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View article: Causal relationship between oral/gut microbiota and lung cancer: a two-sample Mendelian randomization study
Causal relationship between oral/gut microbiota and lung cancer: a two-sample Mendelian randomization study Open
The findings of this study suggest a potential causal relationship between distinct oral and gut microbial communities and lung cancer risk, offering valuable insights into microbial candidates that may serve as targets for future diagnost…
View article: Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner
Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner Open
Clinical studies have suggested that increased plasma oxytocin (OT) levels are a promising biomarker for bipolar disorder (BD), and our earlier post-mortem study found increased OT activity in the hypothalamic paraventricular nucleus (OTPV…
View article: Causal relationship between oral/gut microbiota and lung cancer: a two-sample Mendelian randomization study
Causal relationship between oral/gut microbiota and lung cancer: a two-sample Mendelian randomization study Open
Purpose Several studies have already proven a significant correlation between the microbiota and lung cancer. In this study, we explore the potential relative oral and gut microbiota which influence the risk of lung cancer. Methods We util…
View article: Is Segment Anything Model 2 All You Need for Surgery Video Segmentation? A Systematic Evaluation
Is Segment Anything Model 2 All You Need for Surgery Video Segmentation? A Systematic Evaluation Open
Surgical video segmentation is critical for AI to interpret spatial-temporal dynamics in surgery, yet model performance is constrained by limited annotated data. The SAM2 model, pre-trained on natural videos, offers potential for zero-shot…
View article: MiMo-VL Technical Report
MiMo-VL Technical Report Open
We open-source MiMo-VL-7B-SFT and MiMo-VL-7B-RL, two powerful vision-language models delivering state-of-the-art performance in both general visual understanding and multimodal reasoning. MiMo-VL-7B-RL outperforms Qwen2.5-VL-7B on 35 out o…
View article: MiMo: Unlocking the Reasoning Potential of Language Model -- From Pretraining to Posttraining
MiMo: Unlocking the Reasoning Potential of Language Model -- From Pretraining to Posttraining Open
We present MiMo-7B, a large language model born for reasoning tasks, with optimization across both pre-training and post-training stages. During pre-training, we enhance the data preprocessing pipeline and employ a three-stage data mixing …
View article: Association of hepatitis B virus DNA levels with efficacy and safety and the impact of antiviral therapy on prognosis in liver cancer patients receiving immune checkpoint inhibitors therapy: a systematic review and meta-analysis
Association of hepatitis B virus DNA levels with efficacy and safety and the impact of antiviral therapy on prognosis in liver cancer patients receiving immune checkpoint inhibitors therapy: a systematic review and meta-analysis Open
Background The current evidence regarding the relationship between baseline hepatitis B virus (HBV) DNA levels and survival outcomes in liver cancer patients receiving immune checkpoint inhibitors (ICIs) remains inconsistent. Therefore, th…
View article: The predictive role of tertiary lymphoid structures in the prognosis and response to immunotherapy of lung cancer patients: a systematic review and meta-analysis
The predictive role of tertiary lymphoid structures in the prognosis and response to immunotherapy of lung cancer patients: a systematic review and meta-analysis Open
High TLS/TLS + was associated with improved survival and an improved response to neoadjuvant chemoimmunotherapy in lung cancer patients, suggesting that TLS may be a prognostic biomarker and may also be a promising predictive marker for th…
View article: Systematic Evaluation and Guidelines for Segment Anything Model in Surgical Video Analysis
Systematic Evaluation and Guidelines for Segment Anything Model in Surgical Video Analysis Open
Surgical video segmentation is critical for AI to interpret spatial-temporal dynamics in surgery, yet model performance is constrained by limited annotated data. The SAM2 model, pretrained on natural videos, offers potential for zero-shot …
View article: Association of COVID-19 and Lung Cancer: Short-Term and Long-Term Interactions
Association of COVID-19 and Lung Cancer: Short-Term and Long-Term Interactions Open
Background: COVID-19 has been ravaging the globe for more than three years. Due to systemic immunosuppression of anti-tumor therapy, application of chemotherapy and adverse effects of surgery, the short- and long-term prognosis of cancer p…
View article: CD24 May Serve as an Immunotherapy Target in Triple-Negative Breast Cancer by Regulating the Expression of PD-L1
CD24 May Serve as an Immunotherapy Target in Triple-Negative Breast Cancer by Regulating the Expression of PD-L1 Open
CD24 may attenuate the positive effects of high TIL levels on survival and may facilitate the immune escape of TNBC by regulating PD-L1 expression. Thus, it is a potential target for immunotherapy in TNBC.
View article: Construction and Validation of a Novel Nomogram for Predicting the Risk of Metastasis in a Luminal B Type Invasive Ductal Carcinoma Population
Construction and Validation of a Novel Nomogram for Predicting the Risk of Metastasis in a Luminal B Type Invasive Ductal Carcinoma Population Open
The nomogram has a great predictive accuracy of predicting the risk of breast cancer metastasis. If patients had a score of 60 or more, necessary measures, like more standard treatment methods and higher treatment adherence of patients, ar…
View article: Towards effective wildlife protection law for marine species in China: A stakeholders’ perspective
Towards effective wildlife protection law for marine species in China: A stakeholders’ perspective Open
Introduction As one of the megadiverse countries, the effectiveness of wildlife protection in China is of great significance to global biodiversity conservation. With continued evolution and revisions, China’s Wildlife Protection Law has l…
View article: The Effects of Ammonia Stress Exposure on Protein Degradation, Immune Response, Degradation of Nitrogen-containing Compounds and Energy Metabolism of Chinese Mitten Crab.
The Effects of Ammonia Stress Exposure on Protein Degradation, Immune Response, Degradation of Nitrogen-containing Compounds and Energy Metabolism of Chinese Mitten Crab. Open
The Chinese mitten crab is one of the most economically important crab that is widely farmed in China. Ammonia, which is a main physiological challenge for crab culture, grow rapidly in the intensive culture system over time, but little in…
View article: Facile synthesis of cetyltrimethylammonium bromide-loaded mesoporous silica nanoparticles for efficient inhibition of hepatocellular carcinoma cell proliferation
Facile synthesis of cetyltrimethylammonium bromide-loaded mesoporous silica nanoparticles for efficient inhibition of hepatocellular carcinoma cell proliferation Open
We report the synthesis of cetyltrimethylammonium bromide (CTAB)-loaded mesoporous silica nanoparticles (MSNs) as efficient anticancer agents. The chemical composition and structure, drug loading capacity, and in vitro cytotoxicity of CTAB…
View article: Dexamethasone induces aberrant macrophage immune function and apoptosis
Dexamethasone induces aberrant macrophage immune function and apoptosis Open
Glucocorticoids (GCs) are known potent clinical drugs, however, their mode of action is still complex and debatable. Macrophages are the most important target of GCs and play a key role in tumor immunity in vivo, but their relationship is …
View article: Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway
Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway Open
The human islet amyloid polypeptide (hIAPP), the major component of islet amyloid deposition, is one of the amyloidogenic peptides and has been associated with β cell loss and dysfunction in type 2 diabetes (T2D). Autophagy plays a central…
View article: Clinicopathological significance of TM4SF5 expression in human hepatocellular carcinoma tissues
Clinicopathological significance of TM4SF5 expression in human hepatocellular carcinoma tissues Open
Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality. Recent studies have indicated that transmembrane 4 L six family member 5 (TM4SF5) serves a vital role in tumor progression and metastasis in human cell lines and …
View article: A Novel Pentapeptide Inhibitor Reduces Amyloid Deposit Formation by Direct Interaction with hIAPP
A Novel Pentapeptide Inhibitor Reduces Amyloid Deposit Formation by Direct Interaction with hIAPP Open
Backgrounds . The presence of amyloid deposits of human islet amyloid polypeptide (hIAPP) in islet β -cells has been associated with type 2 diabetes occurrence and islet graft failure. Self-assembly into oligomers and fibrils during the pr…
View article: GSK-3β mediates ischemia-reperfusion injury by regulating autophagy in DCD liver allografts.
GSK-3β mediates ischemia-reperfusion injury by regulating autophagy in DCD liver allografts. Open
To elucidate the role of autophagy in ischemia-reperfusion injury (IRI) and determine whether glycogen synthase kinase-3β (GSK-3β) plays an important role in autophagy, a donors of cardiac death (DCD) liver transplantation model was establ…
View article: Simulated Cholinergic Reinnervation of<i>β</i>(INS-1) Cells: Antidiabetic Utility of Heterotypic Pseudoislets Containing<i>β</i>Cell and Cholinergic Cell
Simulated Cholinergic Reinnervation of<i>β</i>(INS-1) Cells: Antidiabetic Utility of Heterotypic Pseudoislets Containing<i>β</i>Cell and Cholinergic Cell Open
Cholinergic neurons can functionally support pancreatic islets in controlling blood sugar levels. However, in islet transplantation, the level of cholinergic reinnervation is significantly lower compared to orthotopic pancreatic islets. Th…
View article: Diagnosis, treatment and prognosis of small bowel volvulus in adults: A monocentric summary of a rare small intestinal obstruction
Diagnosis, treatment and prognosis of small bowel volvulus in adults: A monocentric summary of a rare small intestinal obstruction Open
To complete an early and accurate diagnosis, a CT scan plus physical exam seems to be the best plan. After diagnosis, an urgent laparotomy must be performed to avoid intestinal necrosis and perforation. After surgery, more than 90% of the …
View article: Influence of SPK with Enteric Drainage on the Pancreatic Exocrine Function in Diabetic Patients with Uremia
Influence of SPK with Enteric Drainage on the Pancreatic Exocrine Function in Diabetic Patients with Uremia Open
Objective . This study aimed to determine the use of fecal elastase in evaluating the effect of simultaneous pancreas–kidney transplantation with enteric drainage on the pancreatic exocrine function of diabetic patients with uremia. Method…