Germ Cell Tumor Treated by Pediatric or Gynecologic Oncologists Open

Wen-Hsuan W. Lin, Ting‐Chi Yeh, Hsi‐Che Liu, Jen‐Yin Hou, Chih‐Long Chang · 2023

Objective The surgical approach, staging system, including the criteria for adjuvant chemotherapy and even the chemotherapeutic regimens between Pediatric and Gynecologic oncologists are different for a same disease- malignant ovarian germ…

Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells Open

Peter H. Wang, Robert S. Washburn, Dylan L. Mariuzza, Wen-Hsuan W. Lin, Amanda L. Gill , et al. · 2023

The ability of activated progenitor T cells to self-renew while producing differentiated effector cell descendants may underlie immunological memory and persistent responses to ongoing infection. The nature of stem-like T cells responding …

Ultrasonic presentation variation of patients with pathological evidence of endometrial atrophy Open

Wen-Hsuan W. Lin, Chih-Long Chang · 2023

In the patients with endometrial atrophy, the endometrial thickness may be variable. There were only 20.8% of patients with endometrial thickness less than 4 mm in our study. Before endometrial sampling, comprehensive evaluation of the mor…

Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open

Clara Reglero, Chelsea L. Dieck, Arie Zask, F. Forouhar, Anouchka P. Laurent , et al. · 2023

Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia

Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open

Clara Reglero, Chelsea L. Dieck, Arie Zask, F. Forouhar, Anouchka P. Laurent , et al. · 2023

Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia

Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open

Clara Reglero, Chelsea L. Dieck, Arie Zask, F. Forouhar, Anouchka P. Laurent , et al. · 2023

Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia

Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open

Clara Reglero, Chelsea L. Dieck, Arie Zask, F. Forouhar, Anouchka P. Laurent , et al. · 2023

Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia

Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open

Clara Reglero, Chelsea L. Dieck, Arie Zask, F. Forouhar, Anouchka P. Laurent , et al. · 2023

Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia

Data from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open

Clara Reglero, Chelsea L. Dieck, Arie Zask, F. Forouhar, Anouchka P. Laurent , et al. · 2023

Low-intensity maintenance therapy with 6-mercaptopurine (6-MP) limits the occurrence of acute lymphoblastic leukemia (ALL) relapse and is central to the success of multiagent chemotherapy protocols. Activating mutations in the 5′-nucleotid…

Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open

Clara Reglero, Chelsea L. Dieck, Arie Zask, F. Forouhar, Anouchka P. Laurent , et al. · 2023

Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia

Data from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open

Clara Reglero, Chelsea L. Dieck, Arie Zask, F. Forouhar, Anouchka P. Laurent , et al. · 2023

Low-intensity maintenance therapy with 6-mercaptopurine (6-MP) limits the occurrence of acute lymphoblastic leukemia (ALL) relapse and is central to the success of multiagent chemotherapy protocols. Activating mutations in the 5′-nucleotid…

The relationship between vaginal microbiota and cervical carcinogenesis process Open

Wen-Hsuan W. Lin, Chao-Chih Wu, Yu-Chia Hsiao, Chih‐Long Chang · 2023

Objective: To develop a novel machine learning-based preoperative prediction model for pelvic lymph node metastasis (PLNM) in early-stage cervical cancer by combining the clinical findings and preoperative computerized tomography (CT) of t…

A comparison of HPV detection between urine and cervical swab sample Open

Wen-Hsuan W. Lin, Chia‐Sui Weng, Yeou-Lih Wang, Chih‐Long Chang · 2023

Proceedings of the 65th Annual Meeting of Japan Society of Gynecologic Oncology Open

Joo-Hyun Nam, Wen-Hsuan W. Lin, Chia‐Sui Weng, Yeou-Lih Wang, Chih-Long Chang , et al. · 2023

Objective: Human papilloma virus (HPV) infection is the leading cause of cervical cancer.Cervical cancer screening includes Pap test, HPV test, or both; however, uncomfortable sampling process lead to low prevalence rate of screening.There…

Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open

Clara Reglero, Chelsea L. Dieck, Arie Zask, F. Forouhar, Anouchka P. Laurent , et al. · 2022

Low-intensity maintenance therapy with 6-mercaptopurine (6-MP) limits the occurrence of acute lymphoblastic leukemia (ALL) relapse and is central to the success of multiagent chemotherapy protocols. Activating mutations in the 5′-nucleotid…

Structural analyses of the plant PRT6-UBR box in the Cys-Arg/N-degron pathway and insights into the plant submergence response Open

Leehyeon Kim, Chih-Cheng Lin, Ting-Jhen Lin, Yan-Cih Cao, Minchun Chen , et al. · 2022

The submergence response in higher plants is highly dependent on the protein stability of group VII ethylene response factors, which are primarily degraded through the oxygen-dependent Cys-Arg branch of the N-degron pathway of targeted pro…

Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma Open

José R. Cortés, Ioan Filip, Robert Alberó, Juan Ángel Patiño-Galindo, S. Aidan Quinn , et al. · 2022

Inflammation and Mortality in COVID-19 Hospitalized Patients With and Without Type 2 Diabetes Open

Jia Guo, Wen-Hsuan W. Lin, Jason Zucker, Renu Nandakumar, Anne‐Catrin Uhlemann , et al. · 2022

Context COVID-19 mortality is increased in patients with diabetes. A common hypothesis is that the relationship of inflammation with COVID-19 mortality differs by diabetes status. Objective The aim of this study was to determine the relati…

Supplemental data for Submission to JCEM: "Inflammation and mortality in COVID-19 hospitalized patients with and without type 2 diabetes" Open

Jia Guo, Wen-Hsuan W. Lin, Jason Zucker, Renu Nandakuamr, Anne‐Catrin Uhlemann , et al. · 2021

Supplemental tables and figures for an analysis of the association of inflammation with mortality among COVID-19 hospitalized patients with and without diabetes.

Incidental intra‐adrenal splenule Open

Wen-Hsuan W. Lin, John P. Crapanzano, Bachir Alobeid · 2021

Splenules can be found in the adrenals and should be considered in the differential diagnosis of adrenal incidentalomas.

A randomized double-blind controlled trial of convalescent plasma in adults with severe COVID-19 Open

Max R. O’Donnell, Beatriz Grinsztejn, Matthew J. Cummings, Jessica Justman, Matthew R. Lamb , et al. · 2021

BACKGROUNDAlthough convalescent plasma has been widely used to treat severe coronavirus disease 2019 (COVID-19), data from randomized controlled trials that support its efficacy are limited.METHODSWe conducted a randomized, double-blind, c…

Approaching the Interpretation of Discordances in SARS-CoV-2 Testing Open

Sandeep N. Wontakal, Robert H. Bortz, Wen-Hsuan W. Lin, Inessa Gendlina, Amy S. Fox , et al. · 2021

The coronavirus disease 2019 pandemic has upended life throughout the globe. Appropriate emphasis has been placed on developing effective therapies and vaccines to curb the pandemic. While awaiting such countermeasures, mitigation efforts …

A randomized, double-blind, controlled trial of convalescent plasma in adults with severe COVID-19 Open

Max R. O’Donnell, Beatriz Grinsztejn, Matthew J. Cummings, Jessica Justman, Matthew R. Lamb , et al. · 2021

Background Although convalescent plasma has been widely used to treat severe coronavirus disease 2019 (COVID-19), data from randomized controlled trials that support its efficacy are limited. Objective To evaluate the clinical efficacy and…

Primary differentiated respiratory epithelial cells respond to apical measles virus infection by shedding multinucleated giant cells Open

Wen-Hsuan W. Lin, Annie J. Tsay, Erin N. Lalime, Andrew Pekosz, Diane E. Griffin · 2021

Significance Measles virus (MeV) is highly infectious by the respiratory route, but respiratory epithelial cells are thought to be resistant to infection through the exposed apical surface and to require infection through the basolateral s…

FYN–TRAF3IP2 induces NF-κB signaling-driven peripheral T-cell lymphoma Open

Christine S. Moon, Clara Reglero, José R. Cortés, S. Aidan Quinn, Silvia Álvarez , et al. · 2021

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum Open

Stuart P. Weisberg, Thomas J. Connors, Yun Zhu, Matthew R. Baldwin, Wen-Hsuan W. Lin , et al. · 2020

Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19 Open

Stuart P. Weisberg, Thomas J. Connors, Yun Zhu, Matthew R. Baldwin, Wen-Hsuan W. Lin , et al. · 2020

Clinical manifestations of COVID-19 caused by the novel coronavirus SARS-CoV-2 are associated with age. While children are largely spared from severe respiratory disease, they can present with a SARS-CoV-2-associated multisystem inflammato…

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