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View article: Intramolecular Thiol‐Promoted Decomposition of Cysteine Ester (ITPDC): A General Platform for Controllable Release of Reactive Sulfur Species
Intramolecular Thiol‐Promoted Decomposition of Cysteine Ester (ITPDC): A General Platform for Controllable Release of Reactive Sulfur Species Open
Endogenously generated reactive sulfur species (RSS) play critical roles in various physiological processes. RSS donors can enhance our understanding of RSS chemical biology and open new avenues for treating RSS‐associated diseases. Nevert…
View article: Computational design and engineering of self-assembling multivalent microproteins with therapeutic potential against SARS-CoV-2
Computational design and engineering of self-assembling multivalent microproteins with therapeutic potential against SARS-CoV-2 Open
Multivalent drugs targeting homo-oligomeric viral surface proteins, such as the SARS-CoV-2 trimeric spike (S) protein, have the potential to elicit more potent and broad-spectrum therapeutic responses than monovalent drugs by synergistical…
View article: A Highly Effective Curcumin-Based Fluorescent Probe with Single-Wavelength Excitation for Simultaneous Detection and Bioimaging of Cys, Hcy and Gsh
A Highly Effective Curcumin-Based Fluorescent Probe with Single-Wavelength Excitation for Simultaneous Detection and Bioimaging of Cys, Hcy and Gsh Open
View article: Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy
Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy Open
View article: Full-Length Model of SaCas9-sgRNA-DNA Complex in Cleavage State
Full-Length Model of SaCas9-sgRNA-DNA Complex in Cleavage State Open
Staphylococcus aureus Cas9 (SaCas9) is a widely used genome editing tool. Understanding its molecular mechanisms of DNA cleavage could effectively guide the engineering optimization of this system. Here, we determined the first cryo-electr…
View article: Three-dimensional DEM investigation of the stress-dilatancy relation of grain-cementing type methane hydrate-bearing sediment
Three-dimensional DEM investigation of the stress-dilatancy relation of grain-cementing type methane hydrate-bearing sediment Open
In this study, the Discrete Element Method (DEM) was employed to investigate numerically the effects of hydrate cementation and intermediate principal stress on the stress-dilatancy relation of grain-cementing type methane hydrate-bearing …
View article: Active-Site Models of Streptococcus pyogenes Cas9 in DNA Cleavage State
Active-Site Models of Streptococcus pyogenes Cas9 in DNA Cleavage State Open
CRISPR-Cas9 is a powerful tool for target genome editing in living cells. Significant advances have been made to understand how this system cleaves target DNA. However, due to difficulty in determining active CRISPR-Cas9 structure in DNA c…
View article: Salinity effects on the mechanical behaviour of methane hydrate bearing sediments: A DEM investigation
Salinity effects on the mechanical behaviour of methane hydrate bearing sediments: A DEM investigation Open
View article: Spontaneous binding of potential COVID-19 drugs (Camostat and Nafamostat) to human serine protease TMPRSS2
Spontaneous binding of potential COVID-19 drugs (Camostat and Nafamostat) to human serine protease TMPRSS2 Open
View article: Spontaneous Binding of Potential COVID-19 Drugs to Human Serine Protease TMPRSS2
Spontaneous Binding of Potential COVID-19 Drugs to Human Serine Protease TMPRSS2 Open
Effective treatment or vaccine is not yet available for combating SARS coronavirus 2 (SARSCoV-2) that caused the COVID-19 pandemic. Recent studies showed that two drugs, Camostat and Nafamostat, might be repurposed to treat COVID-19 by inh…
View article: Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells
Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells Open
View article: Analysis of garlics lateral conveying performance based on EDEM
Analysis of garlics lateral conveying performance based on EDEM Open
This article studied the effect of different conveyor belt speeds on garlics transportation in the process of garlics harvesting and lateral conveying. The lateral conveying process of garlics is simulated by EDEM, and the optimal transpor…
View article: DEM investigation on dissociation characteristics of methane hydrate bearing sediments by chemical injection method
DEM investigation on dissociation characteristics of methane hydrate bearing sediments by chemical injection method Open
Methane hydrate (MH) is regarded as a potential future clean energy source, which has attracted lots of attention in recent decades. The sediment containing MH is called as Methane Hydrates Bearing Sediment (MHBS). The evolutions of mechan…
View article: DEM simulation of triaxial compression tests on MHBS under different back pressures
DEM simulation of triaxial compression tests on MHBS under different back pressures Open
This paper investigates the mechanical behavior of Methane Hydrate-Bearing Sediments (MHBS) at different back pressures via the distinct element method (DEM). A series of triaxial compression test were carried out in order to analyze the m…
View article: The effects of different inorganic salts on the structure and properties of ionic liquid plasticized starch/poly(butylene succinate) blends
The effects of different inorganic salts on the structure and properties of ionic liquid plasticized starch/poly(butylene succinate) blends Open
1-Butyl-3-methylimidazole chloride ([BMIM]Cl) plasticized starch/poly(butylene succinate) (PBS) blends containing inorganic salts with different cations were prepared by a Haake mixer.
View article: The Effects of Inorganic Salts with Different Anions on the Structure and Properties of Starch/Poly (Butylene Succinate) Blends Plasticized with Ionic Liquid
The Effects of Inorganic Salts with Different Anions on the Structure and Properties of Starch/Poly (Butylene Succinate) Blends Plasticized with Ionic Liquid Open
1-butyl-3-methylimidazole chloride ((BMIM) Cl) modified starch/poly (butylene succinate) (PBS) blends with different anions of inorganic salts were prepared by HAAKE mixer. The compatibility and thermal behaviors including crystallinity, c…
View article: The modification mechanism and the effect of magnesium chloride on poly(vinyl alcohol) films
The modification mechanism and the effect of magnesium chloride on poly(vinyl alcohol) films Open
MgCl2 could crosslink with PVA to increase the strength and rigidity of PVA, while water could decrease the interaction.
View article: Effect of oxide film on nanoscale mechanical removal of pure iron
Effect of oxide film on nanoscale mechanical removal of pure iron Open
In this paper, the properties of an oxide film formed on a pure iron surface after being polished with an H 2 O 2 -based acidic slurry were investigated using an atomic force microscope (AFM), Auger electron spectroscopy (AES), and angle-r…
View article: A GAIN-PHASE ERROR CALIBRATION METHOD FOR THE VIBRATION OF WING CONFORMAL ARRAY
A GAIN-PHASE ERROR CALIBRATION METHOD FOR THE VIBRATION OF WING CONFORMAL ARRAY Open