Hongling Wen
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View article: Beyond monotherapy: Combination therapies for HIV-1 cure through joint application of neutralizing antibodies, genome editing, and reservoir management
Beyond monotherapy: Combination therapies for HIV-1 cure through joint application of neutralizing antibodies, genome editing, and reservoir management Open
Despite its potency in suppressing HIV-1 replication, antiretroviral therapy (ART) cannot eliminate latent viral reservoirs and is associated with several limitations, such as the need for lifelong treatment and the inherent risk of drug r…
View article: Association Between the Dietary Index for Gut Microbiota and Frailty: Mediating Role of Body Mass Index
Association Between the Dietary Index for Gut Microbiota and Frailty: Mediating Role of Body Mass Index Open
Dietary composition and quality have been linked to the onset of frailty. Although the recently developed Dietary Index for Gut Microbiota (DI‐GM) offers a means to evaluate diet quality based on its impact on the gut microbiota, its relev…
View article: The mediating role of body mass index in the association between unprocessed or minimally processed foods and gallstones
The mediating role of body mass index in the association between unprocessed or minimally processed foods and gallstones Open
Background The extent of food processing significantly impacts human health, with ultra-processed foods (UPFs) linked to numerous adverse health outcomes. In contrast, research on unprocessed or minimally processed foods (MPFs) and their a…
View article: Molecular evolution and geographic migration of severe fever with thrombocytopenia syndrome virus in Asia
Molecular evolution and geographic migration of severe fever with thrombocytopenia syndrome virus in Asia Open
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a recently identified tick-borne virus that has emerged in the twenty-first century. Its primary clinical manifestations include fever and thrombocytopenia, and its high morbidit…
View article: Functional Bidirectionality of ERV-Derived Long Non-Coding RNAs in Humans
Functional Bidirectionality of ERV-Derived Long Non-Coding RNAs in Humans Open
Human endogenous retroviruses (HERVs) are widely recognized as the result of exogenous retroviruses infecting the ancestral germline, stabilizing integration and vertical transmission during human genetic evolution. To date, endogenous ret…
View article: EV71 5’UTR interacts with 3D protein affecting replication through the AKT-mTOR pathway
EV71 5’UTR interacts with 3D protein affecting replication through the AKT-mTOR pathway Open
Background EV71 is one of the important pathogens of Hand-foot-and-mouth disease (HFMD), which causes serious neurological symptoms. Several studies have speculated that there will be interaction between 5′UTR and 3D protein. However, whet…
View article: A review of the recombination events, mechanisms and consequences of Coxsackievirus A6
A review of the recombination events, mechanisms and consequences of Coxsackievirus A6 Open
View article: LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway
LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway Open
The excessive activation of immune responses will trigger autoimmune diseases or inflammatory injury. The endosomal sorting complexes required for transport (ESCRT) system can capture and mediate ubiquitinated protein degradation, which ti…
View article: Assessing the Relationship between Climate Variables and Hemorrhagic Fever with Renal Syndrome Transmission in Eastern China: A Multi-Cities Time Series Study
Assessing the Relationship between Climate Variables and Hemorrhagic Fever with Renal Syndrome Transmission in Eastern China: A Multi-Cities Time Series Study Open
Hemorrhagic fever with renal syndrome (HFRS) is a climate-sensitive infectious disease. The effect of climatic drivers might predict and prevent HFRS, and understanding their relationship is urgently needed in the face of climate change. T…
View article: Genomic diversity and evolution analysis of severe fever with thrombocytopenia syndrome in East Asia from 2010 to 2022
Genomic diversity and evolution analysis of severe fever with thrombocytopenia syndrome in East Asia from 2010 to 2022 Open
Background Conducting an up-to-date analysis on the genomic diversity and evolution patterns of severe fever with thrombocytopenia syndrome virus (SFTSV) is crucial for elucidating the underlying mechanisms of its emergency and pathogenici…
View article: Identification of differentially expressed HERV-K(HML-2) loci in colorectal cancer
Identification of differentially expressed HERV-K(HML-2) loci in colorectal cancer Open
Colorectal cancer is one of the malignant tumors with the highest mortality rate in the world. Survival rates vary significantly among patients at various stages of the disease. A biomarker capable of early diagnosis is required to facilit…
View article: Transmission of SARS-CoV-2 Omicron Variant under a Dynamic Clearance Strategy in Shandong, China
Transmission of SARS-CoV-2 Omicron Variant under a Dynamic Clearance Strategy in Shandong, China Open
Starting in March 2022, the Omicron epidemic caused a large wave of COVID-19 cases in China. Shandong was one of the most affected regions during this epidemic but was also among those areas that were able to quickly contain the transmissi…
View article: Epidemiology of human papillomavirus on condyloma acuminatum in Shandong Province，China
Epidemiology of human papillomavirus on condyloma acuminatum in Shandong Province，China Open
Condyloma acuminatum (CA) is a sexually transmitted disease (STD) caused by human papillomavirus (HPV) infection. It is important to study the prevalence and distribution of HPV genotypes before implementing the HPV vaccination program. Th…
View article: LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway
LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway Open
The excessive activation of immune responses will trigger autoimmune diseases or inflammatory injury. The endosomal sorting complexes required for transport (ESCRT) system can capture and mediate ubiquitinated protein degradation, which ti…
View article: Severe fever with thrombocytopenia syndrome virus replicates in brain tissues and damages neurons in newborn mice
Severe fever with thrombocytopenia syndrome virus replicates in brain tissues and damages neurons in newborn mice Open
View article: Metagenomic next-generation sequencing identified psittacosis among poultry processing workers in Shandong Province, China
Metagenomic next-generation sequencing identified psittacosis among poultry processing workers in Shandong Province, China Open
Human infection with Chlamydia psittaci is rare but difficult to recognize. We report an outbreak of psittacosis among poultry processing workers in China. We applied metagenomic next-generation sequencing and identified Chlamydi…
View article: Significant Upregulation of HERV-K (HML-2) Transcription Levels in Human Lung Cancer and Cancer Cells
Significant Upregulation of HERV-K (HML-2) Transcription Levels in Human Lung Cancer and Cancer Cells Open
Lung cancer is the second most common cancer worldwide and the leading cause of cancer death in the world. Therefore, there is an urgent need to develop new and effective biomarkers for diagnosis and treatment. Under this circumstance, hum…
View article: Severe Fever with Thrombocytopenia Syndrome Virus Replicates in the Brain Tissue and Damages Neuron in Newborn Mice
Severe Fever with Thrombocytopenia Syndrome Virus Replicates in the Brain Tissue and Damages Neuron in Newborn Mice Open
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is a emerging tick-borne phlebovirus with a high fatality rate of 12–30%, which has an expanding endemic and causes thousands of infections every year. Central nervous system…
View article: High-Throughput Screening and Identification of Human Adenovirus Type 5 Inhibitors
High-Throughput Screening and Identification of Human Adenovirus Type 5 Inhibitors Open
Human adenovirus infections can develop into diffuse multi-organ diseases in young children and immunocompromised patients, and severe cases can lead to death. However, there are no approved antiviral drugs available to treat adenovirus di…
View article: Research progress on coronavirus S proteins and their receptors
Research progress on coronavirus S proteins and their receptors Open
View article: SARS-CoV-2 Variant of Concern 202 012/01 (B.1.1.7) in a traveller from the UK to China
SARS-CoV-2 Variant of Concern 202 012/01 (B.1.1.7) in a traveller from the UK to China Open
We report the complete genome of SARS-CoV-2 VOC 202012/01 in a traveller from the UK to China, representing the first such case in North China. This study highlights that intensive genomic sequencing enables early identification and rapid …
View article: Role of key amino acids in the transmembrane domain of the Newcastle disease virus fusion protein
Role of key amino acids in the transmembrane domain of the Newcastle disease virus fusion protein Open
Newcastle disease (ND), caused by the Newcastle disease virus (NDV), is transmitted by poultry with severe infectivity and a high fatality rate. The fusion (F) protein on the NDV envelope facilitates the merger of the viral and host cell m…
View article: OsCAF2 contains two CRM domains and is necessary for chloroplast development in rice
OsCAF2 contains two CRM domains and is necessary for chloroplast development in rice Open
Background Chloroplasts play an important role in plant growth and development. The chloroplast genome contains approximately twenty group II introns that are spliced due to proteins encoded by nuclear genes. CAF2 is one of these splicing …
View article: Severe fever with thrombocytopenia syndrome virus infection during pregnancy in C57/BL6 mice causes fetal damage
Severe fever with thrombocytopenia syndrome virus infection during pregnancy in C57/BL6 mice causes fetal damage Open
Our study demonstrated that SFTSV was vertically transmitted to the fetus through the placental barrier of immunocompetent mice, and resulted in adverse pregnancy outcomes.
View article: Distribution of <i>Haemaphysalis longicornis</i> and Its Infected Agents: A Pooled Analysis of China Field Survey and Global Published Data
Distribution of <i>Haemaphysalis longicornis</i> and Its Infected Agents: A Pooled Analysis of China Field Survey and Global Published Data Open
View article: Correction to: The epidemiological characteristics of deaths with COVID-19 in the early stage of epidemic in Wuhan, China (Global Health Research and Policy, (2020), 5, 1, (54), 10.1186/s41256-020-00183-y)
Correction to: The epidemiological characteristics of deaths with COVID-19 in the early stage of epidemic in Wuhan, China (Global Health Research and Policy, (2020), 5, 1, (54), 10.1186/s41256-020-00183-y) Open
View article: Enterovirus 71 VP1 Protein Regulates Viral Replication in SH-SY5Y Cells via the mTOR Autophagy Signaling Pathway
Enterovirus 71 VP1 Protein Regulates Viral Replication in SH-SY5Y Cells via the mTOR Autophagy Signaling Pathway Open
Background: Enterovirus 71 (EV71) is the main pathogen that causes severe hand, foot, and mouth disease with fatal neurological complications. However, its neurovirulence mechanism is still unclear. Candidate virulence sites were screened …
View article: Roles of the highly conserved amino acids in the second receptor binding site of the Newcastle disease virus HN protein
Roles of the highly conserved amino acids in the second receptor binding site of the Newcastle disease virus HN protein Open
View article: Analysis of epidemiological characteristics of four natural-focal diseases in Shandong Province, China in 2009-2017: A descriptive analysis
Analysis of epidemiological characteristics of four natural-focal diseases in Shandong Province, China in 2009-2017: A descriptive analysis Open
Our study described and analyzed the prevalence of natural-focal diseases in Shandong Province, and confirmed that age was closely related to the SFTS fatality rate. This study may help to improve the understanding of the prevalence of nat…
View article: Conserved amino acids around the DIII-DI linker region of the Newcastle disease virus fusion protein are critical for protein folding and fusion activity
Conserved amino acids around the DIII-DI linker region of the Newcastle disease virus fusion protein are critical for protein folding and fusion activity Open
Newcastle disease virus (NDV), an avian paramyxovirus, causes Newcastle disease (ND) which is a highly contagious and fatal viral disease affecting poultry and most species of birds. The fusion (F) protein of NDV mediates membrane fusion, …