Wen‐Jun Xin
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View article: A novel protein cRERE encoded by a circular RNA directly targets ERK signaling to alleviate chemotherapy-induced neuropathic pain
A novel protein cRERE encoded by a circular RNA directly targets ERK signaling to alleviate chemotherapy-induced neuropathic pain Open
Circular RNAs (circRNAs), as stable and evolutionarily conserved epigenetic regulators, have attracted growing attention, especially those enriched in the central nervous system (CNS). CNS-specific circRNAs downregulated during disease pro…
View article: Earlier onset of chemotherapy-induced neuropathic pain in females by ICAM-1–mediated accumulation of perivascular macrophages
Earlier onset of chemotherapy-induced neuropathic pain in females by ICAM-1–mediated accumulation of perivascular macrophages Open
Sex differences in the pathogenesis of a variety of diseases have drawn increasing attention. However, it remains unclear whether such differences exist in chemotherapy-induced neuropathic pain. Here, we conducted a retrospective analysis …
View article: Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans
Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans Open
View article: GPNMB and ATP6V1A interact to mediate microglia phagocytosis of multiple types of pathological particles
GPNMB and ATP6V1A interact to mediate microglia phagocytosis of multiple types of pathological particles Open
Pronounced elevation of glycoprotein non-metastatic melanoma B (GPNMB) is a common phenomenon in a variety of brain diseases, but the expression patterns, functions, and molecular signaling of GPNMB have not been well studied. Here, we sho…
View article: Sprouting sympathetic fibres release CXCL16 and norepinephrine to synergistically mediate sensory neuronal hyperexcitability in a rodent model of neuropathic pain
Sprouting sympathetic fibres release CXCL16 and norepinephrine to synergistically mediate sensory neuronal hyperexcitability in a rodent model of neuropathic pain Open
View article: A neural circuit from thalamic paraventricular nucleus via zona incerta to periaqueductal gray for the facilitation of neuropathic pain
A neural circuit from thalamic paraventricular nucleus via zona incerta to periaqueductal gray for the facilitation of neuropathic pain Open
Top-down projections transmit a series of signals encoding pain sensation to the ventrolateral periaqueductal gray (vlPAG), where they converge with various incoming projections to regulate pain. Clarifying the upstream regulatory hierarch…
View article: Sex differences in functional and structural alterations of hippocampus region in chronic pain: a DTI and resting-state fMRI study
Sex differences in functional and structural alterations of hippocampus region in chronic pain: a DTI and resting-state fMRI study Open
Introduction It is well known that there are significant differences in the prevalence of chronic pain between males and females. Human and animal imaging studies have shown that chronic pain profoundly alters the structure and function of…
View article: Distinct Thalamo‐Subcortical Circuits Underlie Painful Behavior and Depression‐Like Behavior Following Nerve Injury
Distinct Thalamo‐Subcortical Circuits Underlie Painful Behavior and Depression‐Like Behavior Following Nerve Injury Open
Clinically, chronic pain and depression often coexist in multiple diseases and reciprocally reinforce each other, which greatly escalates the difficulty of treatment. The neural circuit mechanism underlying the chronic pain/depression como…
View article: Physiology education in China: the current situation and changes over the past 3 decades
Physiology education in China: the current situation and changes over the past 3 decades Open
View article: A Cross-Sectional and Longitudinal Integrated Study on Brain Functional Changes in a Neuropathic Pain Rat Model
A Cross-Sectional and Longitudinal Integrated Study on Brain Functional Changes in a Neuropathic Pain Rat Model Open
Human and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions and even causes mental dysfunctions such as depression and anxiety disorders. In this article, w…
View article: Ac4C Enhances the Translation Efficiency of Vegfa mRNA and Mediates Central Sensitization in Spinal Dorsal Horn in Neuropathic Pain
Ac4C Enhances the Translation Efficiency of Vegfa mRNA and Mediates Central Sensitization in Spinal Dorsal Horn in Neuropathic Pain Open
N4‐Acetylcytidine (ac4C), a highly conserved post‐transcriptional machinery with extensive existence for RNA modification, plays versatile roles in various cellular processes and functions. However, the molecular mechanism by which ac4C mo…
View article: MicroRNA-Based Discovery of Biomarkers, Therapeutic Targets, and Repositioning Drugs for Breast Cancer
MicroRNA-Based Discovery of Biomarkers, Therapeutic Targets, and Repositioning Drugs for Breast Cancer Open
Breast cancer treatment can be improved with biomarkers for early detection and individualized therapy. A set of 86 microRNAs (miRNAs) were identified to separate breast cancer tumors from normal breast tissues (n = 52) with an overall acc…
View article: IPAC integrates rewarding and environmental memory during the acquisition of morphine CPP
IPAC integrates rewarding and environmental memory during the acquisition of morphine CPP Open
The association between rewarding and drug-related memory is a leading factor for the formation of addiction, yet the neural circuits underlying the association remain unclear. Here, we showed that the interstitial nucleus of the posterior…
View article: Supplementary Table 1 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Supplementary Table 1 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition Open
PDF file - 54K, Regression and Spearman (rank-based) correlation analyses between the molecular parameters and cell responsiveness to METi
View article: Supplementary Table 1 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Supplementary Table 1 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition Open
PDF file - 54K, Regression and Spearman (rank-based) correlation analyses between the molecular parameters and cell responsiveness to METi
View article: Supplementary Methods from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Supplementary Methods from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition Open
PDF file - 60K, Methods for cell and tissue culture and Reverse Phase Protein Microarray Construction and Analysis
View article: Supplementary Methods from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Supplementary Methods from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition Open
PDF file - 60K, Methods for cell and tissue culture and Reverse Phase Protein Microarray Construction and Analysis
View article: Supplementary Figure 1 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Supplementary Figure 1 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition Open
PDF file - 296K, Short-time exogenous HGF treatment enhances the in vivo anti-tumor effects of METi
View article: Supplementary Table 2 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Supplementary Table 2 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition Open
XLSX file - 128K, Reverse Phase Protein Microarray data for the cell lines with high HGF vs. cell lines with low HGF
View article: Supplementary Table 2 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Supplementary Table 2 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition Open
XLSX file - 128K, Reverse Phase Protein Microarray data for the cell lines with high HGF vs. cell lines with low HGF
View article: Data from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Data from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition Open
Purpose: The receptor tyrosine kinase (RTK) c-MET and its ligand hepatocyte growth factor (HGF) are deregulated and promote malignancy in cancer and brain tumors. Consequently, clinically applicable c-MET inhibitors have been develo…
View article: Supplementary Figure 1 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Supplementary Figure 1 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition Open
PDF file - 296K, Short-time exogenous HGF treatment enhances the in vivo anti-tumor effects of METi
View article: NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin
NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin Open
Neuropathic pain is a common dose-limiting side effect of oxaliplatin, which hampers the effective treatment of tumors. Here, we found that upregulation of transcription factor NFATc2 decreased the expression of Beclin-1, a critical molecu…
View article: CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain
CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain Open
View article: Somatostatin Neurons from Periaqueductal Gray to Medulla Facilitate Neuropathic Pain in Male Mice
Somatostatin Neurons from Periaqueductal Gray to Medulla Facilitate Neuropathic Pain in Male Mice Open
Projections from the periaqueductal gray (PAG) to the rostral ventromedial medulla (RVM) are known to engage in descending pain modulation, but how the neural substrates of the PAG-RVM projections contribute to neuropathic pain remains lar…
View article: Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats
Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats Open
View article: <scp>SUMOylation</scp> of Kir7.1 participates in neuropathic pain through regulating its membrane expression in spinal cord neurons
<span>SUMOylation</span> of Kir7.1 participates in neuropathic pain through regulating its membrane expression in spinal cord neurons Open
Aims Potassium (K + ) channels have been demonstrated to play a prominent involvement in nociceptive processing. Kir7.1, the newest members of the Kir channel family, has not been extensively studied in the CNS, and its function remains la…
View article: Acrolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: Involvement of RhoA/ROCK2 pathway
Acrolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: Involvement of RhoA/ROCK2 pathway Open
Acrolein, an unsaturated aldehyde, is increased in the brain of Alzheimer's disease (AD) patients and identified as a potential inducer of sporadic AD. Synaptic dysfunction, as a typical pathological change occurring in the early stage of …
View article: The Epigenetic Mechanisms Involved in Chronic Pain in Rodents: A Mini-Review
The Epigenetic Mechanisms Involved in Chronic Pain in Rodents: A Mini-Review Open
: Chronic pain is a common distressing neurological disorder and about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes a heavy economic and social burden. Although substantial progre…
View article: Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain
Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain Open