Wenjia Shi
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View article: Prognostic Value of TyG Index and Right Ventricular Function in HFpEF
Prognostic Value of TyG Index and Right Ventricular Function in HFpEF Open
View article: miR-21-5p Alleviates Retinal Ischemia–Reperfusion Injury by Inhibiting M1 Polarization of Microglia via Suppression of STAT3 Signaling
miR-21-5p Alleviates Retinal Ischemia–Reperfusion Injury by Inhibiting M1 Polarization of Microglia via Suppression of STAT3 Signaling Open
Background/Objectives: Retinal ischemia–reperfusion (I/R) injury is a common mechanism in glaucoma, diabetic retinopathy, and retinal vein occlusion, leading to progressive loss of retinal ganglion cells (RGCs). This study investigates the…
View article: Author response: Dynamical mechanisms of growth-feedback effects on adaptive gene circuits
Author response: Dynamical mechanisms of growth-feedback effects on adaptive gene circuits Open
View article: Association between left ventricular mass and heart failure in chronic kidney disease: a cross-sectional study
Association between left ventricular mass and heart failure in chronic kidney disease: a cross-sectional study Open
Purpose Left ventricular mass (LVM) is an indicator of left ventricular hypertrophy (LVH), and has been studied in a variety of diseases, but the relationship between LVH and its occurrence in heart failure (HF) in patients with chronic ki…
View article: Dynamical mechanisms of growth-feedback effects on adaptive gene circuits
Dynamical mechanisms of growth-feedback effects on adaptive gene circuits Open
The successful integration of engineered gene circuits into host cells remains a significant challenge in synthetic biology due to circuit–host interactions, such as growth feedback, where the circuit influences cell growth and vice versa.…
View article: Integrating multimodal features to predict the malignancy of pulmonary ground−glass nodules: a multicenter prospective model development and validation study
Integrating multimodal features to predict the malignancy of pulmonary ground−glass nodules: a multicenter prospective model development and validation study Open
Background There is a clinical need for accurate noninvasive evaluation of the malignancy of pulmonary ground−glass nodules (GGNs) to reduce risks of overdiagnosis and overtreatment. This study aimed to develop and validate a clinic-biomar…
View article: Association between segmental noninvasive longitudinal strain and quantitative microvascular perfusion in ST-segment elevation myocardial infarction: implications for clinical outcomes
Association between segmental noninvasive longitudinal strain and quantitative microvascular perfusion in ST-segment elevation myocardial infarction: implications for clinical outcomes Open
Segmental LS indices are correlated with qMVP within the infarct zone following reperfused STEMI. Both rLS and r-qMVP are sensitive to myocardial damage and provide prognostic value for clinical events after STEMI. And the combination of r…
View article: Author response: Effects of growth feedback on adaptive gene circuits: A dynamical understanding
Author response: Effects of growth feedback on adaptive gene circuits: A dynamical understanding Open
View article: Effects of growth feedback on adaptive gene circuits: A dynamical understanding
Effects of growth feedback on adaptive gene circuits: A dynamical understanding Open
The successful integration of engineered gene circuits into host cells remains a significant challenge in synthetic biology due to circuit-host interactions, such as growth feedback, where the circuit influences cell growth and vice versa.…
View article: Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila
Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila Open
Propagation of intercellular calcium waves through tissues has been found to coordinate different multicellular responses. Nevertheless, our understanding of how calcium waves operate remains limited. In this study, we explore the real-tim…
View article: The Prognostic Value of TyG Index and Right Ventricular Function in HFpEF Patients with Chronic Kidney Disease
The Prognostic Value of TyG Index and Right Ventricular Function in HFpEF Patients with Chronic Kidney Disease Open
View article: Urban Functional Zone Mapping by Integrating Multi-Source Data and Spatial Relationship Characteristics
Urban Functional Zone Mapping by Integrating Multi-Source Data and Spatial Relationship Characteristics Open
Timely and precise acquisition of urban functional zone (UFZ) information is crucial for effective urban planning, management, and resource allocation. However, current UFZ mapping approaches primarily focus on individual functional units’…
View article: Dietary Amino Acids Promote Glucagon-like Hormone Release to Generate Novel Calcium Waves in Adipose Tissues
Dietary Amino Acids Promote Glucagon-like Hormone Release to Generate Novel Calcium Waves in Adipose Tissues Open
View article: Hill Function-based Model of Transcriptional Response: Impact of Nonspecific Binding and RNAP Interactions
Hill Function-based Model of Transcriptional Response: Impact of Nonspecific Binding and RNAP Interactions Open
Hill function is one of the widely used gene transcription regulation models. Its attribute of fitting may result in a lack of an underlying physical picture, yet the fitting parameters can provide information about biochemical reactions, …
View article: Computed tomography-based radiomics improves non-invasive diagnosis of Pneumocystis jirovecii pneumonia in non-HIV patients: a retrospective study
Computed tomography-based radiomics improves non-invasive diagnosis of Pneumocystis jirovecii pneumonia in non-HIV patients: a retrospective study Open
Background Pneumocystis jirovecii pneumonia (PCP) could be fatal to patients without human immunodeficiency virus (HIV) infection. Current diagnostic methods are either invasive or inaccurate. We aimed to establish an accurate and non-inva…
View article: The Value of Topological Radiomics Analysis in Predicting Malignant Risk of Pulmonary Ground-Glass Nodules: A Multi-Center Study
The Value of Topological Radiomics Analysis in Predicting Malignant Risk of Pulmonary Ground-Glass Nodules: A Multi-Center Study Open
Background Early detection and accurate differentiation of malignant ground-glass nodules (GGNs) in lung CT scans are crucial for the effective treatment of lung adenocarcinoma. However, existing imaging diagnostic methods often struggle t…
View article: Effects of growth feedback on gene circuits: A dynamical understanding
Effects of growth feedback on gene circuits: A dynamical understanding Open
The successful integration of engineered gene circuits into host cells remains a significant challenge in synthetic biology due to circuit-host interactions, such as growth feedback, where the circuit influences cell growth and vice versa.…
View article: Dynamical mechanisms of growth-feedback effects on adaptive gene circuits
Dynamical mechanisms of growth-feedback effects on adaptive gene circuits Open
The successful integration of engineered gene circuits into host cells remains a significant challenge in synthetic biology due to circuit–host interactions, such as growth feedback, where the circuit influences cell growth and vice versa.…
View article: Author Response: Effects of growth feedback on gene circuits: A dynamical understanding
Author Response: Effects of growth feedback on gene circuits: A dynamical understanding Open
The successful integration of engineered gene circuits into host cells remains a significant challenge in synthetic biology due to circuit-host interactions, such as growth feedback, where the circuit influences cell growth and vice versa.…
View article: MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model
MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model Open
The present study focused on the effect of miR-93-5p on apoptosis of retinal neurons in acute ocular hypertension (AOH) model by regulating PDCD4 and explored its related mechanism. We detected that miR-93-5p expression was decreased and P…
View article: Effects of growth feedback on adaptive gene circuits: A dynamical understanding
Effects of growth feedback on adaptive gene circuits: A dynamical understanding Open
The successful integration of engineered gene circuits into host cells remains a significant challenge in synthetic biology due to circuit-host interactions, such as growth feedback, where the circuit influences cell growth and vice versa.…
View article: Establishing a predictive model for tumor mutation burden status based on CT radiomics and clinical features of non-small cell lung cancer patients
Establishing a predictive model for tumor mutation burden status based on CT radiomics and clinical features of non-small cell lung cancer patients Open
The radiomics model based on CT images of NSCLC patients performed well in distinguishing the status of TMB-high and TMB-low, and the nomogram could provide additional information on the timing and regimen of immunotherapy.
View article: (−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase
(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase Open
Nicotinamide adenine dinucleotide kinase (NADK) controls the intracellular NADPH content and provides reducing power for the synthesis of macromolecules and anti-ROS. Moreover, NADK is considered to be a synthetic lethal gene for KRAS muta…
View article: Correlation between PD-L1 expression and radiomic features in early-stage lung adenocarcinomas manifesting as ground-glass nodules
Correlation between PD-L1 expression and radiomic features in early-stage lung adenocarcinomas manifesting as ground-glass nodules Open
Background Immunotherapy might be a promising auxiliary or alternative systemic treatment for early-stage lung adenocarcinomas manifesting as ground-glass nodules (GGNs). This study intended to investigate the PD-L1 expression in these pat…
View article: Tri-Channel Electrochemical Immunobiosensor for Combined Detections of Multiple Exosome Biomarkers of Lung Cancer
Tri-Channel Electrochemical Immunobiosensor for Combined Detections of Multiple Exosome Biomarkers of Lung Cancer Open
Current methods for the early diagnosis of cancer can be invasive and costly. In recent years, exosomes have been recognized as potential biomarkers for cancer diagnostics. The common methods for quantitative detection of exosomes, such as…
View article: A loosened gating mechanism of RIG-I leads to autoimmune disorders
A loosened gating mechanism of RIG-I leads to autoimmune disorders Open
DDX58 encodes RIG-I, a cytosolic RNA sensor that ensures immune surveillance of nonself RNAs. Individuals with RIG-IE510V and RIG-IQ517H mutations have increased susceptibility to Singleton-Merten syndrome (SMS) defects, resulting in tissu…
View article: A computerized tomography-based radiomic model for assessing the invasiveness of lung adenocarcinoma manifesting as ground-glass opacity nodules
A computerized tomography-based radiomic model for assessing the invasiveness of lung adenocarcinoma manifesting as ground-glass opacity nodules Open
Background Clinically differentiating preinvasive lesions (atypical adenomatous hyperplasia, AAH and adenocarcinoma in situ, AIS) from invasive lesions (minimally invasive adenocarcinomas, MIA and invasive adenocarcinoma, IA) manifesting a…
View article: Predicting Ki‐67 labeling index level in early‐stage lung adenocarcinomas manifesting as ground‐glass opacity nodules using intra‐nodular and peri‐nodular radiomic features
Predicting Ki‐67 labeling index level in early‐stage lung adenocarcinomas manifesting as ground‐glass opacity nodules using intra‐nodular and peri‐nodular radiomic features Open
Objectives To explore the diagnostic value of radiomics in differentiating between lung adenocarcinomas appearing as ground‐glass opacity nodules (GGO) with high‐ and low Ki‐67 expression levels. Materials and Methods From January 2018 to …
View article: Synthetic robust perfect adaptation achieved by negative feedback coupling with linear weak positive feedback
Synthetic robust perfect adaptation achieved by negative feedback coupling with linear weak positive feedback Open
Unlike their natural counterparts, synthetic genetic circuits are usually fragile in the face of environmental perturbations and genetic mutations. Several theoretical robust genetic circuits have been designed, but their performance under…
View article: The identifiability of gene regulatory networks: the role of observation data
The identifiability of gene regulatory networks: the role of observation data Open