Wenshi Chen
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View article: Bio-inspired deposition of gold nanoparticles onto the surface of kaolin for in vitro management of human ovarian cancer and modulation of the inflammatory response in adenomyosis-induced mice in vivo via the MAPK signaling pathway
Bio-inspired deposition of gold nanoparticles onto the surface of kaolin for in vitro management of human ovarian cancer and modulation of the inflammatory response in adenomyosis-induced mice in vivo via the MAPK signaling pathway Open
A mild and eco-friendly protocol has been developed for the preparation of kaolin-decorated Au nanoparticles mediated by Ephedra root extract as a green reducing and stabilizing agents without any toxic substrates. Structural features of t…
View article: The Risk Factors for New-Onset Calf Muscle Venous Thrombosis after Hip Fracture Surgery
The Risk Factors for New-Onset Calf Muscle Venous Thrombosis after Hip Fracture Surgery Open
Background: Calf muscle venous thrombosis (CMVT) is among the most important medical complications after hip surgery. CMVT has been known for many years, but many opinions about the incidence and risk factors of CMVT are still controversia…
View article: Dynamic Movement Primitives Based Robot Skills Learning
Dynamic Movement Primitives Based Robot Skills Learning Open
In this article, a robot skills learning framework is developed, which considers both motion modeling and execution. In order to enable the robot to learn skills from demonstrations, a learning method called dynamic movement primitives (DM…
View article: Investigation of the Difference in the Pulse Current in the Double Pulsed Gas Metal Arc Welding of Aluminum Alloys
Investigation of the Difference in the Pulse Current in the Double Pulsed Gas Metal Arc Welding of Aluminum Alloys Open
In this paper, a double pulse gas metal arc welding (DP-GMAW) for an AA6061-T6 aluminum alloy based on fewer basic welding parameters than the traditional DP-GMAW is proposed. This study compared the difference in pulse base currents (ΔIb)…
View article: Rho-Associated Protein Kinase Inhibitor Treatment Promotes Proliferation and Phagocytosis in Trabecular Meshwork Cells
Rho-Associated Protein Kinase Inhibitor Treatment Promotes Proliferation and Phagocytosis in Trabecular Meshwork Cells Open
Y-27632 promoted cell proliferation and phagocytosis of TM cells, and its proliferative effect was demonstrated in a transgenic mouse model. These results revealed a new IOP-lowering mechanism of Y-27632 through effects on TM cells, sugges…
View article: Integrative transcriptomic and proteomic analysis reveals CD9/ITGA4/PI3K‐Akt axis mediates trabecular meshwork cell apoptosis in human glaucoma
Integrative transcriptomic and proteomic analysis reveals CD9/ITGA4/PI3K‐Akt axis mediates trabecular meshwork cell apoptosis in human glaucoma Open
Glaucoma has been the leading cause of irreversible blindness worldwide. High intraocular pressure (IOP) is a high‐risk factor of glaucoma, repression of which has been the important treatment of glaucoma in clinic. Trabecular meshwork is …
View article: Progress of Rho-associated protein kinase inhibitor in the treatment of glaucoma
Progress of Rho-associated protein kinase inhibitor in the treatment of glaucoma Open
Glaucoma is a leading cause of irreversible blindness, which is characterized by characteristic optic atrophy and visual field defects. Elevated intraocular pressure(IOP)is a primary risk factor of glaucoma, while the main cause of elevate…
View article: Compound heterozygous mutations in CYP1B1 gene leads to severe primary congenital glaucoma phenotype
Compound heterozygous mutations in CYP1B1 gene leads to severe primary congenital glaucoma phenotype Open
A novel A330F mutation is identified in the CYP1B1 gene of Chinese PCG patient. Moreover, in combination with other mutation R390H, this PCG patient shows significant difference in the CYP1B1 protein structure, which may specifically contr…
View article: Expressional and functional involvement of gap junctions in aqueous humor outflow into the ocular trabecular meshwork of the anterior chamber.
Expressional and functional involvement of gap junctions in aqueous humor outflow into the ocular trabecular meshwork of the anterior chamber. Open
The GJA1 and GJA8 gap junction proteins, in particular, are robustly expressed in human TM cells and tissues. Pharmacological inhibition of gap junction channels causes an increased resistance of AH outflow and an elevation of IOP in mice.…