Wenjia Weng
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View article: Untargeted metabolomics in a prospective cross-sectional observational study reveals differences in plasma and cerebrospinal fluid between asymptomatic neurosyphilis and serofast syphilis
Untargeted metabolomics in a prospective cross-sectional observational study reveals differences in plasma and cerebrospinal fluid between asymptomatic neurosyphilis and serofast syphilis Open
Asymptomatic neurosyphilis (ANS), a diagnostically elusive complication of Treponema pallidum infection, necessitates invasive cerebrospinal fluid (CSF) analysis for detection. This study investigated metabolic differences between patients…
View article: Assessment of Syphilitic Optic Neuropathy: A Prospective Cross-Sectional Study
Assessment of Syphilitic Optic Neuropathy: A Prospective Cross-Sectional Study Open
The SONs could manifest as asymptomatic optic disc edema or blinding optic atrophy, which were independent episodic reactions from ocular or cerebral syphilis, respectively. Our data highlighted the need for ophthalmic screening and prompt…
View article: Refining a non-invasive prediction model for neurosyphilis diagnosis by using immunoassay to detect serum anti-TP0435 (TP17) and TP0574 (TP47) IgG antibodies: two-centre cross-sectional retrospective study in China
Refining a non-invasive prediction model for neurosyphilis diagnosis by using immunoassay to detect serum anti-TP0435 (TP17) and TP0574 (TP47) IgG antibodies: two-centre cross-sectional retrospective study in China Open
Serum antibodies against TP17 and TP47 exhibited promising diagnostic capability for NS and significantly enhanced the predictive accuracy of model for NS diagnosis. Our study highlights the potential of serum treponemal antibody detection…
View article: TREM2 inhibits rTp47-induced inflammasome activation and pyroptosis via targeting NLRP3
TREM2 inhibits rTp47-induced inflammasome activation and pyroptosis via targeting NLRP3 Open
Background: Microglia surface receptors, particularly TREM2 (triggering receptor expressed on myeloid cells 2), play a crucial role as sensors for pathogen entry and can trigger robust immune responses. However, the specific role of TREM2 …
View article: Evaluating the clinical utility of semi-quantitative luciferase immunosorbent assay using <i>Treponema pallidum</i> antigens in syphilis diagnosis and treatment monitoring
Evaluating the clinical utility of semi-quantitative luciferase immunosorbent assay using <i>Treponema pallidum</i> antigens in syphilis diagnosis and treatment monitoring Open
To assess the clinical applicability of a semi-quantitative luciferase immunosorbent assay (LISA) for detecting antibodies against Treponema pallidum antigens TP0171 (TP15), TP0435 (TP17), and TP0574 (TP47) in diagnosing and monitor…
View article: Large‐Scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis (Adv. Sci. 16/2024)
Large‐Scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis (Adv. Sci. 16/2024) Open
Diagnostic Biomarkers In article number 2307744, Jun Li, Yunping Zhu, Ling Leng, and their co‐workers depict the process of identifying the diagnostic biomarkers for neurosyphilis (NS) through Chinese mythology “Shennong Tastes a Hundred G…
View article: Large‐Scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis
Large‐Scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis Open
Neurosyphilis (NS) is a central nervous system (CNS) infection caused by Treponema pallidum ( T. pallidum ). NS can occur at any stage of syphilis and manifests as a broad spectrum of clinical symptoms. Often referred to as “the great imit…
View article: Diagnosis of neurosyphilis in HIV-negative patients with syphilis: development, validation, and clinical utility of a suite of machine learning models
Diagnosis of neurosyphilis in HIV-negative patients with syphilis: development, validation, and clinical utility of a suite of machine learning models Open
View article: Role of microglia in HIV-1 infection
Role of microglia in HIV-1 infection Open
The usage of antiretroviral treatment (ART) has considerably decreased the morbidity and mortality related to HIV-1 (human immunodeficiency virus type 1) infection. However, ART is ineffective in eradicating the virus from the persistent c…
View article: The benefits of psychosocial interventions for mental health in men who have sex with men living with HIV: a systematic review and meta-analysis
The benefits of psychosocial interventions for mental health in men who have sex with men living with HIV: a systematic review and meta-analysis Open
View article: Factors Associated With Neurosyphilis in Patients With Syphilis Treatment Failure: A Retrospective Study of 165 HIV-Negative Patients
Factors Associated With Neurosyphilis in Patients With Syphilis Treatment Failure: A Retrospective Study of 165 HIV-Negative Patients Open
Background In recent years, the incidence of syphilis has increased year by year. Our study is to explore the risk factors for the development of neurosyphilis in patients who failed syphilis treatment. Methods A total number of 165 patien…
View article: CD8+ stem cell-like memory T cell subset is associated with disease progression in chronic hepatitis C virus infection
CD8+ stem cell-like memory T cell subset is associated with disease progression in chronic hepatitis C virus infection Open
Background The dysfunction of memory CD8 + T cell can not be reverted by successful clearance of hepatitis C virus (HCV) after direct-acting antivirals (DAA) therapy, increasing the risk of reinfection with HCV. Stem cell-like memory T cel…
View article: Improving the Acceptability of Human Papillomavirus Vaccines Among Men Who Have Sex With Men According to the Associated Factors: A Systematic Review and Meta-analysis
Improving the Acceptability of Human Papillomavirus Vaccines Among Men Who Have Sex With Men According to the Associated Factors: A Systematic Review and Meta-analysis Open
Objectives : To investigate the acceptability of human papillomavirus (HPV) vaccination among men who have sex with men (MSM) and its associated factors. Methods : We searched studies written in English in PubMed, EMBASE, and Web of Scienc…
View article: Syphilitic infection impairs immunity by inducing both apoptosis and pyroptosis of CD4<sup>+</sup> and CD8<sup>+</sup> T lymphocytes
Syphilitic infection impairs immunity by inducing both apoptosis and pyroptosis of CD4<sup>+</sup> and CD8<sup>+</sup> T lymphocytes Open
Syphilis is an important health problem worldwide; however, few studies have probed the impact of syphilitic infection on T cell turnover. The mechanisms behind the frequency of T cell subset changes and the associations between these subs…
View article: Improve acceptability of HPV vaccine among men who have sex with men according to the correlated factors: a systematic review and meta-analysis
Improve acceptability of HPV vaccine among men who have sex with men according to the correlated factors: a systematic review and meta-analysis Open