Wenjin Yin
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View article: Leveraging a chromosomal instability-based signature to predict the prognosis and immune landscape of breast cancer
Leveraging a chromosomal instability-based signature to predict the prognosis and immune landscape of breast cancer Open
View article: Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis
Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis Open
Cancer-associated adipocytes (CAAs) reprogram the metabolic status of the tumor microenvironment (TME). The metabolic crosstalk between CAAs and CD8+T cells in the TME remains unclear. Here, we report that CAAs undergo lipolysis…
View article: Genetic variations in CYP2A6 predict efficacy of neoadjuvant letrozole concurrent with chemotherapy in locally advanced hormone receptor-positive breast cancer
Genetic variations in CYP2A6 predict efficacy of neoadjuvant letrozole concurrent with chemotherapy in locally advanced hormone receptor-positive breast cancer Open
The CPY2A6 gene polymorphism may be a novel potential predictive and prognostic biomarker for postmenopausal hormone receptor-positive breast cancer patients receiving neoadjuvant chemotherapy combined with letrozole. Our findings have cli…
View article: EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibility
EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibility Open
View article: Metronomic chemotherapy of paclitaxel plus cisplatin in patients with metastatic breast cancer: a target trial emulation study
Metronomic chemotherapy of paclitaxel plus cisplatin in patients with metastatic breast cancer: a target trial emulation study Open
Background: As metastasis drives the majority of breast cancer-related deaths, improving outcomes for metastatic breast cancer (MBC) remains a crucial challenge. Observational studies using target trial emulation are increasingly applied t…
View article: SHCBP1 drives tumor progression in triple-negative breast cancer
SHCBP1 drives tumor progression in triple-negative breast cancer Open
Backgrounds Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype. The limited treatment options underscore the urgent need to explore novel molecular targets to combat TNBC progression. This study inves…
View article: Dynamic Evolution of Vascular Features Based on Magnetic Resonance Imaging to Predict Pathological Response, Patterns of Recurrence and Survival Outcomes in Breast Cancer Neoadjuvant Chemotherapy
Dynamic Evolution of Vascular Features Based on Magnetic Resonance Imaging to Predict Pathological Response, Patterns of Recurrence and Survival Outcomes in Breast Cancer Neoadjuvant Chemotherapy Open
Neoadjuvant chemotherapy (NAC), followed by surgery and adjuvant therapy, constitutes the prevailing therapeutic paradigm for patients with locally advanced breast cancer (LABC) [...]
View article: The “Hand-as-Foot” teaching method in pituitary anatomy
The “Hand-as-Foot” teaching method in pituitary anatomy Open
View article: RBC balanced immuno-inflammatory signatures identify advanced breast cancer patients on CDK4/6 inhibitors at increased risk of progression and death
RBC balanced immuno-inflammatory signatures identify advanced breast cancer patients on CDK4/6 inhibitors at increased risk of progression and death Open
View article: Measurement of Intratumor Heterogeneity and Its Changing Pattern to Predict Response and Recurrence Risk After Neoadjuvant Chemotherapy in Breast Cancer
Measurement of Intratumor Heterogeneity and Its Changing Pattern to Predict Response and Recurrence Risk After Neoadjuvant Chemotherapy in Breast Cancer Open
The heterogeneity of breast tumors might reflect biological complexity and provide prediction clues for the sensitivity of treatment. This study aimed to construct a model based on tumor heterogeneity in magnetic resonance imaging (MRI) fo…
View article: Metronomic paclitaxel and cisplatin chemotherapy for metastatic breast cancer: insights from a target trial emulation
Metronomic paclitaxel and cisplatin chemotherapy for metastatic breast cancer: insights from a target trial emulation Open
Background: The management of metastatic breast cancer (MBC) poses a significant clinical challenge due to its high incidence of drug resistance and the limited efficacy of conventional therapies. This study aimed to assess the real-world …
View article: Label-free discrimination analysis of breast cancer tumor and adjacent tissues of patients after neoadjuvant treatment using Raman spectroscopy: a diagnostic study
Label-free discrimination analysis of breast cancer tumor and adjacent tissues of patients after neoadjuvant treatment using Raman spectroscopy: a diagnostic study Open
Background and objective: Breast-conserving surgery (BCS) plays a crucial role in breast cancer treatment, with a primary focus on ensuring cancer-free surgical margins, particularly for patients undergoing neoadjuvant treatment. After neo…
View article: Survival outcomes, multidimensional prediction and subsequent therapy in patients with hormone receptor-positive advanced breast cancer receiving palbociclib: a real-world analysis
Survival outcomes, multidimensional prediction and subsequent therapy in patients with hormone receptor-positive advanced breast cancer receiving palbociclib: a real-world analysis Open
CDKI score is a practical and comprehensive tool in predicting OS benefit for ABC patients treated with palbociclib, which deserves further validation. Patients who progressed on palbociclib seem to keep benefiting from chemo-free antineop…
View article: Design Innovation and User Experience of Sensory Interactive Experience in Museum Exhibition Space
Design Innovation and User Experience of Sensory Interactive Experience in Museum Exhibition Space Open
This research examines the influence of multi-sensory experiences on visitor engagement within museums in the United Kingdom, with particular emphasis on the roles of physical design elements, technological integration, and sensory stimuli…
View article: Stable or at least once HER2-low status during neoadjuvant chemotherapy confers survival benefit in patients with breast cancer
Stable or at least once HER2-low status during neoadjuvant chemotherapy confers survival benefit in patients with breast cancer Open
Our study first indicated in patients across all expression levels of HER2 that stable or at least once HER2-low status may confer favourable attributes including less malignant biological behaviour and long-term survival benefit for breas…
View article: Value of CDR1-AS as a predictive and prognostic biomarker for patients with breast cancer receiving neoadjuvant chemotherapy in a prospective Chinese cohort
Value of CDR1-AS as a predictive and prognostic biomarker for patients with breast cancer receiving neoadjuvant chemotherapy in a prospective Chinese cohort Open
View article: LMI1, a DUF292 protein family gene, regulates immune responses and cell death in rice
LMI1, a DUF292 protein family gene, regulates immune responses and cell death in rice Open
A novel rice mutant lmi1 showed increased resistance to bacterial blight. LMI1 encodes a DUF292 protein and regulates defense immune responses and cell death via vesicle trafficking in chloroplasts.
View article: Fluctuations in serum lipid levels during neoadjuvant treatment as novel predictive and prognostic biomarkers for locally advanced breast cancer: a retrospective analysis based on a prospective cohort
Fluctuations in serum lipid levels during neoadjuvant treatment as novel predictive and prognostic biomarkers for locally advanced breast cancer: a retrospective analysis based on a prospective cohort Open
View article: Serum miRNA-1 may serve as a promising noninvasive biomarker for predicting treatment response in breast cancer patients receiving neoadjuvant chemotherapy
Serum miRNA-1 may serve as a promising noninvasive biomarker for predicting treatment response in breast cancer patients receiving neoadjuvant chemotherapy Open
Background MicroRNA-1 (miR-1) is a tumour suppressor that can inhibit cell proliferation and invasion in several cancer types. In addition, miR-1 was found to be associated with drug sensitivity. Circulating miRNAs have been proven to be p…
View article: Structural genomics of the human dopamine receptor system
Structural genomics of the human dopamine receptor system Open
View article: The Modified Neo-Bioscore System for Staging Breast Cancer Treated with Neoadjuvant Therapy Based on Prognostic Significance of HER2-Low Expression
The Modified Neo-Bioscore System for Staging Breast Cancer Treated with Neoadjuvant Therapy Based on Prognostic Significance of HER2-Low Expression Open
Background: Recently, the classification of HER2 status evolves from binary to ternary, and HER2-low expression may exhibit prognostic significance. We aimed to investigate whether HER2-low tumor is distinct from HER2-zero or HER2-positive…
View article: Comprehensive analysis of Linc01436 for neoadjuvant chemotherapy response and its potential enriched pathways in breast cancer
Comprehensive analysis of Linc01436 for neoadjuvant chemotherapy response and its potential enriched pathways in breast cancer Open
Background Linc01436 is a novel long non-coding RNA which is associated with tumor proliferation and progression, but its involvement in breast cancer development and neoadjuvant chemotherapy (NAC) response has not been reported. Here, we …
View article: Strain ultrasonic elastography imaging features of locally advanced breast cancer: association with response to neoadjuvant chemotherapy and recurrence-free survival
Strain ultrasonic elastography imaging features of locally advanced breast cancer: association with response to neoadjuvant chemotherapy and recurrence-free survival Open
Background Due to the highly heterogeneity of the breast cancer, it would be desirable to obtain a non-invasive method to early predict the treatment response and survival outcome of the locally advanced breast cancer (LABC) patients under…
View article: WLP3 Encodes the Ribosomal Protein L18 and Regulates Chloroplast Development in Rice
WLP3 Encodes the Ribosomal Protein L18 and Regulates Chloroplast Development in Rice Open
Plastid ribosomal proteins play a crucial role in the growth and development of plants, mainly in the gene expression and translation of key genes in chloroplasts. While some information is known about the regulatory processes of plastid r…
View article: The effects of dexmedetomidine on postoperative tumor recurrence and patient survival after breast cancer surgery: a feasibility study
The effects of dexmedetomidine on postoperative tumor recurrence and patient survival after breast cancer surgery: a feasibility study Open
Purpose Dexmedetomidine (Dexmed) is a highly selective alpha 2 adrenoceptor (α 2 -AR) agonist with excellent sedation and analgesic effects and is frequently used in breast cancer surgery. However, the exact impact of Dexmed on breast canc…
View article: WLP3 Encodes the Ribosomal Protein L18 and Regulates Chloroplast Development in Rice
WLP3 Encodes the Ribosomal Protein L18 and Regulates Chloroplast Development in Rice Open
Plastid ribosomal proteins play a crucial role in the growth and development of plants, predominantly in key gene translation and expression within chloroplasts. While some information is known about the regulatory processes of plastid rib…
View article: Genetic polymorphisms of GGT1 gene (rs8135987, rs5751901 and rs2017869) are associated with neoadjuvant chemotherapy efficacy and toxicities in breast cancer patients
Genetic polymorphisms of GGT1 gene (rs8135987, rs5751901 and rs2017869) are associated with neoadjuvant chemotherapy efficacy and toxicities in breast cancer patients Open
View article: Multiparametric Contrast-Enhanced Ultrasound in Early Prediction of Response to Neoadjuvant Chemotherapy and Recurrence-Free Survival in Breast Cancer
Multiparametric Contrast-Enhanced Ultrasound in Early Prediction of Response to Neoadjuvant Chemotherapy and Recurrence-Free Survival in Breast Cancer Open
We aimed to explore the value of contrast-enhanced ultrasound (CEUS) in early prediction of pathologic complete response (pCR) and recurrence-free survival (RFS) in locally advanced breast cancer (LABC) patients treated with neoadjuvant ch…
View article: TIMELESS upregulates PD-L1 expression and exerts an immunosuppressive role in breast cancer
TIMELESS upregulates PD-L1 expression and exerts an immunosuppressive role in breast cancer Open
View article: Data from Neoadjuvant Trastuzumab and Pyrotinib for Locally Advanced HER2-Positive Breast Cancer (NeoATP): Primary Analysis of a Phase II Study
Data from Neoadjuvant Trastuzumab and Pyrotinib for Locally Advanced HER2-Positive Breast Cancer (NeoATP): Primary Analysis of a Phase II Study Open
Purpose:Despite accumulating evidence on dual blockade of HER2 for locally advanced HER2-positive breast cancer, no robust evidence supports the addition of pyrotinib to trastuzumab in the neoadjuvant setting. The NeoATP trial aimed to eva…