Wenjun Xiong
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View article: Energy status orchestrates YTHDF1 phase separation and tumorigenesis
Energy status orchestrates YTHDF1 phase separation and tumorigenesis Open
Aberrant energy status impacts the initiation and progression of tumorigenesis, although the underlying mechanisms remain poorly understood. Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a key sensor of cellular energy str…
View article: Knowledge domain and emerging trends on the SGLT2 inhibitor dapagliflozin for heart failure: a bibliometric analysis from 2012 to 2024
Knowledge domain and emerging trends on the SGLT2 inhibitor dapagliflozin for heart failure: a bibliometric analysis from 2012 to 2024 Open
Purpose Dapagliflozin has been formally used to treat heart failure on the basis of extensive data from the DAPA-HF trial, and it now serves as a new quadruple cornerstone drug for heart failure. This study aimed to understand the global r…
View article: Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity Open
Cancer immunotherapies are widely used to treat various cancers but are largely ineffective against pancreatic ductal adenocarcinoma (PDAC), with the underlying mechanisms poorly understood. UFMylation, a ubiquitin-like modification, regul…
View article: ALYREF inhibits ferroptosis in vascular endothelial cells and improves atherosclerosis by epigenetic modification of CISD1
ALYREF inhibits ferroptosis in vascular endothelial cells and improves atherosclerosis by epigenetic modification of CISD1 Open
View article: Correction: Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206)
Correction: Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206) Open
[This corrects the article DOI: 10.3389/fphar.2025.1606857.].
View article: TCM splints versus internal fixation for distal radius fractures: A systematic review and meta-analysis of randomized controlled trials
TCM splints versus internal fixation for distal radius fractures: A systematic review and meta-analysis of randomized controlled trials Open
Background: The optimal treatment of distal radius fractures (DRFs) remains unclear. This study aimed to compare the clinical outcomes of traditional Chinese medicine (TCM) splints and internal fixation in the treatment of DRFs. Methods: A…
View article: Author Correction: ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
Author Correction: ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy Open
View article: Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206)
Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206) Open
Introduction Multidrug resistance (MDR) in cancer therapy, frequently driven by overexpression of ATP-binding cassette (ABC) transporters—particularly ABCG2—continues to undermine the efficacy of chemotherapeutic regimens. Tinodasertib (ET…
View article: Wuda Granule Alleviates DSS-Induced Colitis in Mice by Inhibiting Inflammation, Protecting Intestinal Barrier and Reducing Oxidative Stress Through Nrf2/Keap1/HO-1 Pathway
Wuda Granule Alleviates DSS-Induced Colitis in Mice by Inhibiting Inflammation, Protecting Intestinal Barrier and Reducing Oxidative Stress Through Nrf2/Keap1/HO-1 Pathway Open
WDG alleviates DSS-induced colitis by inhibiting inflammation, enhancing intestinal barrier integrity, and reducing oxidative stress through activation of the Nrf2/Keap1/HO-1 pathway.
View article: USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity
USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity Open
The CD47/SIRPα axis conveys a 'don't eat me' signal, thereby thwarting the phagocytic clearance of tumor cells. Although blocking antibodies targeting CD47 have demonstrated promising anti-tumor effects in preclinical models, clinical tria…
View article: Single-index logistic model for high-dimensional group testing data
Single-index logistic model for high-dimensional group testing data Open
Group testing is an efficient screening method that reduces the number of tests by pooling multiple samples, making it especially effective in low-prevalence settings. This strategy gained significant attention during the COVID-19 pandemic…
View article: Development and interpretation of a pathomics-driven ensemble model for predicting the response to immunotherapy in gastric cancer
Development and interpretation of a pathomics-driven ensemble model for predicting the response to immunotherapy in gastric cancer Open
Background Only a subset of patients with gastric cancer experience long-term benefits from immune checkpoint inhibitors (ICIs). Currently, there is a deficiency in precise predictive biomarkers for ICI efficacy. The aim of this study was …
View article: USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy
USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy Open
Ferroptosis is an iron-dependent type of regulated cell death resulting from extensive lipid peroxidation and plays a critical role in various physiological and pathological processes. However, the regulatory mechanisms for ferroptosis sen…
View article: Construction of Tetrahymena strains with highly active arsenic methyltransferase genes for arsenic detoxification in aquatic environments
Construction of Tetrahymena strains with highly active arsenic methyltransferase genes for arsenic detoxification in aquatic environments Open
Biomethylation is an effective means of arsenic detoxification by organisms living in aquatic environments. Ciliated protozoa (including Tetrahymena species) play an important role in the biochemical cycles of aquatic ecosystems and have a…
View article: Nonparametric Additive Regression for High-Dimensional Group Testing Data
Nonparametric Additive Regression for High-Dimensional Group Testing Data Open
Group testing has been verified as a cost-effective and time-efficient approach, where the individual samples are pooled with a predefined group size for subsequent testing. Recent research has explored the integration of covariate informa…
View article: Comprehensive assessment of immune context and immunotherapy response via noninvasive imaging in gastric cancer
Comprehensive assessment of immune context and immunotherapy response via noninvasive imaging in gastric cancer Open
BACKGROUNDThe tumor immune microenvironment can provide prognostic and therapeutic information. We aimed to develop noninvasive imaging biomarkers from computed tomography (CT) for comprehensive evaluation of immune context and investigate…
View article: Non-invasive CT imaging biomarker to predict immunotherapy response in gastric cancer: a multicenter study
Non-invasive CT imaging biomarker to predict immunotherapy response in gastric cancer: a multicenter study Open
Background Despite remarkable benefits have been provided by immune checkpoint inhibitors in gastric cancer (GC), predictions of treatment response and prognosis remain unsatisfactory, making identifying biomarkers desirable. The aim of th…
View article: Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy
Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy Open
View article: CRISPR/Cas-Based Techniques for Live-Cell Imaging and Bioanalysis
CRISPR/Cas-Based Techniques for Live-Cell Imaging and Bioanalysis Open
CRISPR/Cas systems have found widespread applications in gene editing due to their high accuracy, high programmability, ease of use, and affordability. Benefiting from the cleavage properties (trans- or cis-) of Cas enzymes, the scope of C…
View article: Biology-guided deep learning predicts prognosis and cancer immunotherapy response
Biology-guided deep learning predicts prognosis and cancer immunotherapy response Open
Substantial progress has been made in using deep learning for cancer detection and diagnosis in medical images. Yet, there is limited success on prediction of treatment response and outcomes, which has important implications for personaliz…
View article: Non-invasive tumor microenvironment evaluation and treatment response prediction in gastric cancer using deep learning radiomics
Non-invasive tumor microenvironment evaluation and treatment response prediction in gastric cancer using deep learning radiomics Open
View article: Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration
Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration Open
View article: ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy Open
View article: Moisturizing and aroma enhancing effects of polysaccharides during pyrolysis
Moisturizing and aroma enhancing effects of polysaccharides during pyrolysis Open
The objective of this research was to investigate the moisturizing and aroma enhancing effects of polysaccharides (methylcellulose (MC), locust bean gum (LBG), ganoderma lucidum polysaccharides (GLP), lotus seed polysaccharides (LSP), tea …
View article: Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function Open
Both mitochondrial quality control and energy metabolism are critical in maintaining the physiological function of cardiomyocytes. When damaged mitochondria fail to be repaired, cardiomyocytes initiate a process referred to as mitophagy to…
View article: Data from E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the <i>EGFR</i> and <i>c-MET</i> Oncogenes by Destabilizing the Histone Demethylase KDM5C
Data from E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the <i>EGFR</i> and <i>c-MET</i> Oncogenes by Destabilizing the Histone Demethylase KDM5C Open
The high-risk (HR) human papillomaviruses (HPV) are causative agents of anogenital tract dysplasia and cancers and a fraction of head and neck cancers. The HR HPV E6 oncoprotein possesses canonical oncogenic functions, such as p53 degradat…
View article: Data from E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the <i>EGFR</i> and <i>c-MET</i> Oncogenes by Destabilizing the Histone Demethylase KDM5C
Data from E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the <i>EGFR</i> and <i>c-MET</i> Oncogenes by Destabilizing the Histone Demethylase KDM5C Open
The high-risk (HR) human papillomaviruses (HPV) are causative agents of anogenital tract dysplasia and cancers and a fraction of head and neck cancers. The HR HPV E6 oncoprotein possesses canonical oncogenic functions, such as p53 degradat…
View article: Construction of Tetrahymena Strains with Highly Active Arsenic Methyltransferase Genes for Arsenic Detoxification in Aquatic Environments
Construction of Tetrahymena Strains with Highly Active Arsenic Methyltransferase Genes for Arsenic Detoxification in Aquatic Environments Open
View article: Additional file 3 of Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration
Additional file 3 of Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration Open
Additional file 3: Table S1. Clinicopathologic characteristics of CRC patients.
View article: Additional file 4 of Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration
Additional file 4 of Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration Open
Additional file 4: Table S2. Primer sequence used for mRNA detection in human sample and cell line.