Wenbin Tan
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View article: Vascular Organoids Derived from Capillary malformation-induced Pluripotent Stem Cells Exhibit Disease-Relevant Phenotypes
Vascular Organoids Derived from Capillary malformation-induced Pluripotent Stem Cells Exhibit Disease-Relevant Phenotypes Open
Capillary malformation (CM) is a congenital vascular anomaly that affects the skin, mucosa, eye, and brain. A major obstacle to mechanistic and drug screening studies for CM has been the lack of preclinical models. In this study, we establ…
View article: Single-vessel transcriptome map pathological landscapes and reveal NR2F2-mediated smooth muscle cell phenotype acquisition in capillary malformations
Single-vessel transcriptome map pathological landscapes and reveal NR2F2-mediated smooth muscle cell phenotype acquisition in capillary malformations Open
Summary Background Capillary malformation (CM) is a congenital vascular anomaly affecting the skin, mucosa, and brain, yet the understanding of its vascular pathogenesis remains limited. Methods We applied spatial whole-transcriptome profi…
View article: SeqVLM: Proposal-Guided Multi-View Sequences Reasoning via VLM for Zero-Shot 3D Visual Grounding
SeqVLM: Proposal-Guided Multi-View Sequences Reasoning via VLM for Zero-Shot 3D Visual Grounding Open
3D Visual Grounding (3DVG) aims to localize objects in 3D scenes using natural language descriptions. Although supervised methods achieve higher accuracy in constrained settings, zero-shot 3DVG holds greater promise for real-world applicat…
View article: Letter to the Editor
Letter to the Editor Open
Jiang on our publication "Current clinical evidence is insufficient to support HMME-PDT as the first choice of treatment for young children with port wine birthmarks" [1].We
View article: A Single-Short Partial Reprogramming of the Endothelial Cells decreases Blood Pressure via attenuation of EndMT in Hypertensive Mice
A Single-Short Partial Reprogramming of the Endothelial Cells decreases Blood Pressure via attenuation of EndMT in Hypertensive Mice Open
Background Small artery remodeling and endothelial dysfunction are hallmarks of hypertension. Growing evidence supports a likely causal association between cardiovascular diseases and the presence of endothelial-to-mesenchymal transition (…
View article: Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials Open
Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations in many plants such as green coffee beans. As an active natural substance, CGA exerts diverse therapeutic effects in response to a variety of pathological…
View article: Current clinical evidence is insufficient to support HMME–PDT as the first choice of treatment for young children with port wine birthmarks
Current clinical evidence is insufficient to support HMME–PDT as the first choice of treatment for young children with port wine birthmarks Open
Background Port wine birthmark (PWB) is a congenital vascular malformation of the skin. Pulsed dye laser (PDL) is the “gold standard” for the treatment of PWB globally. Hematoporphyrin monomethyl ether (HMME or hemoporfin)‐mediated photody…
View article: Pharmacological Activities, Therapeutic Effects, and Mechanistic Actions of Trigonelline
Pharmacological Activities, Therapeutic Effects, and Mechanistic Actions of Trigonelline Open
Trigonelline (TRG) is a natural polar hydrophilic alkaloid that is found in many plants such as green coffee beans and fenugreek seeds. TRG potentially acts on multiple molecular targets, including nuclear factor erythroid 2-related factor…
View article: Reprogramming endothelial and vascular smooth muscle cells to prevent and treat hypertension
Reprogramming endothelial and vascular smooth muscle cells to prevent and treat hypertension Open
View article: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark
Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark Open
Lesional induced pluripotent stem cell-derived endothelial cells can resemble pathological vascular phenotypes of port-wine birthmark (PWB). Our data demonstrate that multiple pathways, including Hippo and Wnt, NFκB, TNF, MAPK and choleste…
View article: Clinical factors associated with remission of obese acanthosis nigricans after laparoscopic sleeve gastrectomy: a prospective cohort study
Clinical factors associated with remission of obese acanthosis nigricans after laparoscopic sleeve gastrectomy: a prospective cohort study Open
Background: Acanthosis nigricans (AN) involves skin hyperpigmentation in body folds and creases. Obesity-associated AN (OB_AN) is the most common type of AN. The skin condition of obese patients with AN can be improved through bariatric su…
View article: Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells
Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells Open
Port Wine Birthmarks (PWBs) are a congenital vascular malformation on the skin, occurring in 1–3 per 1000 live births. We have recently generated PWB-derived induced pluripotent stem cells (iPSCs) as clinically relevant disease models. The…
View article: Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells
Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells Open
Port Wine Birthmark (PWB) is a congenital vascular malformation in the skin, occurring in 1-3 per 1,000 live births. We recently generated PWB-derived induced pluripotent stem cells (iPSCs) as clinically relevant disease models. The metabo…
View article: Supporting materials: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark
Supporting materials: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark Open
Background Port wine birthmark (PWB) is a congenital vascular malformation resulting from developmentally defective endothelial cells (ECs). Developing clinically relevant disease models for PWB studies is currently an unmet need. Objectiv…
View article: The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice
The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice Open
Our data demonstrated that the Spike protein could induce long-term transcriptional suppression of mitochondria metabolic genes and cause cardiac fibrosis and myocardial contractile impairment in obese mice, providing mechanistic insights …
View article: The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice
The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice Open
Background As the pandemic evolves, post-acute sequelae of CoV-2 (PACS) including cardiovascular manifestations have emerged as a new health threat. This study aims to study whether the Spike protein plus obesity can exacerbate PACS-relate…
View article: The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2 Open
Coronavirus disease 2019 (COVID-19) patients show lipid metabolic alterations, but the mechanism remains unknown. In this study, we aimed to investigate whether the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV…
View article: The Spike protein of SARS-CoV-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: implication for a role of Nrf2
The Spike protein of SARS-CoV-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: implication for a role of Nrf2 Open
Background/objectives Coronavirus disease 2019 (COVID-19) patients exhibit lipid metabolic alterations, but the mechanism remains unknown. In this study, we aimed to investigate whether the Spike protein of severe acute respiratory syndrom…
View article: From <scp> <i>FOS</i> </scp> fusions to somatic mutations in the <scp>MAPK</scp> pathway, heterogeneous genetic abnormalities cause distinct pathophysiology among subsets of epithelioid haemangiomas
From <span> <i>FOS</i> </span> fusions to somatic mutations in the <span>MAPK</span> pathway, heterogeneous genetic abnormalities cause distinct pathophysiology among subsets of epithelioid haemangiomas Open
Linked Article: Maurus et al. Br J Dermatol 2022; 186:553–563.
View article: Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis
Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis Open
Alterations in the accumulation and composition of the extracellular matrix are part of the normal tissue repair process. During fibrosis, this process becomes dysregulated and excessive extracellular matrix alters the biomechanical proper…
View article: Spike protein of SARS‐CoV‐2 activates macrophages and contributes to induction of acute lung inflammation in male mice
Spike protein of SARS‐CoV‐2 activates macrophages and contributes to induction of acute lung inflammation in male mice Open
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) plays a crucial role in mediating viral entry into host cells. However, whether it contributes to pulmonary hyperinflammation in patients with coronavirus di…
View article: Spike Protein of SARS‐CoV‐2 Activates Macrophages and Contributes to Induction of Acute Lung Inflammations in Mice
Spike Protein of SARS‐CoV‐2 Activates Macrophages and Contributes to Induction of Acute Lung Inflammations in Mice Open
Background Coronavirus disease 2019 (COVID‐19) patients exhibit multiple organ malfunctions with a primary manifestation of acute and diffuse lung injuries. The Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …
View article: Follow-up study on serum cholesterol profiles and potential sequelae in recovered COVID-19 patients
Follow-up study on serum cholesterol profiles and potential sequelae in recovered COVID-19 patients Open
View article: Follow-up study on serum cholesterol profiles in recovered COVID-19 patients
Follow-up study on serum cholesterol profiles in recovered COVID-19 patients Open
COVID-19 patients develop hypolipidemia. However, it is unknown whether lipid levels have improved in recovered patients. In this study, a 3–6 month follow-up study was performed to examine serum levels of laboratory values in 107 discharg…
View article: Spike Protein of SARS-CoV-2 Activates Macrophages and Contributes to Induction of Acute Lung Inflammations in Mice
Spike Protein of SARS-CoV-2 Activates Macrophages and Contributes to Induction of Acute Lung Inflammations in Mice Open
Background Coronavirus disease 2019 (COVID-19) patients exhibit multiple organ malfunctions with a primary manifestation of acute and diffuse lung injuries. The Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
View article: Follow-up study on serum cholesterol profiles in recovered COVID-19 patients
Follow-up study on serum cholesterol profiles in recovered COVID-19 patients Open
Background: COVID-19 patients develop hypolipidemia. However, it is unknown whether lipid levels have improved in recovered patients. Objective: In this follow-up study, we evaluated serum lipidemia and other physiopathological laboratory …
View article: Fecal occult blood and urinary cytology tests for rapid screening of inflammatory infection in the gastrointestinal and urological systems in patients with Coronavirus disease 2019
Fecal occult blood and urinary cytology tests for rapid screening of inflammatory infection in the gastrointestinal and urological systems in patients with Coronavirus disease 2019 Open
Background Gastrointestinal infections (GI) and urological infections (UI) have not been fully addressed in COVID‐19 patients. We aimed to evaluate the values of routine fecal occult blood (FOB) test and urinary cytology test (UCT) for scr…
View article: Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice
Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice Open
Nuclear factor-erythroid factor 2–related factor 2 (Nrf2) may either ameliorate or worsen diabetic cardiomyopathy. However, the underlying mechanisms are poorly understood. Herein we report a novel mechanism of Nrf2-mediated myocardial dam…
View article: Authors’ response to letter by Fogacci, Borghi, and Cicero, “Misinterpreting data in lipidology in the era of COVID-19”
Authors’ response to letter by Fogacci, Borghi, and Cicero, “Misinterpreting data in lipidology in the era of COVID-19” Open
View article: Cholesterol: A new game player accelerating vasculopathy caused by SARS-CoV-2?
Cholesterol: A new game player accelerating vasculopathy caused by SARS-CoV-2? Open
The pandemic of coronavirus disease (COVID-19) has become a global threat to public health. Functional impairments in multiple organs have been reported in COVID-19, including lungs, heart, kidney, liver, brain, and vascular system. Patien…