Ying Yuan
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View article: O-GlcNAcylation of SPOP regulates colorectal cancer progression and ferroptosis by mediating β-catenin degradation
O-GlcNAcylation of SPOP regulates colorectal cancer progression and ferroptosis by mediating β-catenin degradation Open
Current therapeutic approaches for colorectal cancer (CRC) face challenges such as recurrence and drug resistance. Ferroptosis, a novel form of cell death, is a promising therapeutic approach for CRC. SPOP plays an important biological rol…
View article: 1338 Multi-cohort phase II study of autologous centrally manufactured tumor infiltrating lymphocytes
1338 Multi-cohort phase II study of autologous centrally manufactured tumor infiltrating lymphocytes Open
View article: Nomogram Integrating Serological Markers and Clinical Parameters for Predicting Severe Hepatic Steatosis in Patients with Abnormal Glucose Metabolism
Nomogram Integrating Serological Markers and Clinical Parameters for Predicting Severe Hepatic Steatosis in Patients with Abnormal Glucose Metabolism Open
Objective To develop a nomogram integrating serological markers and clinical parameters for predicting severe hepatic steatosis in patients with abnormal glucose metabolism. Methods This prospective study included 186 patients with abnorma…
View article: AI-enhanced flexible ECG patch for accurate heart disease diagnosis, optimal wear positioning, and interactive medical consultation
AI-enhanced flexible ECG patch for accurate heart disease diagnosis, optimal wear positioning, and interactive medical consultation Open
Continuous and reliable electrocardiogram (ECG) monitoring is crucial for the early diagnosis and intervention of heart diseases, which remain a leading threat to global health and mortality. Traditional ECG devices are often bulky, comple…
View article: Macropinocytosis fuels osteoclast differentiation in bone-related diseases
Macropinocytosis fuels osteoclast differentiation in bone-related diseases Open
View article: Knowledge, Attitudes, and Practices Regarding Asthma in Children With Allergic Rhinitis
Knowledge, Attitudes, and Practices Regarding Asthma in Children With Allergic Rhinitis Open
Background Allergic rhinitis (AR) and asthma frequently coexist in children, with substantial overlap in pathophysiology and clinical management. Understanding caregivers' perspectives is important for improving disease control and outcome…
View article: A multicenter randomized phase II trial of lenvatinib plus everolimus versus cabozantinib in patients with metastatic clear-cell RCC that progressed on PD-1 immune checkpoint inhibition (LenCabo)
A multicenter randomized phase II trial of lenvatinib plus everolimus versus cabozantinib in patients with metastatic clear-cell RCC that progressed on PD-1 immune checkpoint inhibition (LenCabo) Open
View article: BE-BOIN: A Dose Optimization Design Accommodating Backfill and Late-Onset Toxicity
BE-BOIN: A Dose Optimization Design Accommodating Backfill and Late-Onset Toxicity Open
The US Food and Drug Administration (FDA) launched Project Optimus and issued guidance to reform dose-finding and selection trials, shifting the paradigm from identifying the maximum tolerable dose (MTD) to determining the optimal biologic…
View article: HypoGeneAgent: A Hypothesis Language Agent for Gene-Set Cluster Resolution Selection Using Perturb-seq Datasets
HypoGeneAgent: A Hypothesis Language Agent for Gene-Set Cluster Resolution Selection Using Perturb-seq Datasets Open
Large-scale single-cell and Perturb-seq investigations routinely involve clustering cells and subsequently annotating each cluster with Gene-Ontology (GO) terms to elucidate the underlying biological programs. However, both stages, resolut…
View article: ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling (Adv. Sci. 33/2025)
ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling (Adv. Sci. 33/2025) Open
View article: Nascent liver proteome reveals enzymes and transcription regulators under physiological and alcohol exposure conditions
Nascent liver proteome reveals enzymes and transcription regulators under physiological and alcohol exposure conditions Open
The liver proteome undergoes dynamic changes while performing hundreds of essential biological functions. Dysregulation of the liver proteome under alcoholic conditions leads to alcohol-associated liver disease (ALD), a major health challe…
View article: 54 ESTIMATING THE INCIDENCE RATE OF POST-DIAGNOSIS BRAIN METASTASES
54 ESTIMATING THE INCIDENCE RATE OF POST-DIAGNOSIS BRAIN METASTASES Open
Brain Cancer Canada Travel Award Recipient Brain metastases (BMs) exceed primary CNS tumours and comprise the majority workload in neuro-oncology. However, estimates of post-diagnosis BMs incidence are lacking. We address this gap and prov…
View article: Safety of fruquintinib in Chinese patients with colorectal cancer: an age subgroup analysis from a phase IV real-world clinical practice study
Safety of fruquintinib in Chinese patients with colorectal cancer: an age subgroup analysis from a phase IV real-world clinical practice study Open
Background: Colorectal cancer (CRC) is increasingly prevalent among young adults (<50 years) in China, a demographic that has been historically underrepresented in clinical studies. While most patients with CRC are aged ⩾65 years, this age…
View article: Resistance or compliance? The impact of algorithmic awareness on people's attitudes toward online information browsing
Resistance or compliance? The impact of algorithmic awareness on people's attitudes toward online information browsing Open
Introduction With the pervasive integration of big data algorithms into daily life, individuals increasingly rely on algorithmic filtering to access information of interest, yet simultaneously face the risk of confinement within “informati…
View article: Efficacy and safety of IBI351 (fulzerasib) monotherapy in KRASG12C inhibitor-naïve Chinese patients with KRASG12C-mutated metastatic colorectal cancer: a pooled analysis from phase I part of two studies
Efficacy and safety of IBI351 (fulzerasib) monotherapy in KRASG12C inhibitor-naïve Chinese patients with KRASG12C-mutated metastatic colorectal cancer: a pooled analysis from phase I part of two studies Open
IBI351 (also known as fulzerasib or GFH925), an irreversible covalent inhibitor of KRAS G12C , has demonstrated promising anti-tumour activity in patients with solid tumours. In this study, data were pooled from the phase I part of two cli…
View article: Fruquintinib in less pretreated patients: Multivariate profile-matching analysis of FRESCO-2 to FRESCO
Fruquintinib in less pretreated patients: Multivariate profile-matching analysis of FRESCO-2 to FRESCO Open
Clinically meaningful efficacy of fruquintinib was maintained in a global patient population with less pretreated mCRC than the FRESCO-2 ITT population, with no new safety signals, demonstrating efficacy regardless of prior treatment lines.
View article: Association between neutrophil-lymphocyte ratio and female breast cancer: an observational study from NHANES 2001-2018 with external validation
Association between neutrophil-lymphocyte ratio and female breast cancer: an observational study from NHANES 2001-2018 with external validation Open
Background In the 21st century, breast cancer is the most frequent malignant tumor threatening women’s health. Previous research has confirmed that inflammatory response processes play key roles in tumor occurrence, development, and metast…
View article: An IL-6-induced STAT3-to-PI3K signaling switch potently drives PD-L1 transcription in cancer stem cells of colorectal cancer
An IL-6-induced STAT3-to-PI3K signaling switch potently drives PD-L1 transcription in cancer stem cells of colorectal cancer Open
View article: The ubiquitin code of RAS proteins: Decoding its role in cancer progression
The ubiquitin code of RAS proteins: Decoding its role in cancer progression Open
View article: Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia
Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia Open
Vascular dementia (VaD) is a neurodegenerative disorder characterized by chronic oxygen insufficiency, leading to the generation of oxygen-free radicals, inflammatory responses, disturbances in iron metabolism, lipid peroxidation, and othe…
View article: Development and validation of a nomogram for predicting postoperative venous thromboembolism risk in patients with hepatocellular carcinoma
Development and validation of a nomogram for predicting postoperative venous thromboembolism risk in patients with hepatocellular carcinoma Open
BACKGROUND Few studies have specifically modeled the risk of venous thromboembolism (VTE) for postoperative hepatocellular carcinoma (HCC) patients, although HCC is the third leading cause of cancer death worldwide. This study aimed to dev…
View article: ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling
ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling Open
Targeting Nampt to modulate NAD + metabolism and exert antitumor effects has become a research hotspot in the field of cancer metabolism. But early clinical trials have only achieved modest results, primarily due to the need for improved e…
View article: Genetically encoding ε-N-methacryllysine into proteins in live cells
Genetically encoding ε-N-methacryllysine into proteins in live cells Open
View article: Uncovering the genetic variation spectrum of colorectal polyposis from a multicentre cohort in China
Uncovering the genetic variation spectrum of colorectal polyposis from a multicentre cohort in China Open
This multicentre study addresses the genetic spectrum of colorectal polyposis in China. We analyzed 120 patients with over 10 adenomas using a 139-gene next-generation sequencing panel and multiplex ligation-dependent probe amplification. …
View article: SlMYB72 and SlMYB75 antagonistically regulate trichome formation via the MYB-bHLH-WD40 complex in tomato
SlMYB72 and SlMYB75 antagonistically regulate trichome formation via the MYB-bHLH-WD40 complex in tomato Open
View article: Study on factors influencing the transport and transformation of polycyclic aromatic hydrocarbons in soil–groundwater systems
Study on factors influencing the transport and transformation of polycyclic aromatic hydrocarbons in soil–groundwater systems Open
In this review, the migration and transformation behavior of polycyclic aromatic hydrocarbons (PAHs) in the soil–groundwater system and their interaction with environmental factors are discussed. The migration and transformation of PAHs ar…
View article: Development and validation of a nomogram prediction model for overall survival in patients with rectal cancer
Development and validation of a nomogram prediction model for overall survival in patients with rectal cancer Open
BACKGROUND Rectal cancer is prevalent and associated with substantial morbidity and mortality. AIM To develop a nomogram prediction model for overall survival (OS) in patients with rectal cancer by leveraging a comprehensive analysis of de…
View article: Circulating fibroblast growth factor 21 levels in gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis
Circulating fibroblast growth factor 21 levels in gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis Open
View article: Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial
Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial Open
We conducted a phase I trial to determine the optimal dose of triplet therapy with the tyrosine kinase inhibitor sitravatinib plus nivolumab plus ipilimumab in 22 previously untreated patients with advanced clear cell renal cell carcinoma.…
View article: A multi-detector neutral helium atom microscope
A multi-detector neutral helium atom microscope Open