Wendy N. Erber
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View article: Megakaryocyte emperipolesis in myeloproliferative neoplasms: Are neutrophils friends or foes?
Megakaryocyte emperipolesis in myeloproliferative neoplasms: Are neutrophils friends or foes? Open
Megakaryocyte emperipolesis is a biological process in which a cell penetrates and exists as a viable intact cell within another. It is a recognized morphological feature of myeloproliferative neoplasms (MPNs), in which neutrophils can be …
View article: Imaging Flow Cytometric Identification of Chromosomal Defects in Paediatric Acute Lymphoblastic Leukaemia
Imaging Flow Cytometric Identification of Chromosomal Defects in Paediatric Acute Lymphoblastic Leukaemia Open
Acute lymphoblastic leukaemia is the most common childhood malignancy that remains a leading cause of death in childhood. It may be characterised by multiple known recurrent genetic aberrations that inform prognosis, the most common being …
View article: Abnormalities in Chromosomes 5 and 7 in Myelodysplastic Syndrome and Acute Myeloid Leukemia
Abnormalities in Chromosomes 5 and 7 in Myelodysplastic Syndrome and Acute Myeloid Leukemia Open
Chromosomes 5 and 7 are large chromosomes that contain close to 1,000 genes each. Deletions of the long arms or loss of the entire chromosome (monosomy) are common defects in myeloid disorders, particularly MDS and AML. Loss of material fr…
View article: Imaging flow cytometric detection of del(<scp>17p</scp>) in bone marrow and circulating plasma cells in multiple myeloma
Imaging flow cytometric detection of del(<span>17p</span>) in bone marrow and circulating plasma cells in multiple myeloma Open
Background Detection of del(17p) in myeloma is generally performed by fluorescence in situ hybridization (FISH) on a slide with analysis of up to 200 nuclei. The small cell sample analyzed makes this a low precision test. We report the uti…
View article: Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis
Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis Open
Transcription factor 3 (TCF3) is a DNA transcription factor that modulates megakaryocyte development. Although abnormal TCF3 expression has been identified in a range of hematological malignancies, to date, it has not been investigated in …
View article: ‘Spill the T’ – a case series of the morphology of T cell lymphomas in leukaemic phase
‘Spill the T’ – a case series of the morphology of T cell lymphomas in leukaemic phase Open
View article: Chromosomal defects in multiple myeloma
Chromosomal defects in multiple myeloma Open
Multiple myeloma is a plasma cell neoplasm driven by primary (e.g. hyperdiploidy; IGH translocations) and secondary (e.g. 1q21 gains/amplifications; del(17p); MYC translocations) chromosomal events. These are important to detect as they in…
View article: PlateletSeq: A novel method for discovery of blood-based biomarkers
PlateletSeq: A novel method for discovery of blood-based biomarkers Open
Platelets are small circulating fragments of cells that play important roles in thrombosis, haemostasis, immune response, inflammation and cancer growth. Although anucleate, they contain a rich RNA repertoire which offers an opportunity to…
View article: Chimeric antigen receptor T‐cells: Properties, production, and quality control
Chimeric antigen receptor T‐cells: Properties, production, and quality control Open
Chimeric antigen receptor (CAR) T‐cell therapy is a novel adoptive T‐cell immunotherapy for haematological malignancies. First introduced into clinical practice in 2017, CAR T‐cell therapy is now finding its place in the management of lymp…
View article: Osteohematology: To be or Notch to be
Osteohematology: To be or Notch to be Open
Osteohematology is an emerging research field that studies the crosstalk between hematopoietic and bone stromal cells, to elucidate the mechanisms of hematological and skeletal malignancies and diseases. The Notch is an evolutionary conser…
View article: Morphology of myeloproliferative neoplasms
Morphology of myeloproliferative neoplasms Open
Myeloproliferative neoplasms (MPN) are a group of clonal haematological malignancies first described by Dameshek in 1957. The Philadelphia‐negative MPN that will be described are polycythaemia vera (PV), essential thrombocythaemia (ET), pr…
View article: The International Council for Standardization in Haematology: 60 years (1963–2023)
The International Council for Standardization in Haematology: 60 years (1963–2023) Open
The International Council for Standardization in Haematology (ICSH) is an international organization that promotes standardization and harmonization in laboratory haematology testing. In 2023 the ICSH celebrates its 60th anniversary. This …
View article: Supplementary Table 4 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Table 4 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 105K, Biological processes and genes differentially expressed among M-MCL (M) and U-MCL (U) validated genes by qPCR
View article: Data from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Data from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an aggressive clinical course, whereas others having an indolent behavior. We conducted an integrative and multidisciplinary analysis of 177 MCL to determin…
View article: Supplementary Table 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Table 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 105K, Normal B-cell types signatures used in the GSEA analysis
View article: Supplementary Table 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Table 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 108K, P-values of the 518 genes differentially expressed between M-MCL and U-MCL
View article: Supplementary Table 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Table 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 108K, P-values of the 518 genes differentially expressed between M-MCL and U-MCL
View article: Supplementary Figure 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Figure 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 198K, Recurrent mutations in rearrangements utilizing the six most frequent IGHV genes. Individual codons are represented in the X-axis. Each color represents a different amino acid (AA) change. CDR: complementary determining re…
View article: Supplementary Table 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Table 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 75K, IGHV, IGHD and IGHJ gene frequencies according to mutational status
View article: Supplementary Table 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Table 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 105K, Normal B-cell types signatures used in the GSEA analysis
View article: Supplementary Table 4 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Table 4 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 105K, Biological processes and genes differentially expressed among M-MCL (M) and U-MCL (U) validated genes by qPCR
View article: Supplementary Figure 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Figure 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 198K, Recurrent mutations in rearrangements utilizing the six most frequent IGHV genes. Individual codons are represented in the X-axis. Each color represents a different amino acid (AA) change. CDR: complementary determining re…
View article: Supplementary Figure 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Figure 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 73K, SOX11 expression evaluated by three different techniques. One-hundred-sixty-one MCL patients were studied, 64 by immunohistochemistry (IHC), 143 by quantitative PCR (qPCR) and 50 by gene expression profiling (GEP). Several …
View article: Supplementary Figure 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Figure 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 332K, Determination of the best cut-off for the percentage of identity of IGHV gene in relation to overall survival. Two cut-offs, 96.6 and 97%, were selected according to a maximally log-rank statistic
View article: Supplementary Figure 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Figure 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 332K, Determination of the best cut-off for the percentage of identity of IGHV gene in relation to overall survival. Two cut-offs, 96.6 and 97%, were selected according to a maximally log-rank statistic
View article: Supplementary Figure 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Figure 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 73K, SOX11 expression evaluated by three different techniques. One-hundred-sixty-one MCL patients were studied, 64 by immunohistochemistry (IHC), 143 by quantitative PCR (qPCR) and 50 by gene expression profiling (GEP). Several …
View article: Supplementary Table 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Supplementary Table 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
PDF file - 75K, IGHV, IGHD and IGHJ gene frequencies according to mutational status
View article: Data from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features
Data from Molecular Subsets of Mantle Cell Lymphoma Defined by the <i>IGHV</i> Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features Open
Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an aggressive clinical course, whereas others having an indolent behavior. We conducted an integrative and multidisciplinary analysis of 177 MCL to determin…
View article: GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements Open
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver test…
View article: Imaging flow cytometry shows monosomy 17 in circulating plasma cells in myeloma
Imaging flow cytometry shows monosomy 17 in circulating plasma cells in myeloma Open