Wenbo Deng
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View article: GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy
GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy Open
Decidualization, a highly programmed differentiation process of the uterine stroma, is characterized by significant biochemical remodeling and is essential for pregnancy. However, the functions and molecular mechanisms of lipid metabolism …
View article: Uterine stromal Erbb3-Igf1 signaling is critical to functional gland development conducive to implantation
Uterine stromal Erbb3-Igf1 signaling is critical to functional gland development conducive to implantation Open
Uterine gland branching is a prerequisite for glandular secretion, such as leukemia inhibitory factor (LIF), thereby establishing uterine receptivity to support embryo implantation. Previous studies have demonstrated that epidermal growth …
View article: Decrypting spatiotemporal code of human endometrial receptivity
Decrypting spatiotemporal code of human endometrial receptivity Open
The mechanism underlying the establishment of human endometrial receptivity remains elusive, constituting a significant obstacle to advancing our knowledge of female infertility. This gap arises from the complexities associated with the dy…
View article: Size-Selective Harvesting Effects on Reproductive Investment in Marine Medaka (Oryzias melastigma)
Size-Selective Harvesting Effects on Reproductive Investment in Marine Medaka (Oryzias melastigma) Open
Long-term selective fishing pressure often leads to miniaturization, smaller size, and early sexual maturity in many commercial fish species. To adapt, these species increase energy allocations toward maturation and reproduction, which can…
View article: Pathogenic mechanism of abnormal expression of HDAC3 in ovulatory granulosa cells inducing oocyte maturation disorder and its application in IVM
Pathogenic mechanism of abnormal expression of HDAC3 in ovulatory granulosa cells inducing oocyte maturation disorder and its application in IVM Open
Female reproductive health is troubled by oocyte maturation disorder. In mammals, granulosa cells (GCs) mediate luteinizing hormone (LH) action on oocyte maturation and ovulation. However, the pathogenesis of disordered GCs in oocyte matur…
View article: Cavitation-Induced Damage in High-Speed Railway Crtsiii Ballastless Track: Mechanism and Numerical Insights
Cavitation-Induced Damage in High-Speed Railway Crtsiii Ballastless Track: Mechanism and Numerical Insights Open
View article: Quantum Dots‐caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome
Quantum Dots‐caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome Open
Quantum dots (QDs) are widely used, but their health impact on the visual system is little known. This study aims to elucidate the effects and mechanisms of typical metallic QDs on retinas using zebrafish. Comprehensive histology, imaging,…
View article: Deciphering decidual deficiencies in recurrent spontaneous abortion and the therapeutic potential of mesenchymal stem cells at single-cell resolution
Deciphering decidual deficiencies in recurrent spontaneous abortion and the therapeutic potential of mesenchymal stem cells at single-cell resolution Open
Background Recurrent spontaneous abortion (RSA) is a challenging condition that affects the health of women both physically and mentally, but its pathogenesis and treatment have yet to be studied in detail. In recent years, Wharton’s jelly…
View article: TFEB safeguards trophoblast syncytialization in humans and mice
TFEB safeguards trophoblast syncytialization in humans and mice Open
Nutrient sensing and adaptation in the placenta are essential for pregnancy viability and proper fetal growth. Our recent study demonstrated that the placenta adapts to nutrient insufficiency through mechanistic target of rapamycin (mTOR) …
View article: PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development
PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development Open
The differentiation of the stroma is a hallmark event during postnatal uterine development. However, the spatiotemporal changes that occur during this process and the underlying regulatory mechanisms remain elusive. Here, we comprehensivel…
View article: Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization
Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization Open
The decidua plays a crucial role in providing structural and trophic support to the developing conceptus before placentation. Following embryo attachment, embryonic components intimately interact with the decidual tissue. While evidence in…
View article: H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation
H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation Open
View article: Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution
Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution Open
View article: Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution
Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution Open
View article: Dingkun pill alleviates metabolic abnormalities in polycystic ovary syndrome through brown adipose tissue activation
Dingkun pill alleviates metabolic abnormalities in polycystic ovary syndrome through brown adipose tissue activation Open
View article: Stromal cells specific retinoic acid determines parturition timing at single cell and spatial-temporal resolution
Stromal cells specific retinoic acid determines parturition timing at single cell and spatial-temporal resolution Open
Original code for the analysis of scRNA data of D16 and D19 decidua.
View article: The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity
The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity Open
The mammalian endometrium is covered by the lumenal epithelium (Le), which directly interacts with the blastocyst and plays an important role in the establishment of reciprocal crosstalk between the embryo and receptive uterus during impla…
View article: Direct and indirect effects of a fishing ban on lacustrine fish community do not result in a full recovery
Direct and indirect effects of a fishing ban on lacustrine fish community do not result in a full recovery Open
Protected areas are increasingly being promoted as an important means of protecting freshwater biological diversity and ecological processes. A robust assessment of ecological changes in protected areas is fundamental to optimize conservat…
View article: Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy
Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy Open
Decidualization, denoting the transformation of endometrial stromal cells into specialized decidual cells, is a prerequisite for normal embryo implantation and a successful pregnancy in human. Here, we demonstrated that knockout of Gαq lea…
View article: Trophoblast PR-SET7 dysfunction induces viral mimicry response and necroptosis associated with recurrent miscarriage
Trophoblast PR-SET7 dysfunction induces viral mimicry response and necroptosis associated with recurrent miscarriage Open
Recurrent miscarriage (RM) is a distressing pregnancy complication. While the etiology of RM remains unclear, growing evidence has indicated the relevance of trophoblast impairment to the pathogenesis of RM. PR-SET7 is the sole enzyme cata…
View article: Tissue‐Specific RNA Localization in the Uterus During Implantation, Decidualization and Placentation: Technical Nuances of Various Labeling Approaches
Tissue‐Specific RNA Localization in the Uterus During Implantation, Decidualization and Placentation: Technical Nuances of Various Labeling Approaches Open
In situ hybridization (ISH) is a sensitive method used to localize a specific sequence of DNA or RNA in biological samples, including cells, tissue sections or whole organs. RNA ISH can be used to determine spatial gene expression using a …
View article: JAZF1 safeguards human endometrial stromal cells survival and decidualization by repressing the transcription of G0S2
JAZF1 safeguards human endometrial stromal cells survival and decidualization by repressing the transcription of G0S2 Open
Decidualization of human endometrial stromal cells (hESCs) is essential for the maintenance of pregnancy, which depends on the fine-tuned regulation of hESCs survival, and its perturbation contributes to pregnancy loss. However, the underl…
View article: Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization
Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization Open
Endogenous retroviruses (ERVs) have been proposed as a driving force for the evolution of the mammalian placenta, however, the contribution of ERVs to placental development and the underlying regulatory mechanism remain largely elusive. A …
View article: Author response: Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy
Author response: Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Decidua…
View article: Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice
Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice Open
National Key Research and Development Program of China (2018YFC1004400), the National Natural Science Foundation of China (82171653, 82271698, 82030040, 81971387 and 30900727), and National Institutes of Health grants (R01HL103869).
View article: Dingkun Pill Alleviates Metabolic Abnormalities in Polycystic Ovary Syndrome Through Brown Adipose Tissue Activation
Dingkun Pill Alleviates Metabolic Abnormalities in Polycystic Ovary Syndrome Through Brown Adipose Tissue Activation Open
View article: Evaluation of the Effect of Regional Integration on Economic Growth—— Empirical Study on Beijing Tianjin Hebei Economic Circle Based on Synthetic Control Method
Evaluation of the Effect of Regional Integration on Economic Growth—— Empirical Study on Beijing Tianjin Hebei Economic Circle Based on Synthetic Control Method Open
Under the dual background of the new normal of China's economic growth slowdown and the high attention paid to the coordinated development of regional economy, whether the regional integrated development policy can promote the common growt…
View article: Eutrophication induces functional homogenization and traits filtering in Chinese lacustrine fish communities
Eutrophication induces functional homogenization and traits filtering in Chinese lacustrine fish communities Open
View article: Gaq-PKD/PKCμ regulates the IkB transcription to limit the NF-kB mediated inflammatory response essential for early pregnancy
Gaq-PKD/PKCμ regulates the IkB transcription to limit the NF-kB mediated inflammatory response essential for early pregnancy Open
Decidualization, denoting the transformation of endometrial stromal cells into specialized decidual cells, is a prerequisite for normal embryo implantation and a successful pregnancy in human. Here we demonstrated that knockout of Gaq lead…
View article: Maternal anxiety affects embryo implantation via impairing adrenergic receptor signaling in decidual cells
Maternal anxiety affects embryo implantation via impairing adrenergic receptor signaling in decidual cells Open