Explanipedia

Dosing patterns of ponatinib in patients with chronic-Phase chronic myeloid leukemia and effect on treatment: Analysis of specialty pharmacy data in the United States Open

Wenhong Liu · 2025

Introduction Ponatinib, the only BCR::ABL1 TKI with no contraindicated mutations, has been evaluated in patients (pts) with chronic-phase chronic myeloid leukemia (CP-CML) in two large, global, phase 2 studies. The PACE study (NCT01207440)…

Resistance profile and influence factors of carbapenem-resistant Klebsiella pneumoniae (CRKP) causing infections in China: a systematic review and meta-analysis Open

Xiaolu Yang, Zhenghao Lou, Xinrui Wang, Zhen Li, Q. Liu , et al. · 2025

The prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections has surged in China over the past decade, posing a significant public health concern. However, comprehensive data on CRKP antimicrobial resistance patterns and …

Comment on Halley C, et al. Open

Z. G. Zhao, Wenhong Liu · 2025

Genomic and phenotypic insights into ST164 blaNDM-1-positive Acinetobacter baumannii from intestinal colonization in China Open

Kun Wang, Weidong Zhu, Lu Gong, Xiaolu Yang, Haowei Ye , et al. · 2025

Genomic insights and epidemiology of mcr-1-Carrying Escherichia albertii isolated from agricultural soil in China Open

Yang Yu, Wenhong Liu, Z. G. Zhao, Kexin Guo, Xinrui Wang , et al. · 2025

Our findings offer new insights into the epidemiology and genomic features of mcr-1-carrying E. albertii, underscoring the need for targeted management strategies to curb its spread. These findings underscore the importance of "One Health"…

CAV1 inhibits Xc- system through IFNGR1 to promote ferroptosis to inhibit stemness and improves anti-PD-1 efficacy in breast cancer Open

Wenhong Liu, Guanghua Luo · 2024

Breast cancer is the most prevalent malignancy among women worldwide, with breast cancer stem cells (BCSCs) being the primary drivers of metastasis and recurrence. Numerous studies have elucidated the relationship between ferroptosis and c…

NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-κB signaling pathway Open

Wenhong Liu, Guanghua Luo · 2024

Cascaded multiplier-free implementation of adaptive anti-jamming filter based on GNSS receiver Open

Jie Song, Lei Chen, Zukun Lu, Baiyu Li, Zhe Liu , et al. · 2024

Evaluating the computational complexity is critical for assessing the time-domain anti-jamming performance of GNSS receivers. The multiplier is the core component that contributes to the computational complexity in time-domain anti-jamming…

Emergence of an Extensive Drug Resistant Citrobacter portucalensis Clinical Strain Harboring blaSFO-1, blaKPC-2, and blaNDM-1 Open

Kexin Guo, Z. G. Zhao, Yu Yang, Xiawei Jiang, Hao Xu , et al. · 2024

We discovered the coexistence of bla _SFO-1, bla _NDM-1, and bla _KPC-2 in C. portucalensis for the first time, delving into plasmid characteristics and transfer mechanisms. Our fin…

Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway Open

Qingling Liu, Liqin Jiang, Yun Zhao, Fang Su, Junfeng Li , et al. · 2024

Ovarian cancer (OC) is one of the most common gynecological malignancies. Currently, chemoradiotherapy is the primary clinical treatment approach for OC; however, it has severe side effects and a high rate of recurrence. Thus, there is an …

Emergence of multidrug-resistant Klebsiella pneumoniae in wild animals in Africa Open

Yu Yang, Xiawei Jiang, Beiwen Zheng, Hao Xu, Wenhong Liu · 2024

Klebsiella pneumoniae, responsible for a range of infections, poses a considerable public health threat because of its wide distribution and propensity for antimicrobial resistance (AMR).1Zou H Zhou Z Berglund B et al.Persistent transmissi…

Correction: Fuling Granule, a Traditional Chinese Medicine Compound, Suppresses Cell Proliferation and TGFβ-Induced EMT in Ovarian Cancer Open

Fangfang Tao, Shanming Ruan, Wenhong Liu, Libin Wang, Yang Xiong , et al. · 2023

[This corrects the article DOI: 10.1371/journal.pone.0168892.].

Pan-cancer Analysis of the Prognostic and Immunological Effects of PIK3C3 Open

Qianxin Xie, Jie Zhou, Junfeng Guan, Siqi She, Junfeng Li , et al. · 2023

Background Autophagy-related protein plays a pivotal role in cancer development, progression, and prognosis. Among these proteins, PIK3C3 holds significant importance as it is involved in canonical autophagy, endocytosis, and vesicle traff…

Regulation of hPCL3 isoforms’ ubiquitination by TRIM21 in non-small cell lung cancer progression Open

Ye Xu, Wenhong Liu, Xiawei Jiang, Junfeng Li, Qingling Liu , et al. · 2023

Non-small cell lung cancer (NSCLC) is the main subtype of lung cancer. The role of hPCL3 isoforms, hPCL3S and hPCL3L, remains ambiguous. This study examines the functional implications of these isoforms in NSCLC, using lung cancer cell lin…

A Three Dimensional Real-time Heat Transfer Model for Continuous Casting Blooms Open

Jian Yang, Zhi Xie, Hongji Meng, Zhenwei Hu, Wenhong Liu , et al. · 2023

Heat transfer model is the basis for control and optimization of continuous casting of steel. In this paper, a three dimensional (3D) real-time heat transfer model has been presented for continuous casting blooms, especially for the initia…

3D Transient Heat Transfer Simulation and Optimization for Initial Stage of Steel Continuous Casting Process Open

Jian Yang, Zhi Xie, Hongji Meng, Zhenwei Hu, Wenhong Liu , et al. · 2023

In this paper, a specially designed three dimensional transient heat transfer model has been developed for initial stage of steel continuous casting process. Firstly, a general three dimensional heat transfer model for continuous casting p…

Nacl-Induced Hot-Corrosion Behavior and Mechanism of Tisicn/Ag Nanocomposite Coatings by Arc Ion Plating Open

Dali Du, Wuming Guo, Zhenrong Gao, Jinlong Li, Wenhong Liu · 2023

Emergence of a NDM-1-producing ST25 Klebsiella pneumoniae strain causing neonatal sepsis in China Open

Junhui Zhao, Beiwen Zheng, Hao Xu, Junfeng Li, Tengfei Sun , et al. · 2022

Carbapenem-resistant Klebsiella pneumoniae (CRKP) seriously threaten the efficacy of modern medicine with a high associated mortality rate and unprecedented transmission rate. In this study, we isolated a clinical K. pneumoniae strain DY19…

Microstructures and mechanical properties of Mg–6Zn–1Y–0.85Zr alloy prepared at different extrusion temperatures and speeds Open

Wenhong Liu, Jiaxin Bao, Mingliang Qiao, Siqi Yin, Zhankun Wang , et al. · 2022

Insights of NaCl water vapor coupling induced hot corrosion behaviors of IN718 superalloy Open

Wenhong Liu, Tiancheng Cui, Minpeng Dong, Miao Yu, Jinlong Li · 2022

The hot corrosion behavior of Ni‐based superalloys induced by NaCl at 600°C, 650°C, and 700°C in a marine‐like environment was investigated. The results show that the corrosion scale on the IN718 alloy includes two distinct layers, of whic…

Effects of deformation twins on microstructure evolution, mechanical properties and corrosion behaviors in magnesium alloys - A review Open

Lianhui Li, Wenhong Liu, Fugang Qi, Di Wu, Zhiqiang Zhang · 2022

Exercise Intervention Modulates Synaptic Plasticity by Inhibiting Excessive Microglial Activation via Exosomes Open

Chen Li, Jiayi Hu, Wenhong Liu, Changkai Ke, Chuan Huang , et al. · 2022

Background Exosomes can activate microglia to modulate neural activity and synaptic plasticity by phagocytosis of neural spines or synapses. Our previous research found that an early 4-week exercise intervention in middle cerebral artery o…

Study on the Correlation between Chinese Medicine Syndrome and Cognitive Dysfunction in Mild Cognitive Impairment Open

Zhiying Lin, Tianwen Huang, Guan-Yi Zheng, Runqiong Chen, Ming-Long Yao , et al. · 2022

Objective. To investigate the correlation between Chinese medicine syndrome and cognitive dysfunction in patients with mild cognitive impairment (MCI). Methods. 121 MCI patients were included for syndrome differentiation and syndrome scori…

Effect of trace copper on the microstructure, corrosion behavior and biological properties of biodegradable Mg–2Zn-1Gd-0.5Zr alloy Open

Mingliang Qiao, Jianchun Sha, Siqi Yin, Wenhong Liu, Zhong Zhao , et al. · 2022

The biodegradable Mg–2Zn-1Gd-0.5Zr-xCu (x = 0, 0.1, 0.3, 0.5 wt.%) alloys are prepared to evaluate their microstructures, corrosion behavior, biocompatibility and antimicrobial properties. When the Cu element adds to the alloys, the new Mg…

Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway Open

Dan Li, Jiang Qian, Junfeng Li, Jia Wang, Wenhong Liu , et al. · 2022

Dexmedetomidine (DEX) protects against acute stress-induced liver injury, but what's less clear lies in the specific mechanism. To elucidate the specific mechanism underlying DEX on acute stress-induced liver injury, an in vivo model was c…

[Retracted] Network Pharmacology, Molecular Docking, and Experimental Validation to Unveil the Molecular Targets and Mechanisms of Compound Fuling Granule to Treat Ovarian Cancer Open

Zhaoyi Li, Qingling Liu, Ying Zhu, Lichao Wu, Wenhong Liu , et al. · 2022

Background . Compound fuling granule (CFG) is a traditional Chinese medicine formula that is used for more than twenty years to treat ovarian cancer (OC) in China. However, the underlying processes have yet to be completely understood. Thi…

Predicting The Effect of Different Magnetic Fields on The Solute Segregation During Direct-Chill Casting Of Large-Size Magnesium Alloy Slab Open

Wenchao Duan, Yiqiang Yang, Wenhong Liu, Zhiqiang Zhang, Jianzhong Cui · 2021

Prevalence of post-traumatic stress disorder after earthquakes among the elderly in China: A meta-analysis Open

Yong Liang, Hong Zeng, Yu-geng Liu, Aimin Xu, Wenhong Liu · 2021

After earthquakes, the occurrence of PTSD is higher among the elderly than among other age groups, and higher among the females than among the males, while there is little difference among different areas within the same province. This ind…

Research on Solve of Heat Transfer Coefficients and Experimental of the Heavy Plate in laminar cooling process Open

Junlin Wang, Zhi Xie, Wenhong Liu · 2020

Heat transfer model is the premise of adjusting cooling control strategy in laminar cooling process. The accuracy of heat transfer coefficient directly affects the accuracy of the temperature model. However the accuracy of heat transfer co…

Study on the Mechanical Properties of 125S Casing for oil and gas wells Open

Lou Qi, Wei Du, Xinli Han, Wenhong Liu, Song Huan · 2020

In the process of evaluating the quality of a batch of 125S casing for oil and gas wells, it was found that the mechanical properties of different casing bodies in the same batch were significantly different, and the fluctuation range of y…

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