Wenjun Mao
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View article: USP18 confers protection against allergic asthma by suppressing CCL8 production in alveolar type II epithelial cells
USP18 confers protection against allergic asthma by suppressing CCL8 production in alveolar type II epithelial cells Open
Overall, these findings reveal a previously unrecognized role for USP18 in regulating CCL8 production during asthma progression, highlighting USP18 and CCL8 as potential therapeutic targets for asthma treatment.
View article: Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target
Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target Open
Cancer immune evasion is orchestrated by tumor‐intrinsic molecular constraints that remain incompletely defined. Here, we performed an in vivo genome‐wide clustered regularly interspaced short palindromic repeats (CRISPR) loss‐of‐function …
View article: Lymph Node Metastasis-Associated Spatiotemporal Mapping of the TFF3-Linked Niche in Breast Cancer: Integrating Radiogenomic Signatures with Immune-Ecosystem Remodeling
Lymph Node Metastasis-Associated Spatiotemporal Mapping of the TFF3-Linked Niche in Breast Cancer: Integrating Radiogenomic Signatures with Immune-Ecosystem Remodeling Open
View article: The interplay between tissue‐resident microbiome and host proteins by integrated multi‐omics during progression of colorectal adenoma to carcinoma
The interplay between tissue‐resident microbiome and host proteins by integrated multi‐omics during progression of colorectal adenoma to carcinoma Open
The intratumoral microbiome is an emerging hallmark of cancer, yet its multi‐kingdom host–microbiome ecosystem in colorectal cancer (CRC) remains poorly characterized. Here, we conducted an integrated analysis using deep shotgun metagenomi…
View article: Delving Into the Dialogue between Epigenetic Modifications and Immunometabolism in Cancer
Delving Into the Dialogue between Epigenetic Modifications and Immunometabolism in Cancer Open
Tumor immunometabolism and epigenetic modifications are intricately linked in reshaping the tumor microenvironment, with their crosstalk offering novel insights into cancer biology. Nutrient deprivation and metabolic byproducts drive metab…
View article: An Incentive Algorithm for Personalized Employee Task Allocation Based on Long Short-Term Memory Model
An Incentive Algorithm for Personalized Employee Task Allocation Based on Long Short-Term Memory Model Open
In modern industrial and service environments, efficiently and reasonably allocating tasks to enhance employee productivity and satisfaction is a key challenge. This study aims to overcome the limitations of traditional bidding models in t…
View article: Meta-analysis on the efficacy and safety of Guanxin Shutong capsule in the treatment of angina pectoris of coronary heart disease
Meta-analysis on the efficacy and safety of Guanxin Shutong capsule in the treatment of angina pectoris of coronary heart disease Open
Objective This study aims to summarize all single clinical studies of Guanxin Shutong (GXST) capsule combined with Western medicine in the treatment of coronary heart disease angina pectoris and to systematically evaluate its efficacy and …
View article: WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma
WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma Open
Esophageal squamous cell carcinoma (ESCC) is a common digestive tract malignant cancer with high incidence and mortality rate. Many studies have shown that long noncoding RNAs (lncRNAs are involved in the progression of various types of tu…
View article: Clinical prognosis evaluation of alpha-fetoprotein-positive gastric cancer: comprehensive analysis and development of a novel nomogram for survival prediction
Clinical prognosis evaluation of alpha-fetoprotein-positive gastric cancer: comprehensive analysis and development of a novel nomogram for survival prediction Open
Background Alpha-fetoprotein (AFP) is an established biomarker for liver cancer, but its role in gastric cancer (GC) remains unclear. This study evaluated AFP’s prognostic value in GC and developed a survival prediction model incorporating…
View article: Pangu Ultra MoE: How to Train Your Big MoE on Ascend NPUs
Pangu Ultra MoE: How to Train Your Big MoE on Ascend NPUs Open
Sparse large language models (LLMs) with Mixture of Experts (MoE) and close to a trillion parameters are dominating the realm of most capable language models. However, the massive model scale poses significant challenges for the underlying…
View article: Preferences for long-term care among elderly patients who had a stroke with disabilities in Eastern China: protocol for a discrete choice experiment study
Preferences for long-term care among elderly patients who had a stroke with disabilities in Eastern China: protocol for a discrete choice experiment study Open
Background Stroke is a leading cause of disability among older adults worldwide, often resulting in significant physical, cognitive and emotional impairments that require long-term care. With ageing populations and increasing stroke preval…
View article: Decoding the causal association between immune cells and three chronic respiratory diseases: Insights from a bi-directional Mendelian randomization study
Decoding the causal association between immune cells and three chronic respiratory diseases: Insights from a bi-directional Mendelian randomization study Open
Our investigation identifies latent correlations of immune traits and three major CRDs, offering novel perspectives on the preventive and therapeutical strategies for CRDs.
View article: Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling
Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling Open
Food allergy (FA) has received increased attention in recent years. Multiple studies have highlighted the crucial role of short‐chain fatty acids (SCFAs) in the development of IgE‐mediated FA. Here, a case‐control approach was employed to …
View article: Assessing demographic and clinical determinants of resilience, personal recovery, and quality of life for psychiatric in-patients before hospital discharge
Assessing demographic and clinical determinants of resilience, personal recovery, and quality of life for psychiatric in-patients before hospital discharge Open
Introduction Many patients with mental health and emotional problems often see the transition period in the community after hospital discharge as a test of their resilience and a threat to their recovery. Most often, some doubt their abili…
View article: Evaluating the Prevalence and Correlates of Low Resilience in Patients Before Discharge from Acute Mental Health Units in Alberta, Canada
Evaluating the Prevalence and Correlates of Low Resilience in Patients Before Discharge from Acute Mental Health Units in Alberta, Canada Open
Introduction Many people experience at least one traumatic event in their lifetime. Although such traumatic events can precipitate psychiatric disorders, many individuals exhibit high resilience by adapting to such events with little disru…
View article: Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications
Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications Open
Epigenomic modifications-such as DNA methylation, histone acetylation, and histone methylation-and their implications in tumorigenesis, progression, and treatment have emerged as a pivotal field in cancer research. Tumors undergo metabolic…
View article: Unveiling the new chapter in nanobody engineering: advances in traditional construction and AI-driven optimization
Unveiling the new chapter in nanobody engineering: advances in traditional construction and AI-driven optimization Open
View article: CDK12-Mediated Phosphorylation of FOXA1 Promotes Prostate Cancer Progression via the MDM2–p53 Axis
CDK12-Mediated Phosphorylation of FOXA1 Promotes Prostate Cancer Progression via the MDM2–p53 Axis Open
Prostate cancer (PCa) progression is driven by intricate molecular mechanisms involving dysregulated signaling networks and posttranslational modifications of key regulatory proteins. In this study, we identify a novel oncogenic pathway wh…
View article: Gut–Brain–Microbiome Axis in the Regulation of Cancer Immune Escape and Immunotherapy in Tumors
Gut–Brain–Microbiome Axis in the Regulation of Cancer Immune Escape and Immunotherapy in Tumors Open
Accumulating evidence demonstrates crosstalk involving the intestine and the brain, with the gut microbiota serving as a critical mediator of this interaction. The gut microbiota, along with its derived metabolites and bioactive compounds,…
View article: Noninvasive Computed Tomography-Based Quantification of Tumor Fibrosis Predicts Pancreatic Cancer Response to Gemcitabine/Nab-Paclitaxel
Noninvasive Computed Tomography-Based Quantification of Tumor Fibrosis Predicts Pancreatic Cancer Response to Gemcitabine/Nab-Paclitaxel Open
Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis. Chemotherapy remains the mainstay for unresectable cases, yet regimens like AG (gemcitabine/nab-paclitaxel) exhibit heterogeneous efficacy. Tumor fibrosis has emerged as a…
View article: Unraveling the Fungi–Cancer Connection
Unraveling the Fungi–Cancer Connection Open
Accumulating evidences indicated that both the intestinal and intratumor microbiota substantially impacted the cancer initiation, progression, and therapeutic responses. Currently, the bacterial roles in cancer are particularly emphasized,…
View article: Challenging Traditional ECMO Anticoagulation in Lung Transplantation: Evidence from Interpretable Machine Learning Models
Challenging Traditional ECMO Anticoagulation in Lung Transplantation: Evidence from Interpretable Machine Learning Models Open
View article: SPP1 <sup>+</sup> TAM: CD8 <sup>+</sup> T Cell Crosstalk Associates with Blocking Radiotherapy Efficacy in Lung Cancer
SPP1 <sup>+</sup> TAM: CD8 <sup>+</sup> T Cell Crosstalk Associates with Blocking Radiotherapy Efficacy in Lung Cancer Open
Radiotherapy (RT) is a cornerstone treatment for non-small cell lung cancer (NSCLC), but its efficacy is often limited by immune suppression in the tumor microenvironment. In this study, we identified SPP1 as a key factor up-regulated afte…
View article: Preferences for long-term care among elderly stroke patients with disabilities : a protocol for a discrete choice experiment
Preferences for long-term care among elderly stroke patients with disabilities : a protocol for a discrete choice experiment Open
Background Stroke is one of the leading causes of disability among older adults worldwide, often resulting in significant physical, cognitive, and emotional impairments that require long-term care (LTC). With aging populations and increasi…
View article: Revolutionizing cancer treatment: the emerging potential and potential challenges of <i>in vivo</i> self-processed CAR cell therapy
Revolutionizing cancer treatment: the emerging potential and potential challenges of <i>in vivo</i> self-processed CAR cell therapy Open
Chimeric antigen receptor (CAR) cell immunotherapies, including CAR-T, CAR-Macrophages, CAR-Natural Killer, CAR-γδ T, etc., have demonstrated significant advancements in the treatment of both hematologic malignancies and solid tumors. Desp…
View article: Ultrasonication outperforms electroporation for extracellular vesicle cargo depletion
Ultrasonication outperforms electroporation for extracellular vesicle cargo depletion Open
Extracellular vesicles (EVs), submicron-sized membranous structures released by cells, serve as vehicles of tissue-specific proteins and nucleic acids, facilitating intercellular communication and playing roles in pathophysiological proces…
View article: Multi‐level insights into the immuno‐oncology‐microbiome axis: From biotechnology to novel therapies
Multi‐level insights into the immuno‐oncology‐microbiome axis: From biotechnology to novel therapies Open
The multifaceted interactions among the immune system, cancer cells and microbial components have established a novel concept of the immuno-oncology-microbiome (IOM) axis. Microbiome sequencing technologies have played a pivotal role in no…
View article: Exploring shared mechanisms between ulcerative colitis and psoriasis and predicting therapeutic natural compounds through bioinformatics and molecular docking
Exploring shared mechanisms between ulcerative colitis and psoriasis and predicting therapeutic natural compounds through bioinformatics and molecular docking Open
MMP9, MMP1, and CXCL10, central mediators in the inflammatory pathways of UC and PS, establish a shared mechanism by triggering cytokine and chemokine activation, leading to tissue damage and positioning them as promising therapeutic targe…
View article: Voluntary exercise sensitizes cancer immunotherapy via the collagen inhibition-orchestrated inflammatory tumor immune microenvironment
Voluntary exercise sensitizes cancer immunotherapy via the collagen inhibition-orchestrated inflammatory tumor immune microenvironment Open
Physical activity reduces cancer-associated mortality through multiple mechanisms, including tumor immune microenvironment (TIME) reprogramming. However, whether and how physiological interventions promote anti-tumor immunity remain elusiv…
View article: Salvage surgery and conversion surgery for patients with nonsmall cell lung cancer: a narrative review
Salvage surgery and conversion surgery for patients with nonsmall cell lung cancer: a narrative review Open
Nonsmall cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths. With the development of screening, patient selection, and treatment strategies, patients’ survival outcomes and living quality significantly improved. Ho…