Li Wan
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View article: Comparative and phylogenetic study on the chloroplast genomes of CMS with the cytoplasm of Aegilops ovata and its maintainer line in wheat
Comparative and phylogenetic study on the chloroplast genomes of CMS with the cytoplasm of Aegilops ovata and its maintainer line in wheat Open
BACKGROUND : Aegilops ovata a wild relative of wheat. As a valuable genetic source, it can be used for wheat breeding and improvement. However, the interspecific variation, evolutionary mechanism and phylogenetic relationship of the chloro…
View article: A Case of Recurrent Multiple Uterine Fibroids Associated with Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC): Insights into Fumarate Hydratase (FH) Deficiency
A Case of Recurrent Multiple Uterine Fibroids Associated with Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC): Insights into Fumarate Hydratase (FH) Deficiency Open
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a rare genetic disorder caused by mutations in fumarate hydratase (FH) gene. The main manifestations include cutaneous leiomyoma, uterine leiomyoma, and type 2 papillary renal c…
View article: Tree Training: Accelerating Agentic LLMs Training via Shared Prefix Reuse
Tree Training: Accelerating Agentic LLMs Training via Shared Prefix Reuse Open
In agentic LLM scenarios, an agent's interaction process during a single rollout often exhibits branching behaviors. Due to memory retrieval and concurrent tool executions at certain decision points, the token trajectory of one task evolve…
View article: Comprehensive Analysis of Aberrant m6A RNA Modifications Identifies Prognostic Biomarkers in Non-Small Cell Lung Cancer
Comprehensive Analysis of Aberrant m6A RNA Modifications Identifies Prognostic Biomarkers in Non-Small Cell Lung Cancer Open
Background: Dysregulation of N6-methyladenosine (m6A) RNA modification plays a critical role in the development and progression of non-small cell lung cancer (NSCLC). Methods: To explore the m6A modification landscape in NSCL…
View article: Comparative study of bronchoscopic and CT-guided percutaneous microwave ablation for inoperable non-small cell lung cancer
Comparative study of bronchoscopic and CT-guided percutaneous microwave ablation for inoperable non-small cell lung cancer Open
Both PTMA and BTMA are effective treatment options for inoperable stage I NSCLC. BTMA offers similar efficacy with fewer complications and may be preferable in selected patients.
View article: Evaluation and genome-wide association study of saline–alkali tolerance in high-latitude rice resource populations
Evaluation and genome-wide association study of saline–alkali tolerance in high-latitude rice resource populations Open
Introduction China is the world’s third largest saline–alkali land country, and the breeding of salt-tolerant rice varieties has always been a key focus of rice breeders. Screening and identifying salt-tolerant varieties and exploring rela…
View article: Hypoxia-induced tumor cell-intrinsic PLAU activation drives immunotherapy resistance in collagenic lung adenocarcinoma
Hypoxia-induced tumor cell-intrinsic PLAU activation drives immunotherapy resistance in collagenic lung adenocarcinoma Open
Activation of the PLAU-PLAUR pathway is essential for the progression of hypoxia-associated LUAD exhibiting a collagenous phenotype. Blocking the pathway provides a new research perspective for the development of immunotherapy for LUAD.
View article: Maresin1 Alleviates Ischemia Reperfusion Injury After Lung Transplantation by Inhibiting Ferroptosis via the PKA-Hippo-YAP Signaling Pathway
Maresin1 Alleviates Ischemia Reperfusion Injury After Lung Transplantation by Inhibiting Ferroptosis via the PKA-Hippo-YAP Signaling Pathway Open
Background: Lung ischemia reperfusion injury (LIRI) is a severe complication after lung transplantation (LT). Ferroptosis contributes to the pathogenesis of LIRI. Maresin1 (MaR1) is an endogenous pro-resolving lipid mediator that exerts pr…
View article: African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis
African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis Open
The African swine fever virus (ASFV) has been reported to cause oxidative damage and inhibit IFN-β production. However, the precise mechanisms through which ASFV-induced lipid peroxidation modulates the innate immune response remain to be …
View article: Bridge Deformation Monitoring Combining 3D Laser Scanning with Multi-Scale Algorithms
Bridge Deformation Monitoring Combining 3D Laser Scanning with Multi-Scale Algorithms Open
To address the inefficiencies and limited spatial resolution of traditional single-point monitoring techniques, this study proposes a multi-scale analysis method that integrates the Multi-Scale Model-to-Model Cloud Comparison (M3C2) algori…
View article: An oxygen-generating nanoplatform remodels the immunosuppressive tumor microenvironment via synergistic lactate depletion and sonodynamic therapy
An oxygen-generating nanoplatform remodels the immunosuppressive tumor microenvironment via synergistic lactate depletion and sonodynamic therapy Open
Lactate is an immunosuppressive molecule that plays an important role in tumor progression. Regulating lactate metabolism to remodel the immunosuppressive microenvironment represents a promising strategy for cancer therapy. However, owing …
View article: Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis
Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis Open
These findings highlight the potential role of ferroptosis and SQLE in mediating PQ toxicity and provide therapeutic strategies to combat PQ toxicity by inhibiting ferroptosis and/or targeting SQLE. Repurposing LNT may be a potential antid…
View article: Dexmedetomidine for cancer pain: mechanisms and opioid-sparing effects
Dexmedetomidine for cancer pain: mechanisms and opioid-sparing effects Open
Background and objective: Cancer pain treatment faces challenges such as ineffective pain management, high-dose opioid use, and insufficient analgesia. Dexmedetomidine (DEX), a novel α2 receptor agonist, is a potential adjuvant analgesic. …
View article: Exploring the causal relationship between immune factors and chondrosarcoma: a Mendelian randomization study
Exploring the causal relationship between immune factors and chondrosarcoma: a Mendelian randomization study Open
Background Previous studies have investigated the potential role of immune factors in chondrosarcoma (CHS). However, the causal relationship is unknown. Methods A two-sample Mendelian randomization (MR) was used to explore potential correl…
View article: BREAKING THE VIRTUAL WALL: WHY BUSINESSES RESIST METAVERSE IN THE RETAIL INDUSTRY?
BREAKING THE VIRTUAL WALL: WHY BUSINESSES RESIST METAVERSE IN THE RETAIL INDUSTRY? Open
While the metaverse is considered the next big thing associated with the information system ecosystem, this disruptive technology has not been widely adopted by many of the enterprises to date. Given its potential to drive the success of b…
View article: The E3 Ubiquitin Ligase ARIH1 Facilitates Colorectal Cancer Progression by Promoting Oxidative Phosphorylation via the Mitochondrial Translocation of K63‐Linked Ubiquitinated PHB1
The E3 Ubiquitin Ligase ARIH1 Facilitates Colorectal Cancer Progression by Promoting Oxidative Phosphorylation via the Mitochondrial Translocation of K63‐Linked Ubiquitinated PHB1 Open
The RBR E3 ubiquitin ligase ARIH1 has been proven to induce specific ubiquitylation of substrates, thereby regulating cell proliferation and the cell cycle. However, the understanding of how ARIH1 influence cancer development is limited. T…
View article: The number of lifetime sexual partners may not be associated with cervical cancer: A Mendelian randomization study
The number of lifetime sexual partners may not be associated with cervical cancer: A Mendelian randomization study Open
Objective: The objective of this study was to investigate the causal relationship between the number of lifetime sexual partners (NLSP) and cervical cancer (CC) using the Mendelian randomization (MR) method. Methods: Genome-wide associatio…
View article: Unveiling the Key Factors for Distilling Chain-of-Thought Reasoning
Unveiling the Key Factors for Distilling Chain-of-Thought Reasoning Open
Large Language Models (LLMs) excel in reasoning tasks through Chain-of-Thought (CoT) prompting. However, CoT prompting greatly increases computational demands, which has prompted growing interest in distilling CoT capabilities into Small L…
View article: Thymoquinone mitigates cardiac hypertrophy by activating adaptive autophagy via the PPAR‑γ/14‑3‑3γ pathway
Thymoquinone mitigates cardiac hypertrophy by activating adaptive autophagy via the PPAR‑γ/14‑3‑3γ pathway Open
Thymoquinone (TQ), the principal active compound derived from the black seed plant, has been extensively utilized in traditional medicine for treating various ailments. Despite its widespread use, its therapeutic mechanisms in the context …
View article: Curcumin attenuates myocardial ischemia‑reperfusion‑induced autophagy‑dependent ferroptosis via Sirt1/AKT/FoxO3a signaling
Curcumin attenuates myocardial ischemia‑reperfusion‑induced autophagy‑dependent ferroptosis via Sirt1/AKT/FoxO3a signaling Open
Curcumin (Cur) effectively attenuates myocardial ischemia/reperfusion injury (MIRI). MIRI has a complex mechanism and is associated with autophagy‑dependent ferroptosis. Therefore, the present study aimed to determine whether autophagy‑dep…
View article: Sigma: Differential Rescaling of Query, Key and Value for Efficient Language Models
Sigma: Differential Rescaling of Query, Key and Value for Efficient Language Models Open
We introduce Sigma, an efficient large language model specialized for the system domain, empowered by a novel architecture including DiffQKV attention, and pre-trained on our meticulously collected system domain data. DiffQKV attention sig…
View article: Role of Arg1+ ILC2s and ILCregs in gestational diabetes progression
Role of Arg1+ ILC2s and ILCregs in gestational diabetes progression Open
Innate lymphoid cells (ILCs) are a newly discovered subset of immune cells that are responsible for regulation of the immune microenvironment. In particular, the ILC categories ILC2s and regulatory ILCs (ILCregs) are associated with immuno…
View article: Targeting immune cellular populations and transcription factors: unraveling the therapeutic potential of JQF for NAFLD
Targeting immune cellular populations and transcription factors: unraveling the therapeutic potential of JQF for NAFLD Open
Background Non-alcoholic fatty liver disease (NAFLD) constitutes the most prevalent chronic liver disease worldwide. Progression to non-alcoholic steatohepatitis (NASH), the immune cell reservoir within the liver undergoes remodeling, exac…
View article: Thermal Activation of Peroxymonosulfate for Enhanced Volatile Fatty Acids Production and Phosphorus Release During the Anaerobic Fermentation of Iron-Rich Sludge
Thermal Activation of Peroxymonosulfate for Enhanced Volatile Fatty Acids Production and Phosphorus Release During the Anaerobic Fermentation of Iron-Rich Sludge Open
View article: Association between <i>P2RX7</i> rs7958311 Polymorphism and Labor Analgesia in Primiparas
Association between <i>P2RX7</i> rs7958311 Polymorphism and Labor Analgesia in Primiparas Open
View article: Effects of Sterilization on Maillard Reaction Intermediate Products and Aroma Quality of Apple Juice: Comparison of HPP and Pasteurization
Effects of Sterilization on Maillard Reaction Intermediate Products and Aroma Quality of Apple Juice: Comparison of HPP and Pasteurization Open
View article: Unveiling the Key Factors for Distilling Chain-of-Thought Reasoning
Unveiling the Key Factors for Distilling Chain-of-Thought Reasoning Open
View article: Structure, Attachment and Transmembrane Internalisation of Peste Des Petits Ruminants Virus
Structure, Attachment and Transmembrane Internalisation of Peste Des Petits Ruminants Virus Open
Peste des petits ruminants virus (PPRV), a single‐stranded negative‐sense RNA virus with an envelope, belongs to the Morbillivirus in the Paramyxoviridae family and is prevalent worldwide. PPRV infection causes fever, stomatitis, diarrhoea…
View article: Working Principle and Experimental Design of Hydraulic Wind Heating
Working Principle and Experimental Design of Hydraulic Wind Heating Open
The wind energy heating system studied in this article mainly consists of three parts: vertical axis wind turbines, heaters, and heat exchange devices. A liquid stirring heating experimental platform was built based on the heating principl…
View article: Identification and validation of autophagy‑related genes in hypertrophic cardiomyopathy.
Identification and validation of autophagy‑related genes in hypertrophic cardiomyopathy. Open
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant cardiac disorder characterized by ventricular hypertrophy resulting from the disordered arrangement of myocardial cells, which leads to impaired cardiac function or death. Autophag…