Explanipedia

Mechanistic Multi-Enzyme Engineering for High-Yield Bilirubin Biosynthesis Open

Rongzhen Zhang, Zhentao Jiang, Jingxin Rao, Chenglin Zhu, Yamiao Li , et al. · 2025

Bilirubin biosynthesis has long been limited by low yields and unclear bottlenecks. Here, we report a fully in vitro pathway that coverts heme to bilirubin with the highest reported titer. Through systematically screening and engineering, …

Kinetic and Mechanism Analysis of Thermal Decomposition of Hexafluorobisphenol A-Containing Polyarylates Open

Xiubo Long, Zhoufeng Wang, Wenlong Yao, Wenchi Zhang, Pei Zheng · 2025

The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation Open

Jiechao Zhou, Yang ‘an Chuang, Javier Redding‐Ochoa, Rongzhen Zhang, Alexander J. Platero , et al. · 2024

Rational Modification of Polyphosphate-Dependent Mannose Kinase for Efficient Synthesis of Mannose-6-Phosphate Open

Yuxin Zou, Zhiwen Xi, Yan Xu, Wenchi Zhang, Rongzhen Zhang · 2024

Study on the Kinetics and Mechanism of Thermal Decomposition of Bisphenol A-Type Polyarylates Open

Zhoufeng Wang, Xiubo Long, Wenlong Yao, Wenchi Zhang, Jinian Yang · 2024

An autophagy adaptor TRIAD3A promotes tau fibrillation by phase separation Open

Jiechao Zhou, Yang ‘an Chuang, Javier Redding‐Ochoa, Alexander J. Platero, Alexander H. Barrett , et al. · 2023

Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report an RBR-type E3 ligase TRIAD3A functions as a novel autophagy adaptor for tau. TRIAD3A (RNF216) is an essential gene with …

NMDA Receptor–Arc Signaling Is Required for Memory Updating and Is Disrupted in Alzheimer’s Disease Open

Liuqing Yang, Wenxue Liu, Linyuan Shi, Jing Wu, Wenchi Zhang , et al. · 2023

Comprehensive screening strategy coupled with structure-guided engineering of l-threonine aldolase from Pseudomonas putida for enhanced catalytic efficiency towards l-threo-4-methylsulfonylphenylserine Open

Lihong Li, Rongzhen Zhang, Yan Xu, Wenchi Zhang · 2023

l -Threonine aldolases (TAs) can catalyze aldol condensation reactions to form β-hydroxy-α-amino acids, but afford unsatisfactory conversion and poor stereoselectivity at the C β position. In this study, a directed evolution coupling high-…

Rational Modification of Polyphosphate-Dependent Mannose Kinase for Efficient Synthesis of Mannose-6-Phosphate Open

Yuxin Zou, Zhiwen Xi, Yan Xu, Wenchi Zhang, Rongzhen Zhang · 2023

Expanding the L-Threonine Transaldolase Toolbox for the Diastereomeric Synthesis of Β-Hydroxy-Α-Amino Acids Open

Zhiwen Xi, Lihong Li, Xinyi Zhang, Zhentao Jiang, Rongzhen Zhang , et al. · 2023

Alanine aminopeptidase from Bacillus licheniformis E7 expressed in Bacillus subtilis efficiently hydrolyzes soy protein to small peptides and free amino acids Open

Yahui Chen, Rongzhen Zhang, Wenchi Zhang, Yan Xu · 2022

Extensive proteolysis has become an important approach to add value to local bioresources. Here, we isolated novel strain Bacillus licheniformis E7 from protein-rich soil. This strain produces an alanine aminopeptidase, PepN, the encoding …

MacRS controls morphological differentiation and natamycin biosynthesis in Streptomyces gilvosporeus F607 Open

Gongli Zong, Guangxiang Cao, Jiafang Fu, Peipei Zhang, Xi Chen , et al. · 2022

Streptomyces gilvosporeus F607 produces large amounts of natamycin in a process regulated by multiple networks, including two-component systems (TCSs). The macR and macS genes, which are annotated as rs12540 and rs12545, respectively, in S…

Use of elicitors to enhance or activate the antibiotic production in <i>streptomyces</i> Open

Gongli Zong, Jiafang Fu, Peipei Zhang, Wenchi Zhang, Yan Xu , et al. · 2021

Streptomyces is the largest and most significant genus of Actinobacteria, comprising 961 species. These Gram-positive bacteria produce many versatile and important bioactive compounds; of these, antibiotics, specifically the enhance…

The carbapenem resistance gene blaOXA-23 is disseminated by a conjugative plasmid containing the novel transposon Tn6681 in Acinetobacter johnsonii M19 Open

Gongli Zong, Chuanqing Zhong, Jiafang Fu, Yu Zhang, Peipei Zhang , et al. · 2020

Background Carbapenem resistant Acinetobacter species have caused great difficulties in clinical therapy in the worldwide. Here we describe an Acinetobacter johnsonii M19 with a novel bla OXA-23 containing transposon Tn 6681 on the conjuga…

The carbapenem resistance gene blaOXA-23 is disseminated by a conjugative plasmid containing the novel transposon Tn6681 in Acinetobacter johnsonii M19 Open

Gongli Zong, Chuanqing Zhong, Jiafang Fu, Yu Zhang, Peipei Zhang , et al. · 2020

Background: Carbapenem resistant Acinetobacter species have caused great difficulties in clinical therapy in the worldwide. Here we describe an Acinetobacter johnsonii M19 with a novel bla OXA-23 containing transposon Tn 6681 on the conjug…

The carbapenem resistance gene blaOXA-23 is disseminated by a conjugative plasmid containing the novel transposon Tn6681 in Acinetobacter johnsonii M19 Open

Gongli Zong, Chuanqing Zhong, Jiafang Fu, Yu Zhang, Peipei Zhang , et al. · 2020

Background Carbapenem resistant Acinetobacter species have caused great difficulties in clinical therapy in the worldwide. Here we describe an Acinetobacter johnsonii M19 with a novel bla OXA−23 containing transposon Tn 6681 on the conjuga…

Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation Open

Wenchi Zhang, Yang-An Chuang, Youn Na, Zengyou Ye, Liuqing Yang , et al. · 2019

Structural Basis of Arc Binding to Synaptic Proteins: Implications for Cognitive Disease Open

Wenchi Zhang, Jing Wu, Matthew Ward, Sunggu Yang, Yang-An Chuang , et al. · 2015

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