Wenhui Xie
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View article: Gut microbiota remodelling alleviates elderly sepsis by microbiota-derived acetic acid via FFAR2/NLRP3 pathway
Gut microbiota remodelling alleviates elderly sepsis by microbiota-derived acetic acid via FFAR2/NLRP3 pathway Open
Gut microbiota remodelling improves elderly sepsis via acetic acid, which can inhibit inflammatory reactions to alleviate myocardial damage by FFAR2/NLRP3 inflammasome inactivation.
View article: Mortality in patients with psoriatic arthritis: a systematic review and meta-analysis
Mortality in patients with psoriatic arthritis: a systematic review and meta-analysis Open
Objective The debate persists regarding whether patients with psoriatic arthritis (PsA) face an increased risk of mortality. We aimed to ascertain the magnitude of all-cause mortality risk in patients with PsA compared to the general popul…
View article: Association between triglyceride-glucose index and subclinical carotid atherosclerosis in systemic lupus erythematosus: a cohort-based study
Association between triglyceride-glucose index and subclinical carotid atherosclerosis in systemic lupus erythematosus: a cohort-based study Open
Objective To investigate the association between triglyceride-glucose (TyG) index and carotid atherosclerosis in patients with systemic lupus erythematosus (SLE). Methods In this tertiary-center cross-sectional study, 333 consecutive SLE p…
View article: From Awareness to Action: Addressing Knowledge Barriers and Promoting Herpes Zoster Vaccination in Chinese Rheumatic Disease Patients
From Awareness to Action: Addressing Knowledge Barriers and Promoting Herpes Zoster Vaccination in Chinese Rheumatic Disease Patients Open
Aim: To investigate the knowledge of and attitudes towards herpes zoster (HZ) and its vaccination, as well as the vaccination status of Chinese patients with rheumatic disease. Method: A face-to-face questionnaire survey was conducted amon…
View article: Penicilazaphilone C triggers ferroptosis in triple-negative breast cancer cells via the MDM2/p53/SLC7 A11/GPX4 pathway
Penicilazaphilone C triggers ferroptosis in triple-negative breast cancer cells via the MDM2/p53/SLC7 A11/GPX4 pathway Open
View article: The concordance of swelling/tenderness with ultrasound-detected inflammatory lesions in patients with psoriatic arthritis
The concordance of swelling/tenderness with ultrasound-detected inflammatory lesions in patients with psoriatic arthritis Open
Background Psoriatic arthritis (PsA) is a complex and varied inflammatory condition that can cause arthritis, enthesitis, dactylitis, and spondylitis. In recent years, ultrasound (US) imaging has emerged as a valuable adjunct to physical e…
View article: Toxicarioside H induces ferroptosis in triple-negative breast cancer cells through Nrf2/HO-1 pathway
Toxicarioside H induces ferroptosis in triple-negative breast cancer cells through Nrf2/HO-1 pathway Open
Recent studies have identified novel cardiac glycosides from natural sources with potential anti-tumor properties. Toxicarioside H (ToxH) is a novel cardiac glycoside isolated by our collaborative research team. However, its ability to ind…
View article: 3'-epi-12β-hydroxyfroside induces autophagic degradation of ABCG2 to overcome drug resistance in lung cancer cells
3'-epi-12β-hydroxyfroside induces autophagic degradation of ABCG2 to overcome drug resistance in lung cancer cells Open
These findings highlight the potential of HyFS in overcoming drug resistance through autophagy-dependent degradation of ABCG2, suggesting its promise as a therapeutic approach against ABCG2-mediated drug resistance in lung cancer cells.
View article: Transitioning from Lupus Low Disease Activity State to remission in systemic lupus erythematosus: real-world evidence
Transitioning from Lupus Low Disease Activity State to remission in systemic lupus erythematosus: real-world evidence Open
Objectives To identify predictors and barriers to achieving remission in systemic lupus erythematosus (SLE) patients after attaining Lupus Low Disease Activity State (LLDAS). Methods This study included patients from the Sle to TARget (STA…
View article: A Mendelian randomization study on the causal effects of dietary components on arterial stiffness
A Mendelian randomization study on the causal effects of dietary components on arterial stiffness Open
Background Arterial stiffness (AS) is a prevalent issue affecting the elderly population, emerges as a significant risk factor for cardiovascular events (CVs), yet the impact of dietary components remains inconclusive. Methods This study e…
View article: Influencing and prognostic factors of end‐stage hypertrophic cardiomyopathy
Influencing and prognostic factors of end‐stage hypertrophic cardiomyopathy Open
Aims End‐stage hypertrophic cardiomyopathy (ES‐HCM) is a disease with severe complications and a poor prognosis. This study aimed to explore the influencing and prognostic factors of ES‐HCM. Methods and results A total of 1282 patients wit…
View article: Association of pulse pressure and aortic root diameter in elderly Chinese patients with chronic heart failure
Association of pulse pressure and aortic root diameter in elderly Chinese patients with chronic heart failure Open
Background High pulse pressure (PP) and aortic root diameter (AoD) are hallmarks of arterial stiffness or vascular aging and they are considered as risk factors for age-related cardiovascular disease, including heart failure (HF). However,…
View article: Association between disease-modifying antirheumatic drugs for rheumatoid arthritis and risk of incident dementia: a systematic review with meta-analysis
Association between disease-modifying antirheumatic drugs for rheumatoid arthritis and risk of incident dementia: a systematic review with meta-analysis Open
Background Dysregulation of several inflammatory cytokines including tumour necrosis factor (TNF) in dementia patients has also been identified as a key factor in the pathogenesis of rheumatoid arthritis (RA). We aimed to investigate the a…
View article: Association Between Triglyceride-glucose Index and Carotid Atherosclerosis in Patients with Systemic Lupus Erythematosus: A Cohort-based Study
Association Between Triglyceride-glucose Index and Carotid Atherosclerosis in Patients with Systemic Lupus Erythematosus: A Cohort-based Study Open
Background: Individuals with systemic lupus erythematosus (SLE) patients confer substantial increased risks of cardiovascular complications that have become the primary cause of premature mortality worldwide. We aimed to investigate the as…
View article: Implementation of a Digital CBT Intervention for Medical Students
Implementation of a Digital CBT Intervention for Medical Students Open
View article: The signature of the gut microbiota associated with psoriatic arthritis revealed by metagenomics
The signature of the gut microbiota associated with psoriatic arthritis revealed by metagenomics Open
Background: Gut microbiota is involved in the development of psoriatic arthritis (PsA), but until now, there has been a lack of understanding of the PsA host–bacteria interaction. Objectives: To reveal the labels of gut microbiota in PsA p…
View article: Risk of New-Onset Inflammatory Central Nervous System Diseases After Tumor Necrosis Factor Inhibitors Treatment for Autoimmune Diseases: A Systematic Review and Meta-Analysis
Risk of New-Onset Inflammatory Central Nervous System Diseases After Tumor Necrosis Factor Inhibitors Treatment for Autoimmune Diseases: A Systematic Review and Meta-Analysis Open
Background: Tumor necrosis factor (TNF) inhibitors have been extensively utilized to treat various autoimmune diseases. However, there are ongoing debates about the risk of inflammatory central nervous system (CNS) diseases events followin…
View article: Cardiovascular and Cerebrovascular Outcomes in Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis
Cardiovascular and Cerebrovascular Outcomes in Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis Open
Background: Cardiovascular and cerebrovascular outcomes in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) remain elusive, especially for some specific cardiovascular and cerebrovascular disease (CCVD). We ai…
View article: Abstract 12 — Prevalence and Risk Factors of Non-Alcoholic Fatty Liver Disease in Patients with Rheumatoid Arthritis: A Nationwide Population-Based Study
Abstract 12 — Prevalence and Risk Factors of Non-Alcoholic Fatty Liver Disease in Patients with Rheumatoid Arthritis: A Nationwide Population-Based Study Open
Background Rheumatoid arthritis (RA) is a debilitating and financially burdensome disease because of frequent presence of comorbidities including metabolic and cardiovascular abnormalities. Growing evidence suggests a link between RA and n…
View article: Abstract 5 — Prediction of Flare Following Glucocorticoids Withdrawal in Rheumatoid Arthritis Patients with Continuation of csDMARDs: A Real-Life Study
Abstract 5 — Prediction of Flare Following Glucocorticoids Withdrawal in Rheumatoid Arthritis Patients with Continuation of csDMARDs: A Real-Life Study Open
Background In patients with rheumatoid arthritis (RA), glucocorticoids (GC) should be firstly discontinued before considering tapering conventional synthetic disease-modifying anti-rheumatic drugs (csDMARD) or other biological agents. We a…
View article: Abstract 6 — Are Disease-Modifying Antirheumatic Drugs: for Rheumatoid Arthritis Associated with a Lower Risk of Dementia? A Systematic Review with Meta-Analysis
Abstract 6 — Are Disease-Modifying Antirheumatic Drugs: for Rheumatoid Arthritis Associated with a Lower Risk of Dementia? A Systematic Review with Meta-Analysis Open
Background Dysregulation of several inflammatory cytokines including tumor necrosis factor (TNF) in dementia patients has also been identified as a key factor in the pathogenesis of rheumatoid arthritis (RA). We aimed to investigate the as…
View article: The universal presence of poor prognostic factors based on EULAR recommendations: A real-world study in 1164 Chinese RA patients
The universal presence of poor prognostic factors based on EULAR recommendations: A real-world study in 1164 Chinese RA patients Open
PPFs are universally present in RA patients. The reasonability of guiding treatment strategies just based on the presence or absence of PPFs requires further investigation. The categories of PPFs can be simplified and the role of different…
View article: Changing epidemiology of cirrhosis from 2010 to 2019: results from the Global Burden Disease study 2019
Changing epidemiology of cirrhosis from 2010 to 2019: results from the Global Burden Disease study 2019 Open
Albeit the global burden of cirrhosis incidence increased from 2010 to 2019, cirrhosis-associated deaths and DALYs declined significantly. Notably, NAFLD exhibited the most significant increase as a contributor to cirrhosis worldwide.
View article: The Recent Outbreak of COVID-19 in China During the Omicron Variant Predominance: Clinical Features and Outcomes in Patients with Autoimmune Inflammatory Rheumatic Diseases
The Recent Outbreak of COVID-19 in China During the Omicron Variant Predominance: Clinical Features and Outcomes in Patients with Autoimmune Inflammatory Rheumatic Diseases Open
Hesitation for vaccination is common among Chinese patients with AIIRDs. The time from last vaccination of less than 3 months and having RA decreased the risk of COVID infection. Older age and having comorbidity or SLE increased the risk o…
View article: AB1139 ASSOCIATION BETWEEN TRIGLYCERIDE‑GLUCOSE INDEX AND CAROTID ATHEROSCLEROSIS IN PATIENTS WITH PSORIATIC ARTHRITIS: A CROSS-SECTIONAL STUDY
AB1139 ASSOCIATION BETWEEN TRIGLYCERIDE‑GLUCOSE INDEX AND CAROTID ATHEROSCLEROSIS IN PATIENTS WITH PSORIATIC ARTHRITIS: A CROSS-SECTIONAL STUDY Open
View article: AB0264 PREDICTION OF FLARE FOLLOWING GLUCOCORTICOIDS WITHDRAWAL IN RHEUMATOID ARTHRITIS PATIENTS RECEIVING CSDMARDS: A REAL-LIFE STUDY
AB0264 PREDICTION OF FLARE FOLLOWING GLUCOCORTICOIDS WITHDRAWAL IN RHEUMATOID ARTHRITIS PATIENTS RECEIVING CSDMARDS: A REAL-LIFE STUDY Open
View article: AB0299 THE RISK OF ATHEROSCLEROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS IS COMPARABLE TO THE GENERAL POPULATION IN THE TREAT-TO-TARGET ERA
AB0299 THE RISK OF ATHEROSCLEROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS IS COMPARABLE TO THE GENERAL POPULATION IN THE TREAT-TO-TARGET ERA Open
View article: The Immune Landscape and Molecular Subtypes of Pediatric Crohn’s Disease: Results from In Silico Analysis
The Immune Landscape and Molecular Subtypes of Pediatric Crohn’s Disease: Results from In Silico Analysis Open
Pediatric Crohn’s disease (CD) presents a distinct phenotype from adult-onset disease. A dysregulated immune response is critical in CD pathogenesis; thus, it is clinically important to describe immune cell alterations and to identify a ne…
View article: Disease activity and health‐related quality of life among patients with rheumatoid arthritis with different alcohol consumption habits: comment on the article by Alfredsson et al
Disease activity and health‐related quality of life among patients with rheumatoid arthritis with different alcohol consumption habits: comment on the article by Alfredsson et al Open
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View article: Dynamic Characteristics and Predictive Profile of Glucocorticoids Withdrawal in Rheumatoid Arthritis Patients Commencing Glucocorticoids with csDMARD: A Real-World Experience
Dynamic Characteristics and Predictive Profile of Glucocorticoids Withdrawal in Rheumatoid Arthritis Patients Commencing Glucocorticoids with csDMARD: A Real-World Experience Open