Dai‐Wen Pang
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View article: Programmable targeted RNA degradation via dCas13d-directed chaperone-mediated autophagy (dCasCMA)
Programmable targeted RNA degradation via dCas13d-directed chaperone-mediated autophagy (dCasCMA) Open
RNA-targeted degradation technologies offer significant promise for treating diseases by selectively disrupting gene expression. However, a robust method to specifically, efficiently, and programmability degrade targeted RNAs in mammalian …
View article: SELEX-HTCFQ Platform: Developing DNA Enhancers of ADAR1 to Suppress ZBP1-Dependent Immunopathology
SELEX-HTCFQ Platform: Developing DNA Enhancers of ADAR1 to Suppress ZBP1-Dependent Immunopathology Open
Excessive immune activation drives pathological inflammation through dysregulated ZBP1 signaling, yet this sensor remains crucial for immune surveillance, necessitating targeted therapies that selectively inhibit pathology while preserving…
View article: Tetrahedral DNA dendritic nanostructure-enhanced FISH for high-speed, sensitive spatial transcriptomics
Tetrahedral DNA dendritic nanostructure-enhanced FISH for high-speed, sensitive spatial transcriptomics Open
Understanding where genes are active within tissues is essential to explain how cells build and maintain organs, yet many spatial RNA assays are slow and weak, limiting short-transcript detection and masking cellular diversity. Here we sho…
View article: Novel function of ribosomal protein RPL14B: regulation of CdSe quantum dots biosynthesis in living Saccharomyces cerevisiae cells
Novel function of ribosomal protein RPL14B: regulation of CdSe quantum dots biosynthesis in living Saccharomyces cerevisiae cells Open
Biosynthesis of CdSe quantum dots is the process of converting metal ions into semiconductor nanomaterials. Studies have shown that CdSe quantum dots synthesized by Saccharomyces cerevisiae are rich in ribosomal proteins, but the role of r…
View article: High‐Performance 721 nm‐Excitable Photon Upconversion Porous Aromatic Frameworks for Broad‐Range Oxygen Sensing and Efficient Heterogeneous Photoredox Catalysis
High‐Performance 721 nm‐Excitable Photon Upconversion Porous Aromatic Frameworks for Broad‐Range Oxygen Sensing and Efficient Heterogeneous Photoredox Catalysis Open
The development of long‐wavelength excitable solid upconversion materials and the regulation of exciton behavior is important for solar energy harvesting, photocatalysis, and other emerging applications. However, the approaches for regulat…
View article: Targeted Degradation of ZBP1 with Covalent PROTACs for Anti‐Inflammatory Treatment of Infections
Targeted Degradation of ZBP1 with Covalent PROTACs for Anti‐Inflammatory Treatment of Infections Open
Z‐DNA binding protein 1 (ZBP1) has emerged as a critical pathogen‐sensing protein that upon activation, triggers necroptotic signaling cascades, leading to a potent inflammatory response and potentially causing significant tissue damage. H…
View article: Targeted Degradation of ZBP1 with Covalent PROTACs for Anti‐Inflammatory Treatment of Infections
Targeted Degradation of ZBP1 with Covalent PROTACs for Anti‐Inflammatory Treatment of Infections Open
Z‐DNA binding protein 1 (ZBP1) has emerged as a critical pathogen‐sensing protein that upon activation, triggers necroptotic signaling cascades, leading to a potent inflammatory response and potentially causing significant tissue damage. H…
View article: Correction to“Simultaneous Mapping of the Nanoscale Organization and Redox State of Extracellular Space in Living Brain Tissue”
Correction to“Simultaneous Mapping of the Nanoscale Organization and Redox State of Extracellular Space in Living Brain Tissue” Open
View article: Urea Enzymolysis‐Induced Ions Replacing: A Promising Strategy for One‐Pot Loading of Core–Shell Heterojunction on 1D Catalyst Support
Urea Enzymolysis‐Induced Ions Replacing: A Promising Strategy for One‐Pot Loading of Core–Shell Heterojunction on 1D Catalyst Support Open
Even distribution of core–shell heterojunction on porous catalyst supports is promising to get the super‐catalysts, yet laborious preparation hinders the wide application. A novel strategy of urea enzymolysis‐induced ions replacement is pr…
View article: Analyzing the factors affecting virus invasion by quantitative single-particle analysis
Analyzing the factors affecting virus invasion by quantitative single-particle analysis Open
Viral diseases are among the main threats to public health. Understanding the factors affecting viral invasion is important for antiviral research. Until now, it was known that most viruses have very low plaque-forming unit (PFU)-to-partic…
View article: Correction to “Magnetic and Folate Functionalization Enables Rapid Isolation and Enhanced Tumor-Targeting of Cell-Derived Microvesicles”
Correction to “Magnetic and Folate Functionalization Enables Rapid Isolation and Enhanced Tumor-Targeting of Cell-Derived Microvesicles” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Magnetic and Folate Functionalization Enables Rapid Isolation and Enhanced Tumor-Targeting of Cell-Derived Microvesic…
View article: <i>In-situ</i> synthesis of quantum dots in the nucleus of live cells
<i>In-situ</i> synthesis of quantum dots in the nucleus of live cells Open
The cell nucleus is the main site for the storage and replication of genetic material, and the synthesis of substances in the nucleus is rhythmic, regular and strictly regulated by physiological processes. However, whether exogenous substa…
View article: Highly Effective Near‐Infrared Light‐Activatable Triplet Fusion Upconversion with BODIPY Annihilators: Triplet Modulation via Non‐Conjugated n–π Spatial Electron Coupling (Advanced Optical Materials 1/2024)
Highly Effective Near‐Infrared Light‐Activatable Triplet Fusion Upconversion with BODIPY Annihilators: Triplet Modulation via Non‐Conjugated n–π Spatial Electron Coupling (Advanced Optical Materials 1/2024) Open
Highly Effective Near-Infrared Light-Activatable Triplet Fusion Upconversion with BODIPY Annihilators: Triplet Modulation via Non-conjugated n–π Spatial Electron Coupling In article number 2301879, Lin-Han Jiang, Ling Huang, Dai-Wen Pang, …
View article: Lipid‐Centric Design of Plasma Membrane‐Mimicking Nanocarriers for Targeted Chemotherapeutic Delivery
Lipid‐Centric Design of Plasma Membrane‐Mimicking Nanocarriers for Targeted Chemotherapeutic Delivery Open
The plasma membranes (PM) of mammalian cells contain diverse lipids, proteins, and carbohydrates that are important for systemic recognition and communication in health and disease. Cell membrane coating technology that imparts unique prop…
View article: Vaccinia virus induces EMT‐like transformation and RhoA‐mediated mesenchymal migration
Vaccinia virus induces EMT‐like transformation and RhoA‐mediated mesenchymal migration Open
The emerging outbreak of monkeypox is closely associated with the viral infection and spreading, threatening global public health. Virus‐induced cell migration facilitates viral transmission. However, the mechanism underlying this type of …
View article: Graphical Abstract: Angew. Chem. Int. Ed. 25/2023
Graphical Abstract: Angew. Chem. Int. Ed. 25/2023 Open
PhotocatalysisThesynthesis of aZ -scheme heterojunction TiO 2 /Ti-MOF-Pt with selectively anchored high-density Pt single
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 25/2023
Graphisches Inhaltsverzeichnis: Angew. Chem. 25/2023 Open
…ofkinetically trapped states of tetraphenylethylene containing glycine (TPE-G) and/or D-/L-alanine moieties leads to the formation of supramolecular multi-block copolymers,such as B-A-B,A-B-A-B-A, and C-B-A-B-C patterns (BCPs;tri-and pent…
View article: Monitoring Neovascularization of Malignant Solid Tumors with Horseradish Peroxidase-Functionalized Near-Infrared-II PbS Quantum Dots
Monitoring Neovascularization of Malignant Solid Tumors with Horseradish Peroxidase-Functionalized Near-Infrared-II PbS Quantum Dots Open
The growth and metastasis of malignant solid tumors depend closely on new blood vessels. Vasculogenic mimicry provides a special pathway of blood supply during the early growth of malignant tumors, and real-time monitoring of its occurrenc…
View article: Real‐Time Dissection of the Transportation and miRNA‐Release Dynamics of Small Extracellular Vesicles (Adv. Sci. 7/2023)
Real‐Time Dissection of the Transportation and miRNA‐Release Dynamics of Small Extracellular Vesicles (Adv. Sci. 7/2023) Open
Single Particle Tracking of Extracellular Vesicles In article number 2205566, by developing a quantum dot‐assisted single particle tracking platform, Wei Zhang, Dai‐Wen Pang, Gang Chen, and co‐workers tracked the three‐stage transportation…
View article: Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme
Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme Open
Nanozymes with superoxide dismutase (SOD)-like activity have attracted increasing interest due to their ability to scavenge superoxide anion, the origin of most reactive oxygen species in vivo. However, SOD nanozymes reported thus far have…
View article: Real‐Time Dissection of the Transportation and miRNA‐Release Dynamics of Small Extracellular Vesicles
Real‐Time Dissection of the Transportation and miRNA‐Release Dynamics of Small Extracellular Vesicles Open
Extracellular vesicles (EVs) are cell‐derived membrane‐enclosed structures that deliver biomolecules for intercellular communication. Developing visualization methods to elucidate the spatiotemporal dynamics of EVs’ behaviors will facilita…
View article: Contents list
Contents list Open
Permissions Request permissions Contents list New J. Chem., 2023, 47, 17613 DOI: 10.1039/D3NJ90150E This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publica…
View article: Single-virus tracking with quantum dots in live cells
Single-virus tracking with quantum dots in live cells Open
Single-virus tracking (SVT) offers the opportunity to monitor the journey of individual viruses in real time and to explore the interactions between viral and cellular structures in live cells, which can assist in characterizing the comple…
View article: Visualization of Vaccine Dynamics with Quantum Dots for Immunotherapy
Visualization of Vaccine Dynamics with Quantum Dots for Immunotherapy Open
The direct visualization of vaccine fate is important to investigate its immunoactivation process to elucidate the detailed molecular reaction process at single‐molecular level. Yet, visualization of the spatiotemporal trafficking of vacci…
View article: Precision photothermal therapy and photoacoustic imaging by <i>in situ</i> activatable thermoplasmonics
Precision photothermal therapy and photoacoustic imaging by <i>in situ</i> activatable thermoplasmonics Open
A tumor microenvironment-activated photoagent is reported for precise photothermal therapy and photoacoustic imaging via controllable thermoplasmonics. The agent can sensitively image tumors and lymph node metastasis and specifically ablat…
View article: Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties
Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties Open
Near-infrared (NIR) fluorescence has attracted much attention in biomedical fields because it offers deep tissue penetration and high spatial resolution. Herein, a method is developed for the preparation of NIR fluorescent nanocomposites (…
View article: Lipid-Specific Labeling of Enveloped Viruses with Quantum Dots for Single-Virus Tracking
Lipid-Specific Labeling of Enveloped Viruses with Quantum Dots for Single-Virus Tracking Open
Virus infection in host cells is a complex process comprising a large number of dynamic molecular events. Single-virus tracking is a versatile technique to study these events. To perform this technique, viruses must be fluorescently labele…
View article: Lipid-specific labeling of enveloped viruses with quantum dots for single-virus tracking
Lipid-specific labeling of enveloped viruses with quantum dots for single-virus tracking Open
Quantum dots (QDs) possess optical properties of superbright fluorescence, excellent photostability, narrow emission spectra, and optional colors. Labeled with QDs, single molecules/viruses can be rapidly and continuously imaged for a long…
View article: Coating Magnetic Nanospheres with PEG To Reduce Nonspecific Adsorption on Cells
Coating Magnetic Nanospheres with PEG To Reduce Nonspecific Adsorption on Cells Open
With the rapid advancement of nanobioscience, the interaction between nanomaterials and cells has become increasingly important, among which, understanding the nonspecific adsorption (NSA) between nanomaterials and cells is beneficial to t…
View article: Bunyaviruses: Single‐Particle Tracking Reveals the Sequential Entry Process of the Bunyavirus Severe Fever with Thrombocytopenia Syndrome Virus (Small 6/2019)
Bunyaviruses: Single‐Particle Tracking Reveals the Sequential Entry Process of the Bunyavirus Severe Fever with Thrombocytopenia Syndrome Virus (Small 6/2019) Open
In article number 1803788, Manli Wang, Yiwu Zhou, and co-workers systematically dissect the dynamic entry process of an emerging tick-borne bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV), by using multicolor tracking…