Wendy S. Weichert
YOU?
Author Swipe
View article: Distinct evolutionary patterns of endemic and emerging parvoviruses, and the origin of a new pandemic virus
Distinct evolutionary patterns of endemic and emerging parvoviruses, and the origin of a new pandemic virus Open
Emergence of epidemic viruses in new hosts threatens both human and animal populations, and often involves virus evolution to overcome barriers that normally prevent efficient infection and spread in that host. After transfer the separated…
View article: Cell binding, uptake, and infection of influenza A virus using recombinant antibody-based receptors
Cell binding, uptake, and infection of influenza A virus using recombinant antibody-based receptors Open
Human and avian influenza A viruses bind to sialic acid (Sia) receptors on cells as their primary receptors, and this results in endocytic uptake of the virus. While the role of Sia on glycoproteins and/or glycolipids for virus entry is cr…
View article: Structures and functions of the limited natural polyclonal antibody response to parvovirus infection
Structures and functions of the limited natural polyclonal antibody response to parvovirus infection Open
Host antibody responses are key components in the protection of animals against pathogens, yet the defining properties of viral antigens and induction of B cell responses that result in varied protection are still poorly understood. Parvov…
View article: Cell binding, uptake and infection of influenza A virus using recombinant antibody-based receptors
Cell binding, uptake and infection of influenza A virus using recombinant antibody-based receptors Open
Human and avian influenza A viruses bind to sialic acid (Sia) receptors on cells as their primary receptors, and this results in endocytic uptake of the virus. While the role of Sia on glycoproteins and/or glycolipids for virus entry is cr…
View article: Viral Capsid, Antibody, and Receptor Interactions: Experimental Analysis of the Antibody Escape Evolution of Canine Parvovirus
Viral Capsid, Antibody, and Receptor Interactions: Experimental Analysis of the Antibody Escape Evolution of Canine Parvovirus Open
Antibodies protect animals against infection by many different viruses and other pathogens, and we are gaining new information about the epitopes that induce antibody responses against viruses and the structures of the bound antibodies. Ho…
View article: Single Particle Analysis of H3N2 Influenza Entry Differentiates the Impact of the Sialic Acids (Neu5Ac and Neu5Gc) on Virus Binding and Membrane Fusion
Single Particle Analysis of H3N2 Influenza Entry Differentiates the Impact of the Sialic Acids (Neu5Ac and Neu5Gc) on Virus Binding and Membrane Fusion Open
Influenza A virus (IAV) infections continue to threaten human health, causing over 300,000 deaths yearly. IAV infection is initiated by the binding of influenza glycoprotein hemagglutinin (HA) to host cell sialic acids (Sias) and the subse…
View article: Viral capsid, antibody, and receptor interactions: experimental analysis of the antibody escape evolution of canine parvovirus
Viral capsid, antibody, and receptor interactions: experimental analysis of the antibody escape evolution of canine parvovirus Open
Canine parvovirus (CPV) is a small non-enveloped single-stranded DNA virus that causes serious diseases in dogs worldwide. The original strain of the virus (CPV-2) emerged in dogs during the late-1970s due to a host range switch of a virus…
View article: Deacetylated sialic acids modulates immune mediated cytotoxicity via the sialic acid-Siglec pathway
Deacetylated sialic acids modulates immune mediated cytotoxicity via the sialic acid-Siglec pathway Open
Cancers utilize glycans to evade the immune system via the Sialic acid (Sia)-Siglec (Sialic-acid-binding immunoglobulin-like lectins) pathway. Specifically, atypical structural forms of sialic acid bind to inhibitory Siglec receptors on na…
View article: Influenza A viruses serially passaged in different MDCK cell lines exhibit limited sequence variation across their genomes, with the exception of the hemagglutinin gene
Influenza A viruses serially passaged in different MDCK cell lines exhibit limited sequence variation across their genomes, with the exception of the hemagglutinin gene Open
New methods for deep sequence analysis provide an opportunity to follow the emergence and dynamics of virus mutations in real time. Although viruses are commonly grown in cell culture for research and for vaccine development, the cells use…
View article: Expression of 9- <i>O</i> - and 7,9- <i>O</i> -Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses
Expression of 9- <i>O</i> - and 7,9- <i>O</i> -Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses Open
Sialic acids are key glycans that are involved in many different normal cellular functions, as well as being receptors for many pathogens. However, Sia come in diverse chemically modified forms. Here, we examined and manipulated the expres…
View article: Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation
Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation Open
Mice are commonly used as a model to study the growth and virulence of influenza A viruses in mammals but are not a natural host and have distinct sialic acid receptor profiles compared to humans. Using experimental infections with differe…
View article: Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation
Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation Open
Influenza A viruses have regularly jumped to new hosts to cause epidemics or pandemics, an evolutionary process that involves variation in the viral traits necessary to overcome host barriers and facilitate transmission. Mice are not a nat…
View article: Expression of 9-O- and 7,9-O-acetyl modified sialic acid in cells and their effects on influenza viruses
Expression of 9-O- and 7,9-O-acetyl modified sialic acid in cells and their effects on influenza viruses Open
Sialic acids (Sia) are widely displayed on the surfaces of cells and tissues. Sia come in a variety of chemically modified forms, including those with acetyl modifications at the C7, C8, and C9 positions. Here, we analyzed the distribution…
View article: Complex and Dynamic Interactions between Parvovirus Capsids, Transferrin Receptors, and Antibodies Control Cell Infection and Host Range
Complex and Dynamic Interactions between Parvovirus Capsids, Transferrin Receptors, and Antibodies Control Cell Infection and Host Range Open
Antibody and receptor binding are key virus-host interactions that control host range and determine the success of infection. Canine and feline parvovirus capsids bind the transferrin receptor type 1 (TfR) to enter host cells, and specific…