Wenjie Xiong
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View article: Characteristics of the esophageal microbiota in patients with Achalasia
Characteristics of the esophageal microbiota in patients with Achalasia Open
Background: Achalasia（AC）is clinically characterized by chronic intraluminal food stasis and bacterial fermentation, which may contribute to esophageal dysbiosis. This study aims to characterize the esoph-ageal microbiome in AC patients, i…
View article: Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma
Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma Open
View article: Zinc deficiency deteriorates ovarian follicle development and function by inhibiting mitochondrial function
Zinc deficiency deteriorates ovarian follicle development and function by inhibiting mitochondrial function Open
Zinc (Zn) is a crucial trace element essential for human growth and development, particularly for reproductive health. Previous research has shown a decrease in serum zinc concentration with age and individuals with conditions such as poly…
View article: Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma
Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma Open
View article: Early progression is associated with worse survival in patients with Waldenström’s macroglobulinemia
Early progression is associated with worse survival in patients with Waldenström’s macroglobulinemia Open
Early progression of disease within 24 months (POD24) of diagnosis is associated with inferior overall survival (OS) in follicular lymphoma, but its prognostic role in Waldenström’s macroglobulinemia (WM) is still unclear. Here, we perform…
View article: Combinational therapy of CAR T-cell and HDT/ASCT demonstrates impressive clinical efficacy and improved CAR T-cell behavior in relapsed/refractory large B-cell lymphoma
Combinational therapy of CAR T-cell and HDT/ASCT demonstrates impressive clinical efficacy and improved CAR T-cell behavior in relapsed/refractory large B-cell lymphoma Open
Background Approximately two-thirds of patients with relapsed or refractory large B-cell lymphoma (R/R LBCL) do not respond to or relapse after anti-CD19 chimeric antigen receptor T (CAR T)-cell therapy, leading to poor outcomes. Previous …
View article: Rituximab plus cyclophosphamide and dexamethasone <i>versus</i> bortezomib plus cyclophosphamide and dexamethasone in newly diagnosed symptomatic Waldenström macroglobulinemia: a randomized controlled trial
Rituximab plus cyclophosphamide and dexamethasone <i>versus</i> bortezomib plus cyclophosphamide and dexamethasone in newly diagnosed symptomatic Waldenström macroglobulinemia: a randomized controlled trial Open
Not available.
View article: Sequential treatment escalation improves survival in patients with Waldenstrom macroglobulinemia
Sequential treatment escalation improves survival in patients with Waldenstrom macroglobulinemia Open
Waldenstrom macroglobulinemia (WM) is a type of incurable, indolent B-cell lymphoma that is prone to relapse. Over time, treatment strategies have progressed from cytotoxic drugs to rituximab (R)- or bortezomib (V)-based regimens, and have…
View article: The optimal time and clinical implications of measurable residual disease detection in mantle cell lymphoma
The optimal time and clinical implications of measurable residual disease detection in mantle cell lymphoma Open
Recent advances in measurable residual disease (MRD) technology have significantly enhanced predictive accuracy for outcomes in various hematologic malignancies, serving as a crucial surrogate endpoint. However, in mantle cell lymphoma (MC…
View article: Oligosecretory Waldenström macroglobulinemia exhibits excellent treatment response and outcomes
Oligosecretory Waldenström macroglobulinemia exhibits excellent treatment response and outcomes Open
Not available.
View article: Estrogen increases the expression of BKCa and impairs the contraction of colon smooth muscle via upregulation of sphingosine kinase 1
Estrogen increases the expression of BKCa and impairs the contraction of colon smooth muscle via upregulation of sphingosine kinase 1 Open
Estrogen (E2) may impair the contraction of colonic smooth muscle (SM) leading to constipation. Large conductance Ca 2+ ‐activated K + channels (BK Ca ) are widely expressed in the smooth muscle cells (SMCs) contributing to hyperpolarizati…
View article: A day-to-day management model improves patient compliance to treatment for Helicobacter pylori infection: a prospective, randomized controlled study
A day-to-day management model improves patient compliance to treatment for Helicobacter pylori infection: a prospective, randomized controlled study Open
Background The day-to-day (DTD) management model encourages patients to actively participate in their healthcare by setting goals. We determined the effectiveness of the DTD model in the treatment of Helicobacter pylori ( H. pylori ) infec…
View article: Real-world treatment patterns, discontinuation and clinical outcomes in patients with B-cell lymphoproliferative diseases treated with BTK inhibitors in China
Real-world treatment patterns, discontinuation and clinical outcomes in patients with B-cell lymphoproliferative diseases treated with BTK inhibitors in China Open
Introduction Bruton tyrosine kinase inhibitor (BTKi) has demonstrated substantial efficacy in treating B-cell lymphoproliferative diseases (BLPD). Nonetheless, the significant discontinuation rates due to toxicity or financial reasons cann…
View article: Minimal residual disease status improved the response evaluation in patients with Waldenström’s macroglobulinemia
Minimal residual disease status improved the response evaluation in patients with Waldenström’s macroglobulinemia Open
Introduction Minimal residual disease (MRD) has been recognized as an important prognostic factor of survival in patients with hematological malignancies. However, the prognostic value of MRD in Waldenström macroglobulinemia (WM) remains u…
View article: Cytogenetic aberrations of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia in Chinese patients
Cytogenetic aberrations of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia in Chinese patients Open
To the Editor: As a rare indolent B cell non-Hodgkin lymphoma, lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (LPL/WM) has unique clinical and biological characteristics.[1] However, due to the difficulties in obtaining tumor m…
View article: Zinc deficiency compromises the maturational competence of porcine oocyte by inducing mitophagy and apoptosis
Zinc deficiency compromises the maturational competence of porcine oocyte by inducing mitophagy and apoptosis Open
Zinc, an essential trace mineral, plays a pivotal role in cell proliferation, maintenance of redox homeostasis, apoptosis, and aging. Serum zinc concentrations are reduced in patients with polycystic ovary syndrome (PCOS). However, the und…
View article: Undetectable minimal residual disease is an independent prognostic factor in splenic marginal zone lymphoma
Undetectable minimal residual disease is an independent prognostic factor in splenic marginal zone lymphoma Open
Summary The role of minimal residual disease (MRD) in splenic marginal zone lymphoma (SMZL) has not been well studied. We prospectively designed a study to evaluate undetectable MRD (uMRD) by multiparameter flow cytometry as a prognostic f…
View article: MALAT1: A Pivotal lncRNA in the Phenotypic Switch of Gastric Smooth Muscle Cells via the Targeting of the miR-449a/DLL1 Axis in Diabetic Gastroparesis
MALAT1: A Pivotal lncRNA in the Phenotypic Switch of Gastric Smooth Muscle Cells via the Targeting of the miR-449a/DLL1 Axis in Diabetic Gastroparesis Open
Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus (DM). Our previous study suggested that the expression of the long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is closel…
View article: Allopurinol-induced drug reaction with eosinophilia and systemic symptoms syndrome associated with reactivation of Epstein–Barr virus leading to secondary hemophagocytic lymphohistiocytosis in an <i>HLA-B</i>*5801-negative patient
Allopurinol-induced drug reaction with eosinophilia and systemic symptoms syndrome associated with reactivation of Epstein–Barr virus leading to secondary hemophagocytic lymphohistiocytosis in an <i>HLA-B</i>*5801-negative patient Open
Allopurinol-induced drug reaction with eosinophilia and systemic symptoms syndrome associated with reactivation of Epstein–Barr virus leading to secondary hemophagocytic lymphohistiocytosis in an HLA-B*5801-negative patient
View article: High incidence of MYD88 and KMT2D mutations in Chinese with chronic lymphocytic leukemia
High incidence of MYD88 and KMT2D mutations in Chinese with chronic lymphocytic leukemia Open
View article: TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia
TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia Open
Background TOSO, also named Fas inhibitory molecule 3 (FAIM3), has recently been identified as an immunoglobulin M (IgM) Fc receptor (FcμR). Previous studies have shown that TOSO is specifically over-expressed in chronic lymphocytic leukem…
View article: <i>Spirulina platensis</i> alleviates chronic inflammation with modulation of gut microbiota and intestinal permeability in rats fed a high‐fat diet
<i>Spirulina platensis</i> alleviates chronic inflammation with modulation of gut microbiota and intestinal permeability in rats fed a high‐fat diet Open
Recent research suggested that taking a high‐fat diet (HFD) may lead to a gut microbiota imbalance and colon tissue damage. This would lead to increased intestinal permeability and consequent constant circulation of low‐grade inflammatory …
View article: Prominent immune signatures of T cells are specifically associated with indolent B‐cell lymphoproliferative disorders and predict prognosis
Prominent immune signatures of T cells are specifically associated with indolent B‐cell lymphoproliferative disorders and predict prognosis Open
Objectives T cells play an essential role in controlling the development of B‐cell lymphoproliferative disorders (BLPDs), but the dysfunction of T cells in BLPDs largely remains elusive. Methods Using multiplexed flow cytometry, we quantif…
View article: Deciphering the Landscape of Peripheral Blood T Cells <i>via</i> Single-Cell RNA-Seq in Chronic Lymphocytic Leukemia
Deciphering the Landscape of Peripheral Blood T Cells <i>via</i> Single-Cell RNA-Seq in Chronic Lymphocytic Leukemia Open
View article: Del17p does not always significantly influence the survival of B-cell chronic lymphoproliferative disorders
Del17p does not always significantly influence the survival of B-cell chronic lymphoproliferative disorders Open
B-cell chronic lymphoproliferative disorders (B-CLPD) comprise several entities with indolent clinical manifestations but heterogeneous survival. Cytogenetic aberrations are now the standard prognostic predictors in chronic lymphocytic leu…
View article: Distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in HBV high prevalent region
Distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in HBV high prevalent region Open
Splenic marginal zone lymphoma (SMZL) is a rare indolent B-cell neoplasm with hepatitis virus supposed to involve in the pathogenesis. The characteristics of SMZL derived from Caucasia population and high hepatitis C virus (HCV) infection …
View article: Efficacy and safety of 5-hydroxytryptamine 3 receptor antagonists in irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials
Efficacy and safety of 5-hydroxytryptamine 3 receptor antagonists in irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials Open
Ramosetron, cilansetron, ondansetron, and alosetron are effective for treating non-constipated IBS and IBS-D. Our systematic review found rare serious adverse events.
View article: Influence of sleep disorders on somatic symptoms, mental health, and quality of life in patients with chronic constipation
Influence of sleep disorders on somatic symptoms, mental health, and quality of life in patients with chronic constipation Open
Sleep disorders may worsen the physical- and mental health of CC patients. Sleep disturbance may lower CC patients' QOL indirectly through the combined effects of anxiety, depression, and constipation.
View article: Chronic Lymphocytic Leukemia Prognostic Index: A New Integrated Scoring System to Predict the Time to First Treatment in Chinese Patients with Chronic Lymphocytic Leukemia.
Chronic Lymphocytic Leukemia Prognostic Index: A New Integrated Scoring System to Predict the Time to First Treatment in Chinese Patients with Chronic Lymphocytic Leukemia. Open
This study developed a weighted, integrated CLL-PI prognostic system of CLL patients which combines the critical genetic prognostic markers with traditional clinical stage. This novel modified PI system could be used to discriminate among …
View article: Intratumoral genetic heterogeneity and number of cytogenetic aberrations provide additional prognostic significance in chronic lymphocytic leukemia
Intratumoral genetic heterogeneity and number of cytogenetic aberrations provide additional prognostic significance in chronic lymphocytic leukemia Open