Wenjing Tao
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View article: Patch Area and Soil Resource Availability Outweigh Heterogeneity in Shaping Karst Plant Diversity During Early Restoration
Patch Area and Soil Resource Availability Outweigh Heterogeneity in Shaping Karst Plant Diversity During Early Restoration Open
Karst landscapes, vital to global terrestrial ecosystems, are characterized by fragmented soil patches with low resource availability and high resource heterogeneity. However, the relative roles of patch properties, soil resource availabil…
View article: Protective Effects of Magnolol, Rutin, and Gallic Acid in Broilers Challenged with Dietary Oxidized Soybean Oil
Protective Effects of Magnolol, Rutin, and Gallic Acid in Broilers Challenged with Dietary Oxidized Soybean Oil Open
This study evaluated the protective effects of magnolol, rutin, and gallic acid in broilers fed oxidized soybean oil. Four hundred seven-day-old male Arbor Acre broilers were randomly assigned to five treatments with eight replicates each:…
View article: Structural analysis of β-cyclodextrin using four essential oil microcapsules
Structural analysis of β-cyclodextrin using four essential oil microcapsules Open
This study used the co-precipitation method to create microcapsules containing four essential oils (camellia, lemon, laurel, and litsea pepper) with β-cyclodextrin (β-CD) as the wall material. The microcapsules were then characterised usin…
View article: Splice-site mutation enhances the efficiency of CRISPR-mediated gene knockout and new germplasm creation in fish
Splice-site mutation enhances the efficiency of CRISPR-mediated gene knockout and new germplasm creation in fish Open
The knockout efficiency of the CRISPR/Cas9 system largely relies on the frameshift mutation caused by random insertions or deletions at target site of coding DNA sequence (CDS). Splice site (SS) mutations result in mRNA mis-splicing, makin…
View article: Evaluation of the thermal stability of β-cyclodextrin inclusion complexes with four essential oils
Evaluation of the thermal stability of β-cyclodextrin inclusion complexes with four essential oils Open
Using Thermogravimetric Analysis (TGA-DSC), the thermal characteristics of the essential oil/β-CD inclusion complexes were assessed. The findings showed that, in comparison to the pure essential oils, the inclusion complexes had noticeably…
View article: Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis
Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis Open
Desert Hedgehog (Dhh) mutations cause Leydig cell dysfunction, yet the mechanisms governing Leydig lineage commitment through Dhh-mediated receptor selectivity, transcriptional effector specificity, and steroidogenic coupling remain elusiv…
View article: Integrated Analysis of Differential Expression Profiles of miRNA and mRNA in Gonads of Scatophagus argus Provides New Insights into Sexually Biased Gene Expression
Integrated Analysis of Differential Expression Profiles of miRNA and mRNA in Gonads of Scatophagus argus Provides New Insights into Sexually Biased Gene Expression Open
The Scatophagus argus (S. argus) is a valuable aquaculture species in southern China, with females exhibiting significantly faster growth rates than males. However, the limited understanding of its sex determination and differentiation mec…
View article: The origin, evolution, and translocation of sex chromosomes in Silurus catfish mediated by transposons
The origin, evolution, and translocation of sex chromosomes in Silurus catfish mediated by transposons Open
View article: Manuscript “Effects of Different Proportions of Concentrate Replaced by Fermented Mulberry Leaves on Growth Performance, Rumen Fermentation, Rumen Microbial and Fungal Community Structure of Heat-Stressed Hu Sheep”
Manuscript “Effects of Different Proportions of Concentrate Replaced by Fermented Mulberry Leaves on Growth Performance, Rumen Fermentation, Rumen Microbial and Fungal Community Structure of Heat-Stressed Hu Sheep” Open
View article: Maternal dnd1 is essential for migration and maintenance of PGCs in Nile tilapia at larval stage
Maternal dnd1 is essential for migration and maintenance of PGCs in Nile tilapia at larval stage Open
As a germ-cell-specific maternal mRNA and RNA binding protein, dead end (dnd1) plays an important role in migration and maintenance of primordial germ cells (PGCs), and therefore, disruption of dnd1 results in no germ cells. However, the e…
View article: Genome Assembly and Annotation of Vietnamese Rice Lines with Diverse Life-Cycle Durations
Genome Assembly and Annotation of Vietnamese Rice Lines with Diverse Life-Cycle Durations Open
This study begins by examining phenotypic variations in field growth among four parental Vietnamese rice lines, consisting of two Indica (PD211/GL37) and two Japonica (J23/SRA2-1) cultivars, which differ in life-cycle durations. Their phen…
View article: Nuclear accumulation of rice UV-B photoreceptors is UV-B- and OsCOP1-independent for UV-B responses
Nuclear accumulation of rice UV-B photoreceptors is UV-B- and OsCOP1-independent for UV-B responses Open
View article: Across two phylogeographic breaks: Quaternary evolutionary history of a mountain aspen (Populus rotundifolia) in the Hengduan Mountains
Across two phylogeographic breaks: Quaternary evolutionary history of a mountain aspen (Populus rotundifolia) in the Hengduan Mountains Open
View article: Nile Tilapia (Oreochromis niloticus) Patched1 Mutations Disrupt Cardiovascular Development and Vascular Integrity through Smoothened Signaling
Nile Tilapia (Oreochromis niloticus) Patched1 Mutations Disrupt Cardiovascular Development and Vascular Integrity through Smoothened Signaling Open
Hedgehog (Hh) signaling is crucial in cardiovascular development and maintenance. However, the biological role of Patched1 (Ptch1), an inhibitory receptor of the Hh signaling pathway, remains elusive. In this study, a Ptch1 ortholog was ch…
View article: Gut–Liver Axis as a Therapeutic Target for Drug-Induced Liver Injury
Gut–Liver Axis as a Therapeutic Target for Drug-Induced Liver Injury Open
Drug-induced liver injury (DILI) is a liver disease that remains difficult to predict and diagnose, and the underlying mechanisms are yet to be fully clarified. The gut–liver axis refers to the reciprocal interactions between the gut and t…
View article: Henmt1 is Indispensable for Female Fertility in Nile Tilapia
Henmt1 is Indispensable for Female Fertility in Nile Tilapia Open
View article: A smart chicken farming platform for chicken behavior identification and feed residual estimation
A smart chicken farming platform for chicken behavior identification and feed residual estimation Open
It is very potential to develop digital villages for promoting smart agriculture. As one of the important research fields of smart agriculture, smart chicken farms encounter management problems such as difficulties in quickly and accuratel…
View article: Enhanced <i>TP53</i> reactivation disrupts <i>MYC</i> transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias
Enhanced <i>TP53</i> reactivation disrupts <i>MYC</i> transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias Open
The tumor suppressor TP53 is frequently inactivated in a mutation-independent manner in cancers and is reactivated by inhibiting its negative regulators. We here cotarget MDM2 and the nuclear exporter XPO1 to maximize transcriptional activ…
View article: Maternal Magnolol Supplementation during Pregnancy and Lactation Promotes Antioxidant Capacity, Improves Gut Health, and Alters Gut Microbiota and Metabolites of Weanling Piglets
Maternal Magnolol Supplementation during Pregnancy and Lactation Promotes Antioxidant Capacity, Improves Gut Health, and Alters Gut Microbiota and Metabolites of Weanling Piglets Open
Maternal nutrition exerts a profound effect on the postnatal performance of offspring, especially during the weaning period. The multifunctional bioactive component magnolol (MAG) has shown promise as a dietary supplement. This study aimed…
View article: Epichaperome inhibition targets <i>TP53-</i>mutant AML and AML stem/progenitor cells
Epichaperome inhibition targets <i>TP53-</i>mutant AML and AML stem/progenitor cells Open
TP 53-mutant acute myeloid leukemia (AML) remains the ultimate therapeutic challenge. Epichaperomes, formed in malignant cells, consist of heat shock protein 90 (HSP90) and associated proteins that support the maturation, activity, and sta…
View article: Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics Open
View article: The evolutionary patterns, expression profiles, and genetic diversity of expanded genes in barley
The evolutionary patterns, expression profiles, and genetic diversity of expanded genes in barley Open
Gene duplication resulting from whole-genome duplication (WGD), small-scale duplication (SSD), or unequal hybridization plays an important role in the expansion of gene families. Gene family expansion can also mediate species formation and…
View article: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics Open
TP53 -mutant acute myeloid leukemia (AML) respond poorly to currently available treatments, including venetoclax-based drug combinations and pose a major therapeutic challenge. Analyses of RNA sequencing and reverse phase protein array dat…
View article: A new species of Megastigmus (Hymenoptera, Megastigmidae) from China
A new species of Megastigmus (Hymenoptera, Megastigmidae) from China Open
Most species of Megastigmus are considered important economic pests that grow in seeds, especially of conifers. Accurate identification of species is a crucial step for the biological research of parasitic pests and the further application…
View article: Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells Open
MCL-1 is known to play a major role in resistance to BCL-2 inhibition, but the contribution of other BCL-2 family proteins has not been fully explored. We, here, demonstrate the ineffectiveness of MCL-1 inhibitor AMG176 in venetoclax-resis…
View article: Supplementary Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
Supplementary Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells Open
Supplementary Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
View article: Supplementary Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
Supplementary Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells Open
Supplementary Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
View article: Supplementary Table 1 and Supplementary Figures 1-3 from Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia
Supplementary Table 1 and Supplementary Figures 1-3 from Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia Open
Supplemental Table 1. Characteristics of AML patient samples used for the study. Supplemental Figure 1. PDX cells (mixed cells of the bone marrow and spleen), cultured alone or co-cultured with MSCs, were treated with VS-4718, ABT-199, or …
View article: Supplementary Methods. Supplementary Figures 1 through 8. Supplementary Tables 1 and 2. from Effective Concentration of a Multikinase Inhibitor within Bone Marrow Correlates with <i>In Vitro</i> Cell Killing in Therapy-Resistant Chronic Myeloid Leukemia
Supplementary Methods. Supplementary Figures 1 through 8. Supplementary Tables 1 and 2. from Effective Concentration of a Multikinase Inhibitor within Bone Marrow Correlates with <i>In Vitro</i> Cell Killing in Therapy-Resistant Chronic Myeloid Leukemia Open
Supplementary Methods. Supplementary Figure 1. 32Dp210T315I cells are resistant to dasatinib treatment. Supplementary Figure 2. Inhibition of Aurora B kinase activity with barasertib causes G2/M arrest and cell apoptosis. Supplementary Fig…
View article: Supplementary Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
Supplementary Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells Open
Supplementary Data from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells