Wencan He
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View article: Opportunities and challenges in the application of spatiotemporal transcriptomics in plant research
Opportunities and challenges in the application of spatiotemporal transcriptomics in plant research Open
Spatiotemporal heterogeneity is recognized as a key driver of functional diversity in tissues. Spatial transcriptomics, which integrates high-throughput transcriptomics with high-resolution tissue imaging, enables the precise mapping of ge…
View article: Mechanism of Tibetan Medicine Ershiwuwei Shanhu Pills Regulating Grp78/Xbp1/Chop Pathway and Inhibiting Endoplasmic Reticulum Stress Mediated Apoptosis in Treating Cerebral Ischemia Based on Metabolomics and Protein Chips
Mechanism of Tibetan Medicine Ershiwuwei Shanhu Pills Regulating Grp78/Xbp1/Chop Pathway and Inhibiting Endoplasmic Reticulum Stress Mediated Apoptosis in Treating Cerebral Ischemia Based on Metabolomics and Protein Chips Open
View article: The mechanism of Tibetan medicine Shibawei Niuhuang Qinggan pills in protecting against acetaminophen-induced acute liver injury in mice by regulating the Keap1-Nrf2 pathway
The mechanism of Tibetan medicine Shibawei Niuhuang Qinggan pills in protecting against acetaminophen-induced acute liver injury in mice by regulating the Keap1-Nrf2 pathway Open
View article: Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress
Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress Open
Diisooctyl phthalate (DIOP), a common phthalate plasticizer, is frequently encountered in everyday life. Despite its widespread use, there is a dearth of toxicological research on DIOP, resulting in incomplete knowledge of its potential ha…
View article: Mechanism of Jizhi syrup’s prevention and treatment of acute bronchitis based on LPS-iNOS inflammatory mediators’ signalling
Mechanism of Jizhi syrup’s prevention and treatment of acute bronchitis based on LPS-iNOS inflammatory mediators’ signalling Open
Preliminary analysis of the chemical components in the lipid soluble fraction of JZTJ can lay the foundation for subsequent research on its effective components. Evaluating the anti-inflammatory effect of JZTJ is helpful for further resear…
View article: Exploring the Mechanism of Jizhi Syrup Prevention and Treatment with Acute Bronchitis Based on the Lps Inos Inflammatory Mediators Signaling Pathway
Exploring the Mechanism of Jizhi Syrup Prevention and Treatment with Acute Bronchitis Based on the Lps Inos Inflammatory Mediators Signaling Pathway Open
View article: Metagenomic and metabolomic analyses show correlations between intestinal microbiome diversity and microbiome metabolites in ob/ob and ApoE−/− mice
Metagenomic and metabolomic analyses show correlations between intestinal microbiome diversity and microbiome metabolites in ob/ob and ApoE−/− mice Open
Obesity and atherosclerosis are the most prevalent metabolic diseases. ApoE −/− and ob/ob mice are widely used as models to study the pathogenesis of these diseases. However, how gut microbes, gut bacteriophages, and metabolites change in …
View article: The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1
The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1 Open
Humans are frequently exposed to bacterial genotoxins of the gut microbiota, such as colibactin and cytolethal distending toxin (CDT). In the present study, whole genome microarray-based identification of differentially expressed genes was…
View article: Etude du rôle de la Cytolethal Distending Toxin dans la carcinogenèse digestive et la survie cellulaire
Etude du rôle de la Cytolethal Distending Toxin dans la carcinogenèse digestive et la survie cellulaire Open
L’homme est fréquemment exposé à des génotoxines bactériennes impliquées dans les cancers digestifs, comme la colibactine et la toxine CDT (Cytolethal Distending Toxin). Ces toxines endommagent l'ADN des cellules hôtes et constituent un fa…
View article: The Nuclear Remodeling Induced by Helicobacter Cytolethal Distending Toxin Involves MAFB Oncoprotein
The Nuclear Remodeling Induced by Helicobacter Cytolethal Distending Toxin Involves MAFB Oncoprotein Open
Enterohepatic Helicobacters, such as Helicobacter hepaticus and Helicobacter pullorum, are associated with several intestinal and hepatic diseases. Their main virulence factor is the cytolethal distending toxin (CDT). In the present study,…
View article: Bazhu Decoction, a Traditional Chinese Medical Formula, Ameliorates Cognitive Deficits in the 5xFAD Mouse Model of Alzheimer’s Disease
Bazhu Decoction, a Traditional Chinese Medical Formula, Ameliorates Cognitive Deficits in the 5xFAD Mouse Model of Alzheimer’s Disease Open
Alzheimer's disease (AD) is the most common neurodegenerative disorder associated with aging. There are currently no effective treatments for AD. Bazhu decoction (BZD), a traditional Chinese medicine (TCM) formula, has been employed clinic…
View article: Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells
Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells Open
Humans are frequently exposed to bacterial genotoxins involved in digestive cancers, colibactin and Cytolethal Distending Toxin (CDT), the latter being secreted by many pathogenic bacteria. Our aim was to evaluate the effects induced by th…
View article: The Cytolethal Distending Toxin Subunit CdtB of Helicobacter hepaticus Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell Lines
The Cytolethal Distending Toxin Subunit CdtB of Helicobacter hepaticus Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell Lines Open
Cytolethal distending toxins (CDTs) are common among pathogenic bacteria of the human and animal microbiota. CDTs exert cytopathic effets, via their active CdtB subunit. No clear description of those cytopathic effects has been reported at…