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View article: Overcoming Limitations in Chan-Lam Amination with Alkylboronic Esters via Aminyl Radical Substitution
Overcoming Limitations in Chan-Lam Amination with Alkylboronic Esters via Aminyl Radical Substitution Open
Copper-catalyzed Chan-Lam coupling represents one of the most reliable methods for constructing C(sp2)−N bonds under mild conditions. However, application of this technology as a general platform for C(sp3)−N bond assembly remains a longst…
View article: A Study on the Formation Mechanism of Academic entrepreneurs' Dual-role Enrichment
A Study on the Formation Mechanism of Academic entrepreneurs' Dual-role Enrichment Open
Scientists engaging in academic entrepreneurship is an important way for enhancing the quality and efficiency of economic and social development. However, when scientists shift from academic research to commercial practice, they often face…
View article: Actuator fault detection method of quadrotor UAV based on dual channel inertial sensors
Actuator fault detection method of quadrotor UAV based on dual channel inertial sensors Open
Aiming at the problem of actuator failure of quadrotor unmanned aerial vehicle (UAV), a novel fault detection method based on dual channel inertial sensors is proposed. Firstly, the actuator partial failure fault model is introduced into t…
View article: Effect of scalp nerve block on postcraniotomy analgesia in children: a randomized, controlled trial
Effect of scalp nerve block on postcraniotomy analgesia in children: a randomized, controlled trial Open
The trial was registered at the Chinese Clinical Trial Registry (ChiCTR1800017386) on 27/07/2018, under the title "A study of scalp nerve block for neurosurgical analgesia in children with craniotomy."
View article: Effect of synbiotic supplementation on obesity and gut microbiota in obese adults: a double-blind randomized controlled trial
Effect of synbiotic supplementation on obesity and gut microbiota in obese adults: a double-blind randomized controlled trial Open
Background Synbiotics, combining specific probiotics and selected prebiotics, may benefit health issues like obesity, but evidence remains inconsistent. Objective This study aimed to verify the effect of a pre-screened synbiotics combinati…
View article: A CIA strategy with eminent drug-loading capacities for tumor ferroptosis-gas synergistic therapy
A CIA strategy with eminent drug-loading capacities for tumor ferroptosis-gas synergistic therapy Open
Rationale: A common challenge of drug loading and delivery using magnetic resonance imaging (MRI) contrast agents (CAs) is the tendency of aggregation and precipitation at high drug loading conditions. Herein, we propose a generic s…
View article: Development and validation of a prognostic score for TIPS placement in patients with viral hepatitis cirrhosis-related portal hypertension: a multi-center retrospective study
Development and validation of a prognostic score for TIPS placement in patients with viral hepatitis cirrhosis-related portal hypertension: a multi-center retrospective study Open
Introduction There is no established scoring model focused on viral hepatitis patients to predict the prognosis after transjugular intrahepatic portosystemic shunt (TIPS). We aimed to develop and validate a novel model based on the largest…
View article: Intraoperative application of low-dose dexmedetomidine or lidocaine for postoperative analgesia in pediatric patients following craniotomy: a randomized double-blind placebo-controlled trial
Intraoperative application of low-dose dexmedetomidine or lidocaine for postoperative analgesia in pediatric patients following craniotomy: a randomized double-blind placebo-controlled trial Open
Background Postoperative pain is a common occurrence in pediatric patients following craniotomy, often leading to negative outcomes. Intravenous dexmedetomidine and lidocaine are commonly used adjuvant medicines in general anesthesia to re…
View article: Development and validation a prognostic score for TIPS placement in patients with viral hepatitis cirrhosis-related portal hypertension: a multi-center retrospective study
Development and validation a prognostic score for TIPS placement in patients with viral hepatitis cirrhosis-related portal hypertension: a multi-center retrospective study Open
Objectives Noninvasive methods are effective and promising way to predict the prognosis after transjugular intrahepatic portosystemic shunt (TIPS). However, there is no established scoring model focus on viral hepatitis including hepatitis…
View article: Effects of carbamazepine on BDNF expression in trigeminal ganglia and serum in rats with trigeminal neuralgia.
Effects of carbamazepine on BDNF expression in trigeminal ganglia and serum in rats with trigeminal neuralgia. Open
CBZ treatment can inhibit the expression of BDNF and TrkB in the TGs of TN rats, reduce the level of BDNF in serum of TN rats and the phosphorylation of ERK signaling pathway, so as to inhibit TN. The serum level of BDNF can be considered …
View article: Effects of small-dose S-ketamine on anesthesia-induced atelectasis in patients undergoing general anesthesia accessed by lung ultrasound: study protocol for a randomized, double-blinded controlled trial
Effects of small-dose S-ketamine on anesthesia-induced atelectasis in patients undergoing general anesthesia accessed by lung ultrasound: study protocol for a randomized, double-blinded controlled trial Open
View article: Effect of Downregulation and Overexpression of the P2X4 Receptor in Satellite Glial Cells in the Trigeminal Ganglion on Allodynia in Trigeminal Neuralgia Rats
Effect of Downregulation and Overexpression of the P2X4 Receptor in Satellite Glial Cells in the Trigeminal Ganglion on Allodynia in Trigeminal Neuralgia Rats Open
View article: Safety and efficacy of carbamazepine in the treatment of trigeminal neuralgia: A metanalysis in biomedicine
Safety and efficacy of carbamazepine in the treatment of trigeminal neuralgia: A metanalysis in biomedicine Open
Trigeminal neuralgia is a debilitating condition characterized by severe facial pain. Carbamazepine has been widely used as a first-line treatment option for trigeminal neuralgia, but there is a need to evaluate its safety and efficacy ba…
View article: Perioperative active warming strategies in children: a protocol for a multicentre, prospective, randomized controlled trial
Perioperative active warming strategies in children: a protocol for a multicentre, prospective, randomized controlled trial Open
Introduction Inadvertent perioperative hypothermia (IPH) refers to a core body temperature lower than 36.0 °C, which can contribute to many adverse events. The special physiological characteristics in children further increase the incidenc…
View article: A novel Chongqing index of post-TIPS survival for predicting survival in Chinese cirrhotic patients after transjugular intrahepatic portosystemic shunt: A multicenter, retrospective study
A novel Chongqing index of post-TIPS survival for predicting survival in Chinese cirrhotic patients after transjugular intrahepatic portosystemic shunt: A multicenter, retrospective study Open
Background & Aims: Transjugular intrahepatic portosystemic shunt is an important method for the treatment of complications related to portal hypertension. However, a prediction model based on Chinese population has not been established. Th…
View article: The effects of laryngeal mask airway versus endotracheal tube on atelectasis in patients undergoing general anesthesia assessed by lung ultrasound: A protocol for a prospective, randomized controlled trial
The effects of laryngeal mask airway versus endotracheal tube on atelectasis in patients undergoing general anesthesia assessed by lung ultrasound: A protocol for a prospective, randomized controlled trial Open
Background The incidence of atelectasis is high in patients undergoing general anesthesia. This may cause oxygenation impairment and further contribute to postoperative pulmonary complications (PPCs). As important airway management devices…
View article: Comparison of survival prediction values of different scoring models for patients undergoing transjugular intrahepatic portal shunt: A multicenter retrospective study
Comparison of survival prediction values of different scoring models for patients undergoing transjugular intrahepatic portal shunt: A multicenter retrospective study Open
Aim The aim of this study is to compare the prognostic values of the Child–Pugh, integrated model for end‐stage liver disease (iMELD), albumin–bilirubin (ALBI), and Freiburg index of postsurvival (FIPS) scores in patients undergoing transj…
View article: Long non-coding RNA MSTRG.81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in type 2 diabetic rats
Long non-coding RNA MSTRG.81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in type 2 diabetic rats Open
View article: Omalizumab is effective in the preseasonal treatment of seasonal allergic rhinitis
Omalizumab is effective in the preseasonal treatment of seasonal allergic rhinitis Open
Background To date no study has evaluated the efficacy of preseasonal omalizumab therapy with cost effective dose and at appropriate time point compared with standard medication in seasonal allergic rhinitis (SAR) patients. Methods This wa…
View article: Inhibitory Effects of Palmatine on P2X7 Receptor Expression in Trigeminal Ganglion and Facial Pain in Trigeminal Neuralgia Rats
Inhibitory Effects of Palmatine on P2X7 Receptor Expression in Trigeminal Ganglion and Facial Pain in Trigeminal Neuralgia Rats Open
Trigeminal Neuralgia (TN) refers to recurrent severe paroxysmal pain in the distribution area of the trigeminal nerve, which seriously affects the quality of life of patients. This research applied the chronic constriction injury of the in…
View article: Effects of Small-Dose S-Ketamine On Anesthesia-Induced Atelectasis In Patients Undergoing General Anesthesia Accessed By Lung Ultrasound: Study Protocol For A Randomized, Double-Blinded Controlled Trial
Effects of Small-Dose S-Ketamine On Anesthesia-Induced Atelectasis In Patients Undergoing General Anesthesia Accessed By Lung Ultrasound: Study Protocol For A Randomized, Double-Blinded Controlled Trial Open
Background: Aelectasis after anesthesia induction in most patients undergoing general anesthesia may lead to postoperative pulmonary complications (PPCs) and affect postoperative outcomes. However, there is still no existing effective meth…
View article: Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy
Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy Open
The result showed that sugammadex provided transient efficacy in prolonging the coagulation parameters, while neostigmine did not change the coagulation profile.
View article: Postoperative analgesia of scalp nerve block with ropivacaine in pediatric craniotomy patients: a protocol for a prospective, randomized, placebo-controlled, double-blinded trial
Postoperative analgesia of scalp nerve block with ropivacaine in pediatric craniotomy patients: a protocol for a prospective, randomized, placebo-controlled, double-blinded trial Open
Background Moderate-to-severe postoperative pain following craniotomy has a high incidence in pediatric patients. Such pain may cause agitation, intracranial hypertension, epileptic seizures, and postoperative hematoma, which affect morbid…
View article: Effects of palmatine on BDNF/TrkB-mediated trigeminal neuralgia
Effects of palmatine on BDNF/TrkB-mediated trigeminal neuralgia Open
Trigeminal neuralgia (TN), a sudden, needle-like pain in the distribution area of the trigeminal nerve, can seriously affect the physical and mental health of patients. In chronic pain conditions including TN, increased levels of brain-der…
View article: Additional file 1 of Postoperative analgesia of scalp nerve block with ropivacaine in pediatric craniotomy patients: a protocol for a prospective, randomized, placebo-controlled, double-blinded trial
Additional file 1 of Postoperative analgesia of scalp nerve block with ropivacaine in pediatric craniotomy patients: a protocol for a prospective, randomized, placebo-controlled, double-blinded trial Open
Additional file 1.
View article: Dihydromyricetin Alleviates Diabetic Neuropathic Pain and Depression Comorbidity Symptoms by Inhibiting P2X7 Receptor
Dihydromyricetin Alleviates Diabetic Neuropathic Pain and Depression Comorbidity Symptoms by Inhibiting P2X7 Receptor Open
Diabetic neuropathic pain (DNP) and major depressive disorder (MDD) are common complications of diabetes mellitus and mutually affect each other. As a member of the ATP-gated ion channel family, P2X7 receptor is associated with …
View article: Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression
Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression Open
View article: The effect of an intraoperative, lung-protective ventilation strategy in neurosurgical patients undergoing craniotomy: study protocol for a randomized controlled trial
The effect of an intraoperative, lung-protective ventilation strategy in neurosurgical patients undergoing craniotomy: study protocol for a randomized controlled trial Open
ClinicalTrials.gov, ID: NCT02386683 . Registered on 18 October 2014.
View article: Protective Effects of Oxymatrine on Vascular Endothelial Cells from High-Glucose-Induced Cytotoxicity by Inhibiting the Expression of A2B Receptor
Protective Effects of Oxymatrine on Vascular Endothelial Cells from High-Glucose-Induced Cytotoxicity by Inhibiting the Expression of A2B Receptor Open
Background/Aims: Diabetes mellitus (DM) has become an increasingly epidemic metabolic disease. Vascular endothelial cells play a key role in developing the cardiovascular complications of DM. The A2B receptor is expressed in vascular endot…
View article: Emodin inhibits the expression of receptor and calcitonin-gene-related peptide release in trigeminal ganglia of trigeminal neuralgia rats.
Emodin inhibits the expression of receptor and calcitonin-gene-related peptide release in trigeminal ganglia of trigeminal neuralgia rats. Open
Trigeminal neuralgia (TN) is one of the most intense forms of facial pain. It has been reported that the P2X3 receptor plays a crucial role in facilitating pain transmission, and the calcitonin-gene-related peptide (CGRP) from t…