Jing‐Ke Weng
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View article: Cyclochlorotine Hydroxylase CctR Reveals DUF3328 as a Family of Copper‐Dependent Metalloenzymes
Cyclochlorotine Hydroxylase CctR Reveals DUF3328 as a Family of Copper‐Dependent Metalloenzymes Open
DUF3328 is a protein family widely found in fungal natural product biosynthesis pathways. Although DUF3328 proteins have long been implicated in diverse modifications of inert C( sp 3 )─H bonds, including halogenation, hydroxylation, and m…
View article: Cyclochlorotine Hydroxylase CctR Reveals DUF3328 as a Family of Copper‐Dependent Metalloenzymes
Cyclochlorotine Hydroxylase CctR Reveals DUF3328 as a Family of Copper‐Dependent Metalloenzymes Open
DUF3328 is a protein family widely found in fungal natural product biosynthesis pathways. Although DUF3328 proteins have long been implicated in diverse modifications of inert C( sp 3 )─H bonds, including halogenation, hydroxylation, and m…
View article: Tracing the stepwise Darwinian evolution of a plant halogenase
Tracing the stepwise Darwinian evolution of a plant halogenase Open
Biohalogenation is rare in plant metabolism, with the Menispermaceae’s chloroalkaloid acutumine being an exception. This involves a specialized dechloroacutumine halogenase (DAH) from the iron- and 2-oxoglutarate–dependent dioxygenase (2OD…
View article: Neural Spectral Prediction for Structure Elucidation with Tandem Mass Spectrometry
Neural Spectral Prediction for Structure Elucidation with Tandem Mass Spectrometry Open
Structural elucidation using untargeted tandem mass spectrometry (MS/MS) has played a critical role in advancing scientific discovery [1, 2]. However, differentiating molecular fragmentation patterns between isobaric structures remains a p…
View article: Genetically encoded fluorescent reporter for polyamines
Genetically encoded fluorescent reporter for polyamines Open
View article: Abstract 1495 Plant UDP-glycosyltransferase in cardiotonic steroid biosynthesis
Abstract 1495 Plant UDP-glycosyltransferase in cardiotonic steroid biosynthesis Open
View article: Calcium Activation Mechanism of a Noncanonical Aromatic L-Amino Acid Decarboxylase from Psilocybin Mushroom
Calcium Activation Mechanism of a Noncanonical Aromatic L-Amino Acid Decarboxylase from Psilocybin Mushroom Open
PcncAAAD is a calcium-activatable noncanonical aromatic L-amino acid decarboxylase (AAAD) featuring a unique appendage C-terminal domain (CTD) and two metal-binding sites. In this study, we establish an in silico RMSD-based evaluation mode…
View article: The emergence and loss of cyclic peptides in <i>Nicotiana</i> illuminate dynamics and mechanisms of plant metabolic evolution
The emergence and loss of cyclic peptides in <i>Nicotiana</i> illuminate dynamics and mechanisms of plant metabolic evolution Open
Specialized metabolism plays a central role in how plants cope with both biotic and abiotic stresses in order to survive and reproduce within dynamic and challenging environments. One recently described class of plant-specific, ribosomally…
View article: Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians
Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians Open
TAS2Rs are a family of G protein-coupled receptors that function as bitter taste receptors in vertebrates. Mammalian TAS2Rs have historically garnered the most attention, leading to our understanding of their roles in taste perception rele…
View article: The emergence and loss of cyclic peptides in<i>Nicotiana</i>illuminate dynamics and mechanisms of plant metabolic evolution
The emergence and loss of cyclic peptides in<i>Nicotiana</i>illuminate dynamics and mechanisms of plant metabolic evolution Open
Specialized metabolism plays a central role in how plants cope with both biotic and abiotic stresses in order to survive and reproduce within dynamic and challenging environments. One recently circumscribed class of plant-specific, ribosom…
View article: Mechanistic basis for the emergence of EPS1 as a catalyst in salicylic acid biosynthesis of Brassicaceae
Mechanistic basis for the emergence of EPS1 as a catalyst in salicylic acid biosynthesis of Brassicaceae Open
View article: Salidroside and exercise performance in healthy active young adults – an exploratory, randomized, double-blind, placebo-controlled study
Salidroside and exercise performance in healthy active young adults – an exploratory, randomized, double-blind, placebo-controlled study Open
Salidroside supplementation may enhance oxygen utilization and mitigate exercise-induced muscle damage and fatigue, warranting further research on its long-term effects and potential as an adaptogen for active individuals.
View article: Genetically encoded fluorescent reporter for polyamines
Genetically encoded fluorescent reporter for polyamines Open
Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson’s disease and …
View article: Genome‐wide association identifies a BAHD acyltransferase activity that assembles an ester of glucuronosylglycerol and phenylacetic acid
Genome‐wide association identifies a BAHD acyltransferase activity that assembles an ester of glucuronosylglycerol and phenylacetic acid Open
SUMMARY Genome‐wide association studies (GWAS) are an effective approach to identify new specialized metabolites and the genes involved in their biosynthesis and regulation. In this study, GWAS of Arabidopsis thaliana soluble leaf and stem…
View article: The evolutionary origin of naturally occurring intermolecular Diels-Alderases from Morus alba
The evolutionary origin of naturally occurring intermolecular Diels-Alderases from Morus alba Open
Biosynthetic enzymes evolutionarily gain novel functions, thereby expanding the structural diversity of natural products to the benefit of host organisms. Diels-Alderases (DAs), functionally unique enzymes catalysing [4 + 2] cycloaddition …
View article: Abstract 1369 Harnessing plant specialized metabolism for new medicines through synthetic biology
Abstract 1369 Harnessing plant specialized metabolism for new medicines through synthetic biology Open
Plants possess an intricate array of specialized metabolites, many of which hold significant value for pharmaceutical and industrial applications to human society. However, the exploration of specialized metabolic pathways that underlie sp…
View article: Author Correction: Genomics and biochemical analyses reveal a metabolon key to β-L-ODAP biosynthesis in Lathyrus sativus
Author Correction: Genomics and biochemical analyses reveal a metabolon key to β-L-ODAP biosynthesis in Lathyrus sativus Open
View article: In Vitro Evaluation of the Potential for Drug Interactions by Salidroside
In Vitro Evaluation of the Potential for Drug Interactions by Salidroside Open
Several studies utilizing Rhodiola rosea, which contains a complex mixture of phytochemicals, reported some positive drug-drug interaction (DDI) findings based on in vitro CYP450’s enzyme inhibition, MAO-A and MAO-B inhibition, and preclin…
View article: transXpress: a Snakemake pipeline for streamlined de novo transcriptome assembly and annotation
transXpress: a Snakemake pipeline for streamlined de novo transcriptome assembly and annotation Open
Background RNA-seq followed by de novo transcriptome assembly has been a transformative technique in biological research of non-model organisms, but the computational processing of RNA-seq data entails many different software tools. The co…
View article: Integrative analysis of multimodal mass spectrometry data in MZmine 3
Integrative analysis of multimodal mass spectrometry data in MZmine 3 Open
to the linking with GNPS to facilitate molecular networking in MZmine
View article: Genomics and biochemical analyses reveal a metabolon key to β-L-ODAP biosynthesis in Lathyrus sativus
Genomics and biochemical analyses reveal a metabolon key to β-L-ODAP biosynthesis in Lathyrus sativus Open
View article: Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY
Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY Open
Plants contain rapidly evolving specialized enzymes that support the biosynthesis of functionally diverse natural products. In coumarin biosynthesis, a BAHD acyltransferase-family enzyme COSY was recently discovered to accelerate coumarin …
View article: LC-HRAM-MS data for "Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY"
LC-HRAM-MS data for "Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY" Open
LC-HRAM-MS data underlying Figures 2b and 3b for "Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY"
View article: LC-HRAM-MS data for "Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY"
LC-HRAM-MS data for "Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY" Open
LC-HRAM-MS data underlying Figures 2b and 3b for "Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY"
View article: Sporopollenin-inspired design and synthesis of robust polymeric materials
Sporopollenin-inspired design and synthesis of robust polymeric materials Open
View article: Advisory Board and Contents
Advisory Board and Contents Open
View article: Lathyrus sativus LS007 genome assembly and annotation Rbp1.0
Lathyrus sativus LS007 genome assembly and annotation Rbp1.0 Open
Genome assembly of grass pea (Lathyrus sativus L.) genotype LS007, assembled from PromethION nanopore data and polished using Illumina HiSeq PE data. The assembly was annotated using the mikado-minos pipeline developed by the Earl…
View article: Lathyrus sativus LS007 genome assembly and annotation Rbp1.0
Lathyrus sativus LS007 genome assembly and annotation Rbp1.0 Open
Genome assembly of grass pea (Lathyrus sativus L.) genotype LS007, assembled from PromethION nanopore data and polished using Illumina HiSeq PE data. The assembly was annotated using the mikado-minos pipeline developed by the Earl…
View article: Lathyrus sativus LS007 genome assembly and annotation Rbp1.0
Lathyrus sativus LS007 genome assembly and annotation Rbp1.0 Open
Genome assembly of grass pea (Lathyrus sativus L.) genotype LS007, assembled from PromethION nanopore data and polished using Illumina HiSeq PE data. The assembly was annotated using the mikado-minos pipeline developed by the Earl…
View article: Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY
Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY Open
Plants contain rapidly evolving specialized metabolic enzymes to support the synthesis of a myriad of functionally diverse natural products. In the case of coumarin biosynthesis, a BAHD acyltransferase-family enzyme COSY was recently disco…