Wenjie Yu
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View article: Porcine airway tissue explant culture at a hydrogel-air interface to model submucosal glands in cystic fibrosis progression and therapy
Porcine airway tissue explant culture at a hydrogel-air interface to model submucosal glands in cystic fibrosis progression and therapy Open
Submucosal glands (SMGs) are critical for airway health; however, replicating their complex structure and function outside the body remains challenging. Here, we establish a method of airway tissue explant culture at a hydrogel-air interfa…
View article: Local large arterial perivascular adipose tissue metabolic and anatomical features are associated with hypertensive clinical outcomes: a PET/CT-based study
Local large arterial perivascular adipose tissue metabolic and anatomical features are associated with hypertensive clinical outcomes: a PET/CT-based study Open
This study confirms the close relationship between the anatomical and metabolic characteristics of localized large arterial PVAT and hypertensive outcomes, and reveals its spatial enrichment pattern during disease progression.
View article: Nonlinear association between serum iron levels and moderate-to-severe uremic pruritus in peritoneal dialysis patients: a cross-sectional study
Nonlinear association between serum iron levels and moderate-to-severe uremic pruritus in peritoneal dialysis patients: a cross-sectional study Open
Purpose To evaluate the occurrence of uremic pruritus among peritoneal dialysis (PD) patients and explore its correlation with serum iron levels. Methods A cross-sectional study was carried out on 189 PD patients at a single center in Chin…
View article: Functions of RNA N6-Methyladenosine Demethylases in Plant Development and Stress Responses
Functions of RNA N6-Methyladenosine Demethylases in Plant Development and Stress Responses Open
N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, regulates gene expression by modulating mRNA metabolism. Demethylases (“erasers”) specifically remove these m6A marks. In mammals, FTO and ALKBH5 (ALKBH …
View article: Physicochemical properties, chemical composition, and against Klebsiella pneumoniae mechanism of Scrophularia ningpoensis honey
Physicochemical properties, chemical composition, and against Klebsiella pneumoniae mechanism of Scrophularia ningpoensis honey Open
View article: Oxidized Phospholipids Aggravate Hepatic Ischemia/Reperfusion Injury by Promoting Macrophage M1 Polarization via Regulating the Wnt/β-Catenin/Autophagy Axis
Oxidized Phospholipids Aggravate Hepatic Ischemia/Reperfusion Injury by Promoting Macrophage M1 Polarization via Regulating the Wnt/β-Catenin/Autophagy Axis Open
Hepatic ischemia-reperfusion injury (IRI) remains an unavoidable consequence of partial hepatic resection and liver transplantation. Oxidative stress damages cellular lipid membranes, causing the formation of oxidized phospholipids (OxPLs)…
View article: Knockdown of TRIM22 regulates the expression of NF-κB/NLRP3 and alleviates inflammation and renal injury in mice with lupus nephritis
Knockdown of TRIM22 regulates the expression of NF-κB/NLRP3 and alleviates inflammation and renal injury in mice with lupus nephritis Open
Lupus nephritis (LN) is a common and clinically challenging complication of the systemic lupus erythematosus (SLE), but effective treatments remain imperative. Tripartite Motif Containing 22 (TRIM22) is a protein involved in various cellul…
View article: Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis
Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis Open
View article: Xenia Effect on Nutritional and Flavor Components of ‘Jingbaili’ Pear
Xenia Effect on Nutritional and Flavor Components of ‘Jingbaili’ Pear Open
The ‘Jingbaili’ pear is a national geographical indication product of China, featuring an oblate shape and being rich in nutrients. But the quality of the ‘Jingbaili’ pear is unstable. Xenia can cause changes in the quality of pears, but t…
View article: Electric Cardiac Axis Deflection on Limb Leads Combined with Precordial Leads Improves the Differentiating Accuracy of Idiopathic Outflow Tract Ventricular Arrhythmias Origin: Retrospective Case Analysis
Electric Cardiac Axis Deflection on Limb Leads Combined with Precordial Leads Improves the Differentiating Accuracy of Idiopathic Outflow Tract Ventricular Arrhythmias Origin: Retrospective Case Analysis Open
View article: eEF2K alleviates doxorubicin-induced cardiotoxicity by inhibiting GSK3β and improving autophagy dysfunction
eEF2K alleviates doxorubicin-induced cardiotoxicity by inhibiting GSK3β and improving autophagy dysfunction Open
View article: Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis
Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis Open
Background Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasis. At the time of diagnosis, 20–30% of CRC patients already present with liver metastases. Colorectal live…
View article: USP22 inhibits microglial M1 polarization by regulating the PU.1/NLRP3 inflammasome pathway
USP22 inhibits microglial M1 polarization by regulating the PU.1/NLRP3 inflammasome pathway Open
USP22 inhibits the M1 polarization of BV-2 mouse microglia. The PU.1/NLRP3 inflammasome pathway may be a critical regulatory pathway of USP22 in BV-2 cell polarization.
View article: SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence
SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence Open
View article: IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption
IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption Open
The airway surface liquid (ASL) plays a crucial role in lung defense mechanisms, and its composition and volume are regulated by the airway epithelium. The cystic fibrosis transmembrane conductance regulator (CFTR) is abundantly expressed …
View article: SYK Promotes the Formation of Neutrophil Extracellular Traps by Inducing PKM2 Nuclear Translocation and Promoting STAT3 Phosphorylation to Exacerbate Hepatic Ischemia-Reperfusion Injury and Tumor Recurrence
SYK Promotes the Formation of Neutrophil Extracellular Traps by Inducing PKM2 Nuclear Translocation and Promoting STAT3 Phosphorylation to Exacerbate Hepatic Ischemia-Reperfusion Injury and Tumor Recurrence Open
Background At present, hepatic ischemia-reperfusion injury (IRI) is an important complication of partial hepatectomy and liver transplantation, and it is an important cause of poor prognosis. Spleen tyrosine kinase(SYK) plays an important …
View article: Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation
Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation Open
How the dorsal-ventral axis of the vertebrate jaw, particularly the position of tooth initiation site, is established remains a critical and unresolved question. Tooth development starts with the formation of the dental lamina, a localized…
View article: Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs
Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs Open
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), a multiorgan disease that is characterized by diverse metabolic defects. However, other than specific CFTR mutations, the factors …
View article: Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage
Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage Open
Apical cilia on epithelial cells defend the lung by propelling pathogens and particulates out of the respiratory airways. Ciliated cells produce ATP that powers cilia beating by densely grouping mitochondria just beneath the apical membran…
View article: Genetic variations at BBX24 and MYB110a loci regulated anthocyanin accumulation in pear bud sports
Genetic variations at BBX24 and MYB110a loci regulated anthocyanin accumulation in pear bud sports Open
Genetic variation contributes to the phenotypic diversity of plants. Most red pear cultivars that accumulate anthocyanins originated from somatic variation and are termed as bud sports. ‘Hongzaosu’ is a bud sport derived from the green pea…
View article: 205 Airway submucosal gland cell biology, physiology, and pathophysiology in cystic fibrosis
205 Airway submucosal gland cell biology, physiology, and pathophysiology in cystic fibrosis Open
View article: Guiding ablation strategies for ventricular tachycardia in patients with structural heart disease by analyzing links and conversion patterns of traceable abnormal late potential zone
Guiding ablation strategies for ventricular tachycardia in patients with structural heart disease by analyzing links and conversion patterns of traceable abnormal late potential zone Open
Background Substrate‐based ablation can treat uninducible or hemodynamically instability scar‐related ventricular tachycardia (VT). However, whether a correlation exists between the critical VT isthmus and late activation zone (LAZ) during…
View article: 6-Gingerol Improves In Vitro Porcine Embryo Development by Reducing Oxidative Stress
6-Gingerol Improves In Vitro Porcine Embryo Development by Reducing Oxidative Stress Open
6-Gingerol, the main active ingredient in ginger, exhibits a variety of biological activities, such as antioxidant, anti-inflammatory, and anticancer activities, and can affect cell development. However, the effects of 6-gingerol on mammal…
View article: Myeloid Trem2 Dynamically Regulates the Induction and Resolution of Hepatic Ischemia-Reperfusion Injury Inflammation
Myeloid Trem2 Dynamically Regulates the Induction and Resolution of Hepatic Ischemia-Reperfusion Injury Inflammation Open
Trem2, a transmembrane protein that is simultaneously expressed in both bone marrow-derived and embryonic-derived liver-resident macrophages, plays a complex role in liver inflammation. The unique role of myeloid Trem2 in hepatic ischemia-…
View article: The ethylene-responsive transcription factor PpERF9 represses <i>PpRAP2.4</i> and <i>PpMYB114</i> via histone deacetylation to inhibit anthocyanin biosynthesis in pear
The ethylene-responsive transcription factor PpERF9 represses <i>PpRAP2.4</i> and <i>PpMYB114</i> via histone deacetylation to inhibit anthocyanin biosynthesis in pear Open
Ethylene induces anthocyanin biosynthesis in most fruits, including apple (Malus domestica) and plum (Prunus spp.). By contrast, ethylene inhibits anthocyanin biosynthesis in pear (Pyrus spp.), but the underlying molecular mechanism remain…
View article: Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice
Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice Open
Citrus honey (CH) is rich in nutrients that have a wide variety of biological functions, such as antibacterial, anti–inflammatory, and antioxidant activities, and which demonstrate therapeutic properties, such as anti–cancer and wound–heal…
View article: Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3
Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3 Open
Background Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases increases the incidence of long-term survival in patients with colorectal liver metastasis (CRLM…
View article: Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3
Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3 Open
Background Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases increases the incidence of long-term survival in patients with colorectal liver metastasis (CRLM…
View article: <i>TBX2</i> affects proliferation, apoptosis and cholesterol generation by regulating mitochondrial function and autophagy in bovine cumulus cell
<i>TBX2</i> affects proliferation, apoptosis and cholesterol generation by regulating mitochondrial function and autophagy in bovine cumulus cell Open
Background T‐box transcription factor 2 ( TBX2 ) is a member of T‐box gene family whose members are highly conserved in evolution and encoding genes and are involved in the regulation of developmental processes. The encoding genes play an …
View article: KRAS Affects the Lipid Composition by Regulating Mitochondrial Functions and MAPK Activation in Bovine Mammary Epithelial Cells
KRAS Affects the Lipid Composition by Regulating Mitochondrial Functions and MAPK Activation in Bovine Mammary Epithelial Cells Open
Kirsten rat sarcoma viral oncogene homolog (KRAS), or guanosine triphosphatase KRAS, is a proto-oncogene that encodes the small guanosine triphosphatase transductor protein. Previous studies have found that KRAS can promote cytokine secret…