Wenjia Zhu
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View article: Platelet activation plays a pro-inflammatory role in myasthenia gravis
Platelet activation plays a pro-inflammatory role in myasthenia gravis Open
Myasthenia gravis (MG) is an autoimmune disorder that disrupts neuromuscular junction function through autoantibodies. Platelets are emerging as key players in the pathogenesis of MG, bridging innate and adaptive immunity. We analyze plate…
View article: Dynamic Changes in Peripheral Immune Cells During Efgartigimod Treatment in Naive Generalized Myasthenia Gravis
Dynamic Changes in Peripheral Immune Cells During Efgartigimod Treatment in Naive Generalized Myasthenia Gravis Open
Background Efgartigimod is a neonatal Fc receptor (FcRn) antagonist that reduces pathogenic IgG and improves clinical symptoms in generalized myasthenia gravis (gMG). However, its immunomodulatory effects on innate and adaptive immune cell…
View article: Efficacy of Tacrolimus Plus Prednisone as Long-Term Immunosuppressive Therapy for Chronic Inflammatory Demyelinating Polyneuropathy: A Retrospective Cohort Study
Efficacy of Tacrolimus Plus Prednisone as Long-Term Immunosuppressive Therapy for Chronic Inflammatory Demyelinating Polyneuropathy: A Retrospective Cohort Study Open
Tacrolimus plus prednisone therapy demonstrated superior clinical outcomes compared to prednisone monotherapy in CIDP maintenance treatment, including accelerated symptomatic improvement, reduced relapse risk, and facilitated corticosteroi…
View article: Preclinical Evaluation of a Novel Carbonic Anhydrase IX-Targeting 68Ga/177Lu Theranostic Pair for Clear Cell Renal Cell Carcinoma
Preclinical Evaluation of a Novel Carbonic Anhydrase IX-Targeting 68Ga/177Lu Theranostic Pair for Clear Cell Renal Cell Carcinoma Open
Background Carbonic anhydrase IX (CAIX) is a hypoxia-regulated enzyme overexpressed in clear cell renal cell carcinoma (ccRCC) but minimally in normal tissues, making it a promising theranostic target. Current imaging modalities for ccRCC …
View article: 68Ga-pentixafor PET/CT versus adrenal venous sampling in guiding surgical management for primary aldosteronism: a prospective cohort study on postoperative outcomes
68Ga-pentixafor PET/CT versus adrenal venous sampling in guiding surgical management for primary aldosteronism: a prospective cohort study on postoperative outcomes Open
Background: Limitations still exist in the surgical strategies for primary aldosteronism (PA), the most common cause of secondary hypertension. This study aimed to compare the effectiveness of 68 Ga-pentixafor PET/CT versus adrenal venous …
View article: Factors associated with early response to efgartigimod in patients with generalized myasthenia gravis: a multicenter retrospective observational study
Factors associated with early response to efgartigimod in patients with generalized myasthenia gravis: a multicenter retrospective observational study Open
Efgartigimod demonstrated robust efficacy in gMG patients. Early response was linked to shorter disease duration and severe bulbar symptoms, which promotes the identification of patients who are likely to benefit quickly from efgartigimod.
View article: An Analysis for <scp>IDH</scp>‐Mutant Grade 4 Astrocytoma Based on <scp>WHO CNS</scp> 5: Implication of Clinical Practice
An Analysis for <span>IDH</span>‐Mutant Grade 4 Astrocytoma Based on <span>WHO CNS</span> 5: Implication of Clinical Practice Open
Purpose There is ongoing debate regarding the therapeutic approach and prognosis for IDH‐mutant grade 4 astrocytoma, a newly defined subtype of diffuse glioma in the 2021 WHO classification system for central nervous system tumors (WHO CNS…
View article: Chemoradiation treatment with or without concurrent tumor-treating fields (TTFields) therapy in newly diagnosed glioblastoma (GBM) patients in China
Chemoradiation treatment with or without concurrent tumor-treating fields (TTFields) therapy in newly diagnosed glioblastoma (GBM) patients in China Open
View article: Response to trastuzumab deruxtecan and delayed immune-related events in a patient with metastatic HER2-positive NSCLC: a case report and literature review
Response to trastuzumab deruxtecan and delayed immune-related events in a patient with metastatic HER2-positive NSCLC: a case report and literature review Open
Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate (ADC) designed to target HER2 mutations. We reported a case study demonstrating a favorable response to DS-8201 in a patient with HER2 mutation-positive non-small cell lung can…
View article: Regional Dopaminergic Dysfunction Patterns Discriminate Parkinson’s Disease from Multiple System Atrophy
Regional Dopaminergic Dysfunction Patterns Discriminate Parkinson’s Disease from Multiple System Atrophy Open
View article: Short-term and long-term prognoses in AChR-Ab positive very-late-onset myasthenia gravis patients
Short-term and long-term prognoses in AChR-Ab positive very-late-onset myasthenia gravis patients Open
Background: Very-late-onset myasthenia gravis (VLOMG) refers to myasthenia gravis (MG) with onset at age 65 or older. Current research on VLOMG prognosis remains limited, especially regarding factors influencing outcomes. Objectives: To id…
View article: Development of Single-Nucleotide Polymorphism (SNP)-Based Species-Specific Real-Time PCR Assays for Authenticating Five Highly Priced Tuna
Development of Single-Nucleotide Polymorphism (SNP)-Based Species-Specific Real-Time PCR Assays for Authenticating Five Highly Priced Tuna Open
Tuna are economically important as food resources in food markets. However, because tuna is often processed into steaks or fillets, the meat can be difficult to identify through morphological features. For effective fishery management and …
View article: The Impact of COVID-19 Vaccination and Infection on the Exacerbation of Myasthenia Gravis
The Impact of COVID-19 Vaccination and Infection on the Exacerbation of Myasthenia Gravis Open
Objectives: Myasthenia Gravis (MG) is an autoimmune disorder that can exacerbate for various reasons, including vaccination and infection. This study aimed to investigate the safety of COVID-19 vaccines for MG patients, factors influencing…
View article: Evaluation of the Bioavailability of Iodine and Arsenic in Raw and Cooked Saccharina japonica Based on Simulated Digestion/Caco-2 Cell Model
Evaluation of the Bioavailability of Iodine and Arsenic in Raw and Cooked Saccharina japonica Based on Simulated Digestion/Caco-2 Cell Model Open
Kelp is a traditional healthy food due to its high nutritional content; however, its relatively high contents of iodine and arsenic have raised concerns about its edible safety. This study explored the effects of different cooking treatmen…
View article: Experience about Chemoradiation treatment with or without Concurrent Tumor-Treating Fields (TTFields) in Newly Diagnosed Glioblastoma (GBM) Patients in China
Experience about Chemoradiation treatment with or without Concurrent Tumor-Treating Fields (TTFields) in Newly Diagnosed Glioblastoma (GBM) Patients in China Open
Background:Tumor-Treating Fields (TTFields) and radiotherapy may have synergistic anti-glioma effect based on preclinical study. Chemoradiation concurrent with TTFields has become a hot topic in clinicians. This study provided preliminary …
View article: Predictive Value of 68Ga‑FAPI PET/CT in Patients Receiving First-Line Therapy for Pancreatic Ductal Adenocarcinoma
Predictive Value of 68Ga‑FAPI PET/CT in Patients Receiving First-Line Therapy for Pancreatic Ductal Adenocarcinoma Open
View article: Chemoradiation treatment with or without Concurrent Tumor-Treating Fields (TTFields) in Patients with Newly Diagnosed Glioblastoma (GBM) in China
Chemoradiation treatment with or without Concurrent Tumor-Treating Fields (TTFields) in Patients with Newly Diagnosed Glioblastoma (GBM) in China Open
Background: The TTFields have received the FDA approval as adjuvant therapy after completing radiotherapy in patients with newly diagnosed glioblastoma (GBM). TTFields and radiotherapy may have synergistic anti-glioma effect based on precl…
View article: Head-to-Head Comparison of<sup>68</sup>Ga-NODAGA-JR11 and<sup>68</sup>Ga-DOTATATE PET/CT in Patients with Metastatic, Well-Differentiated Neuroendocrine Tumors: Interim Analysis of a Prospective Bicenter Study
Head-to-Head Comparison of<sup>68</sup>Ga-NODAGA-JR11 and<sup>68</sup>Ga-DOTATATE PET/CT in Patients with Metastatic, Well-Differentiated Neuroendocrine Tumors: Interim Analysis of a Prospective Bicenter Study Open
The current study aimed to compare 68Ga-NODAGA-Cpa-cyclo(d-Cys-amino-Phe-hydroorotic acid-d-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)-d-Tyr-NH2 (JR11) and 68Ga-DOTATATE PET/CT in patients with metastatic, well-di…
View article: Analysis of Fatty Acid Metabolism in Fetal and Failing Hearts by Single-Cell RNA Sequencing Revealed <i>SLC27A6</i> as a Critical Gene in Heart Maturation.
Analysis of Fatty Acid Metabolism in Fetal and Failing Hearts by Single-Cell RNA Sequencing Revealed <i>SLC27A6</i> as a Critical Gene in Heart Maturation. Open
Overall, our study offers a novel perspective for exploring cardiac fatty acid metabolism in fetal and failing hearts along with new insights into the cellular mechanism underlying fatty acid metabolic alterations in individual cardiac cel…
View article: Changes in brain gray matter volume in nasopharyngeal carcinoma patients after radiotherapy in long-term follow-up
Changes in brain gray matter volume in nasopharyngeal carcinoma patients after radiotherapy in long-term follow-up Open
Objectives The aim of this study was to examine the changes in gray matter in nasopharyngeal carcinoma patients with normal hearing (Group 1) and nasopharyngeal carcinoma patients with hearing loss (Group 2) after radiotherapy using voxel-…
View article: β-hydroxybutyrate inhibits ferroptosis-mediated pancreatic damage in acute liver failure through the increase of H3K9bhb
β-hydroxybutyrate inhibits ferroptosis-mediated pancreatic damage in acute liver failure through the increase of H3K9bhb Open
Acute pancreatitis and hyperamylasemia are often seen in patients with acute liver failure (ALF). However, the underlying mechanisms remain elusive. This study describes pancreatic tissue damage and exocrine dysfunction in a mouse model of…
View article: Impact of antagonist peptides and chelators on the diagnostic performance of PET/CT using gallium-68–labeled somatostatin receptor antagonists
Impact of antagonist peptides and chelators on the diagnostic performance of PET/CT using gallium-68–labeled somatostatin receptor antagonists Open
Objective: Different SSTR2 antagonists have been developed. This study aims to evaluate the impact of different peptides and chelators on the diagnostic performance of SSTR2 antagonists in well-differentiated NETs. Methods: In this prospec…
View article: Discovery of zerumbone as a new agent for cardiac hypertrophy by high-throughput screening using human embryonic stem cell-derived cardiomyocytes
Discovery of zerumbone as a new agent for cardiac hypertrophy by high-throughput screening using human embryonic stem cell-derived cardiomyocytes Open
Background: Pathological cardiac hypertrophy is considered an adaptive response of the heart due to cardiovascular diseases such as hypertension, aortic and valvular stenosis, and inherited cardiomyopathy caused by mutations in sarcomeric …
View article: A Randomized Open-Labeled Trial of Methotrexate as a Steroid-Sparing Agent for Patients With Generalized Myasthenia Gravis
A Randomized Open-Labeled Trial of Methotrexate as a Steroid-Sparing Agent for Patients With Generalized Myasthenia Gravis Open
Background and Purpose Two clinical trials assessing the steroid-sparing effect of methotrexate (MTX) yielded conflicting results. Our objective was to investigate whether MTX would show a steroid-sparing effect in the treatment of general…
View article: Beyond the Motor Cortex: Thalamic Iron Deposition Accounts for Disease Severity in Amyotrophic Lateral Sclerosis
Beyond the Motor Cortex: Thalamic Iron Deposition Accounts for Disease Severity in Amyotrophic Lateral Sclerosis Open
Objective Previous studies have reliably identified iron deposition in the motor cortex as potential pathogenesis of amyotrophic lateral sclerosis (ALS). Here, we intended to investigate iron deposition, gray matter (GM) atrophy, and their…
View article: Tacrolimus treatment for relapsing-remitting chronic inflammatory demyelinating polyradiculoneuropathy: Two case reports
Tacrolimus treatment for relapsing-remitting chronic inflammatory demyelinating polyradiculoneuropathy: Two case reports Open
Neither patient exhibited any adverse effects due to the tacrolimus therapy. Therefore, tacrolimus can be effective for the treatment of patients with steroid-resistant CIDP.
View article: Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osgin1-Mediated Restoration of Efficient Autophagy
Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osgin1-Mediated Restoration of Efficient Autophagy Open
Pancreatitis is the leading cause of hospitalization in gastroenterology, and no medications are available for treating this disease in current clinical practice. FXR plays an anti-inflammatory role in diverse inflammatory diseases, while …
View article: Different sensorimotor mechanism in fast and slow progression amyotrophic lateral sclerosis
Different sensorimotor mechanism in fast and slow progression amyotrophic lateral sclerosis Open
The huge heterogeneity of the disease progression rate may cause inconsistent findings between local activity and functional connectivity of the primary sensorimotor area (PSMA) in amyotrophic lateral sclerosis (ALS). For illustration of t…
View article: Missense Mutations of Codon 116 in the SOD1 Gene Cause Rapid Progressive Familial ALS and Predict Short Viability With PMA Phenotype
Missense Mutations of Codon 116 in the SOD1 Gene Cause Rapid Progressive Familial ALS and Predict Short Viability With PMA Phenotype Open
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease, characterized by a great variety of both clinical presentations and genetic causes. Previous studies had identified two different missense mutations in SO…
View article: 11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma
11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma Open