Wenhua Kuang
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View article: Structural insight into RNA encapsidation by the severe fever with thrombocytopenia syndrome virus nucleocapsid protein
Structural insight into RNA encapsidation by the severe fever with thrombocytopenia syndrome virus nucleocapsid protein Open
Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging highly pathogenic bunyavirus, poses a significant public health threat with a case fatality rate of up to 30%. The viral nucleocapsid protein (NP) encapsidates the geno…
View article: Structure and function of the nairovirus cap-snatching endonuclease
Structure and function of the nairovirus cap-snatching endonuclease Open
Nairoviruses include several human pathogens such as Crimean-Congo hemorrhagic fever virus (CCHFV) and Kasokero virus (KASV). The cap-snatching endonuclease (EN) domain of the viral polymerase is essential for transcription and represents …
View article: Chemo-proteomics reveals dihydrocaffeic acid exhibits anti-inflammation effects via Transaldolase 1 mediated PERK-NF-κB pathway
Chemo-proteomics reveals dihydrocaffeic acid exhibits anti-inflammation effects via Transaldolase 1 mediated PERK-NF-κB pathway Open
This study provide support for the potential advancement of DA for use as a therapeutic agent for the treatment of acute pneumonia and inflammation-associated diseases.
View article: Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1
Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1 Open
View article: Ailanthone induces triple-negative breast cancer cells death involving the inhibition of OTUB1-mediated ERRα deubiquitylation
Ailanthone induces triple-negative breast cancer cells death involving the inhibition of OTUB1-mediated ERRα deubiquitylation Open
AIL is a promising downregulator of ERRα, and the mechanism of this downregulation has been elucidated. Additionally, a new regulatory relationship between ERRα and OTUB1 is identified. The research presented in this article is anticipated…
View article: Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3
Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3 Open
Periodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a …
View article: A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection
A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection Open
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging bunyavirus that causes severe viral hemorrhagic fever and thrombocytopenia syndrome with a fatality rate of up to 30%. No licensed vaccines or therapeutics are curren…
View article: Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway
Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway Open
Exposure to environmentally hazardous substances is recognized as a significant risk factor for neurological associated disorders. Among these substances, polystyrene microplastics (PS-MPs), widely utilized in various consumer products, ha…
View article: Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase
Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase Open
Type II topoisomerase utilizes the energy from ATP hydrolysis to alter DNA topology during genome replication and transcription. The ATPase domain of this enzyme is required for ATP hydrolysis and plays a crucial role in coupling DNA bindi…
View article: Celastrol induces premature ovarian insufficiency by inducing apoptosis in granulosa cells
Celastrol induces premature ovarian insufficiency by inducing apoptosis in granulosa cells Open
Celastrol, a natural compound purified from the Chinese herb Tripterygium wilfordii Hook. f., has excellent pharmacological activity for the treatment of various diseases. Assessing the safety of its use is essential for its development in…
View article: Cryo-EM structures of African swine fever virus topoisomerase
Cryo-EM structures of African swine fever virus topoisomerase Open
Type II topoisomerases ubiquitously exist in cellular organisms, where they play an essential role in resolving the topological problems of DNA. The viral type II topoisomerase encoded by the African swine fever virus (ASFV) is critical fo…
View article: AC81 Is a Putative Disulfide Isomerase Involved in Baculoviral Disulfide Bond Formation
AC81 Is a Putative Disulfide Isomerase Involved in Baculoviral Disulfide Bond Formation Open
Many large DNA viruses, such as poxvirus, asfarvirus, and baculovirus, encode their own sulfhydryl oxidase to facilitate the disulfide bond formation of viral proteins. Here, we show that AC81 functions as a putative disulfide isomerase an…
View article: Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity
Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity Open
View article: Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: <i>Bunyavirales</i> )
Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: <i>Bunyavirales</i> ) Open
The Bunyavirales contain many important human pathogens such as Crimean-Congo hemorrhagic fever virus and Lassa virus that pose serious threats to public health; however, currently there are no specific antiviral drugs against these viruse…
View article: SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility
SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility Open
View article: <i>Per Os</i> Infectivity Factor 5 Identified as a Substrate of P33 in the Baculoviral Disulfide Bond Formation Pathway
<i>Per Os</i> Infectivity Factor 5 Identified as a Substrate of P33 in the Baculoviral Disulfide Bond Formation Pathway Open
Similar to some large DNA viruses that encode their own disulfide bond pathway, baculovirus encodes a viral sulfhydryl oxidase, P33. Enzyme activity of P33 is related to infectious BV production, occlusion-derived virus (ODV) envelopment, …
View article: SLC22A14 is a Mitochondrial Riboflavin Transporter Required for Sperm Oxidative Phosphorylation and Male Fertility
SLC22A14 is a Mitochondrial Riboflavin Transporter Required for Sperm Oxidative Phosphorylation and Male Fertility Open
View article: Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans Open
Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Design We investigated the functional contribution of fatt…
View article: Genome analysis of a novel Group I alphabaculovirus obtained from Oxyplax ochracea
Genome analysis of a novel Group I alphabaculovirus obtained from Oxyplax ochracea Open
Oxyplax ochracea (Moore) is a pest that causes severe damage to a wide range of crops, forests and fruit trees. The complete genome sequence of Oxyplax ochracea nucleopolyhedrovirus (OxocNPV) was determined using a Roche 454 pyrosequencing…
View article: CCDC 1851371: Experimental Crystal Structure Determination
CCDC 1851371: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1851369: Experimental Crystal Structure Determination
CCDC 1851369: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1851370: Experimental Crystal Structure Determination
CCDC 1851370: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function
Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function Open
Baculoviruses encode a conserved sulfhydryl oxidase, P33, which is necessary for budded virus (BV) production and multinucleocapsid occlusion-derived virus (ODV) formation. Here, the structural and functional relationship of P33 was reveal…
View article: A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information Open
View article: Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity
Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity Open
View article: A Network Integration Approach for Drug-Target Interaction Prediction and Computational Drug Repositioning from Heterogeneous Information
A Network Integration Approach for Drug-Target Interaction Prediction and Computational Drug Repositioning from Heterogeneous Information Open
The emergence of large-scale genomic, chemical and pharmacological data provides new opportunities for drug discovery and repositioning. Systematic integration of these heterogeneous data not only serves as a promising tool for identifying…
View article: P33 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus is a functional homolog of AcP33
P33 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus is a functional homolog of AcP33 Open
View article: Characterization of the viral fibroblast growth factor homolog of Helicoverpa armigera single nucleopolyhedrovirus
Characterization of the viral fibroblast growth factor homolog of Helicoverpa armigera single nucleopolyhedrovirus Open