Wenjuan Ye
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View article: Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay
Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay Open
The PACAP receptor PAC1 is a G s -coupled family B1 GPCR for which the highest-affinity endogenous peptide ligands are the pituitary adenylate cyclase-activating peptides PACAP38 and PACAP27, and whose most abundant endogenous ligand is PA…
View article: Exploratory analysis of COVID-19 propagation using logistic model
Exploratory analysis of COVID-19 propagation using logistic model Open
Pandemics pose significant threats to social, economic, and public health. The novel coronavirus (COVID-19), which emerged in late 2019, quickly became a global public health crisis due to its high contagion and pathogenicity. Using data f…
View article: Integrated Network Pharmacology and Proteomics to Elucidate the Mechanism and Potential Targets of <i>Tongfu Guanjie Gao</i> on KOA in a Papain-Induced Rabbit Model
Integrated Network Pharmacology and Proteomics to Elucidate the Mechanism and Potential Targets of <i>Tongfu Guanjie Gao</i> on KOA in a Papain-Induced Rabbit Model Open
Objectives: Knee osteoarthritis (KOA) is a common chronic degenerative joint disease in the world. Tongfu Guanjie Gao (TFGJG) is external preparations of Traditional Chinese Medicine which has remarkable effect on relieving KOA. In this st…
View article: A linear tessellation model for the identification of “food desert”: A case study of Shanghai, China
A linear tessellation model for the identification of “food desert”: A case study of Shanghai, China Open
The "food desert" problem has been treated under a national strategy in the United States and other countries. At present, there is little research on the phenomenon of "food desert" in China. This study takes Shanghai as the research area…
View article: Identification of an antibiotic from an HTS targeting EF-Tu:tRNA interaction: a prospective topical treatment for MRSA skin infections
Identification of an antibiotic from an HTS targeting EF-Tu:tRNA interaction: a prospective topical treatment for MRSA skin infections Open
Because of the urgent need for new antibiotics to treat drug-resistant bacterial pathogens, we employed an assay that rapidly screens large quantities of compounds for their ability to interfere with bacterial protein synthesis, in particu…
View article: A Preliminary Study on Sympathetic Skin Response in Acute Ischemic Cerebrovascular Disease
A Preliminary Study on Sympathetic Skin Response in Acute Ischemic Cerebrovascular Disease Open
There may be inhibition of sympathetic reflex activity in patients with AICVD, SSR abnormality rate in patients with AICVD may be correlated with the degree of neurological impairment and long-term prognosis.
View article: Observation of the effectiveness of whole course of comprehensive nursing in clinical care after the surgery for benign prostatic hyperplasia
Observation of the effectiveness of whole course of comprehensive nursing in clinical care after the surgery for benign prostatic hyperplasia Open
This study discussed the effect of whole course of comprehensive nursing after the operation for benign prostatic hyperplasia (BPH). Eighty-six patients with BPH who were to undergo prostatic hyperplasia surgery were divided into a control…
View article: Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2
Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2 Open
View article: Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome
Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome Open
Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revea…
View article: Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome
Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome Open
Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revea…
View article: A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity
A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity Open
View article: Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening
Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening Open
Inositol hexakisphosphate kinases (IP6Ks) catalyze pyrophosphorylation of inositol hexakisphosphate (IP6) into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (IP7), which is involved in numerous areas of cell physiology including glucose…
View article: Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus
Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus Open
The critical consequences of human cytomegalovirus (HCMV) infection in the transplant population and in congenitally infected infants, the limited treatment options for HCMV, and the rise of resistant mutants toward existing therapies has …
View article: Effects of multiple environmental variables on tundra ecosystem respiration in maritime Antarctica
Effects of multiple environmental variables on tundra ecosystem respiration in maritime Antarctica Open
View article: A modified gene trap approach for improved high-throughput cancer drug discovery
A modified gene trap approach for improved high-throughput cancer drug discovery Open
View article: Potential effects of ultraviolet radiation reduction on tundra nitrous oxide and methane fluxes in maritime Antarctica
Potential effects of ultraviolet radiation reduction on tundra nitrous oxide and methane fluxes in maritime Antarctica Open
Stratospheric ozone has begun to recover in Antarctica since the implementation of the Montreal Protocol. However, the effects of ultraviolet (UV) radiation on tundra greenhouse gas fluxes are rarely reported for Polar Regions. In the pres…
View article: Cell‐based high‐throughput screening identifies galactocerebrosidase enhancers as potential small‐molecule therapies for <scp>K</scp>rabbe's disease
Cell‐based high‐throughput screening identifies galactocerebrosidase enhancers as potential small‐molecule therapies for <span>K</span>rabbe's disease Open
Krabbe's disease, also known as globoid cell leukodystrophy (GLD), is a lysosomal storage disease caused by the deficiency of the lysosomal enzyme β‐galactocerebrosidase (GALC), resulting in severe neurological manifestations related to de…
View article: Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus
Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus Open
Infection with human cytomegalovirus (HCMV) is a threat for pregnant women and immunocompromised hosts. Although limited drugs are available, development of new agents against HCMV is desired. Through screening of the LOPAC library, we ide…
View article: Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease Open
The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.-) is essential for viral replication and is involved in the cytopathic effects (CPE) of the virus. The VEEV nsP2 protease is a mem…
View article: Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols
Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols Open
View article: Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs
Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs Open