Wenlin Bai
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View article: Transcriptome analysis reveals the key long non-coding RNAs and genes related to cashmere shedding in goats
Transcriptome analysis reveals the key long non-coding RNAs and genes related to cashmere shedding in goats Open
This study identified key lncRNAs and genes related to cashmere shedding in goats along with their regulatory relationships. The results provided a basis for revealing the potential molecular mechanisms of cashmere shedding in goats.
View article: Maternal benzo[a]pyrene exposure during critical gestational periods impairs offspring neurological development in rats: a mechanistic study of the Wnt/β-catenin signaling pathway
Maternal benzo[a]pyrene exposure during critical gestational periods impairs offspring neurological development in rats: a mechanistic study of the Wnt/β-catenin signaling pathway Open
Introduction Mid-gestation is a critical period for the development of the nervous system. Exposure to exogenous harmful chemicals during this period may lead to longterm neurological developmental abnormalities in offspring. Benzo[a]pyren…
View article: N6-Methyladenosine (m6A)-Circular RNA Pappalysin 1 (circPAPPA) from Cashmere Goats: Identification, Regulatory Network and Expression Potentially Regulated by Methylation in Secondary Hair Follicles Within the First Intron of Its Host Gene
N6-Methyladenosine (m6A)-Circular RNA Pappalysin 1 (circPAPPA) from Cashmere Goats: Identification, Regulatory Network and Expression Potentially Regulated by Methylation in Secondary Hair Follicles Within the First Intron of Its Host Gene Open
N6-methyladenosine (m6A) is one of the most abundant modifications in eukaryotic RNA molecules and mediates the functional exertion of RNA molecules. We characterized the circPAPPA and validated its potential m6A modification sites in seco…
View article: Scenario-Responsive Siting Framework of CO2 Capture and Electrochemical Conversion Systems Using Integrated Spatial and Multi-Criteria Decision Analysis
Scenario-Responsive Siting Framework of CO2 Capture and Electrochemical Conversion Systems Using Integrated Spatial and Multi-Criteria Decision Analysis Open
View article: N6-methyladenosine (m6A)-circHECA from secondary hair follicle of cashmere goats: identification, regulatory network and expression regulated potentially by methylation of its host gene promoter
N6-methyladenosine (m6A)-circHECA from secondary hair follicle of cashmere goats: identification, regulatory network and expression regulated potentially by methylation of its host gene promoter Open
Objective: The objective of this study was to identify the N6-methyladenosine (m6A)- circHECA molecule in secondary hair follicles (SHFs) of cashmere goats, and generate its potential regulatory network, as wel…
View article: Knockdown of miR-361-5p promotes the induced activation of SHF-stem cells through FOXM1 mediated Wnt/β-catenin pathway in cashmere goats
Knockdown of miR-361-5p promotes the induced activation of SHF-stem cells through FOXM1 mediated Wnt/β-catenin pathway in cashmere goats Open
The inducing activation event of secondary hair follicle (SHF)-stem cells is considered a key biological process in the SHF regeneration, and the morphogenesis of cashmere fiber in cashmere goats. The miR-361-5p was essentially implicated …
View article: Deciphering the impact of greenhouse pesticides on hepatic metabolism profile: Toxicity experiments on HepG2 cells using chlorpyrifos and emamectin benzoate
Deciphering the impact of greenhouse pesticides on hepatic metabolism profile: Toxicity experiments on HepG2 cells using chlorpyrifos and emamectin benzoate Open
Epidemiological evidence on the health effects of pesticide exposure among greenhouse workers is limited, and the mechanisms are lacking. Building upon our team's previous population study, we selected two pesticides, CPF and EB, with high…
View article: Multi‐Channel Wireless Communication Based on Amplitude‐Phase Reconfigurable Space‐Coding Beamforming Metasurface
Multi‐Channel Wireless Communication Based on Amplitude‐Phase Reconfigurable Space‐Coding Beamforming Metasurface Open
Reconfigurable metasurfaces have exhibited significant potential in wireless communication owing to their capacity to transmit information without relying on traditional complex radio frequency (RF) chain transmitters. Nonetheless, the maj…
View article: CircERCC6 Positively Regulates the Induced Activation of SHF Stem Cells in Cashmere Goats via the miR-412-3p/BNC2 Axis in an m6A-Dependent Manner
CircERCC6 Positively Regulates the Induced Activation of SHF Stem Cells in Cashmere Goats via the miR-412-3p/BNC2 Axis in an m6A-Dependent Manner Open
The cashmere, a kind of nature protein fiber, is one of the main use of cashmere goats. The induced activation of secondary hair follicle (SHF) stem cells by the dermal papilla cell-derived signals is a key biological process for the morph…
View article: XGBoost-SHAP-based interpretable diagnostic framework for alzheimer’s disease
XGBoost-SHAP-based interpretable diagnostic framework for alzheimer’s disease Open
View article: Evaluating the effect of gestational diabetes mellitus on macrosomia based on the characteristics of oral glucose tolerance test
Evaluating the effect of gestational diabetes mellitus on macrosomia based on the characteristics of oral glucose tolerance test Open
The effect of abnormal OGTT0h+1h+2h on macrosomia was significantly greater than other OGTT characteristics, especially for those with pre-pregnancy BMI ≥ 24 kg/m2. Individualized management of GDM based on OGTT chara…
View article: Discovery and Functional Analysis of Secondary Hair Follicle miRNAs during Annual Cashmere Growth
Discovery and Functional Analysis of Secondary Hair Follicle miRNAs during Annual Cashmere Growth Open
Secondary hair follicles (SHFs) produce the thermoregulatory cashmere of goats. MicroRNAs (miRNAs) play indispensable roles in hair follicle formation and growth. However, most studies examining miRNAs related to cashmere have been perform…
View article: The role of the gut microbiota in depressive-like behavior induced by chlorpyrifos in mice
The role of the gut microbiota in depressive-like behavior induced by chlorpyrifos in mice Open
Chlorpyrifos (CPF) is associated with depression, cognitive dysfunction, and other neurological disorders. Increasing evidence has suggested that the gut microbiota plays a vital role in regulating the development of depression. However, i…
View article: N6-Methyladenosine modification (m6A) of circRNA-ZNF638 contributes to the induced activation of SHF stem cells through miR-361-5p/Wnt5a axis in cashmere goats
N6-Methyladenosine modification (m6A) of circRNA-ZNF638 contributes to the induced activation of SHF stem cells through miR-361-5p/Wnt5a axis in cashmere goats Open
Objective: The objective of this study was to investigate the effects of N6-Methyladenosine modification-circRNA-zinc finger protein 638 (m6A-circRNA-ZNF638) on the induced activation of secondary hair follicle (SHF) stem cells …
View article: Millimeter-level Resolution Photonic Multiband Radar Using a Single MZM and Sub-GHz-Bandwidth Electronics
Millimeter-level Resolution Photonic Multiband Radar Using a Single MZM and Sub-GHz-Bandwidth Electronics Open
We here propose a novel cost-effective millimeter-level resolution photonic multiband radar system using a single MZM driven by a 1-GHz-bandwidth LFM signal. It experimentally shows an ~8.5-mm range resolution through coherence-processing-…
View article: Estimating Bidirectional Transitions and Identifying Predictors of Mild Cognitive Impairment
Estimating Bidirectional Transitions and Identifying Predictors of Mild Cognitive Impairment Open
The nature of bidirectional transitions cannot be ignored in multidimensional MCI research. We found that postreversion participants remained at an increased risk of progression to MCI or dementia over the longer term and experienced recur…
View article: Cost-effective photonic super-resolution millimeter-wave joint radar-communication system using self-coherent detection
Cost-effective photonic super-resolution millimeter-wave joint radar-communication system using self-coherent detection Open
A cost-effective millimeter-wave (MMW) joint radar-communication (JRC) system with super resolution is proposed and experimentally demonstrated, using optical heterodyne up-conversion and self-coherent detection down-conversion techniques.…
View article: Novel circRNAs from cashmere goats: Discovery, integrated regulatory network, and their putative roles in the regeneration and growth of secondary hair follicles
Novel circRNAs from cashmere goats: Discovery, integrated regulatory network, and their putative roles in the regeneration and growth of secondary hair follicles Open
Circular RNAs (circRNAs) were identified as noncoding RNAs with covalently closed structures differing from other types of RNA molecules. It was thought that circRNAs were implicated in the development of secondary hair follicles (SHFs) of…
View article: Identification and Molecular Analysis of m6A-circRNAs from Cashmere Goat Reveal Their Integrated Regulatory Network and Putative Functions in Secondary Hair Follicle during Anagen Stage
Identification and Molecular Analysis of m6A-circRNAs from Cashmere Goat Reveal Their Integrated Regulatory Network and Putative Functions in Secondary Hair Follicle during Anagen Stage Open
N6-methyladenosine (m6A) is the most abundant modification in linear RNA molecules. Over the last few years, interestingly, many circRNA molecules are also found to have extensive m6A modification sites with temporal and spatial specific e…
View article: CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten the KLF5 expression
CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten the KLF5 expression Open
Circular RNAs (circRNAs) have stable structures, being a covalently closed loop without 5′ and 3′ free ends. They can function as “miRNA sponges” in regulating the expression of their target genes. It was thought that circRNAs are involved…
View article: Effects of pre-pregnancy PM2.5 exposure on vascular remodeling in mother-fetal interface of mice via HIF-1α/VEGF axis
Effects of pre-pregnancy PM2.5 exposure on vascular remodeling in mother-fetal interface of mice via HIF-1α/VEGF axis Open
BackgroundAtmospheric fine particulate matter (PM2.5) can induce abnormal early embryo development, resulting in adverse pregnancy outcomes such as embryo damage and spontaneous abortion. The vascular remodeling of maternal-fetal interface…
View article: Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Related Potentially to the Fineness of Cashmere Fiber
Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Related Potentially to the Fineness of Cashmere Fiber Open
Cashmere fineness is one of the important factors determining cashmere quality; however, our understanding of the regulation of cashmere fineness at the cellular level is limited. Here, we used single-cell RNA sequencing and computational …
View article: Screening of cashmere fineness-related genes and their ceRNA network construction in cashmere goats
Screening of cashmere fineness-related genes and their ceRNA network construction in cashmere goats Open
View article: The path linking disease severity and cognitive function with quality of life in Parkinson’s disease: the mediating effect of activities of daily living and depression
The path linking disease severity and cognitive function with quality of life in Parkinson’s disease: the mediating effect of activities of daily living and depression Open
View article: The path linking disease severity and cognitive function with quality of life in Parkinson's disease:the mediating effect of activities of daily living and depression.
The path linking disease severity and cognitive function with quality of life in Parkinson's disease:the mediating effect of activities of daily living and depression. Open
Background: Research on quality of life (QOL) with Parkinson’s disease (PD) has examined direct influencing factors, not mediators. The study aim was to explore whether PD severity and poor cognitive function may decrease physical and ment…
View article: Investigation on Dietary Behavior Changes in 658 Pregnant Women Before and During Pregnancy in China
Investigation on Dietary Behavior Changes in 658 Pregnant Women Before and During Pregnancy in China Open
Background The extra dietary care women receive after pregnancy, coupled with the effect of their own physiological response during pregnancy, can cause some changes in their dietary habits compared with those before pregnancy. Current stu…
View article: Synergistic Effect of Biejia-Ruangan on Fibrosis Regression in Patients With Chronic Hepatitis B Treated With Entecavir: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
Synergistic Effect of Biejia-Ruangan on Fibrosis Regression in Patients With Chronic Hepatitis B Treated With Entecavir: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Open
Background Long-term nucleos(t)ide analogue (NA) treatment can reverse liver fibrosis in chronic hepatitis B (CHB), but its effect on fibrosis regression remains limited. Biejia-Ruangan (BR) has been approved in China as an antifibrotic tr…
View article: m6A Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats
m6A Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats Open
N6-methyladenosine (m6A) is the most common internal modification in mRNAs of all higher eukaryotes. Here we perform two high-throughput sequencing methods, m6A-modified RNA immunoprecipitation sequence (MeRIP-seq) and RNA sequence (RNA-se…
View article: Comprehensive analysis of circRNAs from cashmere goat skin by next generation RNA sequencing (RNA-seq)
Comprehensive analysis of circRNAs from cashmere goat skin by next generation RNA sequencing (RNA-seq) Open
Circular RNA (circRNA) is endogenous non-coding RNA (ncRNA) with a covalently closed circular structure. It is mainly generated through RNA alternative splicing or back-splicing. CircRNA is known in the majority of eukaryotes and very stab…
View article: On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B
On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B Open
HBcrAg level is associated with liver fibrosis progression. HBcrAg is an excellent monitor of hepatic histological changes, especially in CHB patients treated with nucleoside analogs.