Wenli Mao
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View article: Meta-Analysis of the Effect of Fitness Qigong on Depression in College Students
Meta-Analysis of the Effect of Fitness Qigong on Depression in College Students Open
Objective: To evaluate the therapeutic effects of Health Qigong on depression in college students. Methods: A comprehensive search was conducted across databases including CNKI, Wanfang, PubMed, Embase, Web of Science, and Cochrane Library…
View article: Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation
Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation Open
Non‑small cell lung cancer (NSCLC) exhibits a high incidence and mortality rate worldwide. Elevated cytokinesis cyclin 25 homologous protein C (CDC25C) expression is correlated with a poor prognosis in patients with NSCLC. Transcriptional …
View article: Microwave Chemical Looping Synergistic Gasification of Polypropylene Plastic and Water Hyacinth
Microwave Chemical Looping Synergistic Gasification of Polypropylene Plastic and Water Hyacinth Open
The microwave chemical looping synergistic gasification characteristics of municipal solid waste polypropylene plastic and the organic solid waste water hyacinth are experimentally investigated in this study. In addition, the characterizat…
View article: Discovery of a potent and selective PROTAC degrader for STAT3
Discovery of a potent and selective PROTAC degrader for STAT3 Open
A potent and selective STAT3 degrader S3D5 was developed, inducing potent STAT3 degradation in vitro .
View article: LOXL2 reduces 5-FU sensitivity through the Hedgehog/BCL2 signaling pathway in colorectal cancer
LOXL2 reduces 5-FU sensitivity through the Hedgehog/BCL2 signaling pathway in colorectal cancer Open
Elevated expression of lysyl oxidase-like 2 (LOXL2) contributes to the malignant tumor progression in multiple cancers. However, the role of LOXL2 in the 5-fluorouracil (5-FU) resistance of colorectal cancer (CRC) remains unclear. This stu…
View article: Corrigendum: Comprehensive analysis of the transcriptome-wide m6A methylome in lung adenocarcinoma by MeRIP sequencing
Corrigendum: Comprehensive analysis of the transcriptome-wide m6A methylome in lung adenocarcinoma by MeRIP sequencing Open
[This corrects the article DOI: 10.3389/fonc.2022.791332.].
View article: Copper-catalyzed radical trans-selective hydroboration of ynamides with N-heterocyclic carbene boranes
Copper-catalyzed radical trans-selective hydroboration of ynamides with N-heterocyclic carbene boranes Open
View article: Comprehensive Analysis of the Transcriptome-wide m6A Methylome in Lung Adenocarcinoma by MeRIP Sequencing
Comprehensive Analysis of the Transcriptome-wide m6A Methylome in Lung Adenocarcinoma by MeRIP Sequencing Open
N6-methyladenosine (m6A) is the most abundant internal modification on eukaryotic mRNAs. There is increasing evidence that m6A plays a key role in tumor progression, so it is important to analyze m6A modifications within the transcriptome-…
View article: Improvement of chronic non-bacterial prostatitis by Jiedu Huoxue decoction through inhibiting TGF-β/SMAD signaling pathway
Improvement of chronic non-bacterial prostatitis by Jiedu Huoxue decoction through inhibiting TGF-β/SMAD signaling pathway Open
JDHXD might improve CNBP injury through suppressing inflammation response, ROS, and apoptosis by targeting TGF-β/SMAD signaling pathway. This research might provide a new thought for the prevention and treatment of CNBP through inhibiting …
View article: Jiedu Huoxue decoction improves chronic abacterial prostatitis/chronic pelvic pain syndrome through activating Wnt/GSKβ/β-catenin signaling pathway and alleviating apoptosis
Jiedu Huoxue decoction improves chronic abacterial prostatitis/chronic pelvic pain syndrome through activating Wnt/GSKβ/β-catenin signaling pathway and alleviating apoptosis Open
Jiedu Huoxue decoction improved CP/CPPS through activating Wnt/GSKβ/β-catenin signaling pathway and inhibiting apoptosis. This study might provide a novel insight for the prevention and treatment of CP/CPPS through activating Wnt/GSK-3β/β-…
View article: miRNA-877-5p inhibits malignant progression of prostate cancer by directly targeting SSFA2
miRNA-877-5p inhibits malignant progression of prostate cancer by directly targeting SSFA2 Open
In this study, we aimed to investigate the role of miR-877-5p in the malignant phenotypes of prostate cancer (PCa) cells and its underlying mechanism. RT-qPCR analysis was performed to examine the expression of miR-877-5p and sperm-specifi…
View article: Usage history of scientific literature: Nature metrics and metrics of Nature publications
Usage history of scientific literature: Nature metrics and metrics of Nature publications Open
In this study, we analyze the dynamic usage history of Nature publications over time using Nature metrics data. We conduct analysis from two perspectives. On the one hand, we examine how long it takes before the articles' downloads reach 5…
View article: Efficacy of acupuncture combined with traditional Chinese medicine on chronic prostatitis: a Protocol for Systematic Review and Meta-analysis
Efficacy of acupuncture combined with traditional Chinese medicine on chronic prostatitis: a Protocol for Systematic Review and Meta-analysis Open
Review question / Objective: To evaluate the efficacy of chronic prostate with traditional Chinese medicine combined with acupuncture.Condition being studied: Chronic prostatitis is a common and frequently occurring disease in middle-aged …
View article: Oxidative stress and antioxidant defense in detoxification systems of snake venom-induced toxicity
Oxidative stress and antioxidant defense in detoxification systems of snake venom-induced toxicity Open
Background: Snakebites remain a major life-threatening event worldwide. It is still difficult to make a positive identification of snake species by clinicians in both Western medicine and Chinese medicine. The main reason for this is a sho…
View article: RBBP4 Enhances Platinum Chemo Resistance in Lung Adenocarcinoma
RBBP4 Enhances Platinum Chemo Resistance in Lung Adenocarcinoma Open
Background . The majority of lung cancers are adenocarcinomas, with the proportion being 40%. The patients are mostly diagnosed in the middle and late stages with metastasis and easy recurrence, which poses great challenge to the treatment…
View article: New Approved First-line Combining Therapy of NSCLC in 2020
New Approved First-line Combining Therapy of NSCLC in 2020 Open
In the past decades, lung cancer is considered one of the lethal cancers all across the world due to its evidenced greatest mortality and morbidity. Currently, the main clinical treatment methods for lung cancer involve surgery, chemothera…
View article: <p>Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma</p>
Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma Open
Dioscin suppressed proliferation, invasion and EMT of lung adenocarcinoma cells via the inactivation of AKT/mTOR/GSK3β signaling, probably by binding to AKT and mTOR, and inhibiting their phosphorylation.
View article: The effect of Jiedu Huoxue decoction on rat model of experimental nonbacterial prostatitis via regulation of miRNAs
The effect of Jiedu Huoxue decoction on rat model of experimental nonbacterial prostatitis via regulation of miRNAs Open
Future studies may explore the contributions of the active components in JDHXD. The study design is generalisable. The effect can be repeatedly verified in clinical trials.
View article: Oxidative stress and antioxidant defense in detoxification systems of snake venom-induced toxicity
Oxidative stress and antioxidant defense in detoxification systems of snake venom-induced toxicity Open
Our results show that the pathways of snake venom-induced toxicity may form a protein network of antioxidant defense by regulating oxidative stress through interaction with hydrogen peroxide.
View article: N-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells
N-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells Open
The main mechanistic function of most chemotherapeutic drugs is mediated by inducing mitochondria-dependent apoptosis. Tumor cells usually respond to upregulate autophagy to eliminate impaired mitochondria for survival. Hypothetically, inh…
View article: Myricetin Inhibits Breast Tumor Growth and Angiogenesis by Regulating VEGF/VEGFR2 and p38MAPK Signaling Pathways
Myricetin Inhibits Breast Tumor Growth and Angiogenesis by Regulating VEGF/VEGFR2 and p38MAPK Signaling Pathways Open
Tumor angiogenesis is an important cause of tumor growth and metastasis. Myricetin is a flavonoid component used in traditional Chinese medicine that has been demonstrated to have anticancer activity. However, to the best of our knowledge,…