Wenqin Xie
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View article: Spatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications (Small Methods 5/2025)
Spatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications (Small Methods 5/2025) Open
View article: Precise Characterization of Cellular States and Spatial Variable Patterns within Spatial Transcriptomics
Precise Characterization of Cellular States and Spatial Variable Patterns within Spatial Transcriptomics Open
Spatial transcriptomics enables the simultaneous characterization of gene expression and spatial organization, providing transformative insights into tissue architecture and function. While numerous tools have been developed to identify sp…
View article: Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator
Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator Open
Biased allosteric modulators (BAMs) of G protein-coupled receptors (GPCRs) have been at the forefront of drug discovery owing to their potential to selectively stimulate therapeutically relevant signaling and avoid on-target side effects. …
View article: Biochar modified iron tailings reutilized for Cr(VI) removing in acid mine drainage
Biochar modified iron tailings reutilized for Cr(VI) removing in acid mine drainage Open
View article: Sunlight-Triggered Probiotic Synergistic in red soil: A novel and biosafe strategy for Cr(VI) Remediation
Sunlight-Triggered Probiotic Synergistic in red soil: A novel and biosafe strategy for Cr(VI) Remediation Open
View article: Structural features of arrestin-mediated GPCR signaling
Structural features of arrestin-mediated GPCR signaling Open
G protein-coupled receptors (GPCRs) constitute a diverse and extensive array of cell surface receptors, rendering them essential targets for drugs aimed at various human diseases. Responding to a range of extracellular or intracellular cue…
View article: Resolving tumor evolution: a phylogenetic approach
Resolving tumor evolution: a phylogenetic approach Open
View article: shinyTempSignal: an R shiny application for exploring temporal and other phylogenetic signals
shinyTempSignal: an R shiny application for exploring temporal and other phylogenetic signals Open
The molecular clock model is fundamental for inferring species divergence times from molecular sequences. However, its direct application may introduce significant biases due to sequencing errors, recombination events, and inaccurately lab…
View article: Associated factors of osteoporosis and vascular calcification in patients awaiting kidney transplantation
Associated factors of osteoporosis and vascular calcification in patients awaiting kidney transplantation Open
Introduction Pretransplant osteoporosis and vascular calcification probably increase the risk of fractures and cardiovascular events after kidney transplantation. In the present study, we investigated the related risk factors of osteoporos…
View article: Stemness Analysis Uncovers That The Peroxisome Proliferator-Activated Receptor Signaling Pathway Can Mediate Fatty Acid Homeostasis In Sorafenib-Resistant Hepatocellular Carcinoma Cells
Stemness Analysis Uncovers That The Peroxisome Proliferator-Activated Receptor Signaling Pathway Can Mediate Fatty Acid Homeostasis In Sorafenib-Resistant Hepatocellular Carcinoma Cells Open
Hepatocellular carcinoma (HCC) stem cells are regarded as an important part of individualized HCC treatment and sorafenib resistance. However, there is lacking systematic assessment of stem-like indices and associations with a response of …
View article: GIMICA: host genetic and immune factors shaping human microbiota
GIMICA: host genetic and immune factors shaping human microbiota Open
Besides the environmental factors having tremendous impacts on the composition of microbial community, the host factors have recently gained extensive attentions on their roles in shaping human microbiota. There are two major types of host…
View article: Melanocortin-4 receptor expression in autonomic circuitry involved in gastric function.
Melanocortin-4 receptor expression in autonomic circuitry involved in gastric function. Open
Several studies have shown that CNS provides the regulation of gastric functions. Recent evidence indicated that the activation of melanocortin 4 receptors (MC4R) in brain nuclei played an important role in modulating gastric activity. Thi…