Wenping Lü
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View article: Traditional Chinese medicine as potential adjuvants for tumor vaccines: a review of types, mechanisms, and forms
Traditional Chinese medicine as potential adjuvants for tumor vaccines: a review of types, mechanisms, and forms Open
Therapeutic cancer vaccines are increasingly recognized as a highly promising approach for tumor treatment; however, their clinical efficacy critically depends on the rational design of vaccine adjuvants. Natural compounds derived from Tra…
View article: Isolation of exosome-like nanovesicles from Yiqi Huoxue Jiedu decoction and their anti-ovarian cancer activity
Isolation of exosome-like nanovesicles from Yiqi Huoxue Jiedu decoction and their anti-ovarian cancer activity Open
Background Ovarian cancer, the deadliest gynecologic malignancy, is marked by high recurrence and poor prognosis. Exosome-like nanovesicles (ELNVs) derived from decocted traditional Chinese medicine (TCM) formulas encapsulate key bioactive…
View article: Cancer outcomes of pregnancy after diagnosis of breast cancer in premenopausal women: an updated systematic review and meta-analysis
Cancer outcomes of pregnancy after diagnosis of breast cancer in premenopausal women: an updated systematic review and meta-analysis Open
Introduction Breast cancer is a type of hormone-driven cancer, and pregnancy may increase the risk of recurrence in patients due to hormone surge. Our study was designed to explore the cancer outcomes of premenopausal women who had primary…
View article: Research hotspots and trends in tumor vaccine adjuvants: A bibliometric analysis from 2010 to 2024
Research hotspots and trends in tumor vaccine adjuvants: A bibliometric analysis from 2010 to 2024 Open
Tumor vaccine adjuvants play a critical role in enhancing anti-tumor immune responses, and it is essential to summarize their research hotspots and future trends. This study retrieved and evaluated 6,177 publications on tumor vaccine adjuv…
View article: Reproductive outcomes of pregnancy after breast cancer: an updated systematic review and meta-analysis
Reproductive outcomes of pregnancy after breast cancer: an updated systematic review and meta-analysis Open
Background Reproductive outcomes following pregnancy in premenopausal women with breast cancer (BC) remain contentious, and few meta-analyses have adequately addressed these questions. This systematic review and meta-analysis aimed to prov…
View article: Interpretation of guidelines for diagnosis and treatment of ovarian cancer with integrated traditional Chinese and western medicine
Interpretation of guidelines for diagnosis and treatment of ovarian cancer with integrated traditional Chinese and western medicine Open
Ovarian cancer (OC) has the highest mortality rate among gynecologic malignant tumors and is clinically difficult to cure. Traditional Chinese medicine (TCM) has shown unique advantages in the treatment of OC. However, there is currently a…
View article: Interpretation of diagnosis and treatment guidelines for breast cancer integrated traditional chinese and western medicine
Interpretation of diagnosis and treatment guidelines for breast cancer integrated traditional chinese and western medicine Open
Breast cancer is the most common malignancy among women worldwide, posing a serious threat to women’s physical and mental health. To address this significant global public health challenge, the Guidelines for the Integrated Diagnosis and T…
View article: PD-1/PD-L1 inhibitors related adverse events: A bibliometric analysis from 2014 to 2024
PD-1/PD-L1 inhibitors related adverse events: A bibliometric analysis from 2014 to 2024 Open
Programmed cell death-1 (PD-1) inhibitors and programmed cell death ligand 1 (PD-L1) inhibitors are considered effective alternatives for the primary treatment of recurrent metastatic cancers. However, they can induce various adverse event…
View article: Transcriptomic analysis reveals potential crosstalk genes and immune relationship between triple-negative breast cancer and depression
Transcriptomic analysis reveals potential crosstalk genes and immune relationship between triple-negative breast cancer and depression Open
TNBC, the most aggressive form of breast cancer, lacks accurate and effective therapeutic targets. Immunotherapy presents a promising approach for addressing TNBC. Anxiety and depression are frequently concurrent symptoms in TNBC patients.…
View article: The mechanisms, hallmarks, and therapies for brain aging and age-related dementia
The mechanisms, hallmarks, and therapies for brain aging and age-related dementia Open
Age-related cognitive decline and dementia are significant manifestations of brain aging. As the elderly population grows rapidly, the health and socio-economic impacts of cognitive dysfunction have become increasingly significant. Althoug…
View article: An exosome-derived lncRNA signature identified by machine learning associated with prognosis and biomarkers for immunotherapy in ovarian cancer
An exosome-derived lncRNA signature identified by machine learning associated with prognosis and biomarkers for immunotherapy in ovarian cancer Open
Background Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies. Current treatment options are limited and ineffective, prompting the discovery of reliable biomarkers. Exosome lncRNAs, carrying genetic inform…
View article: Reversal of tamoxifen resistance by artemisinin in ER+ breast cancer: bioinformatics analysis and experimental validation
Reversal of tamoxifen resistance by artemisinin in ER+ breast cancer: bioinformatics analysis and experimental validation Open
Breast cancer is the leading cause of cancer-related deaths in women worldwide, with Hormone Receptor (HR)+ being the predominant subtype. Tamoxifen (TAM) serves as the primary treatment for HR+ breast cancer. However, drug resistance ofte…
View article: Major Depressive Disorder Trait Genes Promote Triple-Negative Breast Cancer Progression and Predict Immunotherapy Responses
Major Depressive Disorder Trait Genes Promote Triple-Negative Breast Cancer Progression and Predict Immunotherapy Responses Open
TNBC is the most malignant subtype of breast cancer and there are no accurate and effective therapeutic targets. Immunotherapy is a promising approach for the treatment of TNBC. Anxiety and depression are among the most common concomitant …
View article: Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the heterogeneity of cancer-associated fibroblasts in TNBC
Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the heterogeneity of cancer-associated fibroblasts in TNBC Open
TNBC has inter- and intra-tumor heterogeneity, and CAF is one of the sources of this heterogeneity. CD74, SASH3, CD2, TAGAP and CCR7 served as significant marker genes with prognostic and therapeutic value.
View article: Severe mental illness and the risk of breast cancer: A two-sample, two-step multivariable Mendelian randomization study
Severe mental illness and the risk of breast cancer: A two-sample, two-step multivariable Mendelian randomization study Open
Background Based on epidemiological reports, severe mental illness (SMI) and breast cancer (BC) risk are linked positively. However, it is susceptible to clinical confounding factors, such as smoking, alcohol consumption, etc. Here, we per…
View article: Effect of ERCC1 polymorphisms on the response to platinum-based chemotherapy: A systematic review and meta-analysis based on Asian population
Effect of ERCC1 polymorphisms on the response to platinum-based chemotherapy: A systematic review and meta-analysis based on Asian population Open
Background Platinum-based chemotherapy is one of the most common treatments for many cancers; however, the effect of chemotherapy varies from individual to individual. Excision repair cross complementation group 1 (ERCC1) is widely recogni…
View article: Macrophages Phenotype Regulated by IL-6 Are Associated with the Prognosis of Platinum-Resistant Serous Ovarian Cancer: Integrated Analysis of Clinical Trial and Omics
Macrophages Phenotype Regulated by IL-6 Are Associated with the Prognosis of Platinum-Resistant Serous Ovarian Cancer: Integrated Analysis of Clinical Trial and Omics Open
Background. The treatment of platinum-resistant recurrent ovarian cancer (PROC) is a clinical challenge and a hot topic. Tumor microenvironment (TME) as a key factor promoting ovarian cancer progression. Macrophage is a component of TME, a…
View article: Levonorgestrel intrauterine system and breast cancer risk: An updated systematic review and meta-analysis of observational studies
Levonorgestrel intrauterine system and breast cancer risk: An updated systematic review and meta-analysis of observational studies Open
There are inconsistencies in existing studies that prevent us from confirming whether LNG-IUS can increase the risk of BC. Our updated meta-analysis preliminarily suggested that LNG-IUS did not increase the risk of BC, providing evidence f…
View article: Lifestyle factors and the risk associated with conventional adenomas and serrated polyps among healthy people undergoing a medical checkup
Lifestyle factors and the risk associated with conventional adenomas and serrated polyps among healthy people undergoing a medical checkup Open
Background: The association between lifestyle factors and the risk of colon adenomas and serrated polyps (SPs) in the in asymptomatic healthy people is unclear. Aims: The aim of this study was to explore and compare the lifestyle-related r…
View article: Additional file 1 of Comprehensive analysis of a cuproptosis-related ceRNA network implicates a potential endocrine therapy resistance mechanism in ER-positive breast cancer
Additional file 1 of Comprehensive analysis of a cuproptosis-related ceRNA network implicates a potential endocrine therapy resistance mechanism in ER-positive breast cancer Open
Additional file 1. The gene list of 38 common checkpoint regulators retrieved from literature.
View article: Additional file 2 of Comprehensive analysis of a cuproptosis-related ceRNA network implicates a potential endocrine therapy resistance mechanism in ER-positive breast cancer
Additional file 2 of Comprehensive analysis of a cuproptosis-related ceRNA network implicates a potential endocrine therapy resistance mechanism in ER-positive breast cancer Open
Additional file 2. The immunotherapy response prediction results of all the BC samples in TCGA-BRCA based on TIDE algorithm.
View article: <i>PTGIS</i> May Be a Predictive Marker for Ovarian Cancer by Regulating Fatty Acid Metabolism
<i>PTGIS</i> May Be a Predictive Marker for Ovarian Cancer by Regulating Fatty Acid Metabolism Open
Background . Ovarian cancer tends to metastasize to the omentum, which is an organ mainly composed of adipose tissue. Many studies have found that fatty acid metabolism is related to the occurrence and metastasis of cancers. Therefore, it …
View article: The role of PKC/PKR in aging, Alzheimer's disease, and perioperative neurocognitive disorders
The role of PKC/PKR in aging, Alzheimer's disease, and perioperative neurocognitive disorders Open
Background The incidence of perioperative neurocognitive disorders (PNDs) is reportedly higher in older patients. Mitochondrial and synaptic dysfunctions have consistently been demonstrated in models of aging and neurodegenerative diseases…