Wentian Chen
YOU?
Author Swipe
View article: Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake
Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake Open
Although histone deacetylase (HDAC) inhibitors have demonstrated significant advantages in the field of targeted cancer therapy, numerous adverse events have been observed due to the high doses required to achieve therapeutic effects. Addi…
View article: N-Glycan Profiles of Neuraminidase from Avian Influenza Viruses
N-Glycan Profiles of Neuraminidase from Avian Influenza Viruses Open
The cleavage of sialic acids by neuraminidase (NA) facilitates the spread of influenza A virus (IV) descendants. Understanding the enzymatic activity of NA aids research into the transmission of IVs. An effective method for purifying NA wa…
View article: Design, Synthesis, and Antitumor Activity Evaluation of Polyamine Protac Conjugates as Degraders of Histone Deacetylase
Design, Synthesis, and Antitumor Activity Evaluation of Polyamine Protac Conjugates as Degraders of Histone Deacetylase Open
View article: Characterization of aberrant glycosylation associated with osteoarthritis based on integrated glycomics methods
Characterization of aberrant glycosylation associated with osteoarthritis based on integrated glycomics methods Open
Background Osteoarthritis (OA) is the most common form of arthritis, affecting millions of aging people. Investigation of abnormal glycosylation is essential for the understanding of pathological mechanisms of OA. Methods The total protein…
View article: Bovine milk glycoproteins inhibit SARS-CoV-2 and influenza virus co-infection
Bovine milk glycoproteins inhibit SARS-CoV-2 and influenza virus co-infection Open
The attachment of S1 subunit of spike (S) protein to angiotensin-converting enzyme 2 (ACE2) is the first and crucial step of SARS-CoV-2 infection. Although S protein and ACE2 are heavily glycosylated, the precise roles of glycans in their …
View article: Ir-Photocatalyzed Radical Cascade Cyclization for the Synthesis of Indoline Derivatives with a C3 Quaternary Center Via Gem-Difluoroalkylation/C(Sp2) − H Functionalization
Ir-Photocatalyzed Radical Cascade Cyclization for the Synthesis of Indoline Derivatives with a C3 Quaternary Center Via Gem-Difluoroalkylation/C(Sp2) − H Functionalization Open
View article: Rational Design of Imine Reductase for Asymmetric Synthesis of Α-Methyl-Benzylaminonitrogen Heterocycles
Rational Design of Imine Reductase for Asymmetric Synthesis of Α-Methyl-Benzylaminonitrogen Heterocycles Open
View article: Efficient Biosynthesis of (S)-1-chloro-2-heptanol Catalyzed by a Newly Isolated Fungi Curvularia hominis B-36
Efficient Biosynthesis of (S)-1-chloro-2-heptanol Catalyzed by a Newly Isolated Fungi Curvularia hominis B-36 Open
(S)-1-chloro-2-heptanol is an enantiopure chemical of great value that can synthesize Treprostinil for treating primary pulmonary hypertension. In this work, a new strain B-36, capable of asymmetric reduction of 1-chloro-2-heptanone to (S)…
View article: Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis
Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis Open
View article: Elevation of α-1,3 fucosylation promotes binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis
Elevation of α-1,3 fucosylation promotes binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis Open
Background: Osteoarthritis (OA) is characterized by ECM degradation in chondrocytes and inflammation of the synovial membrane. Fucosylation is a main type of glycosylation, and is involved in a variety of pathological processes, including …
View article: Salivary protein glycopatterns for natural regulation of oral microbiota
Salivary protein glycopatterns for natural regulation of oral microbiota Open
Background：Little is known about the relationship between salivary protein glycopatterns and oral microbial communities in the patients of gastric cancer (GC) and type 2 diabetes mellitus (T2DM).Methods：In this study, the oral microbiome o…
View article: Author response for "Characterization of Glucose-Binding Proteins Isolated from Health Volunteers and Human Type 2 Diabetes Mellitus Patients"
Author response for "Characterization of Glucose-Binding Proteins Isolated from Health Volunteers and Human Type 2 Diabetes Mellitus Patients" Open
View article: Bioinformatics analysis reveals that ANXA1 and SPINK5 are novel tumor suppressor genes in patients with oral squamous cell carcinoma
Bioinformatics analysis reveals that ANXA1 and SPINK5 are novel tumor suppressor genes in patients with oral squamous cell carcinoma Open
Our findings uncovered 7 potential biomarkers of OSCC patients, with ANXA1 and SPINK5 serving as potential tumor suppressor genes in OSCC.
View article: The N-glycosylation sites and Glycan-binding ability of S-protein in SARS-CoV-2 Coronavirus
The N-glycosylation sites and Glycan-binding ability of S-protein in SARS-CoV-2 Coronavirus Open
The emerging acute respiratory disease, COVID-19, caused by SARS-CoV-2 Coronavirus (SARS2 CoV) has spread fastly all over the word. As a member of RNA viruses, the glycosylation of envelope glycoprotein plays the crucial role in protein fo…
View article: Regulation of N6-Methyladenosine in the Differentiation of Cancer Stem Cells and Their Fate
Regulation of N6-Methyladenosine in the Differentiation of Cancer Stem Cells and Their Fate Open
N6-methyladenosine (m6A) is one of the most common internal RNA modifications in eukaryotes. It is a dynamic and reversible process that requires an orchestrated participation of methyltransferase, demethylase, and methylated binding prote…
View article: Analysis of the Differentially Expressed Genes Induced by Cisplatin Resistance in Oral Squamous Cell Carcinomas and Their Interaction
Analysis of the Differentially Expressed Genes Induced by Cisplatin Resistance in Oral Squamous Cell Carcinomas and Their Interaction Open
In the OSCC cisplatin-resistant cell lines, NOTCH1, JUN, CTNNB1, CEBPA, and ETS1 were found as the hub genes involved in regulating the cisplatin resistance of OSCC. Members of the miR-200 family may reve…
View article: Integrated glycomics strategy for the evaluation of glycosylation alterations in salivary proteins associated with type 2 diabetes mellitus
Integrated glycomics strategy for the evaluation of glycosylation alterations in salivary proteins associated with type 2 diabetes mellitus Open
The strategy to investigate the altered glycosylation associated with T2DM.
View article: The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer
The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer Open
Objective . To investigate the expression patterns and prognostic values of STEAP family members in the occurrence and development of breast cancer. Materials and Methods . The Human Protein Atlas was used to analyze the expression level o…