Wenli Li
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View article: Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities
Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities Open
Vascular aging accelerates the gradual deterioration of systemic organ function, yet its key driving factors are still largely unexplored. Here, it is demonstrated that lysine‐specific demethylase 5A (KDM5A) decreases and histone H3 lysine…
View article: Efficacy of fumigation with traditional Chinese medicine combined with Acanthopanax Senticosus injection in patients with sleep disorders
Efficacy of fumigation with traditional Chinese medicine combined with Acanthopanax Senticosus injection in patients with sleep disorders Open
Objective: To evaluate the efficacy of traditional Chinese medicine (TCM) fumigation and washing combined with Acanthopanax senticosus injection in patients with sleep disorders. Methodology: The clinical data total of 106 patients with sl…
View article: Lysosome dysfunction alters intestinal morphology and lipid metabolism in early neonatal piglets
Lysosome dysfunction alters intestinal morphology and lipid metabolism in early neonatal piglets Open
View article: Predictive Modeling for Colorectal Polyps in Average-Risk Asymptomatic Adults: Optimizing Screening Colonoscopy Decisions
Predictive Modeling for Colorectal Polyps in Average-Risk Asymptomatic Adults: Optimizing Screening Colonoscopy Decisions Open
Objective: To develop a risk prediction model for colorectal polyps in asymptomatic individuals and provide evidence-based guidance for colonoscopy screening prioritization within health examination cohorts. Methods: We retrospectively ana…
View article: Effects of chitosan oligosaccharide on the growth performance, antioxidant capacity, immune function, intestinal digestive capacity and morphological structure in growing female minks
Effects of chitosan oligosaccharide on the growth performance, antioxidant capacity, immune function, intestinal digestive capacity and morphological structure in growing female minks Open
This study aimed to investigate the effects of dietary chitosan oligosaccharide (COS) supplementation on growth performance, antioxidant capacity, immune function, duodenal digestive enzyme activity, and jejunal morphology in growing femal…
View article: Midkine promotes <scp>PDGF</scp>‐<scp>BB</scp>‐induced proliferation, migration, and glycolysis of airway smooth muscle cells via the <scp>PI3K</scp> Akt pathway
Midkine promotes <span>PDGF</span>‐<span>BB</span>‐induced proliferation, migration, and glycolysis of airway smooth muscle cells via the <span>PI3K</span> Akt pathway Open
Airway smooth muscle cell (ASMC) dysfunction drives airway remodeling in asthma, yet the molecular mediators remain incompletely defined. Midkine, a pleiotropic growth factor, has emerged as a potential regulator of inflammatory and prolif…
View article: The impact of different types of brain injuries on cerebral perfusion in preterm infants: an arterial spin labeling
The impact of different types of brain injuries on cerebral perfusion in preterm infants: an arterial spin labeling Open
View article: DHA and EPA exacerbate hypoxia-induced ferroptosis in gastric and small intestinal mucosa by disrupting the balance between SLC7A11 upregulation and PUFA-PL accumulation
DHA and EPA exacerbate hypoxia-induced ferroptosis in gastric and small intestinal mucosa by disrupting the balance between SLC7A11 upregulation and PUFA-PL accumulation Open
Hypoxia, resulting from environmental factors or diseases, can disrupt the gastrointestinal mucosal barrier. Our previous study demonstrated that hypoxia induced ferroptosis in the gastric and small intestinal mucosa by upregulating ALOX5,…
View article: ROS-activated CD147-type I interferon signaling axis drives vascular smooth muscle cell fate transition and abdominal aortic aneurysm progression
ROS-activated CD147-type I interferon signaling axis drives vascular smooth muscle cell fate transition and abdominal aortic aneurysm progression Open
View article: DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions
DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions Open
O-linked β-N-acetylglucosamine (O-GlcNAc), a critical post-translational modification predominantly found in the nucleus, plays a substantial role in regulating gene expression by modulating transcription factors (TFs) activity. However, q…
View article: Comparison of the efficacy and safety of TACE-HAIC-MTTs-ICIs and TACE-MTTs-ICIs in the hepatocellular carcinoma: a prognostic analysis based on the dynamic changes of serum AFP
Comparison of the efficacy and safety of TACE-HAIC-MTTs-ICIs and TACE-MTTs-ICIs in the hepatocellular carcinoma: a prognostic analysis based on the dynamic changes of serum AFP Open
Background: To evaluate the efficacy and safety of two combination treatments for hepatocellular carcinoma (HCC): 1) transarterial chemoembolization (TACE) with hepatic arterial infusion chemotherapy (HAIC) combined with molecular targeted…
View article: Camrelizumab combined with Lenvatinib and RALOX-HAIC for unresectable hepatocellular carcinoma (Cal Era): a prospective, single-arm, phase II trial
Camrelizumab combined with Lenvatinib and RALOX-HAIC for unresectable hepatocellular carcinoma (Cal Era): a prospective, single-arm, phase II trial Open
Introduction: Combining systemic agents with hepatic arterial infusion chemotherapy (HAIC) has produced promising outcomes in advanced hepatocellular carcinoma (HCC). Raltitrexed, an antimetabolite recognized for its extended plasma half-l…
View article: Laparoscopic associating liver partition and portal vein ligation for staged hepatectomy for colorectal liver metastases: A single-center experience
Laparoscopic associating liver partition and portal vein ligation for staged hepatectomy for colorectal liver metastases: A single-center experience Open
BACKGROUND Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a procedure used for patients with initially unresectable colorectal liver metastases (CRLM). However, the procedure has been reported to be …
View article: Effects of dietary ε-polylysine supplementation on growth performance, antioxidant capacity, immune function, and intestinal microbiota in growing male minks
Effects of dietary ε-polylysine supplementation on growth performance, antioxidant capacity, immune function, and intestinal microbiota in growing male minks Open
Introduction This study investigated the effects of dietary ε -polylysine (ε-PL) supplementation on the growth performance, antioxidant capacity, immune function and intestinal microbiota in growing male minks. Methods Ninety-six 12-week-o…
View article: DNA Probe Pulldown Screening Uncovers O-GlcNAcylation Modulation of Transcription Factor DNA Interactions
DNA Probe Pulldown Screening Uncovers O-GlcNAcylation Modulation of Transcription Factor DNA Interactions Open
O-linked β-N-acetylglucosamine (O-GlcNAc), a critical post-translational modification (PTM) predominantly found in the nucleus, plays a substantial role in regulating gene expression by modulating transcription factors (TFs) activity. Howe…
View article: Low‐Level Viremia Impairs Efficacy of Immune Checkpoint Inhibitors in Unresectable Hepatocellular Carcinoma
Low‐Level Viremia Impairs Efficacy of Immune Checkpoint Inhibitors in Unresectable Hepatocellular Carcinoma Open
Background and Aims The impact of low‐level viremia(LLV) on the efficacy of immune checkpoint inhibitors (ICIs) in unresectable hepatocellular carcinoma(uHCC) patients remains unclear. This study aims to investigate the effect of LLV on th…
View article: Nutritional targeting circulating eNAMPT attenuates NLRP3 inflammasome activation in alcoholic liver injury: therapeutic potential of nicotinamide riboside
Nutritional targeting circulating eNAMPT attenuates NLRP3 inflammasome activation in alcoholic liver injury: therapeutic potential of nicotinamide riboside Open
Brown adipose tissue-derived eNAMPT is a key upstream driver of NLRP3 inflammasome activation in alcoholic liver injury. Dietary nicotinamide riboside is a promising nutritional intervention for alcoholic liver disease by targeting eNAMPT.
View article: Investigating immune dysregulation and hub genes in septic cardiomyopathy development
Investigating immune dysregulation and hub genes in septic cardiomyopathy development Open
Septic cardiomyopathy is a life-threatening heart dysfunction caused by severe infection. Considering the complexity of pathogenesis and high mortality, the identification of efficient biomarkers are needed to guide clinical practice. Base…
View article: Cadonilimab (PD-1/CTLA-4) in combination with lenvatinib in unresectable hepatocellular carcinoma (uHCC): A retrospective real-world study
Cadonilimab (PD-1/CTLA-4) in combination with lenvatinib in unresectable hepatocellular carcinoma (uHCC): A retrospective real-world study Open
View article: A study on the mediating-moderate effect of the types of illicit drugs on mental health in China
A study on the mediating-moderate effect of the types of illicit drugs on mental health in China Open
Background In China, over 5 million people have been identified and registered by the public security institutions for using illicit drugs. The aim of this study is to compare the influence of different types of illicit drugs on the self-r…
View article: Inhibition of ethanol-induced eNAMPT secretion attenuates liver ferroptosis through BAT-Liver communication
Inhibition of ethanol-induced eNAMPT secretion attenuates liver ferroptosis through BAT-Liver communication Open
Inhibition of ethanol-induced eNAMPT secretion from BAT attenuates liver injury and ferroptosis. Our study reveals a previously uncharacterized critical role of eNAMPT-mediated BAT-Liver communication in ALD and highlights its potential as…
View article: Transarterial chemoembolization with/without immune checkpoint inhibitors plus tyrosine kinase inhibitors for unresectable hepatocellular carcinoma: a single center, propensity score matching real-world study
Transarterial chemoembolization with/without immune checkpoint inhibitors plus tyrosine kinase inhibitors for unresectable hepatocellular carcinoma: a single center, propensity score matching real-world study Open
View article: Clostridium perfringens α toxin damages the immune function, antioxidant capacity and intestinal health and induces PLCγ1/AMPK/mTOR pathway-mediated autophagy in broiler chickens
Clostridium perfringens α toxin damages the immune function, antioxidant capacity and intestinal health and induces PLCγ1/AMPK/mTOR pathway-mediated autophagy in broiler chickens Open
View article: Prognostic characteristics of a six-gene signature based on ssGSEA in sarcoma
Prognostic characteristics of a six-gene signature based on ssGSEA in sarcoma Open
This six-gene signature is an independent prognostic factor in patients with sarcoma and is expected to be a potential therapeutic target for sarcoma.
View article: Structure-Activity Relationships of Coarse Organic Flocculant for Organic Carbon Capture in Municipal Wastewater
Structure-Activity Relationships of Coarse Organic Flocculant for Organic Carbon Capture in Municipal Wastewater Open
View article: Cadonilimab (Pd-1/Ctla-4) in Combination with Lenvatinib in Unresectable Hepatocellular Carcinoma (Uhcc): A Retrospective Real-World Study
Cadonilimab (Pd-1/Ctla-4) in Combination with Lenvatinib in Unresectable Hepatocellular Carcinoma (Uhcc): A Retrospective Real-World Study Open
View article: A Novel Flocculant Based on "Happy Molecules" for the Efficient Removal of Nsaids and Nom Complexes: Role of Parallel Π-Π Stacking Force
A Novel Flocculant Based on "Happy Molecules" for the Efficient Removal of Nsaids and Nom Complexes: Role of Parallel Π-Π Stacking Force Open
View article: Association between bronchopulmonary dysplasia and death or neurodevelopmental impairment at 3 years in preterm infants without severe brain injury
Association between bronchopulmonary dysplasia and death or neurodevelopmental impairment at 3 years in preterm infants without severe brain injury Open
Objective We investigated the association between bronchopulmonary dysplasia (BPD) and 3 years death or neurodevelopmental impairment (NDI) in very preterm infants without severe brain injury. Method Our prospective cohort study recruited …
View article: Tyrosine kinase inhibitors, immune checkpoint inhibitors combined with hepatic arterial infusion of oxaliplatin and raltitrexed versus oxaliplatin, 5-fluorouracil and leucovorin for intermediate and advanced hepatocellular carcinoma: A retrospective study
Tyrosine kinase inhibitors, immune checkpoint inhibitors combined with hepatic arterial infusion of oxaliplatin and raltitrexed versus oxaliplatin, 5-fluorouracil and leucovorin for intermediate and advanced hepatocellular carcinoma: A retrospective study Open
The effectiveness and safety of HAIC with RALOX were comparable to HAIC with FOLFOX in intermediate and advanced HCC patients.
View article: Ultrasound and clinicopathological characteristics of papillary thyroid carcinoma predict the coexistence of TERT promoter and BRAFV600E mutations
Ultrasound and clinicopathological characteristics of papillary thyroid carcinoma predict the coexistence of TERT promoter and BRAFV600E mutations Open
Purpose: The coexistence of TERT promoter and BRAFV600E mutations is strongly associated with high aggressiveness and poor prognosis in papillary thyroid carcinoma. The aim of this study was to construct a preoperative and posto…