Weyland Cheng
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View article: Research progress on sarcopenia in the musculoskeletal system
Research progress on sarcopenia in the musculoskeletal system Open
View article: Environmental exposure pathways of microplastics and their toxic effects on ecosystems and the nervous system
Environmental exposure pathways of microplastics and their toxic effects on ecosystems and the nervous system Open
Microplastics are a troubling consequence of modern civilization, permeating ecosystems worldwide and posing a risk to both the environment and human health. As studies have revealed their extensive distribution throughout bodies of water,…
View article: A RT-ERA-CRISPR/Cas12a assay for rapid point-of-care duck hepatitis A virus detection
A RT-ERA-CRISPR/Cas12a assay for rapid point-of-care duck hepatitis A virus detection Open
View article: <i>Klebsiella pneumoniae</i> derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications
<i>Klebsiella pneumoniae</i> derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications Open
Klebsiella pneumoniae is a gram-negative pathogen that can cause multiple diseases including sepsis, urinary tract infections, and pneumonia. The escalating detections of hypervirulent and antibiotic-resistant isolates are giving ri…
View article: Epidemiological and molecular characteristics of carbapenem-resistant Klebsiella pneumoniae from pediatric patients in Henan, China
Epidemiological and molecular characteristics of carbapenem-resistant Klebsiella pneumoniae from pediatric patients in Henan, China Open
View article: A new vacuum-assisted low-pressure investment casting process for K446 alloy
A new vacuum-assisted low-pressure investment casting process for K446 alloy Open
View article: Comparison of Glisson traction, soft or rigid cervical collars for the treatment of acute atlantoaxial rotatory subluxation in children: a retrospective study
Comparison of Glisson traction, soft or rigid cervical collars for the treatment of acute atlantoaxial rotatory subluxation in children: a retrospective study Open
To examine the clinical effect of different conservative therapies (Glisson traction, soft and rigid cervical collar) in the treatment of children with acute atlantoaxial rotatory subluxation. One hundred and forty-four children with acute…
View article: Pan-cancer analysis of the role of MPP7 in human tumors
Pan-cancer analysis of the role of MPP7 in human tumors Open
MAGUK p55 subfamily member 7, a part of the membrane palmitoylated protein subfamily, is an essential adapter that promotes epithelial cell polarity and has increasing significance in multiple cancers, including esophageal cancer, clear ce…
View article: A Statistical Framework for Assessing the Relationship between Biomarkers and Clinical Endpoints in Alzheimer's Disease
A Statistical Framework for Assessing the Relationship between Biomarkers and Clinical Endpoints in Alzheimer's Disease Open
View article: Clinical characteristics of neonatal and infant osteomyelitis and septic arthritis: a multicenter retrospective study
Clinical characteristics of neonatal and infant osteomyelitis and septic arthritis: a multicenter retrospective study Open
Distinct differences were found between neonatal and infants with osteoarticular infections. Future studies should focus on improving diagnosis and subsequent treatment regimens for younger age groups.
View article: Relationship between biofilm formation and antibiotic resistance of Klebsiella pneumoniae and updates on antibiofilm therapeutic strategies
Relationship between biofilm formation and antibiotic resistance of Klebsiella pneumoniae and updates on antibiofilm therapeutic strategies Open
Klebsiella pneumoniae is a Gram-negative bacterium within the Enterobacteriaceae family that can cause multiple systemic infections, such as respiratory, blood, liver abscesses and urinary systems. Antibiotic resistance is a global health …
View article: Anticancer therapy-induced adverse drug reactions in children and preventive and control measures
Anticancer therapy-induced adverse drug reactions in children and preventive and control measures Open
In recent years, considerable achievements have been made in pediatric oncology with the innovation and development of antitumor drugs. However, compared to adults, children as a special group have not yet matured fully in terms of liver a…
View article: Function and therapeutic prospects of next-generation probiotic Akkermansia muciniphila in infectious diseases
Function and therapeutic prospects of next-generation probiotic Akkermansia muciniphila in infectious diseases Open
Akkermansia muciniphila is a gram-negative bacterium that colonizes the human gut, making up 3–5% of the human microbiome. A. muciniphila is a promising next-generation probiotic with clinical application prospects. Emerging studies have r…
View article: Joint analysis of the metabolomics and transcriptomics uncovers the dysregulated network and develops the diagnostic model of high-risk neuroblastoma
Joint analysis of the metabolomics and transcriptomics uncovers the dysregulated network and develops the diagnostic model of high-risk neuroblastoma Open
View article: Clinical Associations of Bitter Taste Perception and Bitter Taste Receptor Variants and the Potential for Personalized Healthcare
Clinical Associations of Bitter Taste Perception and Bitter Taste Receptor Variants and the Potential for Personalized Healthcare Open
Bitter taste receptors (T2Rs) consist of 25 functional receptors that can be found in various types of cells throughout the human body with responses ranging from detecting bitter taste to suppressing pathogen-induced inflammation upon act…
View article: Efficacy and safety of vancomycin-loaded calcium sulfate versus conventional surgical debridement for pediatric acute osteomyelitis: a retrospective study
Efficacy and safety of vancomycin-loaded calcium sulfate versus conventional surgical debridement for pediatric acute osteomyelitis: a retrospective study Open
View article: A systematic review of circulating-free MYCN amplification status as a noninvasive and prominent prognostic and recurrence monitoring indicator for neuroblastoma
A systematic review of circulating-free MYCN amplification status as a noninvasive and prominent prognostic and recurrence monitoring indicator for neuroblastoma Open
MYCN gene plays an important role in neuroblastoma cell growth, apoptosis, differentiation, tumor infiltration, metastasis, and angiogenesis. MYCN gene amplification status in tumor tissue is one of the important clinical indicators of neu…
View article: Plasma circulating cell‐free <scp><i>MYCN</i></scp> gene: A noninvasive and prominent recurrence monitoring indicator of neuroblastoma
Plasma circulating cell‐free <span><i>MYCN</i></span> gene: A noninvasive and prominent recurrence monitoring indicator of neuroblastoma Open
The postoperative recurrence of neuroblastoma (NB) patients is an essential reason for the high mortality of NB due to the lack of early, non‐invasive, and dynamic strategies for monitoring NB recurrence. Therefore, whether the plasma circ…
View article: Plasma circulating cell-free MYCN gene: a noninvasive and prominent recurrence monitoring indicator of neuroblastoma
Plasma circulating cell-free MYCN gene: a noninvasive and prominent recurrence monitoring indicator of neuroblastoma Open
The postoperative recurrence of neuroblastoma (NB) patients is an essential reason for the high mortality of NB due to the lack of early, non-invasive, and dynamic strategies for monitoring NB recurrence. Therefore, whether the plasma circ…
View article: Six-Year Follow-Up of a Rare Bifid Talus and Eight-Toed Central Polydactyly: A Case Report
Six-Year Follow-Up of a Rare Bifid Talus and Eight-Toed Central Polydactyly: A Case Report Open
View article: Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors
Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors Open
The screened compound DYT-1 from our in-house library was taken as a lead (inhibiting tubulin polymerisation: IC50=25.6 µM, anti-angiogenesis in Zebrafish: IC50=38.4 µM, anti-proliferation against K562 and Jurkat: IC<…
View article: A systematic review of Vaccine Breakthrough Infections by SARS-CoV-2 Delta Variant
A systematic review of Vaccine Breakthrough Infections by SARS-CoV-2 Delta Variant Open
Vaccines are proving to be highly effective in controlling hospitalization and deaths associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as shown by clinical trials and real-world evidence. However, a d…
View article: Dual Isothermal Amplification All-in-One Approach for Rapid and Highly Sensitive Quantification of Plasma Circulating Mycn Gene of Neuroblastoma
Dual Isothermal Amplification All-in-One Approach for Rapid and Highly Sensitive Quantification of Plasma Circulating Mycn Gene of Neuroblastoma Open
View article: Rapid electrochemical quantification of trace Hg<sup>2+</sup> using a hairpin DNA probe and quantum dot modified screen-printed gold electrodes
Rapid electrochemical quantification of trace Hg<sup>2+</sup> using a hairpin DNA probe and quantum dot modified screen-printed gold electrodes Open
A ratiometric hairpin DNA probe based electrochemical biosensor, which relies on hairpin DNA probes conjugated with water-soluble and carboxyl functionalized quantum dot on screen-printed gold electrodes, was developed for Hg 2+ detection.
View article: Carbapenem-Resistant Klebsiella pneumoniae Osteomyelitis Treated with Ceftazidime-Avibactam in an Infant: A Case Report
Carbapenem-Resistant Klebsiella pneumoniae Osteomyelitis Treated with Ceftazidime-Avibactam in an Infant: A Case Report Open
Increasing cases of carbapenem-resistant Klebsiella pneumoniae (CR-KP) infections have been observed globally where multi-drug resistance to CR-KP can make the infection difficult to treat. In recent years, the β-lactam/β-lactamase …
View article: MRI recovery of the Achilles tendon after percutaneous tenotomy in older children
MRI recovery of the Achilles tendon after percutaneous tenotomy in older children Open
Background An observational study was conducted to evaluate the recovery of older children with relapsed congenital clubfoot who underwent an Achilles tenotomy for the second time as part of the Ponseti treatment. Methods Thirteen patients…
View article: Bitter Taste Receptor as a Therapeutic Target in Orthopaedic Disorders
Bitter Taste Receptor as a Therapeutic Target in Orthopaedic Disorders Open
Non-gustatory, extraoral bitter taste receptors (T2Rs) are G-protein coupled receptors that are expressed throughout the body and have various functional responses when stimulated by bitter agonists. Presently, T2Rs have been found to be e…
View article: Additional file 1 of MRI recovery of the Achilles tendon after percutaneous tenotomy in older children
Additional file 1 of MRI recovery of the Achilles tendon after percutaneous tenotomy in older children Open
Additional file 1:. Supplementary data.
View article: CRISPR-Based Approaches for Efficient and Accurate Detection of SARS-CoV-2
CRISPR-Based Approaches for Efficient and Accurate Detection of SARS-CoV-2 Open
An outbreak of COVID-19, caused by infection with SARS-CoV-2 in Wuhan, China in December 2019, spread throughout the country and around the world, quickly. The primary detection technique for SARS-CoV-2, the reverse-transcription polymeras…
View article: Feedforward Coordinate Control of a Robotic Cell Injection Catheter
Feedforward Coordinate Control of a Robotic Cell Injection Catheter Open
Remote and robotically actuated catheters are the stepping-stones toward autonomous catheters, where complex intravascular procedures may be performed with minimal intervention from a physician. This article proposes a concept for the posi…