Wenjun Ouyang
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View article: COPD-associated proteins as biomarkers and drug targets: Insights from genetic and proteomic analyses
COPD-associated proteins as biomarkers and drug targets: Insights from genetic and proteomic analyses Open
Chronic obstructive pulmonary disease (COPD) is a major global health burden with significant morbidity and mortality. Identifying circulating protein biomarkers may help understand COPD pathogenesis and develop novel therapeutic targets. …
View article: Exploring the mechanisms by which common inhalational anesthetics influence malignant tumor metastasis: A data mining study based on comparative toxicogenomic databases
Exploring the mechanisms by which common inhalational anesthetics influence malignant tumor metastasis: A data mining study based on comparative toxicogenomic databases Open
Surgery remains the primary treatment for solid malignant tumors, but controlling postoperative tumor recurrence and metastasis continues to be a major challenge. Understanding the factors that influence tumor recurrence and metastasis aft…
View article: Unlocking the small RNAs: local and systemic modulators for advancing agronomic enhancement
Unlocking the small RNAs: local and systemic modulators for advancing agronomic enhancement Open
Small regulatory RNAs (sRNAs) are essential regulators of gene expression across a wide range of organisms to precisely modulate gene activity based on sequence-specific recognition. In model plants like Arabidopsis thaliana, extensive res…
View article: Liver Metastasis Modulate Responses of Suppressive Macrophages and Exhausted T Cells to Immunotherapy Revealed by Single Cell Sequencing
Liver Metastasis Modulate Responses of Suppressive Macrophages and Exhausted T Cells to Immunotherapy Revealed by Single Cell Sequencing Open
Liver metastasis is associated with immunotherapy resistance, although the underlying mechanisms remain incompletely understood. By applying single cell RNA‐sequencing to a concurrent subcutaneous and liver tumor murine model to recapitula…
View article: STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets
STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets Open
Single-cell RNA sequencing is a powerful tool to examine cellular heterogeneity, novel markers and target genes, and therapeutic mechanisms in human cancers and animal models. Here, we analyzed single-cell RNA sequencing data of T cells ob…
View article: Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis
Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis Open
T cells are crucial for the success of immune-based cancer therapy. Reinvigorating antitumor T cell activity by blocking checkpoint inhibitory receptors has provided clinical benefits for many cancer patients. However, the efficacy of thes…
View article: LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody–Induced Tumor Cell Killing by Effector CD8+ T Cells
LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody–Induced Tumor Cell Killing by Effector CD8+ T Cells Open
Elicitation of tumor cell killing by CD8+ T cells is an effective therapeutic approach for cancer. In addition to using immune checkpoint blockade to reinvigorate existing but unresponsive tumor-specific T cells, alternative therapeutic ap…
View article: Nonclinical safety assessment of a human interleukin‐22<scp>FC IG</scp> fusion protein demonstrates in vitro to in vivo and cross‐species translatability
Nonclinical safety assessment of a human interleukin‐22<span>FC IG</span> fusion protein demonstrates in vitro to in vivo and cross‐species translatability Open
Although Interleukin‐22 ( IL ‐22) is produced by various leukocytes, it preferentially targets cells with epithelial origins. IL ‐22 exerts essential roles in modulating various tissue epithelial functions, such as innate host defense agai…
View article: TRIMming TGF-β signals in Th17 cells
TRIMming TGF-β signals in Th17 cells Open
The precise downstream mediators of TGF-β signaling in Th17 and T reg cells remain unclear. In this issue of JEM, Tanaka et al. report that Trim33 transduces TGF-β signals in Th17 cells to generate an optimal proinflammatory cytokine profi…
View article: Proteomic Analysis of NRROS Interactome Reveals the Presence of Chaperones and Mediators of the ERAD Pathway
Proteomic Analysis of NRROS Interactome Reveals the Presence of Chaperones and Mediators of the ERAD Pathway Open
Negative regulator of reactive oxygen species (NRROS, previously called LRRC33) is a leucine-rich repeat (LRR) domain containing, ER-resident transmembrane protein expressed primarily in lymphoid organs, especially in myeloid cells. We hav…
View article: Inflammatory Bowel Disease Susceptibility Gene <i>C1ORF106</i> Regulates Intestinal Epithelial Permeability
Inflammatory Bowel Disease Susceptibility Gene <i>C1ORF106</i> Regulates Intestinal Epithelial Permeability Open
Intestinal epithelial cells form a physical barrier that is tightly regulated to control intestinal permeability. Proinflammatory cytokines, such as TNF-α, increase epithelial permeability through disruption of epithelial junctions. The re…
View article: Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB
Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB Open
Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulator…
View article: IL-17A–Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis
IL-17A–Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis Open
This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling in mice attenuated tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and m…
View article: Targeting IL-10 Family Cytokines for the Treatment of Human Diseases
Targeting IL-10 Family Cytokines for the Treatment of Human Diseases Open
Members of the interleukin (IL)-10 family of cytokines play important roles in regulating immune responses during host defense but also in autoimmune disorders, inflammatory diseases, and cancer. Although IL-10 itself primarily acts on leu…
View article: IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice
IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice Open
Diabetic foot ulcers (DFU) are one of the major complications in type II diabetes patients and can result in amputation and morbidity. Although multiple approaches are used clinically to help wound closure, many patients still lack adequat…
View article: Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases
Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases Open
Retinoic acid-related orphan receptor gamma t (RORγt) is a nuclear receptor, which is selectively expressed by various lymphocytes. RORγt is critical for the development of secondary and tertiary lymphoid organs, and for the thymic develop…
View article: Understanding the Surface Hopping View of Electronic Transitions and Decoherence
Understanding the Surface Hopping View of Electronic Transitions and Decoherence Open
We present a current, up-to-date review of the surface hopping methodology for solving nonadiabatic problems, 25 years after Tully published the fewest switches surface hopping algorithm. After reviewing the original motivation for and fai…
View article: Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome
Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome Open
Commensal microbiota are critical for the development of local immune responses. In this article, we show that gut microbiota can regulate CD4 T cell polarization during pulmonary fungal infections. Vancomycin drinking water significantly …