Wenhu Li
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View article: Integrated machine learning analysis of 30 cell death patterns identifies a novel prognostic signature in glioma
Integrated machine learning analysis of 30 cell death patterns identifies a novel prognostic signature in glioma Open
Background Glioma heterogeneity and therapeutic resistance are closely linked to dysregulated programmed cell death (PCD). While individual PCD pathways have been studied, the integrated network of multi-modal PCD interactions and their cl…
View article: LLaMEA-BO: A Large Language Model Evolutionary Algorithm for Automatically Generating Bayesian Optimization Algorithms
LLaMEA-BO: A Large Language Model Evolutionary Algorithm for Automatically Generating Bayesian Optimization Algorithms Open
Bayesian optimization (BO) is a powerful class of algorithms for optimizing expensive black-box functions, but designing effective BO algorithms remains a manual, expertise-driven task. Recent advancements in Large Language Models (LLMs) h…
View article: Ultrafast preparation of dense textured ZrB <sub>2</sub>-based ceramics via heavy continuous DC Joule heating and pressing
Ultrafast preparation of dense textured ZrB <sub>2</sub>-based ceramics via heavy continuous DC Joule heating and pressing Open
The preparation of dense ZrB2-based ceramics typically requires high temperatures and long sintering time, which often result in significant grain coarsening and thus deterioration of mechanical properties. Ultrafast sintering techniques o…
View article: Robot-assisted PFNA surgery improves clinical outcomes in the treatment of unstable femoral intertrochanteric fractures in elderly patients compared with traditional PFNA surgery
Robot-assisted PFNA surgery improves clinical outcomes in the treatment of unstable femoral intertrochanteric fractures in elderly patients compared with traditional PFNA surgery Open
To assess the clinical outcomes of robot-assisted proximal femoral nail antirotation (PFNA) surgery in elderly patients with unstable femoral intertrochanteric fractures (UFIFs). 151 patients who underwent UFIF and PFNA surgery between Jan…
View article: Multifunctional NR/MXene/SiO2 Film with Core-Shell Structure for All-Weather Thermal Management and Electromagnetic Interference Shielding
Multifunctional NR/MXene/SiO2 Film with Core-Shell Structure for All-Weather Thermal Management and Electromagnetic Interference Shielding Open
View article: Multifunctional Integrated Separator Based on Electrospinning Structure Engineering for High-Stability Lithium Sulfur Batteries
Multifunctional Integrated Separator Based on Electrospinning Structure Engineering for High-Stability Lithium Sulfur Batteries Open
View article: <i>Clostridium Scindens</i> Protects Against Vancomycin‐Induced Cholestasis and Liver Fibrosis by Activating Intestinal FXR‐FGF15/19 Signaling
<i>Clostridium Scindens</i> Protects Against Vancomycin‐Induced Cholestasis and Liver Fibrosis by Activating Intestinal FXR‐FGF15/19 Signaling Open
Primary sclerosing cholangitis (PSC) is characterized by abnormal bile acid metabolites and altered gut microbiota, with no effective treatments available. Vancomycin, a glycopeptide antibiotic, has emerged as a promising candidate. Howeve…
View article: Spatial transcriptomics analysis identifies therapeutic targets in diffuse high-grade gliomas
Spatial transcriptomics analysis identifies therapeutic targets in diffuse high-grade gliomas Open
Introduction Diffuse high-grade gliomas are the most common malignant adult neuroepithelial tumors in humans and a leading cause of cancer-related death worldwide. The advancement of high throughput transcriptome sequencing technology enab…
View article: Study of Mo3NiB3 and Mo2NiB2 cermets by first-principles calculation and experiment
Study of Mo3NiB3 and Mo2NiB2 cermets by first-principles calculation and experiment Open
In this work, the mechanical properties of Mo3NiB3 and Mo2NiB2 phases in Mo-Ni-B cermets were studied. The first-principles calculation results demonstrate the thermodynamic and mechanical stability of both Mo3NiB3 and Mo2NiB2. Among them,…
View article: Development of PCR-based markers associated with powdery mildew resistance using bulked segregant analysis (BSA-seq) in melon
Development of PCR-based markers associated with powdery mildew resistance using bulked segregant analysis (BSA-seq) in melon Open
Powdery mildew (PM) is a fungus that causes disease in both the field and the greenhouse. Utilizing resistant cultivars is the most effective approach of disease management. To develop insertion-deletion (InDel) markers associated to this …
View article: Synergistic Effect of P Doping and Mo-Ni-Based Heterostructure Electrocatalyst for Overall Water Splitting
Synergistic Effect of P Doping and Mo-Ni-Based Heterostructure Electrocatalyst for Overall Water Splitting Open
Heterostructure construction and heteroatom doping are powerful strategies for enhancing the electrolytic efficiency of electrocatalysts for overall water splitting. Herein, we present a P-doped MoS2/Ni3S2 electrocatalyst on nickel foam (N…
View article: Exosomes: A new option for osteoporosis treatment
Exosomes: A new option for osteoporosis treatment Open
Osteoporosis is a systemic bone disease characterized by reduced bone mass and destruction of bone microarchitecture, leading to increased bone fragility and susceptibility to fracture. However, the pathogenesis and molecular mechanisms of…
View article: Comprehensive analysis of m6A/m5C/m1A-related gene expression, immune infiltration, and sensitivity of antineoplastic drugs in glioma
Comprehensive analysis of m6A/m5C/m1A-related gene expression, immune infiltration, and sensitivity of antineoplastic drugs in glioma Open
This research aims to develop a prognostic glioma marker based on m 6 A/m 5 C/m 1 A genes and investigate the potential role in the tumor immune microenvironment. Data for patients with glioma were downloaded from The Cancer Genome Atlas (…
View article: Long non-coding RNA Gm37494 alleviates osteoarthritis chondrocyte injury via the microRNA-181a-5p/GABRA1 axis
Long non-coding RNA Gm37494 alleviates osteoarthritis chondrocyte injury via the microRNA-181a-5p/GABRA1 axis Open
Objective This study was conducted to investigate the effect of long non-coding RNA (lncRNA) Gm37494 on osteoarthritis (OA) and its related molecular mechanism. Methods The cartilage tissues were obtained from OA patients, and an OA mouse …
View article: Synthesis and electrochemical performance of V2O5 nanosheets for supercapacitor
Synthesis and electrochemical performance of V2O5 nanosheets for supercapacitor Open
Electrode materials are the key to the electrochemical performance of supercapacitors. This study reports the electrochemical properties of V2O5 supercapacitors. V2O5 nanosheets with different morphologies were prepared by controlling the …
View article: TaNRT2.1-6B is a dual-affinity nitrate transporter contributing to nitrogen uptake in bread wheat under both nitrogen deficiency and sufficiency
TaNRT2.1-6B is a dual-affinity nitrate transporter contributing to nitrogen uptake in bread wheat under both nitrogen deficiency and sufficiency Open
View article: Enrichment of Wee1/CDC2 and NF-κB Signaling Pathway Constituents Mutually Contributes to CDDP Resistance in Human Osteosarcoma
Enrichment of Wee1/CDC2 and NF-κB Signaling Pathway Constituents Mutually Contributes to CDDP Resistance in Human Osteosarcoma Open
Purpose Osteosarcoma (OS) universally exhibits heterogeneity and cisplatin (CDDP) resistance. Although the Wee1/CDC2 and nuclear factor кB (NF-κB) pathways were reported to show abnormal activation in some tumor cells with CDDP resistance,…
View article: Application of Magnetic Resonance Diffusion Tensor Imaging in the Clinical Diagnosis of Disc Herniation after Lumbar Spine Injury
Application of Magnetic Resonance Diffusion Tensor Imaging in the Clinical Diagnosis of Disc Herniation after Lumbar Spine Injury Open
Magnetic resonance diffusion-weighted imaging (DTI) provides a unique perspective on the pathophysiological and microstructural changes during spinal cord injury, with high spatial specificity; meanwhile, NM reflects the conduction and int…
View article: Agarose-resolvable InDel markers based on whole genome re-sequencing in cucumber
Agarose-resolvable InDel markers based on whole genome re-sequencing in cucumber Open
View article: Study on microstructure and mechanical properties of W-Ni<sub>3</sub>Al alloys prepared by ball milling and two-step sintering
Study on microstructure and mechanical properties of W-Ni<sub>3</sub>Al alloys prepared by ball milling and two-step sintering Open
In this paper, W-Ni 3 Al alloys with the different Ni 3 Al contents were prepared via ball milling and two-step sintering processes. The relationship of Ni 3 Al contents, microstructural evolution, and mechanical properties of W-Ni 3 Al al…
View article: Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis
Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis Open
Circular RNAs (circRNAs) are a type of non-coding RNAs generated from back splicing to enhance or inhibit the progression of multiple human cancers including osteosarcoma (OS). Although circ_0102049 has been found to be highly expressed in…
View article: MicroRNA‑15a‑5p promotes the proliferation and invasion of T98G glioblastoma cells via targeting cell adhesion molecule 1
MicroRNA‑15a‑5p promotes the proliferation and invasion of T98G glioblastoma cells via targeting cell adhesion molecule 1 Open
Glioblastoma (GBM) is a type of malignant tumor occurring in the brain that severely influences the life of affected individuals. GBM cells are highly infiltrative, which is one of the main obstacles in the treatment of the disease. Numero…
View article: PLK2 modulation of enriched TAp73 affects osteogenic differentiation and prognosis in human osteosarcoma
PLK2 modulation of enriched TAp73 affects osteogenic differentiation and prognosis in human osteosarcoma Open
There are three subtypes of undifferentiated human conventional osteosarcoma (HCOS): osteoblastic osteosarcoma (OOS), chondroblastic osteosarcoma (COS), and fibroblastic osteosarcoma (FOS). HCOS also exhibits heterogeneous pathological mal…
View article: Praeruptorin C alleviates cognitive impairment in Type 2 diabetic mice through restoring PI3K/AKT/ GSK3β pathway
Praeruptorin C alleviates cognitive impairment in Type 2 diabetic mice through restoring PI3K/AKT/ GSK3β pathway Open
Diabetic encephalopathy is a common complication of diabetes, leading to cognitive impairment. In this study, we investigated the therapeutic effects of Praeruptorin C (Pra-C), an active component of traditional Chinese herb medicine Peuce…
View article: Study on substitution of Ni with Ni<sub>3</sub>Al on structure and properties of W–6Ni<sub>3</sub>Al–4Co alloys by two-step sintering process
Study on substitution of Ni with Ni<sub>3</sub>Al on structure and properties of W–6Ni<sub>3</sub>Al–4Co alloys by two-step sintering process Open
Herein, the effect of substitution of Ni with Ni 3 Al and two-step sintering on the phase transformation, microstructure evolution, and properties of W–6Ni–4Co alloys were evaluated. The results show that the reaction products of Ni 3 Al a…
View article: Validation of some disease-resistance molecular markers associated with multiple diseases in tomato for marker-assisted selection program
Validation of some disease-resistance molecular markers associated with multiple diseases in tomato for marker-assisted selection program Open
Marker-assisted selection (MAS) is a tool that is widely applied in tomato resistance breeding.To determine the robustness of some molecular markers commonly used in MAS, extensive screening of 964 tomato lines was performed under a contro…
View article: Tribological Properties of Mo-Si-B Alloys Doped with La2O3 and Tested at 293–1173 K
Tribological Properties of Mo-Si-B Alloys Doped with La2O3 and Tested at 293–1173 K Open
According to the stoichiometric ratios of Mo-10Si-7B, Mo-12Si-8.5B, Mo-14Si-9.8B, and Mo-25Si-8.5B, some new Mo-Si-B alloys doped with 0.3 wt % lanthanum (III) oxide (La2O3) were prepared via liquid-liquid (L-L) doping, mechanical alloying…
View article: Mechanical Properties and Microstructure of W-6Ni-4Co Alloy by a Two-Step Sintering Process
Mechanical Properties and Microstructure of W-6Ni-4Co Alloy by a Two-Step Sintering Process Open
The mechanical properties and microstructure of W-6Ni-4Co alloy through solid phase sintering and two-step sintering process were investigated. The results demonstrated that the particle sizes of W-6Ni-4Co alloy milled powders increased fi…
View article: Photoluminescence Properties of Indium-doped ZnO/Cu-graphene Thin Films Synthesized by Hydrothermal Method
Photoluminescence Properties of Indium-doped ZnO/Cu-graphene Thin Films Synthesized by Hydrothermal Method Open
Indium-doped ZnO/Cu-graphene thin films were successfully synthesized by a hydrothermal method at 90 °C for 6 h.The crystalline structure, elementary compositions, morphologies, and photoluminescence properties were investigated.The result…
View article: Design and Vibration Isolation Performance of Truss‐Type CFRP Raft Frame
Design and Vibration Isolation Performance of Truss‐Type CFRP Raft Frame Open
Traditional raft frame is single in the form of materials and structures. To give full play to its vibration isolation performance, a truss‐type CFRP (carbon fiber‐reinforced plastics) raft frame was designed and prepared. Based on the com…