Wenping Huang
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View article: Personalized Cancer Immunotherapy Boosted by cGAS‐STING‐Targeted Nanovaccines in Combination With Nutrient Modulation
Personalized Cancer Immunotherapy Boosted by cGAS‐STING‐Targeted Nanovaccines in Combination With Nutrient Modulation Open
Cyclic dinucleotides, which act as agonists for the stimulator of interferon genes (STING), are pivotal in stimulating both adaptive and innate immune reactions for advancing cancer immunotherapy. However, their therapeutic potential is ha…
View article: Spatiotemporal expression of carnitine palmitoyltransferase I genes during zebrafish development and heart regeneration
Spatiotemporal expression of carnitine palmitoyltransferase I genes during zebrafish development and heart regeneration Open
Carnitine palmitoyltransferase 1 (CPT1) is a key regulatory enzyme in fatty acid metabolism, responsible for the translocation of long-chain fatty acids into the mitochondria for β-oxidation in diverse biological contexts. Recent studies i…
View article: cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish
cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish Open
Carnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation d…
View article: Novel multiple extraction thermal desorption approach prior to gas chromatography for the determination of residual solvents applied to modified cellulose
Novel multiple extraction thermal desorption approach prior to gas chromatography for the determination of residual solvents applied to modified cellulose Open
View article: Knockdown of circSOD2 ameliorates osteoarthritis progression via the miR-224-5p/PRDX3 axis
Knockdown of circSOD2 ameliorates osteoarthritis progression via the miR-224-5p/PRDX3 axis Open
Background Although the implications of circular RNAs (circRNAs) with the progression of diverse pathological conditions have been reported, the circRNA players in osteoarthritis (OA) are barely studied. Methods In this study, twenty-five …
View article: Targeting L‐Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment
Targeting L‐Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment Open
Inflammation induced by autoreactive CD4 + T lymphocytes is a major factor in the pathogenesis of multiple sclerosis (MS). Immunosuppressive drugs, such as FTY720, are subsequently developed to prevent the migration of CD4 + T lymphocytes …
View article: Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere
Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere Open
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high mortality, and the efficacy of monotherapy for TNBC is still disappointing. Here, we developed a novel combination therapy for TNBC based on a multifunctional nan…
View article: Verification of Fasting-Mimicking Diet to Assist Monotherapy of Human Cancer
Verification of Fasting-Mimicking Diet to Assist Monotherapy of Human Cancer Open
View article: Regulation of Nucleotide Metabolism with Nutrient‐Sensing Nanodrugs for Cancer Therapy
Regulation of Nucleotide Metabolism with Nutrient‐Sensing Nanodrugs for Cancer Therapy Open
The continual growth of tumor cells requires considerable nutrient consumption. Methotrexate (MTX) is used to treat certain types of cancer by blocking the DNA and RNA productions through interfering one‐carbon metabolism and de novo purin…
View article: Effects of Pueraria lobata leaf powder as a feed additive on the immune system and growth performance of broiler chickens
Effects of Pueraria lobata leaf powder as a feed additive on the immune system and growth performance of broiler chickens Open
The present research assessed the effect of different levels of Pueraria lobate leaf (PLL) on growth performance, immunity, antioxidant capacity, and blood index in broiler feed. A total of 384 at 21 days old chicks were assigned to 1 of 4…
View article: Targeted Degradation of STAT3 via Chaperone-Mediated Autophagy by nanoCMATAC Platform
Targeted Degradation of STAT3 via Chaperone-Mediated Autophagy by nanoCMATAC Platform Open
View article: Quality Assessment and Antioxidant Activities of the Blossoms of<i>Inula Nervosa</i>Wall
Quality Assessment and Antioxidant Activities of the Blossoms of<i>Inula Nervosa</i>Wall Open
Background Currently, although Inula nervosa Wall is substantially investigated, little is understood about blossoms of Inula nervosa Wall (BINW). Objective In this work, we systematically investigated the antioxidant activity of the extra…
View article: Eurycomanone regulates lipid metabolism by activating the cAMP/PKA pathway
Eurycomanone regulates lipid metabolism by activating the cAMP/PKA pathway Open
Eurycoma longifolia Jack (ELJ) contains mainly alkaloids, and quassinoids, which are the main active ingredients. Eurycomanone (EN), one of the most common quassinoids, is said to have beneficial effects on lipid and glucose metabolism. In…
View article: Distribution of 31 endocrine-disrupting compounds in the Taihu Lake and application of the fish plasma model
Distribution of 31 endocrine-disrupting compounds in the Taihu Lake and application of the fish plasma model Open
Background The successful application of Fish plasma model (FPM) will greatly simplify the risk assessment of drugs. At present, the FPM has been applied to the risk assessment of several human drugs with high hydrophobicity. However, its …
View article: Distribution of 31 endocrine disrupting compounds in the Taihu Lake and application of the fish plasma model
Distribution of 31 endocrine disrupting compounds in the Taihu Lake and application of the fish plasma model Open
Background: The successful application of Fish plasma model (FPM) will greatly simplify the risk assessment of drugs. At present, the FPM has been applied to the risk assessment of several human drugs with high hydrophobicity. However, its…
View article: Distribution of 31 endocrine disrupting compounds in the Taihu Lake and application of the fish plasma model
Distribution of 31 endocrine disrupting compounds in the Taihu Lake and application of the fish plasma model Open
Background: The successful application of Fish plasma model (FPM) will greatly simplify the risk assessment of drugs. At present, the FPM has been applied to the risk assessment of several human drugs with high hydrophobicity. However, its…
View article: Development of Real-Time Immuno-PCR Based on Phage Displayed an Anti-Idiotypic Nanobody for Quantitative Determination of Citrinin in Monascus
Development of Real-Time Immuno-PCR Based on Phage Displayed an Anti-Idiotypic Nanobody for Quantitative Determination of Citrinin in Monascus Open
Citrinin (CIT) is a mycotoxin that has been detected in agricultural products, feedstuff, and Monascus products. At present, research has been performed to develop methods for CIT detection, mainly through TLC, HPLC, biosensor, and immunoa…