Wenbin Lin
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View article: Low‐Dose X‐Ray Radiation Enhances Intratumoral Accumulation and Antitumor Effects of Nanoscale Coordination Polymers via Neutrophil‐Mediated Trafficking
Low‐Dose X‐Ray Radiation Enhances Intratumoral Accumulation and Antitumor Effects of Nanoscale Coordination Polymers via Neutrophil‐Mediated Trafficking Open
Nanoscale coordination polymers (NCPs) have emerged as a promising hybrid platform for drug delivery and cancer therapy. However, their potential in combination with radiotherapy (RT) remains largely unexplored. This study unveils a novel …
View article: Steering artificial photosynthesis via photoinduced conversion of monometallic to bimetallic sites in FeCo nitroprussides
Steering artificial photosynthesis via photoinduced conversion of monometallic to bimetallic sites in FeCo nitroprussides Open
View article: Metal–Organic Frameworks for Precision Catalysis
Metal–Organic Frameworks for Precision Catalysis Open
View article: Unveiling the potential of flexible perovskite photovoltaics: From lab to fab
Unveiling the potential of flexible perovskite photovoltaics: From lab to fab Open
View article: Production of Portable Temporary Power Supply for Cellular Phone
Production of Portable Temporary Power Supply for Cellular Phone Open
Since most people nowadays use smart phones, they need a power bank as a backup power source. However, most of the mobile power supplies available in the market are heavy, making them inconvenient to carry. If we are traveling and have dif…
View article: Innate Immune Activation with Multifunctional Nanoparticles for Cancer Immunotherapy
Innate Immune Activation with Multifunctional Nanoparticles for Cancer Immunotherapy Open
Immune checkpoint blockade (ICB) has revolutionized the treatment of many cancers by leveraging the immune system to combat malignancies. However, its efficacy is limited by the immunosuppressive tumor microenvironment and other regulatory…
View article: Innate Immune Activation with Multifunctional Nanoparticles for Cancer Immunotherapy
Innate Immune Activation with Multifunctional Nanoparticles for Cancer Immunotherapy Open
Immune checkpoint blockade (ICB) has revolutionized the treatment of many cancers by leveraging the immune system to combat malignancies. However, its efficacy is limited by the immunosuppressive tumor microenvironment and other regulatory…
View article: Isostructural chiral metal–organic frameworks for enantioselective luminescence sensing of 1-phenyl-1,2-ethanediol
Isostructural chiral metal–organic frameworks for enantioselective luminescence sensing of 1-phenyl-1,2-ethanediol Open
Three chiral MOFs with BINOL-derived tetrabenzoate ligands were developed for luminescence sensing of 1-phenyl-1,2-ethandiol (PE) enantiomers, with hydroxy groups significantly enhancing luminescence quenching by S -PE.
View article: Light-triggered toll-like receptor activation in a nanoscale metal–organic framework for synergistic PDT and cancer immunotherapy
Light-triggered toll-like receptor activation in a nanoscale metal–organic framework for synergistic PDT and cancer immunotherapy Open
A MOF with photosensitizers and TLR agonists synergized PDT and immune activation. Upon irradiation, it generates ROS to induce immunogenic cell death and release TLR agonists to enhance DC maturation, T-cell infiltration, and antitumour i…
View article: Nitric Oxide‐Releasing Nanoscale Metal‐Organic Layer Overcomes Hypoxia and Reactive Oxygen Species Diffusion Barriers to Enhance Cancer Radiotherapy
Nitric Oxide‐Releasing Nanoscale Metal‐Organic Layer Overcomes Hypoxia and Reactive Oxygen Species Diffusion Barriers to Enhance Cancer Radiotherapy Open
Hafnium (Hf)‐based nanoscale metal‐organic layers (MOLs) enhance radiotherapeutic effects of tissue‐penetrating X‐rays via a unique radiotherapy‐radiodynamic therapy (RT‐RDT) process through efficient generation of hydroxy radical (RT) and…
View article: Metal–organic layer delivers 3-bromopyruvate to mitochondria for metabolic regulation and cancer radio-immunotherapy
Metal–organic layer delivers 3-bromopyruvate to mitochondria for metabolic regulation and cancer radio-immunotherapy Open
We design a mitochondria-targeted, BP-loaded nanoscale MOL for metabolic reprogramming and radiosensitization, disrupting energy production and hypoxia to suppress tumor growth and prevent metastasis by enhancing radiotherapy and antitumor…
View article: Surveillance and optimal culture conditions for <i>Burkholderia gladioli</i> pv. <i>cocovenenans</i> and bongkrekic acid in Taiwan’s food chain
Surveillance and optimal culture conditions for <i>Burkholderia gladioli</i> pv. <i>cocovenenans</i> and bongkrekic acid in Taiwan’s food chain Open
In March 2024, a foodborne outbreak associated with bongkrekic acid occurred in Taiwan, resulting in 35 of confirmed cases, including six fatalities. To address public health concerns and mitigate the risk of recurrence, this study systema…
View article: Teukolsky-like equations with various spins in a deformed Kerr spacetime
Teukolsky-like equations with various spins in a deformed Kerr spacetime Open
We study the wave equations with the various spins on the background of the Kerr metric deformed by a function of the radial coordinate, on which background we have studied the gravitational-wave equations previously. We obtain the unified…
View article: Cationic Metal‐Organic Layer Delivers siRNAs to Overcome Radioresistance and Potentiate Cancer Radiotherapy
Cationic Metal‐Organic Layer Delivers siRNAs to Overcome Radioresistance and Potentiate Cancer Radiotherapy Open
Radiotherapy plays an important role in modern oncology, but its treatment efficacy is limited by the radioresistance of tumor cells. As a member of the inhibitor of apoptosis protein family, survivin plays a key role in developing radiore…
View article: Cationic Metal‐Organic Layer Delivers siRNAs to Overcome Radioresistance and Potentiate Cancer Radiotherapy
Cationic Metal‐Organic Layer Delivers siRNAs to Overcome Radioresistance and Potentiate Cancer Radiotherapy Open
Radiotherapy plays an important role in modern oncology, but its treatment efficacy is limited by the radioresistance of tumor cells. As a member of the inhibitor of apoptosis protein family, survivin plays a key role in developing radiore…
View article: A novel fault ride through strategy for grid-connected virtual synchronous Generators: Power angle stability enhancement and current limiting
A novel fault ride through strategy for grid-connected virtual synchronous Generators: Power angle stability enhancement and current limiting Open
View article: Bifunctional Metal–Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio‐Immunotherapy
Bifunctional Metal–Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio‐Immunotherapy Open
The activation of the stimulator of interferon genes (STING) protein by cyclic dinucleotide metabolites plays a critical role in antitumor immunity. However, synthetic STING agonists like 4‐(5,6‐dimethoxybenzo[b]thiophen‐2‐yl)‐4‐oxobutanoi…
View article: Bifunctional Metal–Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio‐Immunotherapy
Bifunctional Metal–Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio‐Immunotherapy Open
The activation of the stimulator of interferon genes (STING) protein by cyclic dinucleotide metabolites plays a critical role in antitumor immunity. However, synthetic STING agonists like 4‐(5,6‐dimethoxybenzo[b]thiophen‐2‐yl)‐4‐oxobutanoi…
View article: Optically accessible long-lived electronic biexcitons at room temperature in strongly coupled H- aggregates
Optically accessible long-lived electronic biexcitons at room temperature in strongly coupled H- aggregates Open
View article: Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis
Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis Open
The efficacy of radiotherapy (RT) is limited by inefficient X‐ray absorption and reactive oxygen species generation, upregulation of immunosuppressive factors, and a reducing tumor microenvironment (TME). Here, the design of a mitochondria…
View article: Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment
Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment Open
Cholesterol is an essential membrane component, and the metabolites from cholesterol play important biological functions to intricately support cancer progression and dampen immune responses. Preclinical and clinical studies have demonstra…
View article: Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment
Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment Open
Cholesterol is an essential membrane component, and the metabolites from cholesterol play important biological functions to intricately support cancer progression and dampen immune responses. Preclinical and clinical studies have demonstra…
View article: STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition
STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition Open
The low success rate of cancer nanomedicines has raised debate on the role of the enhanced permeability and retention (EPR) effect on tumor deposition of nanotherapeutics. Here, we report a bifunctional nanoscale coordination polymer (NCP)…
View article: Mitochondria‐Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death‐1 Downregulation for Cancer Immunotherapy
Mitochondria‐Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death‐1 Downregulation for Cancer Immunotherapy Open
The combination of cuproptosis and immune checkpoint inhibition has shown promise in treating malignant tumors. However, it remains a challenge to deliver copper ions and immune checkpoint inhibitors efficiently and simultaneously to tumor…
View article: Nanoscale Metal‐Organic Layer Reprograms Cellular Metabolism to Enhance Photodynamic Therapy and Antitumor Immunity
Nanoscale Metal‐Organic Layer Reprograms Cellular Metabolism to Enhance Photodynamic Therapy and Antitumor Immunity Open
Abnormal cancer metabolism causes hypoxic and immunosuppressive tumor microenvironment (TME), which limits the antitumor efficacy of photodynamic therapy (PDT). Herein, we report a photosensitizing nanoscale metal–organic layer (MOL) with …
View article: A Stable Site‐Isolated Mono(phosphine)‐Rhodium Catalyst on a Metal‐Organic Layer for Highly Efficient Hydrogenation Reactions
A Stable Site‐Isolated Mono(phosphine)‐Rhodium Catalyst on a Metal‐Organic Layer for Highly Efficient Hydrogenation Reactions Open
Phosphine‐ligated transition metal complexes play a pivotal role in modern catalysis, but our understanding of the impact of ligand counts on the catalysis performance of the metal center is limited. Here we report the synthesis of a low‐c…
View article: Nanoscale Metal‐Organic Layer Reprograms Cellular Metabolism to Enhance Photodynamic Therapy and Antitumor Immunity
Nanoscale Metal‐Organic Layer Reprograms Cellular Metabolism to Enhance Photodynamic Therapy and Antitumor Immunity Open
Abnormal cancer metabolism causes hypoxic and immunosuppressive tumor microenvironment (TME), which limits the antitumor efficacy of photodynamic therapy (PDT). Herein, we report a photosensitizing nanoscale metal–organic layer (MOL) with …
View article: A Stable Site‐Isolated Mono(phosphine)‐Rhodium Catalyst on a Metal‐Organic Layer for Highly Efficient Hydrogenation Reactions
A Stable Site‐Isolated Mono(phosphine)‐Rhodium Catalyst on a Metal‐Organic Layer for Highly Efficient Hydrogenation Reactions Open
Phosphine‐ligated transition metal complexes play a pivotal role in modern catalysis, but our understanding of the impact of ligand counts on the catalysis performance of the metal center is limited. Here we report the synthesis of a low‐c…
View article: STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses
STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses Open
Radiotherapy is widely used for cancer treatment, but its clinical utility is limited by radioresistance and its inability to target metastases. Nanoscale metal-organic frameworks (MOFs) have shown promise as high-Z nanoradiosensitizers to…
View article: Ultrathin Metal-Organic-Layer Mediated Radiotherapy-Radiodynamic Therapy
Ultrathin Metal-Organic-Layer Mediated Radiotherapy-Radiodynamic Therapy Open