Explanipedia

Retraction Note: Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway Open

Weilong Zhong, Baoxin Qian, Shuang Chen, Kailiang Qiao, Yue-Yang Lei , et al. · 2025

Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma Open

Xiaonan Xi, Xiaojing Ding, Qianqian Wang, Ning Liu, Bangmao Wang , et al. · 2025

Background Temozolomide (TMZ), which is an alkylating agent, is the standard chemotherapeutic drug used for glioma treatment. However, the development of resistance to TMZ limits its efficacy. Thus, identifying novel therapeutic targets is…

Thymic stromal lymphopoietin-activated basophil promotes lung inflammation in mouse atopic march model Open

Xu Li, Zizhuo Li, Mindan Tang, Kaoyuan Zhang, Ting Yang , et al. · 2025

Background Atopic dermatitis (AD), a prevalent inflammatory skin disease affecting 10%-20% of the population, is linked to the development of asthma through atopic march (AM). This study aims to explore the role of basophils in OVA-induced…

Clostridium butyricum ameliorates indomethacin-induced enteropathy by promoting MUC2 secretion via suppressing the Notch pathway Open

Lanping Zhu, Yang Luo, Yaxin Liu, Siyuan Sun, Junjie Yuan , et al. · 2025

Nonsteroidal anti-inflammatory drug (NSAID) enteropathy is a serious clinical complication with no effective treatments available. Modulating the intestinal microbiota through dietary and nutritional targets is a promising strategy for pre…

Biosynthesis of Potential Inhibitors Against Tobacco Mosaic Virus by Bacillus Licheniformis T6: L-Cysteine-Functionalized Selenium Nanoparticles Open

Zhangqian Wang, Siyang Zhao, Jieya Deng, Ying Zhu, Weilong Zhong , et al. · 2025

Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway Open

Yue Dong, Fanyi Meng, Jingyi Wang, Jingge Wei, Kexin Zhang , et al. · 2024

The initiation and progression of colorectal cancer (CRC) are intimately associated with genetic, environmental and biological factors. Desulfovibrio vulgaris (DSV), a sulfate-reducing bacterium, has been found excessive growth in C…

Luteolin exerts anti‐tumour immunity in hepatocellular carcinoma by accelerating CD8+ T lymphocyte infiltration Open

Shijiao Cai, Yidan Gou, Yanyan Chen, Xiaoran Hou, Jing Zhang , et al. · 2024

Luteolin, a commonly used traditional Chinese medicine, has been utilized for several decades in the treatment of hepatocellular carcinoma (HCC). Previous research has demonstrated its anti‐tumour efficacy, but its underlying mechanism rem…

WRN Nuclease‐Mediated EcDNA Clearance Enhances Antitumor Therapy in Conjunction with Trehalose Dimycolate/Mesoporous Silica Nanoparticles Open

Yinan Li, Xiu Huang, Yingying Li, Q. Q. Qiao, Caihong Chen , et al. · 2024

Current research on tumor fibrosis has focused on cancer‐associated fibroblasts, which may exert dual functions of tumor promotion and inhibition. Little attention has been paid to whether tumor cells themselves can undergo fibrotic transf…

A Saccharomyces boulardii-derived antioxidant protein, thioredoxin, ameliorates intestinal inflammation through transactivating epidermal growth factor receptor Open

Xiali Qin, Qing Zhao, Qianjing Zhao, Lijiao Yang, Wanyu Li , et al. · 2024

Saccharomyces boulardii (Sb) is a probiotic yeast for the treatment of gastrointestinal disorders, including inflammatory bowel disease (IBD). Little is known about the modulatory capacity of the Sb in IBD. Here, we found that oral gavage …

Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation Open

Mengfan Li, Yiyun Ding, Jingge Wei, Yue Dong, Jingyi Wang , et al. · 2024

The global incidence and prevalence of inflammatory bowel disease (IBD) are gradually increasing. A high-fat diet (HFD) is known to disrupt intestinal homeostasis and aggravate IBD, yet the underlying mechanisms remain largely undefined. H…

Corrigendum to “Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1α signaling pathway” [EBioMedicine 38 (2018) 25–36] Open

Yuan Qin, Huijuan Liu, Meng Li, Denghui Zhai, Yuanhao Tang , et al. · 2024

Atorvastatin improved ulcerative colitis in association with gut microbiota-derived tryptophan metabolism Open

Yidan Gou, Shijiao Cai, Yanyan Chen, Xiaoran Hou, Jing Zhang , et al. · 2024

These findings indicated that atorvastatin could alleviate UC by regulating intestinal flora disorders, promoting microbial tryptophan metabolism, and repairing the intestinal barrier.

Microbial metabolite deoxycholic acid-mediated ferroptosis exacerbates high-fat diet-induced colonic inflammation Open

Chen Wang, Qiao Chu, Wenxiao Dong, Xin Wang, Wenjing Zhao , et al. · 2024

High-fat diet (HFD) has long been recognized as risk factors for the development and progression of ulcerative colitis (UC), but the exact mechanism remained elusive. Here, HFD increased intestinal deoxycholic acid (DCA) levels, and DCA fu…

Correction to: Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling Open

Wanru Zhang, Xiali Qin, Kexin Zhang, Jiahui Ma, Mengfan Li , et al. · 2024

Editorial: Key proteins of tumor angiogenesis: potential therapeutic targets for gastrointestinal tumors Open

Weilong Zhong · 2024

EDITORIAL article Front. Med., 12 March 2024Sec. Gastroenterology Volume 11 - 2024 | https://doi.org/10.3389/fmed.2024.1387567

XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis Open

Renjie Hong, Yanjie Tan, Xiaoyu Tian, Zhenzhou Huang, Jiaying Wang , et al. · 2024

Activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. However, the molecular basis for HSC activation remains poorly understood. Herein, we demonstrate that primary cilia are present on quiescent HSCs but exh…

Anti‐angiogenesis in colorectal cancer therapy Open

Zhenni Yang, Xuqian Zhang, Xiaozhe Bai, Xiaonan Xi, Wentian Liu , et al. · 2024

The morbidity of colorectal cancer (CRC) has risen to third place among malignant tumors worldwide. In addition, CRC is a common cancer in China whose incidence increases annually. Angiogenesis plays an important role in the development of…

Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis Open

Runxiang Xie, Yu Gu, Mengfan Li, Lingfeng Li, Yunwei Yang , et al. · 2024

Background The overgrowth of Desulfovibrio , an inflammation promoting flagellated bacteria, has been found in ulcerative colitis (UC) patients. However, the molecular mechanism in promoting colitis remains unestablished. Methods The relat…

A Saccharomyces Boulardii-Derived Antioxidant Protein, Thioredoxin, Ameliorates Intestinal Inflammation Through Transactivating Epidermal Growth Factor Receptor Open

Xiali Qin, Lijiao Yang, Qing Zhao, Qianjing Zhao, Wanyu Li , et al. · 2024

The mechanisms of nerve injury caused by viral infection in the occurrence of gastrointestinal motility disorder-related diseases Open

Yaqian Li, Qiuyu Chen, Liwei Wang, Xin Chen, Bangmao Wang , et al. · 2023

Gastrointestinal motility refers to the peristalsis and contractility of gastrointestinal muscles, including the force and frequency of gastrointestinal muscle contraction. Gastrointestinal motility maintains the normal digestive function …

Construction and Validation of a Reliable Disulfidptosis-Related LncRNAs Signature of the Subtype, Prognostic, and Immune Landscape in Colon Cancer Open

Xiaoqian Dong, Pan Liao, Xiaotong Liu, Zhenni Yang, Yali Wang , et al. · 2023

Disulfidptosis, a novel form of regulated cell death (RCD) associated with metabolism, represents a promising intervention target in cancer therapy. While abnormal lncRNA expression is associated with colon cancer development, the prognost…

Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis Open

Yaping An, Zihan Zhai, Xin Wang, Yiyun Ding, Linlin He , et al. · 2023

Editorial: Epithelial-mesenchymal transition (EMT) as a therapeutic target in cancer, Volume II Open

Weilong Zhong, Tao Sun · 2023

EDITORIAL article Front. Oncol., 20 June 2023Sec. Pharmacology of Anti-Cancer Drugs Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1218855

Clostridium butyricum inhibits epithelial–mesenchymal transition of intestinal carcinogenesis through downregulating METTL3 Open

Kexin Zhang, Yue Dong, Mengfan Li, Wanru Zhang, Yiyun Ding , et al. · 2023

Colorectal cancer (CRC) is related to gut microbiota dysbiosis, especially butyrate‐producing bacteria reduction. Our previous study suggested that administration of Clostridium butyricum , a butyrate‐producing bacterium, exerts a crucial …

Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau Open

Xingguang Zhang, Wei Xu, Weilong Zhong, Wencheng Zhang, Cheng Yang , et al. · 2023

The gut microbiome shows changes under a plateau environment, while the disbalance of intestinal microbiota plays an important role in the pathogenesis of irritable bowel syndrome (IBS); however, the relationship between the two remains un…

Transgelin promotes ferroptosis to inhibit the malignant progression of esophageal squamous cell carcinoma Open

Qiuyu Chen, Lingyun Zhang, Changshan Wan, Boli Yang, Xiangxu Kong , et al. · 2023

The aim of the present study was to examine the function of transgelin (TAGLN) and its underlying mechanism in the ferroptosis of esophageal squamous cell carcinoma (ESCC) cells. To meet this aim, the association between TAGLN expression a…

Microbiota regulation in constipation and colorectal cancer Open

Liwei Wang, Hao Ruan, Bangmao Wang, Yuan Qin, Weilong Zhong · 2023

The relevance of constipation to the development and progression of colorectal cancer (CRC) is currently a controversial issue. Studies have shown that changes in the composition of the gut microbiota, a condition known as ecological imbal…

Discovery of microsized RNA-derived RNAs and polypeptides in human cells Open

Xiaoqiang Huang, Haidong Wu, Weilong Zhong, Wenbo Li, Zhiyong Liu , et al. · 2023

MicroRNAs (miRNAs) are short noncoding RNAs that can regulate gene expression through the binding of their 5’-ends to mRNAs. However, the biological effects of miRNA binding via their 3’-ends remain unclear. Here, we discover that the exac…

Supplementary Data from Antimalarial Drug Pyrimethamine Plays a Dual Role in Antitumor Proliferation and Metastasis through Targeting DHFR and TP Open

Huijuan Liu, Qin Yuan, Denghui Zhai, Qiang Zhang, Ju Gu , et al. · 2023

Figure S1 Chemical structure of Pyrimethamine and Methotrexate; Figure S2 Changes of E-cadherin and vimentin expression in A549 cells treated with Pyr or MTX (immunofluorescence assay); Figure S3 Changes in E-cadherin and vimentin expressi…

Data from Antimalarial Drug Pyrimethamine Plays a Dual Role in Antitumor Proliferation and Metastasis through Targeting DHFR and TP Open

Huijuan Liu, Qin Yuan, Denghui Zhai, Qiang Zhang, Ju Gu , et al. · 2023

Pyrimethamine (Pyr), an antimalarial drug that targeting plasmodium dihydrofolate reductase (pDHFR), has been proved to have antitumor activity. However, its direct target on cancer cells remains unclear. Methotrexate (MTX) is a widely use…

Weilong Zhong YOU? Author Swipe