Wen‐Jun Li
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View article: Horizontal gene transfer and gene loss drove the divergent evolution of host dependency in Micrarchaeota
Horizontal gene transfer and gene loss drove the divergent evolution of host dependency in Micrarchaeota Open
The DPANN superphylum is a deep-branching radiation of Archaea with small cell and genome sizes. Most DPANN lineages are predicted or validated to be host-dependent. However, certain lineages have substantial biosynthetic capacities and ar…
View article: Graminoides A-D, antibacterial cyclic octaketides from the desert-derived Streptomyces
Graminoides A-D, antibacterial cyclic octaketides from the desert-derived Streptomyces Open
View article: Dual role of ROS-dependent anti-cancer activity and photocatalytic degradation of graphene oxide against MCF-7 breast cancer cells and organic dye
Dual role of ROS-dependent anti-cancer activity and photocatalytic degradation of graphene oxide against MCF-7 breast cancer cells and organic dye Open
Graphene oxide (GO), a two-dimensional nanomaterial, was synthesized using a modified Hummers' method and evaluated for its dual biomedical and environmental applications. Structural characterization confirmed the successful formation of G…
View article: Improving the functional performance of anthocyanin indicator films through antimicrobial peptides incorporation: Enhanced stability, swelling control, and antibacterial efficacy
Improving the functional performance of anthocyanin indicator films through antimicrobial peptides incorporation: Enhanced stability, swelling control, and antibacterial efficacy Open
View article: Nurture over nature in new <i>Micromonospora</i> spp. strains’ metabolism: multi-omics analyses reveal fermentation conditions as the dominant driver over phylogeny
Nurture over nature in new <i>Micromonospora</i> spp. strains’ metabolism: multi-omics analyses reveal fermentation conditions as the dominant driver over phylogeny Open
The genus Micromonospora , a key member of the actinomycetes, has demonstrated considerable potential for natural product biosynthesis. In this study, we isolated 15 Micromonospora spp. strains from desert soil and marine sediment samples,…
View article: MDG-DDI: multi-feature drug graph for drug-drug interaction prediction
MDG-DDI: multi-feature drug graph for drug-drug interaction prediction Open
By jointly modeling substructure-level semantics and molecular graph structure, MDG-DDI achieves robust and accurate DDI prediction. The framework demonstrates improved generalization and offers potential for enhancing drug safety assessme…
View article: Neutrophil extracellular traps: a novel contributor to vascular calcification in chronic kidney disease
Neutrophil extracellular traps: a novel contributor to vascular calcification in chronic kidney disease Open
Background Among patients with chronic kidney disease (CKD), vascular calcification significantly contributes to cardiovascular health issues, though the underlying molecular mechanisms remain unclear. Recent research highlights neutrophil…
View article: Effect of <i>Lactobacillus pentosus</i> fermentation on the quality of peanut protein-chicken sausage composite gel
Effect of <i>Lactobacillus pentosus</i> fermentation on the quality of peanut protein-chicken sausage composite gel Open
This study aimed to analyze the effects of adding different peanut protein fractions before and after Lactobacillus pentosus fermentation on the water-holding capacity, cooking loss rate, texture, gel strength, rheological properties, chro…
View article: Rare and abundant taxa in Artemisia desertorum rhizosphere soils demonstrate disparate responses to drought stress
Rare and abundant taxa in Artemisia desertorum rhizosphere soils demonstrate disparate responses to drought stress Open
View article: Enhancing anthocyanin stability via co-assembled nanoencapsulation with tripeptides by intermolecular interaction
Enhancing anthocyanin stability via co-assembled nanoencapsulation with tripeptides by intermolecular interaction Open
The high sensitivity of anthocyanins to environmental stressors poses significant challenges for their application in food. Encouraging progress has been made with peptide encapsulation strategies, which have enhanced the stability of anth…
View article: Akkermansia muciniphila Enhances Resistance to Infectious Bronchitis Virus in Chickens Through γ-Aminobutyric Acid-Mediated Anti-Inflammatory Pathways
Akkermansia muciniphila Enhances Resistance to Infectious Bronchitis Virus in Chickens Through γ-Aminobutyric Acid-Mediated Anti-Inflammatory Pathways Open
Background Infectious bronchitis virus (IBV) is a major viral pathogen causing substantial economic losses in the global poultry industry. However, the limited efficacy of commercial vaccines and the absence of approved antiviral drugs und…
View article: Targeting microglial PPARα ameliorates the outcome of ischemic stroke by enhancing interaction with infiltrating peripheral monocytes/macrophages
Targeting microglial PPARα ameliorates the outcome of ischemic stroke by enhancing interaction with infiltrating peripheral monocytes/macrophages Open
The interaction between infiltrating immune cells and brain-resident cells is critical for inducing an inflammatory response to ischemic stroke. However, the direct effects of CD11b+CD45int microglia in the brain on i…
View article: Progress of Immune‐Inducible Biomaterials for Post‐Ablation Cancers
Progress of Immune‐Inducible Biomaterials for Post‐Ablation Cancers Open
Locoregional ablation therapies have considerable potential in eradicating cancers by killing tumor cells directly with different mechanisms, inducing immunogenic cell death, and subsequently forming the “in situ vaccine”. Nevertheless, a …
View article: A wearable self-aid microneedle chip based on actively transdermal delivery of epinephrine
A wearable self-aid microneedle chip based on actively transdermal delivery of epinephrine Open
View article: Enhancing chrysanthemum rooting: The role of Stenotrophomonas pavanii KC 98 in physiological and microbial dynamics
Enhancing chrysanthemum rooting: The role of Stenotrophomonas pavanii KC 98 in physiological and microbial dynamics Open
View article: Author Correction: Genome-guided isolation of the hyperthermophilic aerobe Fervidibacter sacchari reveals conserved polysaccharide metabolism in the Armatimonadota
Author Correction: Genome-guided isolation of the hyperthermophilic aerobe Fervidibacter sacchari reveals conserved polysaccharide metabolism in the Armatimonadota Open
View article: Phylogenomics provides new insight into the phylogeny and diversification of Asian Lappula (Boraginaceae)
Phylogenomics provides new insight into the phylogeny and diversification of Asian Lappula (Boraginaceae) Open
The application of omics data serves as a powerful tool for investigating the roles of incomplete lineage sorting (ILS) and hybridization in shaping genomic diversity, offering deeper insights into complex evolutionary processes. In this s…
View article: Branched-chain amino acid specialization drove diversification within Calditenuaceae (Caldarchaeia) and enables their cultivation
Branched-chain amino acid specialization drove diversification within Calditenuaceae (Caldarchaeia) and enables their cultivation Open
Many thermophiles that are abundant in high-temperature geothermal systems have never been cultivated and are poorly understood, including deeply branching Thermoproteota. Here, we describe the genome-guided cultivation of one such organis…
View article: Tailored anthocyanin delivery through modulating -COOH groups in pH-responsive peptide gels
Tailored anthocyanin delivery through modulating -COOH groups in pH-responsive peptide gels Open
With the continuous advancement of precision nutrition, researchers have increasingly recognized the need for tailored, stable delivery of food bioactive compounds, such as anthocyanins, in response to the varying conditions of the gastroi…
View article: Open-Sora 2.0: Training a Commercial-Level Video Generation Model in $200k
Open-Sora 2.0: Training a Commercial-Level Video Generation Model in $200k Open
Video generation models have achieved remarkable progress in the past year. The quality of AI video continues to improve, but at the cost of larger model size, increased data quantity, and greater demand for training compute. In this repor…
View article: Inhibitory mechanism of CMP-LSOPC nanoparticles on advanced glycation end products released during digestion
Inhibitory mechanism of CMP-LSOPC nanoparticles on advanced glycation end products released during digestion Open
View article: Recovery of nearly 3,000 archaeal genomes from 152 terrestrial geothermal spring metagenomes
Recovery of nearly 3,000 archaeal genomes from 152 terrestrial geothermal spring metagenomes Open
View article: Application of bacterioruberin from Arthrobacter sp. isolated from Xinjiang desert to extend the shelf-life of fruits during postharvest storage
Application of bacterioruberin from Arthrobacter sp. isolated from Xinjiang desert to extend the shelf-life of fruits during postharvest storage Open
View article: Design and Process Analysis of a Split-Gate Trench Power MOSFET With Bottom-Trench High-<i>k</i> Pillar Superjunction for Enhanced Performance
Design and Process Analysis of a Split-Gate Trench Power MOSFET With Bottom-Trench High-<i>k</i> Pillar Superjunction for Enhanced Performance Open
In this paper, we propose a simulation-based novel Split-Gate Trench MOSFET structure with an optimized fabrication process to enhance power efficiency, switching speed, and thermal stability for high-performance semiconductor applications…
View article: Characterization of Sphingomicrobium Aquimarinum Sp. Nov. And Sphingomicrobium Maritimum Sp. Nov. Highlights Astaxanthin-Producing Bacteria in the Family Sphingomonadaceae
Characterization of Sphingomicrobium Aquimarinum Sp. Nov. And Sphingomicrobium Maritimum Sp. Nov. Highlights Astaxanthin-Producing Bacteria in the Family Sphingomonadaceae Open
View article: Modulation of soil microenvironment and plant gene expression by earthworms reduces polypropylene microplastic-induced growth stress in Chinese milk vetch (Astragalus sinicus L.)
Modulation of soil microenvironment and plant gene expression by earthworms reduces polypropylene microplastic-induced growth stress in Chinese milk vetch (Astragalus sinicus L.) Open
Earthworms can mitigate the detrimental effects of polypropylene microplastics (PP-MPs) on plant growth. This study employed pot-grown experiments to investigate how earthworms mitigate growth stress in Astragalus sinicus L. (CMV) exposed …
View article: Polyethylene Microplastics Generally Mitigate Rather than Exacerbate Soil Salinization Hazards to Earthworms
Polyethylene Microplastics Generally Mitigate Rather than Exacerbate Soil Salinization Hazards to Earthworms Open
View article: Polyphasic taxonomy and genome mining of Desertivibrio insolitus gen. nov., sp. nov., a novel psychrotolerant pectin-degrading actinobacterium isolated from desert soil
Polyphasic taxonomy and genome mining of Desertivibrio insolitus gen. nov., sp. nov., a novel psychrotolerant pectin-degrading actinobacterium isolated from desert soil Open
View article: Light-driven diel oscillations in microbial metabolism underpin estuarine biogeochemical resilience
Light-driven diel oscillations in microbial metabolism underpin estuarine biogeochemical resilience Open
Diel light cycles profoundly influence estuarine biogeochemical processes, yet the mechanistic responses of planktonic prokaryotic communities to these rhythmic cues remain incompletely understood. This study employed an integrative multi-…
View article: Metagenomic analysis sheds light on the mixotrophic lifestyle of bacterial phylum <i>Zhuqueibacterota</i>
Metagenomic analysis sheds light on the mixotrophic lifestyle of bacterial phylum <i>Zhuqueibacterota</i> Open
Zhuqueibacterota is a novel bacterial phylum proposed based on hot spring metagenomes and public metagenome-assembled genomes, classified within the Fibrobacterota-Chlorobiota-Bacteroidota superphylum. This glob…