Wenbin Yuan
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View article: The Dual Role of RASSF4 in Tumorigenesis: Mechanisms and Epigenetic Targeting Strategies
The Dual Role of RASSF4 in Tumorigenesis: Mechanisms and Epigenetic Targeting Strategies Open
RASSF4 is a key member of the Ras-associated domain family (RASSF) that exhibits dual functionality in tumorigenesis, playing critical yet context-dependent roles in various malignancies. Its expression is epigenetically regulated through …
View article: The effectiveness of the chronic disease management for hypertension: A systematic review and meta-analysis
The effectiveness of the chronic disease management for hypertension: A systematic review and meta-analysis Open
Background: Chronic disease management (CDM) is becoming more crucial in optimizing the management of hypertension and related risk control while enhancing the self-efficacy of patients. However, there is a lack of systematic summaries on …
View article: Regulation of the PKD2 channel function and associated disease phenotypes by RASSF4
Regulation of the PKD2 channel function and associated disease phenotypes by RASSF4 Open
ADPKD is caused by mutations in receptor PKD1 and ion channel PKD2. As no effective treatment is available for ADPKD, further studies on the function and regulation of PKD1 and PKD2 are required. Using biotin-neighborhood labeling in HEK29…
View article: Evaluating the scope of human leukocyte antigen polymorphisms influencing hepatitis B virus-related liver cancer and cirrhosis through multi-clustering analysis
Evaluating the scope of human leukocyte antigen polymorphisms influencing hepatitis B virus-related liver cancer and cirrhosis through multi-clustering analysis Open
Hepatitis B virus remains a major cause of cirrhosis and hepatocellular carcinoma, with genetic polymorphisms and mutations influencing immune responses and disease progression. Nguyen et al present novel findings on specific human leukocy…
View article: Understanding Botrytis cinerea infection and gray mold management: a review paper on deciphering the rose's thorn
Understanding Botrytis cinerea infection and gray mold management: a review paper on deciphering the rose's thorn Open
Gray mold of roses, caused by the necrotrophic fungal pathogen Botrytis cinerea, is an economically notorious disease and a well-known economic menace, leading to substantial annual losses estimated at no less than 30% of production. This …
View article: Screening and identification of miRNAs negatively regulating FAM83A/Wnt/β-catenin signaling pathway in non-small cell lung cancer
Screening and identification of miRNAs negatively regulating FAM83A/Wnt/β-catenin signaling pathway in non-small cell lung cancer Open
View article: Efficacy and safety of PD‑1 inhibitors combined with/without chemotherapy in patients with recurrent or metastatic nasopharyngeal carcinoma: A systematic review and meta‑analysis of Randomized Controlled Trials
Efficacy and safety of PD‑1 inhibitors combined with/without chemotherapy in patients with recurrent or metastatic nasopharyngeal carcinoma: A systematic review and meta‑analysis of Randomized Controlled Trials Open
View article: Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies
Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies Open
tRNA is the RNA type that undergoes the most modifications among known RNA, and in recent years, tRNA methylation has emerged as a crucial process in regulating gene translation. Dysregulation of tRNA abundance occurs in cancer cells, alon…
View article: Fluorescence-Based Image Analysis of Seepage Behavior in Drip Irrigation: Exploring Varied Fractal Grading in Media Permeability
Fluorescence-Based Image Analysis of Seepage Behavior in Drip Irrigation: Exploring Varied Fractal Grading in Media Permeability Open
In the recycling of low-value metallic elements, heap leaching is commonly employed. The particle size distribution is a crucial parameter in heap leaching implementation, and the percolation behavior of a heap has always been a focal poin…
View article: Iprodione induces hepatotoxicity in zebrafish by mediating ROS generation and upregulating p53 signalling pathway
Iprodione induces hepatotoxicity in zebrafish by mediating ROS generation and upregulating p53 signalling pathway Open
Iprodione is an effective and broad-spectrum fungicide commonly used for early disease control in fruit trees and vegetables. Due to rainfall, iprodione often finds its way into water bodies, posing toxicity risks to non-target organisms a…
View article: Research on care preferences for the elderly and influencing factors in Zhejiang Province: A statistical and geographical approach
Research on care preferences for the elderly and influencing factors in Zhejiang Province: A statistical and geographical approach Open
The aging of the population is becoming an increasingly severe issue. How can we develop caring services for the elderly and promote healthy aging? Investigating care preferences is an essential step in addressing this issue. A self-design…
View article: Molecular Characterization of bHLH Transcription Factor Family in Rose (Rosa chinensis Jacq.) under Botrytis cinerea Infection
Molecular Characterization of bHLH Transcription Factor Family in Rose (Rosa chinensis Jacq.) under Botrytis cinerea Infection Open
Rose (Rosa chinensis Jacq.) is an important economic ornamental crop and its yield is affected by different biotic and abiotic stresses. Among the biotic stresses, the gray mold disease caused by Botrytis cinerea is a serious threat to ros…
View article: Functional Characterization, Antimicrobial Effects, and Potential Antibacterial Mechanisms of NpHM4, a Derived Peptide of Nautilus pompilius Hemocyanin
Functional Characterization, Antimicrobial Effects, and Potential Antibacterial Mechanisms of NpHM4, a Derived Peptide of Nautilus pompilius Hemocyanin Open
Hemocyanins present in the hemolymph of invertebrates are multifunctional proteins that are responsible for oxygen transport and play crucial roles in the immune system. They have also been identified as a source of antimicrobial peptides …
View article: The complete chloroplast genome and phylogenetic analysis of <i>Gentiana arethusae</i> Burkill (Gentianaceae) from China
The complete chloroplast genome and phylogenetic analysis of <i>Gentiana arethusae</i> Burkill (Gentianaceae) from China Open
Gentiana arethusae Burkill is a perennial herb classified in the Gentianaceae. In this study, the complete chloroplast genome of G. arethusae was sequenced and analyzed. The chloroplast genome is 137,458 bp in length and enco…
View article: Erratum to: Genomic Insights into the Origin and Evolution of Molluscan Red-Bloodedness in the Blood Clam <i>Tegillarca granosa</i>
Erratum to: Genomic Insights into the Origin and Evolution of Molluscan Red-Bloodedness in the Blood Clam <i>Tegillarca granosa</i> Open
View article: The complete chloroplast genome of Lilium rosthornii Diels (Liliopsida: Liliaceae) from Hunan, China
The complete chloroplast genome of Lilium rosthornii Diels (Liliopsida: Liliaceae) from Hunan, China Open
Lilium rosthornii is the perennial herbaceous bulbous plant belonging to the Lily of the Liliaceae, with high ornamental value and medicinal values. In this present study, we sequenced the complete chloroplast genome of Lilium ro…
View article: Genomic Insights into the Origin and Evolution of Molluscan Red-Bloodedness in the Blood Clam<i>Tegillarca granosa</i>
Genomic Insights into the Origin and Evolution of Molluscan Red-Bloodedness in the Blood Clam<i>Tegillarca granosa</i> Open
Blood clams differ from their molluscan kins by exhibiting a unique red-blood (RB) phenotype; however, the genetic basis and biochemical machinery subserving this evolutionary innovation remain unclear. As a fundamental step toward resolvi…
View article: Clinical analysis of treatment strategies to cholecystocholedocholithiasis patients with previous subtotal or total gastrectomy: a retrospective cohort study
Clinical analysis of treatment strategies to cholecystocholedocholithiasis patients with previous subtotal or total gastrectomy: a retrospective cohort study Open
View article: Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis
Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis Open
Pancreatic cancer is one of the most lethal types of cancer; owing to low early detection rates and high metastasis rates, it is associated with an extremely poor prognosis. Therefore, a better understanding of the molecular mechanisms tha…
View article: Laparoscopic Cholecystectomy in Patients With History of Gastrectomy
Laparoscopic Cholecystectomy in Patients With History of Gastrectomy Open
LC plays an important role in the treatment of benign gallbladder diseases in patients with a history of gastrectomy, and a comprehensive preoperative evaluation and accomplished surgical technique are necessary for successful outcomes. Pr…