Wenkui Dai
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View article: One-year restoration of vaginal health: synergistic dynamics of microbiome and metabolome following the elimination of high-grade cervical intraepithelial neoplasia
One-year restoration of vaginal health: synergistic dynamics of microbiome and metabolome following the elimination of high-grade cervical intraepithelial neoplasia Open
Therapeutic elimination of high-grade cervical intraepithelial neoplasia (CIN) is widely implemented for cervical cancer prevention. Despite the demonstrated dysbiosis of vaginal microenvironment in high-grade CIN, its post-therapy restora…
View article: Expanding access to cervical cancer screening: The performance of self-sampled urine HPV testing
Expanding access to cervical cancer screening: The performance of self-sampled urine HPV testing Open
Urine-based HPV testing using a DNA purification and concentration process is noninferior to the gold standard Cobas4800 test on provider-collected samples for the detection of high-risk HPV types and the high grades of cervical precancero…
View article: Shared and distinct molecular pathways in eutopic endometrium of endometriosis and adenomyosis patients: a transcriptomic study in Chinese women
Shared and distinct molecular pathways in eutopic endometrium of endometriosis and adenomyosis patients: a transcriptomic study in Chinese women Open
View article: Immunological dynamics in orthotopic compared with subcutaneous murine models of HPV-positive oropharyngeal cancer
Immunological dynamics in orthotopic compared with subcutaneous murine models of HPV-positive oropharyngeal cancer Open
The necessity of reliable preclinical models for evaluating the efficacy of novel therapeutic strategies is imperative. Nevertheless, the degree to which tumor-bearing murine models represent the immunological characteristics of human papi…
View article: Jian-Pi-Yi-Shen formula improves kidney function by regulating gut microbiome in rats with chronic kidney disease
Jian-Pi-Yi-Shen formula improves kidney function by regulating gut microbiome in rats with chronic kidney disease Open
Introduction Recent studies have underscored the role of interactions between Traditional Chinese Medicine (TCM) and the gut microbiome (GM) in mediating therapeutic effects. Jian-Pi-Yi-Shen Formula (JPYSF) has shown efficacy in ameliorati…
View article: Inferred bi-directional interactions between vaginal microbiota, metabolome and persistent HPV infection accompanied by high-grade cervical intraepithelial neoplasia
Inferred bi-directional interactions between vaginal microbiota, metabolome and persistent HPV infection accompanied by high-grade cervical intraepithelial neoplasia Open
View article: The inferred modulation of correlated vaginal microbiota and metabolome by cervical differentially expressed genes across distinct CIN grades
The inferred modulation of correlated vaginal microbiota and metabolome by cervical differentially expressed genes across distinct CIN grades Open
Our findings provide valuable population-based evidence for the inferred modulation of correlated VM and metabolome by cervical DEGs across different CIN stages.
View article: Skin microbiota: pathogenic roles and implications in atopic dermatitis
Skin microbiota: pathogenic roles and implications in atopic dermatitis Open
Atopic dermatitis (AD) is a chronic and inflammatory skin disorder characterized by impaired barrier function and imbalanced immunity. Recent advances have revealed that dysbiosis of skin microbiota plays important roles in the pathogenesi…
View article: A biparatopic HER2-targeting ADC constructed <i>via</i> site-specific glycan conjugation exhibits superior stability, safety, and efficacy
A biparatopic HER2-targeting ADC constructed <i>via</i> site-specific glycan conjugation exhibits superior stability, safety, and efficacy Open
Site-specific glycan conjugation enables a stable and efficacious biparatopic HER2-targeting ADC.
View article: Comparative effectiveness of vitrification and slow freezing after heterotopic transplantation of human ovarian tissues
Comparative effectiveness of vitrification and slow freezing after heterotopic transplantation of human ovarian tissues Open
View article: Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study in China
Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study in China Open
Introduction Gut microbiota (GM) has been implicated in gestational diabetes mellitus (GDM), yet longitudinal changes across trimesters remain insufficiently explored. Methods This nested cohort study aimed to investigate GM alterations be…
View article: The depletion of gut microbiome impairs the beneficial effect of Gui-Shen-Wan in restoring mice ovarian function and associated protein expression of ovarian tissues
The depletion of gut microbiome impairs the beneficial effect of Gui-Shen-Wan in restoring mice ovarian function and associated protein expression of ovarian tissues Open
Introduction Traditional Chinese Medicine (TCM), specifically Gui-Shen-Wan, has shown promise in restoring ovarian function among reproductive-age women who had impaired ovarian functions, yet the underlying mechanisms remain elusive. Rece…
View article: Co-altered vaginal Lactobacillus, metabolome and host gene expression associate with the grade of cervical intraepithelial neoplasia in Chinese women
Co-altered vaginal Lactobacillus, metabolome and host gene expression associate with the grade of cervical intraepithelial neoplasia in Chinese women Open
Background Vaginal Lactobacillus has been implicated in modulating the risk of cervical intraepithelial neoplasia (CIN) progression. However, there remains a gap in population-based studies elucidating the underlying mechanisms that link L…
View article: Comparative Effectiveness of Vitrification and Slow Freezing after Heterotopic Transplantation of Human Ovarian Tissues
Comparative Effectiveness of Vitrification and Slow Freezing after Heterotopic Transplantation of Human Ovarian Tissues Open
Background The aim of this study was to compare the effectiveness of two different vitrification methods and slow freezing in terms of the recovery of endocrine function, follicular morphology and proliferation, apoptosis of stromal cells,…
View article: Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection
Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection Open
View article: AI-assisted system improves the work efficiency of cytologists via excluding cytology-negative slides and accelerating the slide interpretation
AI-assisted system improves the work efficiency of cytologists via excluding cytology-negative slides and accelerating the slide interpretation Open
Given the shortage of cytologists, women in low-resource regions had inequitable access to cervical cytology which plays an pivotal role in cervical cancer screening. Emerging studies indicated the potential of AI-assisted system in promot…
View article: Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection
Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection Open
There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study investigated the dynamics of vaginal mic…
View article: Outcome of uterine functional structures protection by fertility preservative PUSH surgery in diffuse adenomyosis
Outcome of uterine functional structures protection by fertility preservative PUSH surgery in diffuse adenomyosis Open
This study reports the outcomes of an innovative fertility-preserving surgery for the treatment of diffuse adenomyosis that is known as a surgery for protection of uterine structure for healing (PUSH Surgery). Developed at Peking Universit…
View article: Diagnostic Potential of Endometrial Cancer DNA from Pipelle, Pap-Brush, and Swab Sampling
Diagnostic Potential of Endometrial Cancer DNA from Pipelle, Pap-Brush, and Swab Sampling Open
Endometrial cancer (EC) is a major gynecological malignancy with rising morbidity and mortality worldwide. The aim of this study was to explore a safe and readily available sample and a sensitive and effective detection method and its biom…
View article: Baseline gut microbiome impacts probiotics <i>Bacillus licheniformis</i> CMCC63516 in modulating the gut microbiome and preventing antibiotic‐associated diarrhea: A double‐blind, randomized controlled trial
Baseline gut microbiome impacts probiotics <i>Bacillus licheniformis</i> CMCC63516 in modulating the gut microbiome and preventing antibiotic‐associated diarrhea: A double‐blind, randomized controlled trial Open
Dear Editor, Here, we report that baseline gut microbiome (GM) associate with the protection of probiotics against pediatric antibiotic-associated diarrhea (AAD) via the double-blind randomized control trial (RCT). Antibiotics are widely p…
View article: Comparison of cycle threshold values of the Cobas HPV test and viral loads of the BMRT HPV test in cervical cancer screening
Comparison of cycle threshold values of the Cobas HPV test and viral loads of the BMRT HPV test in cervical cancer screening Open
Objective To validate the HPV viral loads that are reflected by the cycle threshold values of Cobas4800 as the viral load indicators by verifying the consistency of the viral loads per unit (10,000 cells) from the BMRT assay. Methods The a…
View article: The association of cervicovaginal Langerhans cells with clearance of human papillomavirus
The association of cervicovaginal Langerhans cells with clearance of human papillomavirus Open
Human papillomavirus (HPV) clearance is important in eliminating cervical cancer which contributes to high morbidity and mortality in women. Nevertheless, it remains largely unknown about key players in clearing pre-existing HPV infections…
View article: Cervicovaginal microbiota significantly changed for HPV-positive women with high-grade squamous intraepithelial lesion
Cervicovaginal microbiota significantly changed for HPV-positive women with high-grade squamous intraepithelial lesion Open
Lower female genital tract is colonized by a variety of microbes (cervicovaginal microbiota, CVM) which associate with the risk of genital infection. This study characterized CVM for 149 Chinese women with different status of human papillo…
View article: The Tibetan-Yi region is both a corridor and a barrier for human gene flow
The Tibetan-Yi region is both a corridor and a barrier for human gene flow Open
The Tibetan-Yi Corridor (TYC) region between Tibet and the rest of east Asia has served as a crossroads for human migrations for thousands of years. The lack of whole-genome sequencing data specific to the TYC populations has hindered the …
View article: Dynamic changes of gut microbiota and hepatic functions are different among biliary atresia patients after Kasai portoenterostomy
Dynamic changes of gut microbiota and hepatic functions are different among biliary atresia patients after Kasai portoenterostomy Open
Biliary atresia (BA) is a fatal neonatal disease resulting in cholestasis and progressive hepatic failure.1 Despite the fact that Kasai portoenterostomy (KP) can restore bile drainage, impaired hepatic functions and even advanced cirrhosis…
View article: Bacterial Signatures of Paediatric Respiratory Disease: An Individual Participant Data Meta-Analysis
Bacterial Signatures of Paediatric Respiratory Disease: An Individual Participant Data Meta-Analysis Open
Introduction: The airway microbiota has been linked to specific paediatric respiratory diseases, but studies are often small. It remains unclear whether particular bacteria are associated with a given disease, or if a more general, non-spe…
View article: The Effects of Chinese Medicine QRD, Antibiotics, and Probiotics on Therapy and Gut Microbiota in Septic Rats
The Effects of Chinese Medicine QRD, Antibiotics, and Probiotics on Therapy and Gut Microbiota in Septic Rats Open
Sepsis is a common and often treacherous medical emergency with a high mortality and long-term complications in survivors. Though antibiotic therapy can reduce death rate of sepsis significantly, it impairs gut microbiota (GM), which play …
View article: Association between metabolic status and gut microbiome in obese populations
Association between metabolic status and gut microbiome in obese populations Open
Despite that obesity is associated with many metabolic diseases, a significant proportion (10–30 %) of obese individuals is recognized as ‘metabolically healthy obeses’ (MHOs). The aim of the current study is to characterize the gut microb…
View article: Cervicovaginal Microbiome Factors in Clearance of Human Papillomavirus Infection
Cervicovaginal Microbiome Factors in Clearance of Human Papillomavirus Infection Open
Persistent high-risk human papillomavirus (hrHPV) infection is the highest risk to cervical cancer which is the fourth most common cancer in women worldwide. A growing body of literatures demonstrate the role of cervicovaginal microbiome (…
View article: Clinical Efficacy and Safety of Fertility-Preservative PUSH Surgery for Diffuse Adenomyosis: Evidence from a 11-Year Prospective Investigation
Clinical Efficacy and Safety of Fertility-Preservative PUSH Surgery for Diffuse Adenomyosis: Evidence from a 11-Year Prospective Investigation Open