Wenkuan Chen
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View article: MicroRNA-mediated autophagy regulation in thyroid cancer drug resistance
MicroRNA-mediated autophagy regulation in thyroid cancer drug resistance Open
Thyroid cancer, particularly papillary thyroid cancer (PTC), represents the most prevalent endocrine malignancy. Despite advancements in therapeutic strategies, drug resistance significantly hampers clinical outcomes. Autophagy, an evoluti…
View article: Response to “A commentary on ‘Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery’”
Response to “A commentary on ‘Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery’” Open
View article: Cancer-associated fibroblast-derived extracellular vesicles: regulators and therapeutic targets in the tumor microenvironment
Cancer-associated fibroblast-derived extracellular vesicles: regulators and therapeutic targets in the tumor microenvironment Open
Cancer-associated fibroblasts (CAFs) constitute a critical component of the tumor microenvironment (TME). CAFs can be reprogrammed by cancer cells, leading to the production of extracellular vesicles (EVs). These EVs serve as carriers for …
View article: Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective
Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective Open
Gut microbiota is crucial for protecting the homeostasis of immune locally and systemically, and its dysbiosis is essentially correlated to tumorigenesis, cancer progression, and refractoriness to cancer treatments, including the novel imm…
View article: Enhancing Community E-Commerce Repurchase Prediction Through Information Entropy Analysis
Enhancing Community E-Commerce Repurchase Prediction Through Information Entropy Analysis Open
In this study, we delve into the prediction and recommendation algorithm for user repurchase behavior within the community e-commerce landscape, leveraging the framework of information entropy. By analyzing consumer behavior data from a pr…
View article: Multidrug resistance transporters P-gp and BCRP limit the efficacy of ATR inhibitor ceralasertib in cancer cells
Multidrug resistance transporters P-gp and BCRP limit the efficacy of ATR inhibitor ceralasertib in cancer cells Open
The therapeutic effect of chemotherapy and targeted therapy are known to be limited by drug resistance. Substantial evidence has shown that ATP-binding cassette (ABC) transporters P-gp and BCRP are significant contributors to multidrug res…
View article: FSCN1 promotes proliferation, invasion and glycolysis via the IRF4/AKT signaling pathway in oral squamous cell carcinoma
FSCN1 promotes proliferation, invasion and glycolysis via the IRF4/AKT signaling pathway in oral squamous cell carcinoma Open
Background Oral squamous cell carcinoma (OSCC) is a disease with increasing incidence worldwide that leads to deformity and death. In OSCC, fascin actin-bundling protein 1 (FSCN1) is an oncogene involved in the tumorigenesis process. Howev…
View article: Treatment outcomes of mucosal melanoma of the head and neck: Analysis of 190 cases from a single institution
Treatment outcomes of mucosal melanoma of the head and neck: Analysis of 190 cases from a single institution Open
Objectives To analyze the treatment outcomes and prognostic factors of mucosal melanoma of the head and neck (MMHN) from a single institution. Methods From December 1989 to November 2018, 190 patients diagnosed with MMHN were included. Sur…
View article: The Prognostic Significance of FOXD1 Expression in Head and Neck Squamous Cell Carcinoma
The Prognostic Significance of FOXD1 Expression in Head and Neck Squamous Cell Carcinoma Open
It has been reported that forkhead box D1 (FOXD1) plays an established role in human early embryonic development and is broadly involved in various malignancies. However, there is limited information regarding FOXD1 expression in head and …
View article: Evaluation of Sustainable Development Policy of Sichuan Citrus Industry in China Based on DEA–Malmquist Index and DID Model
Evaluation of Sustainable Development Policy of Sichuan Citrus Industry in China Based on DEA–Malmquist Index and DID Model Open
The citrus industry is an important fruit industry, with the widest cultivation area and the most crucial economic status in southern China. Evaluating the sustainable development of citrus industry is the basis for accurately grasping the…
View article: Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery
Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery Open
Objective Transoral robotic surgery (TORS) has become an effective treatment for early‐stage oropharyngeal squamous cell carcinomas (OPSCCs). We aimed to analyze the clinical safety and efficacy of TORS for human papilloma virus (HPV)‐posi…
View article: FSCN1 promotes proliferation, migration and glycolysis via the IRF4/AKT signalling pathway in oral squamous cell carcinoma
FSCN1 promotes proliferation, migration and glycolysis via the IRF4/AKT signalling pathway in oral squamous cell carcinoma Open
Background: Oral squamous cell carcinoma (OSCC) is an increasing disease worldwide that leads to lethal and deforming consequences. In OSCC, Fascin actin-bundling protein 1 (FSCN1) is identified as an oncogene involved in the tumorigenesis…
View article: Postoperative radiotherapy to the neck for pN1 status HNSCC patients after neck dissection
Postoperative radiotherapy to the neck for pN1 status HNSCC patients after neck dissection Open
The significance of postoperative radiotherapy (PORT) to the neck for pN1 status head and neck squamous cell carcinomas (HNSCC) after neck dissection is unclear. A total of 208 patients with pN1 status HNSCC treated from January 1, 2001, t…
View article: Research on the Effect of Authenticity on Revisit Intention in Heritage Tourism
Research on the Effect of Authenticity on Revisit Intention in Heritage Tourism Open
The authenticity of heritage tourism is an important factor for attracting tourists. Research has shown that authenticity is related to revisit intention. However, little attention has been paid to the impact of heritage tourism authentici…
View article: Retraction Notice to: Upregulation of OIP5-AS1 Predicts Poor Prognosis and Contributes to Thyroid Cancer Cell Proliferation and Migration
Retraction Notice to: Upregulation of OIP5-AS1 Predicts Poor Prognosis and Contributes to Thyroid Cancer Cell Proliferation and Migration Open
[This retracts the article DOI: 10.1016/j.omtn.2019.11.036.].
View article: Corrigendum: Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size
Corrigendum: Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size Open
[This corrects the article DOI: 10.3389/fendo.2021.716082.].
View article: Upregulated circRAD18 promotes tumor progression by reprogramming glucose metabolism in papillary thyroid cancer
Upregulated circRAD18 promotes tumor progression by reprogramming glucose metabolism in papillary thyroid cancer Open
This study verified the novel function of the circRAD18-miR-516b-PDK1 axis in papillary thyroid cancer metabolic reprogramming progression, which has potential to be a novel therapeutic target.
View article: The Effects of COVID-19 Risk Perception on Travel Intention: Evidence From Chinese Travelers
The Effects of COVID-19 Risk Perception on Travel Intention: Evidence From Chinese Travelers Open
This study attempts to assess the relationship between risk perception, risk knowledge, and travel intentions of Chinese leisure travelers during the COVID-19 pandemic in the framework of social contagion and risk communication theories by…
View article: Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size
Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size Open
Objective To analyze the incidence and risk factors for lateral lymph node metastases (LNMs) in T1a papillary thyroid carcinoma (PTC) with a focus on tumor location and size. Materials and Methods The incidence of lateral LNM in 345 cases …
View article: Net Carbon Sequestration Performance of Cropland Use in China’s Principal Grain-Producing Area: An Evaluation and Spatiotemporal Divergence
Net Carbon Sequestration Performance of Cropland Use in China’s Principal Grain-Producing Area: An Evaluation and Spatiotemporal Divergence Open
As cropland possess dual carbon effects of emitting and sequestering, giving full attention to its net carbon sequestration is an effective option for mitigating global warming. By analyzing the carbon cycle of a cropland use system, we de…
View article: Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer
Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer Open
Circular RNAs (circRNAs) are one type of non-coding RNA. They act as important role in regulating various biological processes in the malignant progression. But we don't clearly know the specific mechanism of the majority circRNAs in papil…
View article: A hybrid heterogeneous Pythagorean fuzzy group decision modelling for crowdfunding development process pathways of fintech-based clean energy investment projects
A hybrid heterogeneous Pythagorean fuzzy group decision modelling for crowdfunding development process pathways of fintech-based clean energy investment projects Open
This study aims to evaluate the crowdfunding alternatives regarding new service development process pathways of clean energy investment projects. In this framework, a new model has been generated by considering the consensus-based group de…
View article: Older age is a risk factor associated with poor prognosis of patients with squamous cell carcinoma of the oral cavity
Older age is a risk factor associated with poor prognosis of patients with squamous cell carcinoma of the oral cavity Open
View article: High SOX8 expression promotes tumor growth and predicts poor prognosis through GOLPH3 signaling in tongue squamous cell carcinoma
High SOX8 expression promotes tumor growth and predicts poor prognosis through GOLPH3 signaling in tongue squamous cell carcinoma Open
According to our previous study, GOLPH3 is markedly up‐expressed in tongue squamous cell carcinoma (TSCC), which is also associated with poor survival. However, it remains unclear about key upstream and downstream mechanisms of GOLPH3. Thi…
View article: Study on Estimation and Improvement of Agricultural Carbon Emission Efficiency in China
Study on Estimation and Improvement of Agricultural Carbon Emission Efficiency in China Open
In order to have a better understanding of agricultural carbon emission efficiency in China and in east, west and central regions, slack based measure (SBM) under the undesirable outputs is used for measuring the agricultural carbon emissi…
View article: RETRACTED: Upregulation of OIP5-AS1 Predicts Poor Prognosis and Contributes to Thyroid Cancer Cell Proliferation and Migration
RETRACTED: Upregulation of OIP5-AS1 Predicts Poor Prognosis and Contributes to Thyroid Cancer Cell Proliferation and Migration Open
View article: Clinical Analysis of 208 Cases of pN1 Staged Head and Neck Squamous Cell Carcinoma with or Without Neck Post-Operation Radiotherapy after High-Quality Neck Dissection: A Retrospective Cohort Study
Clinical Analysis of 208 Cases of pN1 Staged Head and Neck Squamous Cell Carcinoma with or Without Neck Post-Operation Radiotherapy after High-Quality Neck Dissection: A Retrospective Cohort Study Open
View article: Net Greenhouse Gas Emissions from Agriculture in China: Estimation, Spatial Correlation and Convergence
Net Greenhouse Gas Emissions from Agriculture in China: Estimation, Spatial Correlation and Convergence Open
The agricultural ecosystem has dual attributes of greenhouse gas (GHG) emission and absorption, which both influence the net amount of GHG. To have a clearer understanding of the net GHG effect, we linked up the emission and absorption of …
View article: Supply forecast of animal product in Sichuan Province based on GM Model
Supply forecast of animal product in Sichuan Province based on GM Model Open
The research on the present situation and forecast of the supply of animal products in Sichuan Province is conducive to accelerating the agricultural supply-side structural reform and guaranteeing the effective supply of agricultural produ…
View article: Weighted gene co-expression network analysis and prognostic analysis identifies hub genes and the molecular mechanism related to head and neck squamous cell carcinoma
Weighted gene co-expression network analysis and prognostic analysis identifies hub genes and the molecular mechanism related to head and neck squamous cell carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) is a lethal disease with suboptimal survival outcomes. In this study, we aimed to find an independent prognostic factor of head and neck squamous cell carcinoma and investigate its effect on tu…