Wenhui Xing
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View article: Telomere-to-telomere gap-free genome assembly of a male donkey and the identification of novel SVs associated with functional genes
Telomere-to-telomere gap-free genome assembly of a male donkey and the identification of novel SVs associated with functional genes Open
Previous assemblies of the donkey genome remain with gaps and structural errors, and a complete donkey genome will greatly facilitate genetic research related to donkeys. In the present study, a 2.78-Gb telomere-to-telomere gap-free donkey…
View article: Multi-perspective analysis of daVinci surgical virtual reality training: a prospective randomized controlled study
Multi-perspective analysis of daVinci surgical virtual reality training: a prospective randomized controlled study Open
View article: Piezo1 balances the osteogenic-tenogenic plasticity of periosteal progenitor cells through the YAP pathway
Piezo1 balances the osteogenic-tenogenic plasticity of periosteal progenitor cells through the YAP pathway Open
The extremity tendons and bones are derived from limb bud mesenchyme, which eventually becomes cells of different tissues. Despite their common origin, it was widely believed that tenocytes and skeletal cells are distinct lineages without …
View article: Tenascin-C promotes bone regeneration via inflammatory macrophages
Tenascin-C promotes bone regeneration via inflammatory macrophages Open
During the early stage of tissue injury, macrophages play important roles in the activation of stem cells for further regeneration. However, the regulation of macrophages during bone regeneration remains unclear. Here, the extracellular ma…
View article: Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing
Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing Open
The periosteum contains skeletal stem/progenitor cells that contribute to bone fracture healing. However, the in vivo identity of periosteal skeletal stem cells (P-SSCs) remains unclear, and membrane protein markers of P-SSCs that facilita…
View article: The effect of fear-avoidance intervention on kinesiophobia and self-efficacy in patients after percutaneous coronary intervention: study protocol for a clinical randomized controlled trial
The effect of fear-avoidance intervention on kinesiophobia and self-efficacy in patients after percutaneous coronary intervention: study protocol for a clinical randomized controlled trial Open
View article: Robust Artificial Intelligence Tool for Atrial Fibrillation Diagnosis: Novel Development Approach Incorporating Both Atrial Electrograms and Surface ECG and Evaluation by Head‐to‐Head Comparison With Hospital‐Based Physician ECG Readers
Robust Artificial Intelligence Tool for Atrial Fibrillation Diagnosis: Novel Development Approach Incorporating Both Atrial Electrograms and Surface ECG and Evaluation by Head‐to‐Head Comparison With Hospital‐Based Physician ECG Readers Open
Background Atrial fibrillation (AF) increases risk of embolic stroke, and in postoperative patients, increases cost of care. Consequently, ECG screening for AF in high‐risk patients is important but labor‐intensive. Artificial intelligence…
View article: Skeletal stem cells: origins, definitions, and functions in bone development and disease
Skeletal stem cells: origins, definitions, and functions in bone development and disease Open
Skeletal stem cells (SSCs) are tissue-specific stem cells that can self-renew and sit at the apex of their differentiation hierarchy, giving rise to mature skeletal cell types required for bone growth, maintenance, and repair. Dysfunction …
View article: Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration
Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration Open
Intervertebral disc degeneration (IDD) results from the dysfunction of nucleus pulposus (NP) cells and the exhaustion of NP progenitors (ProNPs). The cellular applications of NP cells during IDD are currently limited due to the lack of in …
View article: Novel-Dataset Based Electrocardiogram Diagnosis of Atrial Fibrillation with Deep Learning: A Prospective Study
Novel-Dataset Based Electrocardiogram Diagnosis of Atrial Fibrillation with Deep Learning: A Prospective Study Open
View article: Portable Device Improves the Detection of Atrial Fibrillation After Ablation
Portable Device Improves the Detection of Atrial Fibrillation After Ablation Open
Asymptomatic recurrences of atrial fibrillation (AF) have been found to be common after ablation.A randomized controlled trial of AF screening using a handheld single-lead ECG monitor (BigThumb®) or a traditional follow-up strat…
View article: Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing
Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing Open
We provide the first genetic evidence that LSD1 in skeletal cells is critical for endochondral ossification during bone repair.
View article: A gene prioritization method based on a swine multi-omics knowledgebase and a deep learning model
A gene prioritization method based on a swine multi-omics knowledgebase and a deep learning model Open
View article: Tendon-derived cathepsin K–expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification
Tendon-derived cathepsin K–expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification Open
Heterotopic ossification (HO) is pathological bone formation characterized by ossification within muscle, tendons, or other soft tissues. However, the cells of origin and mechanisms involved in the pathogenesis of HO remain elusive. Here w…
View article: The portable device improves the detection of atrial fibrillation after ablation
The portable device improves the detection of atrial fibrillation after ablation Open
Background: Asymptomatic recurrences of atrial fibrillation (AF) are common after ablation of AF. Objective: We aimed to analyze the performance of the mobile ECG device using artificial intelligence (AI) algorithm in detection of AF after…
View article: A Federated Learning Framework for Healthcare IoT devices
A Federated Learning Framework for Healthcare IoT devices Open
The Internet of Things (IoT) revolution has shown potential to give rise to many medical applications with access to large volumes of healthcare data collected by IoT devices. However, the increasing demand for healthcare data privacy and …
View article: Diagnosing Cardiac Abnormalities from 12-Lead Electrocardiograms Using Enhanced Deep Convolutional Neural Networks
Diagnosing Cardiac Abnormalities from 12-Lead Electrocardiograms Using Enhanced Deep Convolutional Neural Networks Open
We train an enhanced deep convolutional neural network in order to identify eight cardiac abnormalities from the standard 12-lead electrocardiograms (ECGs) using the dataset of 14000 ECGs. Instead of straightforwardly applying an end-to-en…
View article: Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development
Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development Open
Mutagenic screening is powerful for identifying key genes involved in developmental processes. However, such screens are successful only in lower organisms. Here, we develop a targeted genetic screening approach in mice through combining a…
View article: Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation
Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation Open
Bone osteogenic sarcoma has a poor prognosis as the exact cell of origin and the signaling pathways underling tumor formation remain undefined. Here, we report an osteogenic tumor mouse model based on the conditional knockout of liver kina…
View article: Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts Open
View article: A gene–phenotype relationship extraction pipeline from the biomedical literature using a representation learning approach
A gene–phenotype relationship extraction pipeline from the biomedical literature using a representation learning approach Open
Motivation The fundamental challenge of modern genetic analysis is to establish gene-phenotype correlations that are often found in the large-scale publications. Because lexical features of gene are relatively regular in text, the main cha…