Wenhao Ouyang
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View article: Exploring the carcinogenic potential of bisphenol A in lung adenocarcinoma: molecular mechanisms, key gene insights, and immune microenvironment impacts
Exploring the carcinogenic potential of bisphenol A in lung adenocarcinoma: molecular mechanisms, key gene insights, and immune microenvironment impacts Open
Background Bisphenol A (BPA) is an endocrine-disrupting chemical that may contribute to cancer development. However, its role in lung adenocarcinoma (LUAD) remains poorly understood. This study aimed to investigate how BPA affects LUAD dev…
View article: Single-cell RNA sequencing identifies CD8Teff cell activation as a predictive biomarker in triple-negative breast cancer immunotherapy
Single-cell RNA sequencing identifies CD8Teff cell activation as a predictive biomarker in triple-negative breast cancer immunotherapy Open
Immunotherapy has emerged as a promising treatment option for triple-negative breast cancer (TNBC); however, the pronounced heterogeneity of the tumor immune microenvironment significantly hinders the prediction of therapeutic efficacy, wi…
View article: Integration of Single-Cell Analysis and Bulk RNA Sequencing Data Using Multi-Level Attention Graph Neural Network for Precise Prognostic Stratification in Thyroid Cancer
Integration of Single-Cell Analysis and Bulk RNA Sequencing Data Using Multi-Level Attention Graph Neural Network for Precise Prognostic Stratification in Thyroid Cancer Open
Background: The prognosis management of thyroid cancer remains a significant challenge. This study highlights the critical role of T cells in the tumor microenvironment and aims to improve prognostic precision by integrating bulk RNA-seq a…
View article: MRI-based multimodal AI model enables prediction of recurrence risk and adjuvant therapy in breast cancer
MRI-based multimodal AI model enables prediction of recurrence risk and adjuvant therapy in breast cancer Open
Timely intervention and improved prognosis for breast cancer patients rely on early metastasis risk detection and accurate treatment predictions. This study introduces an advanced multimodal MRI and AI-driven 3D deep learning model, termed…
View article: Targeting immune checkpoints in hepatocellular carcinoma therapy: toward combination strategies with curative potential
Targeting immune checkpoints in hepatocellular carcinoma therapy: toward combination strategies with curative potential Open
Hepatocellular carcinoma (HCC) is a primary liver cancer characterized by poor immune cell infiltration and a strongly immunosuppressive microenvironment. Traditional treatments have often yielded unsatisfactory outcomes due to the insidio…
View article: Assessing the neurotoxic risks of triethyl citrate in daily environmental exposure using network toxicology and molecular docking
Assessing the neurotoxic risks of triethyl citrate in daily environmental exposure using network toxicology and molecular docking Open
View article: Machine learning-based identification of cuproptosis-related lncRNA biomarkers in diffuse large B-cell lymphoma
Machine learning-based identification of cuproptosis-related lncRNA biomarkers in diffuse large B-cell lymphoma Open
Multiple machine learning techniques were employed to identify key long non-coding RNA (lncRNA) biomarkers associated with cuproptosis in Diffuse Large B-Cell Lymphoma (DLBCL). Data from the TCGA and GEO databases facilitated the identific…
View article: Neoadjuvant Strategies for Triple Negative Breast Cancer: Current Evidence and Future Perspectives
Neoadjuvant Strategies for Triple Negative Breast Cancer: Current Evidence and Future Perspectives Open
Triple‐negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, characterized by poor prognosis and limited therapeutic options. Although neoadjuvant chemotherapy (NACT) remains the established treatment approach, its…
View article: Erratum to “Integrative analysis of cuproptosis-related lncRNAs: Unveiling prognostic significance, immune microenvironment, and copper-induced mechanisms in prostate cancer” [Cancer Pathog Ther, 3 (2025):48–59]
Erratum to “Integrative analysis of cuproptosis-related lncRNAs: Unveiling prognostic significance, immune microenvironment, and copper-induced mechanisms in prostate cancer” [Cancer Pathog Ther, 3 (2025):48–59] Open
[This corrects the article DOI: 10.1016/j.cpt.2024.03.004.].
View article: Red light promotes dermis-epidermis remodeling via TGFβ and AKT-mediated collagen dynamics in naturally aging mice
Red light promotes dermis-epidermis remodeling via TGFβ and AKT-mediated collagen dynamics in naturally aging mice Open
Red light therapy is a clinically validated, noninvasive approach for improving skin structure and stimulating collagen renewal. However, the molecular mechanisms by which light therapy reverses collagen-related skin degeneration remain un…
View article: Exploring the causal link between low‑density lipoprotein cholesterol and cataract: Evidence from Mendelian randomization analysis
Exploring the causal link between low‑density lipoprotein cholesterol and cataract: Evidence from Mendelian randomization analysis Open
View article: 171MO Unraveling iCAF and tumor cell communication: Advancing novel adjuvant immunotherapy response and prognostic prediction via single-cell analysis and multimodal data-based models
171MO Unraveling iCAF and tumor cell communication: Advancing novel adjuvant immunotherapy response and prognostic prediction via single-cell analysis and multimodal data-based models Open
View article: Multimodal data fusion AI model uncovers tumor microenvironment immunotyping heterogeneity and enhanced risk stratification of breast cancer
Multimodal data fusion AI model uncovers tumor microenvironment immunotyping heterogeneity and enhanced risk stratification of breast cancer Open
Breast cancer is the leading cancer among women, with a significant number experiencing recurrence and metastasis, thereby reducing survival rates. This study focuses on the role of long noncoding RNAs (lncRNAs) in breast cancer immunother…
View article: Claudin-9 (CLDN9) promotes gastric cancer progression by enhancing the glycolysis pathway and facilitating PD-L1 lactylation to suppress CD8+ T cell anti-tumor immunity
Claudin-9 (CLDN9) promotes gastric cancer progression by enhancing the glycolysis pathway and facilitating PD-L1 lactylation to suppress CD8+ T cell anti-tumor immunity Open
CLDN9 expression is associated with GC development and progression. Mechanistically, CLDN9 enhances the glycolysis pathway and facilitates PD-L1 lactylation through the PI3K/AKT/HIF1α signaling pathway, thereby suppressing an…
View article: Artificial intelligence-based multi-modal multi-tasks analysis reveals tumor molecular heterogeneity, predicts preoperative lymph node metastasis and prognosis in papillary thyroid carcinoma: a retrospective study
Artificial intelligence-based multi-modal multi-tasks analysis reveals tumor molecular heterogeneity, predicts preoperative lymph node metastasis and prognosis in papillary thyroid carcinoma: a retrospective study Open
Background: Papillary thyroid carcinoma (PTC) is the predominant form of thyroid cancer globally, especially when lymph node metastasis (LNM) occurs. Molecular heterogeneity, driven by genetic alterations and tumor microenvironment compone…
View article: Exploring the impact of N4-acetylcytidine modification in RNA on non-neoplastic disease: unveiling its role in pathogenesis and therapeutic opportunities
Exploring the impact of N4-acetylcytidine modification in RNA on non-neoplastic disease: unveiling its role in pathogenesis and therapeutic opportunities Open
RNA modifications include not only methylation modifications, such as m6A, but also acetylation modifications, which constitute a complex interaction involving “writers,” “readers,” and “erasers” that play crucial roles in growth, genetics…
View article: Unraveling the influence of metabolic signatures on immune dynamics for predicting immunotherapy response and survival in cancer
Unraveling the influence of metabolic signatures on immune dynamics for predicting immunotherapy response and survival in cancer Open
Metabolic reprogramming in cancer significantly impacts immune responses within the tumor microenvironment, but its influence on cancer immunotherapy effectiveness remains uncertain. This study aims to elucidate the prognostic significance…
View article: Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer
Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer Open
The study developed a UPR-related gene classifier and risk signature for predicting survival in stomach cancer, identifying IGFBP1 as a key factor promoting the disease's malignancy and a potential therapeutic target. IGFBP1's role in enha…
View article: Deciphering the role of apoptosis signature on the immune dynamics and therapeutic prognosis in breast cancer: Implication for immunotherapy
Deciphering the role of apoptosis signature on the immune dynamics and therapeutic prognosis in breast cancer: Implication for immunotherapy Open
Background: In breast cancer oncogenesis, the precise role of cell apoptosis holds untapped potential for prognostic and therapeutic insights. Thus, it is important to develop a model predicated for breast cancer patients’ prognosis and im…
View article: Deep learning-based multi-modal data integration enhancing breast cancer disease-free survival prediction
Deep learning-based multi-modal data integration enhancing breast cancer disease-free survival prediction Open
Background The prognosis of breast cancer is often unfavorable, emphasizing the need for early metastasis risk detection and accurate treatment predictions. This study aimed to develop a novel multi-modal deep learning model using preopera…
View article: Integrative analysis of cuproptosis-related lncRNAs: Unveiling prognostic significance, immune microenvironment, and copper-induced mechanisms in prostate cancer
Integrative analysis of cuproptosis-related lncRNAs: Unveiling prognostic significance, immune microenvironment, and copper-induced mechanisms in prostate cancer Open
View article: Unveiling the best predictive models for early‑onset metastatic cancer: Insights and innovations (Review)
Unveiling the best predictive models for early‑onset metastatic cancer: Insights and innovations (Review) Open
Cancer metastasis is the primary cause of cancer deaths. Metastasis involves the spread of cancer cells from the primary tumors to other body parts, commonly through lymphatic and vascular pathways. Key aspects include the high mutation ra…
View article: Synergistic role of activated CD4+ memory T cells and CXCL13 in augmenting cancer immunotherapy efficacy
Synergistic role of activated CD4+ memory T cells and CXCL13 in augmenting cancer immunotherapy efficacy Open
The development of immune checkpoint inhibitors (ICIs) has significantly advanced cancer treatment. However, their efficacy is not consistent across all patients, underscoring the need for personalized approaches. In this study, we examine…
View article: Unraveling the role of M1 macrophage and CXCL9 in predicting immune checkpoint inhibitor efficacy through multicohort analysis and single‐cell RNA sequencing
Unraveling the role of M1 macrophage and CXCL9 in predicting immune checkpoint inhibitor efficacy through multicohort analysis and single‐cell RNA sequencing Open
The exact function of M1 macrophages and CXCL9 in forecasting the effectiveness of immune checkpoint inhibitors (ICIs) is still not thoroughly investigated. We investigated the potential of M1 macrophage and C‐X‐C Motif Chemokine Ligand 9 …
View article: Tumor-associated macrophages in non-small-cell lung cancer: From treatment resistance mechanisms to therapeutic targets
Tumor-associated macrophages in non-small-cell lung cancer: From treatment resistance mechanisms to therapeutic targets Open
Non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related deaths worldwide. Different treatment approaches are typically employed based on the stage of NSCLC. Common clinical treatment methods include surgical …
View article: Mri-Based Multimodal-Data Fusion Enhanced Postoperative Risk Stratification to Support Clinical Decisions of Breast Cancer Using 3d Ai Analysis: A Multicenter Study
Mri-Based Multimodal-Data Fusion Enhanced Postoperative Risk Stratification to Support Clinical Decisions of Breast Cancer Using 3d Ai Analysis: A Multicenter Study Open
View article: Nanotechnology-enabled sonodynamic therapy against malignant tumors
Nanotechnology-enabled sonodynamic therapy against malignant tumors Open
This review systematically describes and summarizes the application of nanotechnology-enabled sonodynamic therapy in malignant tumors.
View article: Machine learning radiomics of magnetic resonance imaging predicts recurrence-free survival after surgery and correlation of LncRNAs in patients with breast cancer: a multicenter cohort study
Machine learning radiomics of magnetic resonance imaging predicts recurrence-free survival after surgery and correlation of LncRNAs in patients with breast cancer: a multicenter cohort study Open
View article: 170P Clinical significance and functional role of GPR56 (ADGRG1) in breast cancer
170P Clinical significance and functional role of GPR56 (ADGRG1) in breast cancer Open
View article: Unraveling the Unfolded Protein Response Signature: Implications for Tumor Immune Microenvironment Heterogeneity and Clinical Prognosis in Stomach Cancer
Unraveling the Unfolded Protein Response Signature: Implications for Tumor Immune Microenvironment Heterogeneity and Clinical Prognosis in Stomach Cancer Open
Background Stomach cancer is a leading cause of cancer-related deaths globally due to its high grade and poor response to treatment. Understanding the molecular network driving the rapid progression of stomach cancer is crucial for improvi…