Wenhao Chen
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View article: From blueprint to practice: an innovative dynamic 9-box grid improves exercise participation and aerobic capacity in graduate students
From blueprint to practice: an innovative dynamic 9-box grid improves exercise participation and aerobic capacity in graduate students Open
Background Graduate students face considerable health risks due to sedentary behavior and academic stress, often demonstrating a marked intention–behavior gap in physical activity (PA). This study developed a two-dimensional 9-box grid mod…
View article: The impact of physical activity on sleep architecture and cognitive function among college students
The impact of physical activity on sleep architecture and cognitive function among college students Open
Background Sleep constitutes approximately one-third of human life and is vital for health maintenance. Although previous studies have established an association between physical activity (PA) and sleep quality, research on the effect of P…
View article: <scp>CYP2C19</scp> Loss‐of‐Function Is an Independent Risk Factor of Coronary Artery Disease in Patients With Hypertension
<span>CYP2C19</span> Loss‐of‐Function Is an Independent Risk Factor of Coronary Artery Disease in Patients With Hypertension Open
Objective Cytochrome P450 2C19 (CYP2C19) is affected by its gene polymorphisms and is involved in the occurrence and development of diseases. To assess the relationship between CYP2C19 polymorphisms and coronary artery disease (CAD) suscep…
View article: Effectiveness of different therapeutic measures combined with aerobic exercise as an intervention in patients with depression: a systematic review and network meta-analysis
Effectiveness of different therapeutic measures combined with aerobic exercise as an intervention in patients with depression: a systematic review and network meta-analysis Open
Background Aerobic exercise (AE), as a non-pharmacological therapy, is an effective supplement to conventional depression treatments. However, a comprehensive assessment of combined AE interventions remains insufficient. This study aims to…
View article: Integrative spatial and single-cell transcriptomics elucidate programmed cell death-driven tumor microenvironment dynamics in hepatocellular carcinoma
Integrative spatial and single-cell transcriptomics elucidate programmed cell death-driven tumor microenvironment dynamics in hepatocellular carcinoma Open
Purpose Programmed cell death (PCD) mechanisms play crucial roles in cancer progression and treatment response. This study aims to develop a PCD scores prediction model to evaluate the prognosis of hepatocellular carcinoma (HCC) and elucid…
View article: Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy
Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy Open
View article: Integrative multi-omics and Mendelian randomization analysis reveal SPP1+ tumor-associated macrophage-driven prognostic signature for hepatocellular carcinoma
Integrative multi-omics and Mendelian randomization analysis reveal SPP1+ tumor-associated macrophage-driven prognostic signature for hepatocellular carcinoma Open
Background The SPP1 + tumor-associated macrophages (TAMs) have been implicated in tumor metastasis and immune evasion. However, the prognostic significance of SPP1 + TAMs in hepatocellular carcinoma (HCC) remains largely unexplored. This s…
View article: Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway
Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway Open
Rhein protects against CDDP-induced AKI by inhibiting oxidative stress and inflammation through targeting the NOX4-NFκB-COX2/PGFS pathway, without compromising CDDP's antitumor activity. These findings highlight Rhein as a promising adjunc…
View article: The UBR5 protein facilitates mesangial cell hypertrophy and glycolysis induced by high glucose by increasing the phosphorylation levels of AKT
The UBR5 protein facilitates mesangial cell hypertrophy and glycolysis induced by high glucose by increasing the phosphorylation levels of AKT Open
Aims One of the primary pathological features in the early stages of diabetic nephropathy is mesangial cell (MC) hypertrophy in the glomerulus. Considering the role of E3 ubiquitin ligases in regulating MC hypertrophy, the aim of this stud…
View article: Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease
Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease Open
The study suggested the potential roles of ferroptosis-related genes in IVDD and further revealed the role of PDK4 in the progression of IVDD.
View article: Deep Root Architecture and Ecohydrological Dynamics of Caragana Korshinskii: Implications for Ecological Restoration in Water-Limited Environments
Deep Root Architecture and Ecohydrological Dynamics of Caragana Korshinskii: Implications for Ecological Restoration in Water-Limited Environments Open
View article: Factors of intention to learning transfer in apprenticeships: Results and implications of a chain mediation model
Factors of intention to learning transfer in apprenticeships: Results and implications of a chain mediation model Open
View article: Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models
Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models Open
T cells have a remarkable capacity to clonally expand, a process that is intricately linked to their effector activities. As vigorously proliferating T cell also incur substantial DNA lesions, how the dividing T cells safeguard their genom…
View article: Transient Anti‐<scp>TCRβ mAb</scp> Treatment Induces <scp>CD4</scp><sup>+</sup><scp>T</scp> Cell Exhaustion and Prolongs Survival in a Mouse Model of Systemic Lupus Erythematosus
Transient Anti‐<span>TCRβ mAb</span> Treatment Induces <span>CD4</span><sup>+</sup><span>T</span> Cell Exhaustion and Prolongs Survival in a Mouse Model of Systemic Lupus Erythematosus Open
T cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). Chronic T cell receptor (TCR) signalling induces T cell exhaustion, characterised by reduced capacity to induce tissue damage. Here, we investigated th…
View article: CYP2C19 Loss-of-Function is an Associated Risk Factor for Premature Coronary Artery Disease: A Case–Control Study
CYP2C19 Loss-of-Function is an Associated Risk Factor for Premature Coronary Artery Disease: A Case–Control Study Open
CYP2C19 PM or IM+PM phenotypes, overweight, smoking, hypertension, and diabetes mellitus were associated with PCAD.
View article: Neurofeedback technique for treating male schizophrenia patients with impulsive behavior: a randomized controlled study
Neurofeedback technique for treating male schizophrenia patients with impulsive behavior: a randomized controlled study Open
Background Schizophrenia is one of the most severe mental disorders, frequently associated with aggression and violence, particularly in male patients. The underlying mechanisms of violent behavior in these patients remain unclear, limitin…
View article: Apolipoprotein E E3/E4 genotype is associated with an increased risk of coronary atherosclerosis in patients with hypertension
Apolipoprotein E E3/E4 genotype is associated with an increased risk of coronary atherosclerosis in patients with hypertension Open
Objective Apolipoprotein E ( APOE ) gene polymorphisms were associated with coronary atherosclerosis and hypertension. However, the relationship between APOE polymorphisms and coronary atherosclerosis susceptibility in hypertensive patient…
View article: Goosecoid promotes pancreatic adenocarcinoma metastasis through TGF-βsignaling
Goosecoid promotes pancreatic adenocarcinoma metastasis through TGF-βsignaling Open
Goosecoid (GSC), translated from a homeobox gene, is a protein that participates in metastasis of various cancers. Pancreatic adenocarcinoma (PAAD) is one of the deadliest malignancies associated with a poor diagnosis and prognosis. To dev…
View article: Resistin as a potential diagnostic biomarker for sepsis: insights from DIA and ELISA analyses
Resistin as a potential diagnostic biomarker for sepsis: insights from DIA and ELISA analyses Open
Purpose The primary objective of this investigation is to systematically screen and identify differentially expressed proteins (DEPs) within the plasma of individuals afflicted with sepsis. This endeavor employs both Data-Independent Acqui…
View article: Advances in Migratory Plant Endoparasitic Nematode Effectors
Advances in Migratory Plant Endoparasitic Nematode Effectors Open
Unlike sedentary plant-parasitic nematodes, migratory plant endoparasitic nematodes (MPENs) are unable to establish permanent feeding sites, and all developmental stages (except eggs) can invade and feed on plant tissues and can be easily …
View article: Integrative analysis of metabolomics and transcriptomics to uncover biomarkers in sepsis
Integrative analysis of metabolomics and transcriptomics to uncover biomarkers in sepsis Open
To utilize metabolomics in conjunction with RNA sequencing to identify biomarkers in the blood of sepsis patients and discover novel targets for diagnosing and treating sepsis. In January 2019 and December 2020, blood samples were collecte…
View article: Aerobic glycolysis enables the effector differentiation potential of stem-like CD4+ T cells to combat cancer
Aerobic glycolysis enables the effector differentiation potential of stem-like CD4+ T cells to combat cancer Open
View article: Apolipoprotein E E3/E4 genotype is associated with an increased risk of type 2 diabetes mellitus complicated with coronary artery disease
Apolipoprotein E E3/E4 genotype is associated with an increased risk of type 2 diabetes mellitus complicated with coronary artery disease Open
Objective Dyslipidemia is a co-existing problem in patients with diabetes mellitus (DM) and coronary artery disease (CAD), and apolipoprotein E (APOE) plays an important role in lipid metabolism. However, the relationship between the APOE …
View article: Microstructure changes and miRNA-mRNA network in a developmental dysplasia of the hip rat model
Microstructure changes and miRNA-mRNA network in a developmental dysplasia of the hip rat model Open
View article: Trilobolide-6-O-isobutyrate exerts anti-tumor effects on cholangiocarcinoma cells through inhibiting JAK/STAT3 signaling pathway
Trilobolide-6-O-isobutyrate exerts anti-tumor effects on cholangiocarcinoma cells through inhibiting JAK/STAT3 signaling pathway Open
Trilobolide-6-O-isobutyrate exhibits significant antitumor effects on cholangiocarcinoma (CCA) cells by effectively inhibiting the JAK/STAT3 signaling pathway. This study aims to investigate the mechanisms underlying the antitumor properti…
View article: Mental illness stigma and its influential factors among psychiatrists in China
Mental illness stigma and its influential factors among psychiatrists in China Open
Purpose Mental illness stigma is a global health issue, and psychiatrists themselves may be stigmatisers of mental illness. Research on psychiatrists’ mental illness stigma has primarily been conducted in developed regions, while China, a …
View article: TRIM6 Promotes ROS-Mediated Inflammasome Activation and Pyroptosis in Renal Tubular Epithelial Cells via Ubiquitination and Degradation of GPX3 Protein
TRIM6 Promotes ROS-Mediated Inflammasome Activation and Pyroptosis in Renal Tubular Epithelial Cells via Ubiquitination and Degradation of GPX3 Protein Open
Background: Pyroptosis is a critical form of cell death during the development of chronic kidney disease (CKD). Tripartite motif 6 (TRIM6) is an E3-ubiquitin ligase that participates in the progression renal fibrosis (RF). The aim of this …
View article: REG1A may be a new biological marker for diagnosing sepsis
REG1A may be a new biological marker for diagnosing sepsis Open
Objective The aim of this study was to analyze the proteomic mass spectrometry of sepsis patients as well as normal subjects, and then to explore the characteristic proteins related to the pathogenesis of sepsis, and then to provide the ba…
View article: Stem the tide of graft rejection
Stem the tide of graft rejection Open
View article: CD4+ T cell immunity is dependent on an intrinsic stem-like program
CD4+ T cell immunity is dependent on an intrinsic stem-like program Open