Explanipedia

Urban airborne PM2.5 induces pulmonary fibrosis through triggering glycolysis and subsequent modification of histone lactylation in macrophages Open

Jingyi Li, Guodong Zeng, Zezhong Zhang, Yuanli Wang, Mengyao Shao , et al. · 2024

Airborne fine particulate matter (PM_2.5) can cause pulmonary inflammation and even fibrosis, however, the underlying molecular mechanisms of the pathogenesis of PM_2.5 exposure have not been fully appreciated. In the p…

‘Dumpling suture method’ versus traditional suture method of protective loop ileostomy in laparoscopic anterior rectal resection with specimen extraction through stoma incision: a retrospective comparative cohort study Open

Jiani Gu, Jin Wang, Xingwang Hu, Wenjun Ding, Long Cui , et al. · 2023

Background: A diverting loop ileostomy (DLI) is performed in laparoscopic anterior rectal resection (LAR) surgery at high risk of anastomotic fistula. Minimally invasive surgery promotes postoperative recovery and cosmetics. To reduce abdo…

Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress Open

Junling Gao, Lei Tong, Hongyun Wang, Kai Luo, Yuanli Wang , et al. · 2022

Background Airborne fine particulate matter with aerodynamic diameter ≤ 2.5 μm (PM 2.5 ) pollution is associated with the prevalence of respiratory diseases, including asthma, bronchitis and chronic obstructive pulmonary disease. In patien…

Tetramethylpyrazine: A review of the most recent research Open

Tongwen Xu, Guang‐Hong Chen, Tong Xue, Yuting Wu, Honglin Xu , et al. · 2022

TGF-β-Containing Small Extracellular Vesicles From PM2.5-Activated Macrophages Induces Cardiotoxicity Open

Xiaoqi Hu, Mo Chen, Xue Cao, Xinyi Yuan, Fang Zhang , et al. · 2022

Numerous epidemiological and experimental studies have demonstrated that the exposure to fine particulate matter (aerodynamic diameter <2.5 μm, PM 2.5 ) was closely associated with cardiovascular morbidity and mortality. Our previous st…

Role of exosomes in respiratory diseases Open

Xiaoqi Hu, Chunyan Wu, Fang Zhang, Wenjun Ding · 2022

Respiratory diseases are a group of different conditions affecting the airways, including acute lung injury, asthma, chronic obstructive pulmonary disorder, and idiopathic pulmonary fibrosis. Recent studies have demonstrated the extracellu…

Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling Open

Tengyu Zhu, Xue Chen, Huan Qiu, Yang Liu, James Mwangi , et al. · 2021

As an important source of air pollutant, airborne particulate matter (PM) has become a major threat to public health. Orchitis is characterized by acute or chronic testicular inflammation and is a primary cause of male infertility. Althoug…

Hypertrophic cardiomyopathy with latent obstruction: Clinical characteristics and surgical results Open

Qiang Ji, Yulin Wang, FangYu Liu, Ye Yang, Limin Xia , et al. · 2021

Dihydrotanshinone I inhibits the growth of hepatoma cells by direct inhibition of Src Open

Xiaoli Jiang, Bo Deng, Suihui Deng, Min Cai, Wenjun Ding , et al. · 2021

Our results suggest that DHI inhibits the growth of hepatoma cells by direct inhibition of Src.

Adipose-derived stem cells therapy effectively attenuates PM2.5-induced lung injury Open

Junling Gao, Jun-Tao Yuan, Qun Liu, Yuanli Wang, Huiwen Wang , et al. · 2021

Background The adverse health effects of fine particulate matter (PM 2.5 ) exposure are associated with marked inflammatory responses. Adipose-derived stem cells (ADSCs) have immunosuppressive effects, and ADSC transplantation could attenu…

Surgical Septal Myectomy for the Treatment of Residual Left Ventricular Outflow Tract Obstruction Following Failed Alcohol Septal Ablation Open

Qiang Ji, Yulin Wang, Ye Yang, Hao Lai, Wenjun Ding , et al. · 2021

The reasons of residual left ventricular outflow tract (LVOT) obstruction following alcohol septal ablation (ASA) remain unclear, and outcomes of myectomy following failed ASA remain underreported.Thirteen symptomatic patients (10 women, a…

Mini-invasive surgical instruments in transaortic myectomy for hypertrophic obstructive cardiomyopathy: A single-center experience with 168 cases Open

Qiang Ji, Yulin Wang, Yang Ye, Hao Lai, Wenjun Ding , et al. · 2021

Background: Although septal myectomy is a standard strategy for managing patients with hypertrophic obstructive cardiomyopathy (HOCM) and drug-refractory symptoms, so far, only a few experienced myectomy centers exist globally. Mainly, thi…

Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice Open

Tengyu Zhu, Huan Qiu, Qiqi Cao, Zilei Duan, Feng‐Liang Liu , et al. · 2021

The global outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as of 8 May 2021, has surpassed 150 700 000 infections and 3 279 000 deaths worldwide. Evidence in…

Surgical Correction of Coronary Artery Ectasia Combining Congenital Coronary Artery Fistula Open

Yulin Wang, Ye Yang, Limin Xia, Wenjun Ding, Qiang Ji , et al. · 2020

Background: Coronary artery ectasia (CAE) complicated with concomitant congenital coronary artery fistula (CCAF) is rare. This study characterizes the clinical characteristics of CAE combining CCAF, and reports a single-institution experie…

Characteristics and Surgical Results of Patients with Hypertrophic Obstructive Cardiomyopathy without Intrinsic Mitral Valve Diseases Undergoing Mitral Subvalvular Procedures during Myectomy Open

Qiang Ji, Yulin Wang, Ye Yang, Limin Xia, Wenjun Ding , et al. · 2020

Background. Mitral subvalvular procedures have acquired a major role during hypertrophic obstructive cardiomyopathy (HOCM) surgery. However, few studies have focused on characterizing the clinical feature of HOCM patients without intrinsic…

Mitral valve repair and surgical ablation for atrial functional mitral regurgitation Open

Jinmiao Chen, Yulin Wang, Minzhi Lv, Zhaohua Yang, Shijie Zhu , et al. · 2020

Our results suggest that MV repair for AFMR is safe and effective. It improves heart failure symptoms and results in reverse-remodeling of both the LA and LV. Concomitant SA might benefit patients in terms of recurrent MR, especially in th…

Learning curve of mitral valve repair: cumulative sum failure analysis from single high-volume center Open

Jun Li, Yun Zhao, Tianyu Zhou, Kai Zhu, Junyu Zhai , et al. · 2020

The number of cases required to overcome the learning curve for repair rate is substantial, although there is marked variation among surgeons. Individuals' learning curves accelerate as the institution accumulates experience. MV repair is …

Application of mini-invasive surgical instruments in transaortic myectomy for hypertrophic obstructive cardiomyopathy: A single-center experience with 168 cases Open

Qiang Ji, Yulin Wang, Yang Ye, Hao Lai, Wenjun Ding , et al. · 2020

Background: Septal myectomy has been a standard treatment option for patients with hypertrophic obstructive cardiomyopathy (HOCM) and drug refractory symptoms. However, there are only a few experienced myectomy centers in the world so far,…

Ovarian Dysfunction Induced by Chronic Whole‐Body PM2.5 Exposure Open

Su Zhou, Yueyue Xi, Yingying Chen, Zezhong Zhang, Chunyan Wu , et al. · 2020

Fine particulate matter (PM2.5) pollution arouses public health concerns over the world. Increasing epidemiologic evidence suggests that exposure to ambient airborne PM2.5 increases the risk of female infertility. However, relatively few s…

Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb Open

Xiaoyu Chen, Jing Guo, Yunlong Huang, Shan Liu, Ying Huang , et al. · 2020

Impacts of Skeletonized Bilateral Internal Mammary Artery Bypass Grafting on the Risk of Deep Sternal Wound Infection Open

Qiang Ji, Yun Zhao, Huan Liu, Ye Yang, Yulin Wang , et al. · 2020

This single-center study aimed to evaluate the incidence of deep sternal wound infection (DSWI) following skeletonized bilateral internal mammary artery (BIMA) harvest in a Chinese cohort. Using propensity score matching, this study also p…

Intravenous transfusion of iron sucrose reduces blood transfusions and improves postoperative anaemia after a second thoracotomy: a propensity-score matching study Open

Chentao Luo, Yunqing Shi, Yi Lin, RunHua Ma, Qi Xia , et al. · 2020

Objective To evaluate the efficacy of intravenous iron sucrose (IS) in the perioperative period of a second thoracotomy after open-heart surgery. Methods This study enrolled patients that underwent a second thoracotomy after previous open-…

Patients over 70 years of age with moderate ischemic mitral regurgitation undergoing surgical revascularization plus mitral valve repair: insights from a single-center study of propensity-matched data Open

Qiang Ji, Xiao-Min Qi, JinQiang Shen, Yulin Wang, Ye Yang , et al. · 2019

Patients over 70 years of age with moderate chronic IMR undergoing combined CABG and mitral valve repair may receive favorable in-hospital and midterm clinical outcomes.

PM2.5, Fine Particulate Matter: A Novel Player in the Epithelial-Mesenchymal Transition? Open

Zihan Xu, Wenjun Ding, Xiaobei Deng · 2019

Epithelial-mesenchymal transition (EMT) refers to the conversion of epithelial cells to mesenchymal phenotype, which endows the epithelial cells with enhanced migration, invasion, and extracellular matrix production abilities. These charac…

Risk Factors for Moderate or More Residual Regurgitation in Patients with Moderate Chronic Ischemic Mitral Regurgitation Undergoing Surgical Revascularization Alone Open

Qiang Ji, Yun Zhao, JinQiang Shen, Yulin Wang, Ye Yang , et al. · 2019

Few reports have focused on which patients with moderate ischemic mitral regurgitation (IMR) were not good candidates for coronary artery bypass grafting (CABG) alone. This single-center study aimed to assess risk factors for moderate or m…

Moderate Chronic Ischemic Mitral Regurgitation Open

JinQiang Shen, Limin Xia, Kai Song, Yulin Wang, Ye Yang , et al. · 2019

The benefits of concomitant mitral valve procedure (MVP) for treating moderate chronic ischemic mitral regurgitation (IMR) during coronary artery bypass grafting (CABG) have not been clearly established. This study aimed to determine the i…

The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis Open

Hongyun Wang, Xiyue Shen, Jingli Liu, Chunyan Wu, Junling Gao , et al. · 2019

Impacts of incomplete revascularization following off-pump coronary artery bypass grafting on clinical outcomes of patients with triple-vessel lesions: insights from a single-center study of propensity-matched data Open

Qiang Ji, Yun Zhao, Kai Zhu, Kai Song, JinQiang Shen , et al. · 2019

CR can be achieved in the majority of off-pump CABG cases. Compared with off-pump CR, off-pump IR with the LIMA grafting to the LAD was associated with acceptable clinical outcomes.

Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy Open

Wenhui Yue, Lei Tong, Xiaohong Liu, Xinyu Weng, Xiaoyu Chen , et al. · 2019

Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often progress to right ventricular (RV) failure even with optimal medical care. An increase…

TMT-Based Quantitative Proteomics Analysis Reveals Airborne PM2.5-Induced Pulmonary Fibrosis Open

Shan Liu, Wei Zhang, Fang Zhang, Peter Roepstorff, Fuquan Yang , et al. · 2018

Epidemiological and experimental studies have documented that long-term exposure to fine particulate matter (PM2.5) increases the risk of respiratory diseases. However, the details of the underlying mechanism remain unclear. In this study,…

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